Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Screening of Chinese Herbal Medicines with Inhibitory Effect on Aldose Reductase (V)

중국 약용식물 추출물의 알도즈 환원 효소 억제 효능 검색 (V)

  • Lee, Yun-Mi (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine) ;
  • Kim, Young-Sook (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine) ;
  • Kim, Joo-Hwan (Department of Life Science, Kyungwon University) ;
  • Kim, Jin-Sook (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine)
  • 이윤미 (한국한의학연구원 한의융합연구본부 당뇨합병증연구센터) ;
  • 김영숙 (한국한의학연구원 한의융합연구본부 당뇨합병증연구센터) ;
  • 김주환 (경원대학교 생명과학과) ;
  • 김진숙 (한국한의학연구원 한의융합연구본부 당뇨합병증연구센터)
  • Received : 2011.04.14
  • Accepted : 2011.06.07
  • Published : 2011.06.30
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Abstract

Aldose reductase (AR), the key enzyme in the polyol pathway, plays an important role in the development of the diabetic complications. None of Aldose reductase Inhibitor (ARI) has achieved worldwide use because of limited efficacy or undesirable side effects. Therefore, evaluating natural sources for ARI potential may lead to the development of safer and more effective agents against diabetic complications. Fifty two Chinese herbal medicines have been investigated for inhibitory activities on AR. Among them, twelve herbal medicines, Artemisia anomala (aerial part), Centella asiatica (aerial part), Scutellaria baicalensis (root), Senecio chrysanthermoides (whole plant), Gleditsia japonica (twig), Zizyphus jujube (twig, leaf), Citrus aurantium (fruit), Hydnocarpus anthelmintica (fruit), Potaninia mongolica (aerial part), Tribulus terrestris (fruit), Artemisia apiacea (aerial part) and Eclipta prostrate (aerial part) exhibited a significant inhibitory activity against AR. Particularly, Artemisia anomala, Centella asiatica and Scutellaria baicalensis showed four times more potent inhibitory activity than the positive control, 3,3-tetramethyleneglutaric acid (TMG).

Keywords

References

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