• 한방재활의학과학회지
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• 제32권3호
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• pp.119-129
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• 2022

Objectives This study aimed to evaluate the effects of Integrative treatment of traditional Korean medicine (TKM) on 7 hospitalized patients after hip fracture surgery, and to identify significant herbs and co-prescribed herbs by using network analysis and association rule mining. Methods A retrospective chart review of the 7 hospitalized patients treated for postoperative hip fractures between January and December 2021 was performed. All TKM treatments for the patients were identified and Wilcoxon signed-rank test was performed to compare hip pain and mobility on admission and discharge. We visualized the network of herbal medicines and complications. By using network analysis, we also identified the significant herbs (high centrality of degree, eigenvector, and sub-graph). Co-prescription patterns for the hip fracture patients were further analyzed by association rule mining. Results We found that TKM treatment significantly relieved hip pain and improved mobility. Accompanying symptoms reported by the patients were general weakness, anorexia, dizziness, delirium, edema, sputum, sore throat, cough, rhinorrhea, and chills. Herbs composed of Sagunja-tang and Samul-tang showed high centralities and high associations with other herbs. In addition, Gupan, Nokyong, Yukjongyong, Useul, and Hyunhosaek were identified as important herbs for postoperative hip fracture patients. Conclusions This study provides evidence for clinical TKM use as an effective postoperative treatment for pain relief and improvement of mobility in patients with hip fractures. In addition, herbs that can be considered in the treatment of patients after hip fracture surgery were identified through network analysis and association rule mining.

• 생약학회지
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• 제42권4호
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• pp.371-378
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• 2011

Aldose reductase (AR) has been implicated in the development of the diabetic complications. To discover novel treatments for diabetic complications from natural sources, 65 Korean herbal medicines have been investigated for inhibitory activities on AR. Of these, 23 herbal medicines exhibited a significant inhibitory activity compared with 3,3-tetramethyleneglutaric acid (TMG). Particularly, 8 herbal medicines, Acer tataricum (twig, stem and leaf), Acer tataricum (fruit), Rhododendron schlippenbachii (twig, stem and leaf), Weigela subsessilis (twig, stem and leaf), Acer mono (branch and leaf), Ailanthus altissima (twig, stem and leaf), Lindera obtusiloba (branch and leaf), Solidago serotina (whole plant) showed three times more potent inhibitory activity than the positive control, TMG.

• 한방재활의학과학회지
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• 제31권3호
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• pp.1-17
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• 2021

Objectives The present study examined the recent domestic and international trends of non-surgical treatment of lumbar spinal stenosis (LSS). Methods The studies on non-surgical treatment of LSS were investigated via searching Korean web databases and PubMed. As a result, 39 studies were analyzed according to the authors, the types of study, the relationship to surgical treatment and the method of treatment. Results The first authors' occupations were identified as 17 doctors, 12 Korean medicine doctors, six physiotherapists, three chiropractic doctors and one doctor of science. The most common type of study in Korea was the case report and most of the studies were retrospective. Overseas, there were many prospective or experimental studies including randomized controlled trials (RCT). In Korea, non-surgical treatment was performed independently of surgical treatment in most cases. Among non-surgical treatments, the most researched treatment was traditional Korean medicine (TKM), followed by injection therapy, exercise therapy, and physical therapy. Conclusions Through this review, we can determine the effectiveness of TKM and its research direction. TKM should be studied experimentally including RCT and it should be conducted not only on acupuncture, but also on other treatment methods such as acupotomy, chuna, and herbal medicine. It is also necessary to conduct studies on TKM before and after surgery to compare the effects of surgery and TKM together, as well the effects on non-surgical treatments.

• 생약학회지
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• 제42권1호
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• pp.46-53
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• 2011

Advanced glycation end products (AGEs) have been postulated to play a central role in the development of diabetic complications. A variety of different agents that inhibit AGEs have been under investigation. In this study, 66 herbal medicines from China have been investigated with an in vitro evaluation system using AGEs formation inhibitory activity. Of these, 31 herbal medicines ($IC_{50}$ < $50\;{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Particularly, 5 herbal medicines, Camptotheca acuminata (branches and leaves), Quercus franchetii (branches), Camellia pitardii (leaves, branches, and fruits), Antidesma bunius (whole plants), and Loranthus parasiticus (whole plants) showed more potent inhibitory activity (approximately 6-20 fold) than the positive control aminoguanidine ($IC_{50}=52.96\;{\mu}g/ml$).

• 생약학회지
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• 제42권2호
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• pp.187-194
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• 2011

Aldose reductase (AR), the key enzyme in the polyol pathway, plays an important role in the development of the diabetic complications. None of Aldose reductase Inhibitor (ARI) has achieved worldwide use because of limited efficacy or undesirable side effects. Therefore, evaluating natural sources for ARI potential may lead to the development of safer and more effective agents against diabetic complications. Fifty two Chinese herbal medicines have been investigated for inhibitory activities on AR. Among them, twelve herbal medicines, Artemisia anomala (aerial part), Centella asiatica (aerial part), Scutellaria baicalensis (root), Senecio chrysanthermoides (whole plant), Gleditsia japonica (twig), Zizyphus jujube (twig, leaf), Citrus aurantium (fruit), Hydnocarpus anthelmintica (fruit), Potaninia mongolica (aerial part), Tribulus terrestris (fruit), Artemisia apiacea (aerial part) and Eclipta prostrate (aerial part) exhibited a significant inhibitory activity against AR. Particularly, Artemisia anomala, Centella asiatica and Scutellaria baicalensis showed four times more potent inhibitory activity than the positive control, 3,3-tetramethyleneglutaric acid (TMG).

• 생약학회지
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• 제42권2호
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• pp.161-168
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• 2011

Advanced glycation end products (AGEs) has been shown to play an important role in the development of the diabetic complications. The AGEs inhibitors or cross-link breakers attenuate various functional and structural manifestations of diabetic complications. In this study, 69 China herbal medicines have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, 28 herbal medicines $IC_{50}$=<50 ${\mu}g/ml$) were found to have stronger AGEs inhibitory activity compared with aminoguanidine ($IC_{50}$=59.77 ${\mu}g/ml$). Particularly, 5 herbal medicines, Camptotheca acuminata (stem, leaf), Eurya groffii (stem, leaf), Cornus Capitata (leaf), Mucuna birdwoodiana (root), Nelumbo nucifera (fruit, seed) showed more potent inhibitory activity (approximately 6-27 fold) than the positive control aminoguanidine.

• 대한한방내과학회지
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• 제42권3호
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• pp.444-454
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• 2021

Objectives: High natural killer cell activity (NKA) is associated with a clinically favorable status in patients with cancer. This study explores whether traditional Korean medicine (TKM) improves NKA in patients with cancer. Methods: We report three clinical cases involving patients with cancer who underwent NKA tests while they received TKM treatment, including acupuncture, moxibustion, wild ginseng pharmacopuncture, and Korean herbal medicines. We analyzed the treatment process and NKA test results of each patient. Results: The NKA of all three patients presented with an increasing tendency during the treatment process. Patient 1, who had been diagnosed with breast cancer, received inpatient treatment 3 times between September 16, 2017 and February 27, 2019. The NKA increased from 7.2 pg/mL to 571.7 pg/mL. Patient 2, who had thyroid cancer, was hospitalized 4 times between July 23, 2019 and August 27, 2020. The NKA improved from 317.4 pg/mL to 2000 pg/mL. Patient 3, who had liver cancer, received inpatient treatment 4 times between May 27, 2016 and January 10, 2017. The NKA increased from 22.2 pg/mL to 459.5 pg/mL. The chief complaints of these patients also were alleviated. Conclusions: TKM may be an effective treatment for accelerating NKA. Further research is needed to establish evidence that TKM stimulates NKA.

• 대한예방한의학회지
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• 제24권1호
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• pp.57-64
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• 2020

Objective : This study was conducted to development of public health promotion programs for menopausal women using Traditional Korean Medicine (TKM). Method : 4 domestic data bases were used to derive TKM intervention that could improve women's menopausal symptoms. Based on this, the program was organized through consultation with experts from the academic community. Results : Program was composed of 3 categories, lecture, therapy and practical exercise. The lecture was made with 'Understanding of menopause', 'Understanding of meditation', and 'Dietary therapy on menopause'. In therapy, 少府(HT8), 合谷(LI4), 內關(PC6), 三陰交(SP6) and 加味逍遙散(Gamisoyo-san) were chosen by expert discussion. Meditation, aromatherapy, walking and palate test were selected for practical exercise. Conclusion : Programs could be used to improve women's health in menopause.

• 대한예방한의학회지
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• 제14권3호
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• pp.93-105
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• 2010

Objective : Recently the number of health functional food (HFF) made with Traditional Korean Medicine (TKM) herbs have been increasing. However, there was a lack of the functional and safety information on HFF. Thus, this study was performed to investigate perceptions and consumptions of the HFF in Daegu area. Method : We used the data of 'Survey in Daegu' in 2010 and analyzed characteristics of perceptions and intake conditions of HFF of 1,208 participated inhabitants. Result : Among the 1,208 respondents, 30.4% were male and 63.5% were female. Most respondents (69.3%) were between 30's and 50's decade. The recognition rate of HFF made with TKM herb appeared to 86.2%. The major route of acquiring HFF information was 'mass-media' (49.8%) ; the primary reason of using HFF was 'For health promotion and anti-aging' (69.2%). On the other hand, the recognition rate of adverse effects was 53.3%. As for intake effect, 41.5% were satisfied at HFF consumption, while 56.0% did not feel special effects through the HFF consumption. In regards to purchase place, 'HFF store' was most selected by 38.0%. 69.1% of respondents selected to TKM decoction, the reason is that it made according to TKM physician's diagnosis considered their health condition. Conclusion : HFF intake was purpose to health promotion, but HFF made with TKM was consumed without any information about that. In order that HFF be used properly to promote health, the scientific and reasonable information of HFF made with TKM herb is need for consumers.

• 대한한의정보학회지
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• 제15권2호
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• pp.1-6
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• 2009

The discipline of terminology is based on its own theoretical principles and consists primarily of the following aspects: analysing the concepts and concept structures used in a field or domain of activity, identifying the terms assigned to the concepts, in the case of bilingual or multilingual terminology, establishing correspondences between terms in the various languages, creating new terms, as required. The word properties has syntax, morphology and orthography. The syntax is that how words are put together. The morphology is consist of inflection, derivation, and compounding. The orthography is spelling. Otherwise, the terms of TKM(Traditional Korean Medicine) is two important element of visual character and phonetic notation. A visual character consist of spell, sort words, stop words, etc. For example, that is a case of sort words in which this '다한', '한다', '多汗', '汗多' as same. A phonetic notation consist of palatalization, initial law, etc. For example, that is a case of palatalization in which this '수족랭', '수족냉', '手足冷', '手足冷' as same. Therefore, to enlarged reference terminology is a method by term's normalization. For such a reason, TKM's terms of normalization is necessary.