Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Uncaria sinensis(OIi.) Havil Suppressendotoxin-induced Proinflammatory Responses through Blocking ERK Signaling Pathways

  • Park, Tai-Guang (Department of Herbology, Wonkwang University) ;
  • Moon, Hyung-Cheal (Acupuncture & Moxibustion, College of Oriental Medicine, Wonkwang University) ;
  • Cho, Hae-Joong (Department of Obstetrics and Gynecology, College of Medicine, Wonkwang University) ;
  • Seo, Sang-Wan (Department of Herbology, Wonkwang University) ;
  • Jung, Won-Sek (Department of Herbology, Wonkwang University) ;
  • Song, Ho-Joon (Department of Herbology, Wonkwang University) ;
  • Park, Sung-Joo (Department of Herbology, Wonkwang University)
  • Published : 2007.10.25
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Abstract

Uncaria sinensis(OIi.) Havil (USH) is used in traditional Korean medicine to treat inflammation such as amebic dysentery. In this study, we investigated the anti-inflammatory effect of USH. The water extract of USH significantly inhibits lipopolysaccharide (LPS)-induced nitrite oxide (NO), tumor necrosis factor $(TNF)-{\alpha}$, interleukin (IL)-6and IL-12 productions in murine peritoneal macrophages. Furthermore, USH selectively inhibited activation of the extracellular signal-regulated kinase (ERK) but not of p38 MAPK, c-Jun N-terminal kinase (JNK) and nuclear $factor-{\kappa}B$ $(NF-{\kappa}B)$. In murine model, we found that administration of USH reduced serum levels of $TNF-{\alpha}$, IL-6 and IL-12 productions in LPS-treated mice. Our results suggest that USH exerts ant-inflammatory effects in macrophages via inhibition of ERK activation and may be a useful therapeutic approach to inflammatory diseases.

Keywords

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