• Molecules and Cells
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• 제43권3호
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• pp.276-285
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• 2020

Circadian rhythm is an endogenous oscillation of about 24-h period in many physiological processes and behaviors. This daily oscillation is maintained by the molecular clock machinery with transcriptional-translational feedback loops mediated by clock genes including Period2 (Per2) and Bmal1. Recently, it was revealed that gut microbiome exerts a significant impact on the circadian physiology and behavior of its host; however, the mechanism through which it regulates the molecular clock has remained elusive. 3-(4-hydroxyphenyl)propionic acid (4-OH-PPA) and 3-phenylpropionic acid (PPA) are major metabolites exclusively produced by Clostridium sporogenes and may function as unique chemical messengers communicating with its host. In the present study, we examined if two C. sporogenes-derived metabolites can modulate the oscillation of mammalian molecular clock. Interestingly, 4-OH-PPA and PPA increased the amplitude of both PER2 and Bmal1 oscillation in a dose-dependent manner following their administration immediately after the nadir or the peak of their rhythm. The phase of PER2 oscillation responded differently depending on the mode of administration of the metabolites. In addition, using an organotypic slice culture ex vivo, treatment with 4-OH-PPA increased the amplitude and lengthened the period of PER2 oscillation in the suprachiasmatic nucleus and other tissues. In summary, two C. sporogenes-derived metabolites are involved in the regulation of circadian oscillation of Per2 and Bmal1 clock genes in the host's peripheral and central clock machineries.

• 대한임베디드공학회논문지
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• 제13권5호
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• pp.261-268
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• 2018

Phase Change Memory(PCM) with low power consumption and high integration attracts attention as a next generation nonvolatile memory replacing DRAM. However, there is a problem that PCM has long latency and high energy consumption due to the writing operation. The PCM & DRAM hybrid memory structure is a fruitful structure that can overcome the disadvantages of such PCM. However, the page replacement algorithm is important, because these structures use two memory of different characteristics. The purpose of this document is to effectively manage pages that can be referenced in memory, taking into account the characteristics of DRAM and PCM. In order to manage these pages, this paper proposes an page replacement algorithm based on frequently accessed and recently paged. According to our simulation, the proposed algorithm for the DRAM&PCM hybrid can reduce the energy-delay product by around 10%, compared with Clock-DWF and CLOCK-HM.

• JSTS:Journal of Semiconductor Technology and Science
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• 제10권1호
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• pp.1-10
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• 2010

This paper proposes a two-phase clocked adiabatic static CMOS logic (2PASCL) circuit that utilizes the principles of adiabatic switching and energy recovery. The low-power 2PASCL circuit uses two complementary split-level sinusoidal power supply clocks whose height is equal to $V_{dd}$. It can be directly derived from static CMOS circuits. By removing the diode from the charging path, higher output amplitude is achieved and the power consumption of the diode is eliminated. 2PASCL has switching activity that is lower than dynamic logic. We also design and simulate NOT, NAND, NOR, and XOR logic gates on the basis of the 2PASCL topology. From the simulation results, we find that 2PASCL 4-inverter chain logic can save up to 79% of dissipated energy as compared to that with a static CMOS logic at transition frequencies of 1 to 100 MHz. The results indicate that 2PASCL technology can be advantageously applied to low power digital devices operated at low frequencies, such as radio-frequency identifications (RFIDs), smart cards, and sensors.

• 전자공학회논문지T
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• 제35T권3호
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• pp.128-133
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• 1998

본 논문은 클록 초기치 누적 방식의 직접 디지털 주파수 합성기를 이용한 변조기의 성능해석에 관하여 연구한 것이다. 기존에는 랜덤한 주파수 도약을 실현하기 위하여 PLL 방식이나 디지털 주파수 합성 방식이 사용되어 왔다. 븐 논문에서는 두 방식의 단점을 개선하기 위하여 클록 초기치 누적 방식의 DDFS를 이용한 변조기 시스템을 구성하여 순시적인 주파수 도약 상태와 위상제어의 가능성 등을 확인하였다. 실험 결과 합성된 출력 주파수는 주파수 Index에 따라 기준주파수에 정확히 정수배가 되며, 합성된 정현파형의 스펙트럼은 기본파와 여러 고조파의 크기가 50 [㏈] 이상의 차이가 남으로서 고조파 성분들이 상당히 감소되었고, PN 코드를 사용한 순시적인 주파수 도약 상태는 스위칭 시간이 빠르기 때문에 주파수 도약 특성이 뛰어남을 알 수 있었다. 또한, 누산기의 set/reset상태변화에 따라 위상이 변한다는 사실도 입증하였다.

• Animal cells and systems
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• 제6권3호
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• pp.239-245
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• 2002

Plasma melatonin, thyroid-stimulating hormone (TSH) and body temperature were measured simultaneously and continuously before and after the sleep-wake cycle was shifted in 4 healthy males and changes in the circadian rhythm itself and in the phase relationship among these circadian rhythms were determined. Normal sleep-wake cycle (sleep hours: 2300-0700) was delayed by 10 h (sleep hours: 0900-1700) during the experiment. Even after this shift the typical melatonin rhythm was maintained: low during daytime and high during night. The melatonin rhythm was gradually delayed day by day. The TSH rhythm was also maintained fundamentally during 3 consecutive days of altered sleep-wake cycle. The phase was also delayed gradually but remarkably. The daily rhythm of body temperature was changed by the alteration of sleep-wake cycle. The body temperature began to decrease at the similar clock time as in the control but the decline during night awake period was less steep and the lowered body temperature persisted during sleep. The hormonal profiles during the days of shifted sleep/wake cycle suggest that plasma melatonin and TSH rhythms are basically regulated by an endogenous biological clock. The parallel phase shift of melatonin and TSH upon the change in sleep-wake cycle suggests that a common unitary pacemaker probably regulates these two rhythms. The reversal phase relationship between body temperature and melatonin suggests that melatonin may have a hypothermic effect on body temperature. The altered body temperature rhythm suggests that the awake status during night may inhibit the circadian decrease in body temperature and that sleep sustains the lowered body temperature. It is probable but uncertain that there ave causal relationships among sleep, melatonin, TSH, and body temperature.

• 한국통신학회논문지
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• 제26권12C호
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• pp.255-260
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• 2001

본 논문에서는 새로운 locking 알고리즘을 사용하여 저전력의 특정을 가지면서 locking 속도가 빠른 Register Controlled DLL(Delay-Locked Loop)을 설계하였다. Locking 속도의 향상을 위해 제안한 알고리즘은 coarse와 fine controller를 각각 동작시키는 것으로, phase detector에서 출력되는 up/down 신호를 먼저 coarse controller에 인가하여 외부 클럭과 내부 클럭의 큰 위상차를 줄이고, coarse controller를 고정시킨 상태에서 up/down 신호를 fine controller에 인가하여 미세 지연 시간을 조정하도록 하는 것이다. 또한 제안한 DLL은 dual controller를 사용하지만 locking 동작시 한 개의 controller만 동작하므로 소비 전력을 줄일 수 있었으며 lock indicator를 사용하여 좋은 지터 특성을 보였다. 제안한 DLL은 0.6 $\mu\textrm{m}$ CMOS 공정 파라메타를 이용하여 설계하였고, SPICE 모의실험결과 50 MHz에서 200MHz가지 동작하였다. 200MHz 동작시 소비되는 전류는 15mA이며 모든 주파수에서 7 주기 이내에 locking 되었다.

• 전자공학회논문지C
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• 제35C권12호
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• pp.77-84
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• 1998

0.8㎛ single poly CMOS 공정을 이용하여 집적화 된 전압제어형 카오스 발생회로를 설계, 제작하였다. 제작된 카오스 집적회로는 비선형함수 발생회로와 op-amp, 2상 클럭발생회로, 2개의 샘플&홀드 회로 등으로 이루어진다. 측정결과 ±2.5V 전원, 20kHz의 클럭 인가시 입력제어전압에 따라 주기상태, 준주기 상태, 카오스 상태 등 다양한 형태의 분기현상 및 시계열 파형을 관측할 수 있었다. 또한 이 회로의 직렬, 병렬 연결에 의한 2차원 카오스 패턴도 관측하였다.

• 전기전자학회논문지
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• 제12권4호
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• pp.246-254
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• 2008

본 논문에서는 멀티 스레드와 듀얼 페이즈 명령어 파이프라인을 가진 4way SIMD 프로세서를 설계하였다. 8개의 스레드가 round-robin 방식으로 실행되어, 해저드를 발생시키지 않는다. 또한 듀얼 페이즈 기능은 1개의 코어가 2개의 프로세서처럼 동작하도록 명령어를 최대 4개를 입력 받아 처리한다. 이 가변 명령어 구조는 1차와 2차 페이즈로 나뉘어 명령어를 수식할 수 있으며, 이 기능을 통해 분기명령이나 어드레싱 명령을 단일 클럭에 수행할 수 있도록 한다. 이 프로세서는 명령어 수행 시간을 일반적인 SIMD 구조에 비하여 50% 이하로 단축시킬 수 있으며, 최대 2배의 성능향상을 보이고 25%까지 코드 크기를 줄일 수 있다..

• 한국통신학회논문지
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• 제40권12호
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• pp.2503-2510
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• 2015

본 논문에서는 전력 정보를 측정하기 위한 단상 에너지 측정용 IC의 구현 방법을 제안한다. 제안된 전력 측정용 IC는 2개의 PGA(Programmable Gain Amplifier), 2개의 ${\sum}{\Delta}$ modulator, reference 회로, LDO(Low-dropout) regulator, 온도 센서, 필터부, 계산 엔진, 보정 제어부, 레지스터, 외부 인터페이스로 구성된다. $0.18-{\mu}m$ CMOS 공정으로 제작되었고, 32-pin QFN package로 제작되었다. 구현된 IC는 3.3V 전원을 공급받아 동작하며, 동작 클럭 주파수는 4,096 kHz이고, IC 동작시 소비 전력은 10 mW이다.

• Journal of Information Display
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• 제9권2호
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• pp.9-13
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• 2008

A novel push-pull voltage converter structure, using a switched capacitor type voltage doubler, is proposed. The circuit is constructed with a two-stage push-pull voltage doubler that has a stable operation with small output ripple. The two-stage voltage doubler creates the output voltage 4Vdd. The high clock signal is cross-coupled to the input of the second stage with the opposite phase to reduce two switching transistors and capacitors. Simulation results verify that even with a reduced number of transistor and capacitor, there is no circuit performance loss. Adding one capacitor and two switching transistors the circuit can be changed to eight times of Vdd maker.