• International Journal of Fuzzy Logic and Intelligent Systems
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• v.14 no.4
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• pp.268-275
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• 2014

In future, hospitals are expected to automatically issue remote transcriptions. Many general hospitals are planning to encrypt their medical database to secure personal information as mandated by law. The electronic medical record system, picture archiving communication system, and the clinical data warehouse, amongst others, are the preferred targets for which stronger security is planned. In the near future, medical systems can be assumed to be automated and connected to remote locations, such as rural areas, and islands. Connecting patients who are in remote locations to medical complexes that are usually based in larger cities requires not only automatic processing, but also a certain amount of security in terms of medical data that is of a sensitive and critical nature. Unauthorized access to patients' transcription data could result in the data being modified, with possible lethal results. Hence, personal and sensitive data on telemedicine and medical information systems should be encrypted to protect patients from these risks. Login passwords, personal identification information, and biological information should similarly be protected in a systematic way. This paper proposes the use of electronic acupuncture with a built-in multi-pad, which has the advantage of being able to establish a patient's physical condition, while simultaneously treating the patient with acupuncture. This system implements a sensing pad, amplifier, a small signal drive circuit, and a digital signal processing system, while the use of a built-in fuzzy technique and a control algorithm have been proposed for performing analyses.

• Journal of Life Science
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• v.22 no.9
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• pp.1201-1206
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• 2012

The Crlz1 gene is known to be expressed specifically in the pre-B cell stage during B-cell development. With regards to the specific expression of the pre-B cell stage of the Crlz1 gene, we have previously identified three pre-B cell-specific DNase I hypersensitive sites (HSS), which are named HSS8, 9, and 10, in the upstream vicinity of this gene. In this paper, we report that HSS8 increases further the strong Crlz1 promoter activity driven by HSS9/10 and, therefore, acts as its enhancer. Furthermore, HSS8 has been finely mapped between -1055 and -1159 from the transcription start site of the Crlz1 gene.

• Journal of Veterinary Science
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• v.22 no.6
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• pp.84.1-84.10
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• 2021

Background: Enteritis of an infectious origin is a major cause of productivity and economic losses to cattle producers worldwide. Several pathogens are believed to cause or contribute to the development of calf diarrhea. Astroviruses (AstVs) are neglected enteric pathogens in ruminants, but they have recently gained attention because of their possible association with encephalitis in humans and various animal species, including cattle. Objectives: This paper describes a large outbreak of neonatal diarrhea in buffalo calves (Bubalus bubalis), characterized by high mortality, which was associated with an AstV infection. Methods: Following an enteritis outbreak characterized by high morbidity (100%) and mortality (46.2%) in a herd of Mediterranean buffaloes (B. bubalis) in Italy, 16 samples from buffalo calves were tested with the molecular tools for common and uncommon enteric pathogens, including AstV, kobuvirus, and torovirus. Results: The samples tested negative for common enteric viral agents, including Rotavirus A, coronavirus, calicivirus, pestivirus, kobuvirus, and torovirus, while they tested positive for AstV. Overall, 62.5% (10/16) of the samples were positive in a single round reverse transcription polymerase chain reaction (PCR) assay for AstV, and 100% (16/16) were positive when nested PCR was performed. The strains identified in the outbreak showed a clonal origin and shared the closest genetic relationship with bovine AstVs (up to 85% amino acid identity in the capsid). Conclusions: This report indicates that AstVs should be included in a differential diagnosis of infectious diarrhea in buffalo calves.

• KIPS Transactions on Software and Data Engineering
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• v.12 no.8
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• pp.365-370
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• 2023

This paper aims to compare the performance of speech data classification into two groups, adult and elderly, based on the acoustic and linguistic characteristics that change due to aging, such as changes in respiratory patterns, phonation, pitch, frequency, and language expression ability. For acoustic features we used attributes related to the frequency, amplitude, and spectrum of speech voices. As for linguistic features, we extracted hidden state vector representations containing contextual information from the transcription of speech utterances using KoBERT, a Korean pre-trained language model that has shown excellent performance in natural language processing tasks. The classification performance of each model trained based on acoustic and linguistic features was evaluated, and the F1 scores of each model for the two classes, adult and elderly, were examined after address the class imbalance problem by down-sampling. The experimental results showed that using linguistic features provided better performance for classifying adult and elderly than using acoustic features, and even when the class proportions were equal, the classification performance for adult was higher than that for elderly.

• The Journal of the Convergence on Culture Technology
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• v.9 no.1
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• pp.427-436
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• 2023

Je Baek-seok, who is well versed in poetry, calligraphy, painting, and sculpture, has established himself as the most outstanding painter and pavilion in the history of modern and contemporary Chinese art. During the Ming and Qing Dynasties, the art of the pavilion was developed greatly during the enlightenment period, with the emergence of many masters of the pavilion, including Jeonggyeong, Hwanghwangseokyeo, Oyangji, Jo Ji-gyeom, Hwang Mok-bo, and Oh Chang-seok. Je Baek-seok formed an original ritual under this social background. Je Baek-seok's tactics were formed by imitating works from the Hanwi period, and he harmonized Jin Kwon, Sopan, and Janggunin while using the penmanship of the Cheonbal Shinchambi based on the "Sasam Gongsanbi." In addition, by boldly using the Danipdo method, it is possible to use the human face as much as possible while fully exhibiting the artistry of calligraphy and adding to the atmosphere of gold stone. This paper mainly analyzed and reviewed the process of Je Baek-seok's transcription transformation and humanities practice from two aspects. First, it is planned to summarize the process of Je Baek-seok's transformation into a Jeonseo. Second, Je Baek-seok's humanities practice was analyzed. This paper will further understand Je Baek-seok's humanistic ideas and practical search by clarifying the originality of Je Baek-seok's engraving art with examples of Je Baek-seok's works, and it is believed that this will provide future scholars with learning paths and rich experiences.

• Journal of Conservation Science
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• v.26 no.3
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• pp.341-348
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• 2010

After excavation work of relics, historical site which has historically meaningful, are preserved using the various methods. There are three method in the relocation methods that are original relocation method, the remaining structure-peel method, and soil peel method. The original relocation method is restored after relocating in historical site such as residential site, iron foundry site, kiln site, old mound. The remaining structure-peel method are restored only the feature of exposed remaining structure using polymeric resin, when it is difficult to relocate the entire remaining structure. And soil-peel method is exhibited after peeling in case when soil layers such as grave of old mound, foundation of building site, sedimentary deposit layer, shell heap, and etc. Soil-peel method becomes important historical data of changes according to environment at that time, that is, flooding by storm, traces of fire and living features of that time such as heaps of shells discarded after eating shellfish and living wastes. In particular, in case of soil layer for preparing foundation sites of building by compacting in turn soils with different components such as clay soil, rough sand soil and etc, it becomes important data which can judge foundation technology of that time. It can be said to be an important data preservation method for utilizing these historical data as historical data as well as for the purpose of education, exhibitions and public relations which can be shared not only by experts but also by general public. In this paper, we present the reliable definition of soil-peel method in various preservation methods and explain the using polymer in this method. So, we will come up with the accurate index about this method that is used the eminent analysis method for soil layer.

• The KIPS Transactions:PartB
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• v.11B no.1
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• pp.107-116
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• 2004

This paper introduces ISAAC (An Interface for Sentence Analysis & Abstraction with Cogitation) which provides an integrated user interface for sentence analysis. Into ISAAC, the various linguistic tools and resources are integrated. They are necessary for sentence analysis. Most of the tools and resources for sentence analysis are developed and accumulated independently. In the sentence analyzing with these tools and resources, it is difficult for sentence analyst to manage and control information which is taken on each step. In this respect, we have integrated the usable tools and resources, and made ISAAC to provide the consistent user oriented interface to each function. We have been able to divide sentence analysis process Into 14 steps. In ISAAC, these steps are processed by four individual modules $\cicled1$syntactic analysis of sentence,$\cicled2$retrieval of a root word,$\cicled3$searching category information in Roget s Thesaurus, and $\cicled4$searching category information in OfN(Ontology for Narratives). Therefore, in case of sentence analysis with ISAAC, the process of total 14 steps falls into 4 steps. This means that it is able to improve the performance of sentence analyst to the extent 3.5 times or more. Furthermore, ISAAC undertaking tedious transcription needed to process each step, we expect that ISAAC can help the analyst to maintain the accuracy of sentence analysis.

• Microbiology and Biotechnology Letters
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• v.31 no.2
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• pp.140-144
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• 2003

Type Ⅰ signal peptidase is an integral membrane protein that functions to cleave signal peptides from secreted and membrane proteins. The enzyme serves as a potential target for the development of novel antibacterial agents due to its unique physiological properties. Despite being one of the best characterized enzymes, the catalysis of Type Ⅰ signal peptidase still remains controversy over the catalytic serine/lysine dyad mechanism. It appears that the dyad proteases are generally less efficient than the prototypical serine/histidine/aspartic acid triad found in most enzymes, although Type Ⅰ signal peptidase is an exception to this rule. In this paper, we have proposed that Type Ⅰ signal peptidase may act as the serine/lysine/aspartic acid triad cataltytic mechanism. Therefore, the aspartic acid 99 residue in the E. coli signal peptidase was chosen and mutated to an alanine to see if there is any possible role of the aspartic acid in the catalytic function. Type Ⅰ signal peptidase D99A protein was inactive in vitro assay using the procoat synthesized by in vitro transcription translation. However, the mutant was active using a highly sensitive in vivo assay. Pulse-chase experiments show that the replacement of aspartic acid 99 with alanine results in a very unstable signal peptidase molecule. Therefore, we conclude that it is unlikely that the residue is directly involved in catalysis, but rather plays an important role in stabilizing the protein structure.

• Applied Microscopy
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• v.38 no.1
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• pp.29-34
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• 2008

Small amounts of zinc ions regulate a plentitude of enzymatic proteins, receptors and transcription factors, thus cells need accurate homeostasis of zinc ions. Some neurons have developed mechanisms to accumulate zinc in specific membrane compartment ("vesicular zinc"), which can be evidenced using histochemical techniques. These neurons are the socalled zinc enriched (ZEN) neurons, which accumulate glutamate and zinc inside their synaptic vesicles and release it during synaptic transmission. In the present paper we have studied the distribution of the ZEN terminals in the rat hippo-campus using ZnSe autometallography, Neo-Timm staining, ZnT3 immunohistochemistry and TSQ fluorescence staining.

• BMB Reports
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• v.44 no.1
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• pp.58-63
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• 2011

Zinc finger (ZNF) proteins play a critical role in cell growth, proliferation, apoptosis, and intracellular signal transduction. In this paper, we cloned and characterized a novel human KRAB-related zinc finger gene, ZNF425, which encodes a protein of 752 amino acids. ZNF425 is strongly expressed in the three month old human embryos and then is almost undetectable in six month old embryos and in adult tissues. An EGFP-ZNF425 fusion protein can be found in both the nucleus and the cytoplasm. ZNF425 appears to act as a transcription repressor. Over-expression of ZNF425 inhibits the transcriptional activities of SRE, AP-1, and SRF. Deletion analysis indicates that the C2H2 domain is the main region responsible for the repression. Our results suggest that the ZNF425 gene is a new transcriptional inhibitor that functions in the MAPK signaling pathway.