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Screening of Korean Herbal Medicines with Inhibitory Effect on Aldose Reductase (VI)  

Lee, Yun-Mi (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine)
Kim, Young-Sook (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine)
Kim, Joo-Hwan (Department of Life Science, Kyungwon University)
Kim, Jin-Sook (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine)
Publication Information
Korean Journal of Pharmacognosy / v.42, no.4, 2011 , pp. 371-378 More about this Journal
Abstract
Aldose reductase (AR) has been implicated in the development of the diabetic complications. To discover novel treatments for diabetic complications from natural sources, 65 Korean herbal medicines have been investigated for inhibitory activities on AR. Of these, 23 herbal medicines exhibited a significant inhibitory activity compared with 3,3-tetramethyleneglutaric acid (TMG). Particularly, 8 herbal medicines, Acer tataricum (twig, stem and leaf), Acer tataricum (fruit), Rhododendron schlippenbachii (twig, stem and leaf), Weigela subsessilis (twig, stem and leaf), Acer mono (branch and leaf), Ailanthus altissima (twig, stem and leaf), Lindera obtusiloba (branch and leaf), Solidago serotina (whole plant) showed three times more potent inhibitory activity than the positive control, TMG.
Keywords
Aldose reductase inhibitor; Diabetic complications; herbal medicines;
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