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Uncaria sinensis(OIi.) Havil Suppressendotoxin-induced Proinflammatory Responses through Blocking ERK Signaling Pathways  

Park, Tai-Guang (Department of Herbology, Wonkwang University)
Moon, Hyung-Cheal (Acupuncture & Moxibustion, College of Oriental Medicine, Wonkwang University)
Cho, Hae-Joong (Department of Obstetrics and Gynecology, College of Medicine, Wonkwang University)
Seo, Sang-Wan (Department of Herbology, Wonkwang University)
Jung, Won-Sek (Department of Herbology, Wonkwang University)
Song, Ho-Joon (Department of Herbology, Wonkwang University)
Park, Sung-Joo (Department of Herbology, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.5, 2007 , pp. 1297-1302 More about this Journal
Abstract
Uncaria sinensis(OIi.) Havil (USH) is used in traditional Korean medicine to treat inflammation such as amebic dysentery. In this study, we investigated the anti-inflammatory effect of USH. The water extract of USH significantly inhibits lipopolysaccharide (LPS)-induced nitrite oxide (NO), tumor necrosis factor $(TNF)-{\alpha}$, interleukin (IL)-6and IL-12 productions in murine peritoneal macrophages. Furthermore, USH selectively inhibited activation of the extracellular signal-regulated kinase (ERK) but not of p38 MAPK, c-Jun N-terminal kinase (JNK) and nuclear $factor-{\kappa}B$ $(NF-{\kappa}B)$. In murine model, we found that administration of USH reduced serum levels of $TNF-{\alpha}$, IL-6 and IL-12 productions in LPS-treated mice. Our results suggest that USH exerts ant-inflammatory effects in macrophages via inhibition of ERK activation and may be a useful therapeutic approach to inflammatory diseases.
Keywords
LPS; Uncaria sinensis(OIi.) Havil; Inflammation; MAPK;
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1 Parrillo, J.E., N. Engl. J. Med. 328: 1471-1477, 1993
2 Butcha, J.P., Parsa, K.V., Marsh, C.B. Tridandapani S Curr Pharm Des. 12(32):4143-4153, 2006   DOI   ScienceOn
3 Lopez-Bojorquez, L.N., Dehesa, A.Z. & Reyes-Teran, G. Arch. Med. Res. 35: 465-479, 2004   DOI   ScienceOn
4 Liew, F.Y., Xu, D., Brint, E.K. & O'Neill, L.A. J. Nat. Rev. Immunol. 5: 446-458, 2005   DOI   ScienceOn
5 Medzhitov, R. and C.A. Janeway Jr. Cell. 91: 295-298, 1997   DOI   ScienceOn
6 Angus, D.C., W.T. Linde-Zwirble, J. Lidicker, G. Clermont, J. Carcillo and M.R. Pinsky. Crit. Care Med. 29: 1303-1310, 2001   DOI   ScienceOn
7 Bryan, N.S. Free Radic Biol Med. 1;41(5):691-701, 2006
8 Varfolomeev, E.E., Ashkenazi, A., Cell. 116: 491-497, 2004   DOI   ScienceOn
9 Han, J., J.D. Lee, L. Bibbs and R.J. Ulevitch. Science. 265: 808-811, 1994   DOI
10 Wu, G.H., Zhang, Y.W., Wu, Z,H. World J Gastroenterol 7: 357-362, 2001   DOI
11 Wu, Q., Feng, Y. Cell Mol Immunol. 1(1):57-62, 2004
12 Cohen, J Nature. 420: 885-891, 2002   DOI   ScienceOn
13 Dumitru, C.D., Ceci, J.D., Tsatsanis, C., Kontoyiannis, D., Stamatakis, K., Lin, J.H., Patriotis, C., Jenkins, N.A., Copeland, N.G., Kollias, G., Tsichlis, P.N., Cell, 103: 1071-1083, 2000   DOI   ScienceOn
14 Lee, J.C., J.T. Laydon, P.C. McDonnell, T.F. Gallagher, S. Kumar, D. Green, D. McNulty, M.J. Blumenthal, J.R. Heys and S.W. Landvatter, Nature, 372: 739-746, 1994   DOI   ScienceOn
15 la Sala, A., Gadina, M., Kelsall, B.L., J. Immunol. 175: 2994- 2999, 2005   DOI
16 Wu, Q., Feng, Y. Cell Mol Immunol. Feb; 1(1):57-62, 2004
17 Kotlyarov, A., Neininger, A., Schubert, C., Eckert, R., Birchmeier, C., Volk, H.D., Gaestel, M., Nat. Cell Biol. 1: 94-97, 1999   DOI   ScienceOn
18 Lopez-Bojorquez, L.N., Dehesa, A.Z. & Reyes-Teran, G. Arch. Med. Res. 35: 465-479, 2004   DOI   ScienceOn
19 Dumitru, C.D., J.D. Ceci, C. Tsatsanis, D. Kontoyiannis, K. Stamatakis, J.H. Lin, C. Patriotis, N.A. Jenkins, N.G. Copeland, G. Kollias, and P.N. Tsichlis. Cell. 103: 1071-1083, 2000   DOI   ScienceOn
20 Dunn, A.J., Swiergiel, A.H., de Beurapaira, R. Neurosci Biobehav Rev 29(4-5):891-909, 2005   DOI   ScienceOn
21 Gross, C.L., Innace, J.K., Hovatter, R.C., Meier, H.L., Smith, W.J. Cell Biol Toxicol, 9(3):259-267, 1993   DOI   ScienceOn
22 Beutler, B. Curr. Opin. Immunol. 12: 20-26, 2000   DOI   ScienceOn
23 Kadar, T., Turetz, J., Fishbine, E., Sahar, R., Chapman, S., Amir, A. Curr Eye Res, 22(1):42-53, 2001   DOI   ScienceOn
24 Martin, G.S., D.M. Mannino, S. Eaton and M. Moss. N. Engl. J. Med. 348: 1546-1554, 2003   DOI   ScienceOn