• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.4
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• pp.1078-1082
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• 2004

The purpose of this study was to investigate the possibility of medicinal plants application as an edible functional food resources. We carried out to develop a traditional functional beverage by using hot-water extraction of 4 medicinal plants(Polygonatun sibiricum, Ophiopogonis radix, Lycii fructus, Schizandriae fructus) and we examined the effects of drink on physiological function in aorta relaxation. Thus, the effect of developed beverage on phenylephrine induced contraction of isolated rat thoracic aorta. Contractile force was measured with force displacement transducer under 1.5g loading tension. Brix, pH and titratable acidity of developed drink were 9.5%, 3.3 and 0.22%. The approximate nutritional composition of beverage was carbohydrate, 5.98%, crude protein, 0.70%, crude fat, 0.20% and crude ash, 0.20%. Developed beverage contained K(4.00 ㎎%), Na(3.68 ㎎%), Ca(2.54 ㎎%), Mg(1.60 ㎎%) and Fe(0.29㎎%). The contraction forces by injection of phenylephrine in isolated thoracic aorta were significantly low in each experimental groups compared with control groups, These results that developed drink with medicinal plants can be used as a functional material to decrease aorta contraction.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.1
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• pp.19-28
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• 2005

According to each developing type, we study a concept, contents and a consideration about in oriental medicine industry. The divisions of each developing speciality are followings: Urban industry type - The development of urban industry type has difficulties; The lack of technical development and social adaptation, etc. If it overcomes these difficulties, it will be activated in the oriental medicine industry. Rural industry type - The oriental medicine industry of rural type needs the model of rural oriental medicine industry which leads an activity and an independence of the rural region. Within the industrialization of the oriental medicine industry, if rural resource makes a specialized brand, it can have great effects in the future industry. Resort industry type - When The resort type is related the characters of natural circumstances, cultural industry and health management, it has many effects. If we gain the clear direction which is activated the regional specialities, the oriental medicine industry of resort type can estabilishs the high value industry. Event industry type - The event type is a festival, an exhibition, etc. Within this event, the promoter must provide visitors the specialized sights, the food things, the enjoyable things. And using traditional image, we have the regional resource is recognized good things and the nomination of open place can inform.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.1
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• pp.159-166
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• 2005

We observed the efficacy of natural herbs and mixture in treating atopic dermatitis using anti-human IgE treated Human HMC-I cell and NCNga mice model. First, we selected three herbs, Cynonchum witfordii, Diospyros kaki, Ilite which were used to treat skin disease in Traditional Korea Medicine. Using Human HMC-I cell treated with anti-human IgE, we investigate in vitro whether each herb effects on IL-4, IL-13, $TNF-{\alpha}$ expression and $TNF-{\alpha}$, Histamine secretion value. Finally, we conducted study whether the mixture of the selected herbs is more effective than each herb which consist the mixture and control group. The results show that the mixture is better in improving atopic dermatitis condition.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.5
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• pp.876-880
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• 2011

Gammakdaejo-Tang (GMT) is a traditional oriental medicinal formula, a mixture of 3 crude drugs, and it has been clinically used for treating mild depressive disorders. The purpose of the study was to examine the effect of Gammakdaejo-Tang (GMT) on repeated stress-induced alterations of learning and memory on a passive avoidance test (PAT) test and also the anxiety-related behavior on the elevated pulse maze (EPM) in ovariectomized female rats. We assessed the changes in the reactivity of the cholinergic system by measuring the immunoreactive neurons of choline acetyltransferase (ChAT) in the hippocampus after behavioral testing. The rats were exposed to the immobilization (IMO) stress for 14 days (2hours/day), and Gammakdaejo-Tang (400 mg/kg, p.o.) was administered 30 min before IMO stress. Treatments with GMT caused significant reversals of the stress-induced deficits in learning and memory on a working memory test, and it also produced an anxiolytic-like effect on the EPM, and increased the ChAT reactivities (p<0.001, respectively). These results suggest that Gammakdaejo-Tang might prove to be an effective antidepressant agent.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.5
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• pp.848-853
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• 2010

Bone maintains its homeostasis through balance between bone resorbing osteoclasts and bone forming osteoblasts. Thus, unusual balance between osteoclasts and osteoblasts leads to pathological bone diseases, such as osteoporosis, rheumatoid arthritis, autoimmune arthritis, periodontitis. Schisandra chinensis well known traditional herbal has been used for treatment of diseases in China, Korea, Japan, andothers. Recently, research studies have demonstrated that the lignans found in Schisandra chinensis stimulate osteoblasts and suggest that it may be helpful against osteoporosis. However, the inhibitory effect of water extract of Schisandra chinensis on osteoclast differentiation remains largely unknown. In this study, Water extract of Schisandra chinensis markedly suppressed RANKL-induced osteoclast differentiation in cultures of BMMs without cytotoxicity. The mRNA expression of c-Fos, NFATc1, and TRAP induced by RANKL was inhibited by water extract of Schisandra chinensis. It also suppressed c-Fos and NFATc1 protein expression. Taken together, these results suggest that water extract of Schisandra chinensis has the potential to serve as a treatment of bone disease such as osteoporosis.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.5
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• pp.1297-1302
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• 2007

Uncaria sinensis(OIi.) Havil (USH) is used in traditional Korean medicine to treat inflammation such as amebic dysentery. In this study, we investigated the anti-inflammatory effect of USH. The water extract of USH significantly inhibits lipopolysaccharide (LPS)-induced nitrite oxide (NO), tumor necrosis factor $(TNF)-{\alpha}$, interleukin (IL)-6and IL-12 productions in murine peritoneal macrophages. Furthermore, USH selectively inhibited activation of the extracellular signal-regulated kinase (ERK) but not of p38 MAPK, c-Jun N-terminal kinase (JNK) and nuclear $factor-{\kappa}B$ $(NF-{\kappa}B)$. In murine model, we found that administration of USH reduced serum levels of $TNF-{\alpha}$, IL-6 and IL-12 productions in LPS-treated mice. Our results suggest that USH exerts ant-inflammatory effects in macrophages via inhibition of ERK activation and may be a useful therapeutic approach to inflammatory diseases.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.2
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• pp.517-521
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• 2004

The total phenolic contents and antioxidative activities of the ethanol and methanol extracts from 9 Korean medicinal herbs were tested for the application of skin care products such as soaf and lotion. For the evaluation of antioxidative activity of the extract the method of electron donating ability with resolution reagent DPPH(1 ,1-diphenyl-2-picryl hydrazyl) and TBARS (Thiobarbituric acid reactive substances) value were used in comparison with α-tocopherol and BHA. As the results, the total phenolic contents of the extracts calculated as chlorogenic acid were ranged from 0.063-0.124 mg/ml. All the medicinal plant extracts showed some appreciable antioxidative effects. Among them, Zanthoxylum piperitum, Cinnamomum cassia and Caesalpinia sappan were shown to have relatively high antioxidative effects comparable with BHA and α-tocopherol..

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.4
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• pp.383-390
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• 2013

In order to improve the integrating accuracy and to elevate the serviceability of the KM(Korean Medicine) ontology constructed by the Korea Institute of Oriental Medicine, this research simplified the many-to-many corresponding relationship between groups of methods of treatment and groups of accompanied symptoms from disease ontology and categorized systematically the relationship. We first extracted the combinations of methods of treatment and accompanied symptoms from the KM ontology, then categorized the attributes of combinations that their frequencies were over 10 times by analyzing KM terms definition and the basic KM theory. We constructed the classification hierarchy having 14 kinds of classification in 4 steps and extracted 450 meaningful combinations. This research improved the integrating accuracy and elevated the serviceability of KM information by the classification system.

• The Journal of Internal Korean Medicine
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• v.14 no.1
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• pp.43-54
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• 1993

Observing after enforcing the medication and the acupuncture theraphy on the CVA patient sick with the cerebral embolus by organic pathology of the heart and whose desease was from heat symptoms caused by exessive pathogenic factors of which caused from affection due to exogeneous factors, we obtained the results as follows; 1. Serious condition could be relieved by removing acute symptoms according to the principle of the 'In emergency causes treat the acute symptoms first, when these being relieved treat it's fundament cause'. 2. The lesion could be disable for which the traditional medication theraphy through the differentiation of symptoms-complexes had removed the symptoms caused by organic pathology of heart. 3. The acupuncture stimulation through the differentiation of symptoms seemed to influence electric conduction system. Through this case, If we objectify the diagnosis and the medical treatment, the part of the curing diseases can progress more effectively.

• Journal of Haehwa Medicine
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• v.13 no.1
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• pp.89-96
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• 2004

The Sasang constitutional medicine, a traditional Korean medical typology, was initially proposed to the oriental medical field in 1894 by the Korean Confucian scholar Jae-Ma Lee. The key principle of his theory is that all humans can be categorized into four groups (Tae-Yang, Tae-Eum, So-Yang, and So-Eum) based on the function of major organs such as the heart, liver, kidney and lungs as well as other characteristics of the body. Now there are many scientists that try to confirm the method to classify the four group using genetics. In this study, we hypothesized that some genes are may associated with Sasang constitution on the basis of the theory of Jae-Ma Lee who insist everybody can be divided from the birth and can not be changed during the life. Before the genetic research, we first suggest the genetic research model. It may be effective to carry out genetic research concerned with Sasang constitution.