• 동의생리병리학회지
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• 제35권3호
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• pp.87-96
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• 2021

The purpose of this study was to investigate the effect of single herbal medicines and Korean herbal medicine complex prescriptions for osteoporosis in Korea. We targeted studies published in domestic journals from January 1, 2013 to April 1, 2021. For domestic databases, RISS, NDSL, OASIS, DBpia, KISS, KISTI, and Korean Traditional Knowledge Portal were used. Words such as "osteoporosis", "herbal medicine", "herbal combination prescription" and "herbal" were combined and searched. A total of 32 studies were selected. Among them, 8 studies were conducted exclusively for animal studies, 18 studies were conducted on cell experiments, and 6 studies were conducted on both animal and cell experiments. There were 18 studies using a single herb and 14 studies using a combination of Herbal medicine. As a result of the investigation of a single herb, it was found that 補陽藥 was most widely used, and it was found that it was mainly used in the herbal combination prescription, mainly for 補陽藥, 補氣藥, and 補陰藥. Studies in animal experiments revealed significant results mainly in bone mineral density, serological indicators, and morphological indicators of bone tissue. In the study of cell experiments, the effects were found in factors related to the differentiation of osteoclasts and inhibitors of inflammation. Through the results of this study, we are able to confirm the effective single herbal medicines and herbal medicine complex prescriptions for the treatment of osteoporosis, and it is expected that they will contribute to clinical treatment.

• 동의생리병리학회지
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• 제16권3호
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• pp.547-552
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• 2002

To investigate an efficacy of mixed extract with Ginseng radix, Puerariae lobata, Puerariae radix, Rubi pructus, Gomi pructus, Hoelen, Dried orange peel and Parvum comus cervi etc., on the hangover elimination, 12 hr-fasted male Sprague-Dawley rats weighing 150-200 g were given mixed extract (5 mL/kg, p.o.) and administered ethanol at a dose of 3 g/kg bw (25% in distilled water) orally 30 min postdosing. Blood was collected from caudal artery at 0.25, 0.5, 1, 2, 4, 6, 8, 10, and 12hr and then the animals were sacrificed at 24hr after the ethanol treatment. In these experiments, liver function indices, such as alanine aminotransferase and alkaline phosphatase activities, showed unaltered results in all treated groups compared with the normal group. The pharmacokinetics of ethanol after oral administration of mixed extract were also evaluated. From 0 min to 12hr, the administration of mixed extract showed 14% reduction of the area under the serum concentrations-versus-time curves (AUC) compared with the control group. The activities of alcohol dehydrogenase and aldehyde dehydrogenase measured at 24hr postdosing were also not altered by the administration of mixed extract compared with the control group. These studies demonstrate that oral administration of mixed extract, prepared by traditional prescription, decreases the ethanol concentration in serum and reduces AUC, suggesting that the mixed extract is effective for elimination of ethanol-induced hangover.

• 생명과학회지
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• 제32권7호
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• pp.550-566
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• 2022

뇌졸중은 세계적으로 사망과 장기간인 신체적, 인지적 장애의 주요 원인들 중 하나이며, 매년 약 1,500만명의 사람들에게 영향을 미친다. 뇌졸중의 병태 생리학적 과정은 다수의 사건들이 관여하는 복잡한 과정으로, 그 중 혈액-뇌 장벽(blood-brain barrier: BBB)의 붕괴는 허혈성 뇌손상의 진행에 크게 기여하는 것으로 알려져 있다. 따라서 BBB 붕괴는 뇌졸중의 특징으로 인식되므로 허혈성 뇌졸중에서 BBB 기능 장애를 보호할 수 있는 새로운 치료 전략을 개발하는 것이 뇌졸중 치료에 매우 중요하다. 전통한약은 천연물로 구성되어 있으며, 이는 뇌졸중 치료약 개발을 위한 유망한 원천이 될 수 있다. 실제로 여러 연구에서 뇌졸중에 대한 한의학의 효능이 밝혀져 허혈성 뇌졸중에 대한 한의학적 치료 가치가 부각되고 있다. 본 리뷰에서는 허혈성 뇌졸중으로 인한 BBB 붕괴에 대한 전통적인 한의학의 처방, 탕약, 약재 및 활성 성분의 개선효과에 관한 현재 정보와 기본 메커니즘을 요약 정리하였다. 이러한 연구가 한의학의 신경보호 효과에 대한 추가 조사를 촉진하고 뇌졸중 환자에 대한 한방유래의 임상시험 시행을 활성화하는데 도움이 되기를 기대한다.

• Journal of Microbiology
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• 제37권2호
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• pp.80-85
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• 1999

The purification system of glucoamylase (glucan 1,4-${\alpha}$-glucosidase, EC 3. 2. 1. 3), some characteristics of the purified enzyme and hydrolysis rate of various raw starch were investigated through several experiments. The enzyme was produced on a solid, uncooked wheat bran medium of Aspergillus oryzae NR 3-6 isolated from traditional Korean Nuruk. The enzyme was homogeneously purified 6.8-fold with an overall yield of 28.3% by the criteria of disc- and SDS-polyacrylamide gel electrophoresis. The molecular weight was estimated to be 48 kDa by SDS-PAGE. The optimum temperature and pH were 55$^{\circ}C$ and 4.0, respectively. The enzyme was stable at a pH range of 3.0∼10.0 and below 45$^{\circ}C$. Enzyme activity was inhibited about 27% by 1mM Hg2+. The hydrolysis rate of raw wheat starch was shown to be 17.5-fold faster than the hydrolysis rate of soluble starch. The purified enzyme was identified as glucoamylase because the product of soluble starch by the purified enzyme was mainly glucose by thin layer chromatography.

• 한국컴퓨터정보학회논문지
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• 제21권5호
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• pp.1-10
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• 2016

Magnetic disks have been used for decades in auxiliary storage devices of computer systems. In recent years, the use of NAND flash memory, which is called SSD, is increased as auxiliary storage devices. However, NAND flash memory, unlike traditional magnetic disks, necessarily performs the erase operation before the write operation in order to overwrite data and this leads to degrade the system lifetime and performance of overall NAND flash memory system. Moreover, NAND flash memory has the lower endurance, compared to traditional magnetic disks. To overcome this problem, this paper proposes EPET (Enhanced Prediction and Elapsed Time) wear leveling technique, which is especially efficient to portable devices. EPET wear leveling uses the advantage of PET (Prediction of Elapsed Time) wear leveling and solves long-term system failure time problem. Moreover, EPET wear leveling further improves space efficiency. In our experiments, EPET wear leveling prolonged the first bad time up to 328.9% and prolonged the system lifetime up to 305.9%, compared to other techniques.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제9권3호
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• pp.1231-1245
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• 2015

People have transferred their business model from traditional commerce to e-commerce in recent decades. Both shopping and payment can be completed through the Internet and bring convenience to consumers and business opportunities to industry. These trade techniques are mostly set up based on the Secure Sockets Layer (SSL). SSL provides the security for transaction information and is easy to set up, which makes it is widely accepted by individuals. Although attackers cannot obtain the real content even when the transferred information is intercepted, still there is risk for online trade. For example, it is impossible to prevent credit card information from being stolen by virtual merchant. Therefore, we propose a new mechanism to solve such security problem. We make use of the disposable dynamic security code (DSC) to replace traditional card security code. So even attackers get DSC for that round of transaction, they cannot use it for the next time. Besides, we apply visual secret sharing techniques to transfer the DSC, so that interceptors cannot retrieve the real DSC even for one round of trade. This way, we can improve security of credit card transaction and reliability of online business. The experiments results validate the applicability and efficiency of the proposed mechanism.

• 한국정보시스템학회지:정보시스템연구
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• 제21권3호
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• pp.137-161
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• 2012

The increasing interest in big data analysis using various data mining techniques indicates that many commercial data mining tools now need to be equipped with fundamental text analysis modules. The most essential prerequisite for accurate analysis of text documents is an understanding of the exact semantics of each term in a document. The main difficulties in understanding the exact semantics of terms are mainly attributable to homonym and synonym problems, which is a traditional problem in the natural language processing field. Some major text mining tools provide a thesaurus to solve these problems, but a thesaurus cannot be used to resolve complex synonym problems. Furthermore, the use of a thesaurus is irrelevant to the issue of homonym problems and hence cannot solve them. In this paper, we propose a semantic text mining methodology that uses ontologies to improve the quality of text mining results by resolving the semantic ambiguity caused by homonym and synonym problems. We evaluate the practical applicability of the proposed methodology by performing a classification analysis to predict customer churn using real transactional data and Q&A articles from the "S" online shopping mall in Korea. The experiments revealed that the prediction model produced by our proposed semantic text mining method outperformed the model produced by traditional text mining in terms of prediction accuracy such as the response, captured response, and lift.

• 비파괴검사학회지
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• 제31권2호
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• pp.134-138
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• 2011

회전기기의 고장 탐지에 있어 기존의 진단법과 달리 동적 하중조건 하에서 비접촉, 비파괴의 적외선 열화상 기법이 제안된다. 본 논문에서는 단열 깊은 홈 볼 베어링을 시편으로 하여, 회전기기의 기존의 고장 진단법 대신 수동형 열화상 기법을 이용한 시험을 수행하였다. 추가적으로, 제안된 방법의 효율성을 평가하기 위해 기존의 진동 스펙트럼 분석법을 적용하여 열화상 시험법을 비교하였다. 시혐의 결과로써, 동적 하중조건 하 볼 베어령의 온도분포 특성이 철저히 분석되었다.

• 물과 미래
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• 제28권2호
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• pp.155-168
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• 1995

본고는 개수로 마찰계수를 산정하거나 단면평균유속을 구하는 전통적인 방법의 경험식을 논의하였으며, 새로운 형태의 산정식을 제시하였다. 기존 경험식중 형태가 가능한 것은 차원의 일치를 기하기 위하여 수정하였으며, 등가조고를 도입하여 새로운 형태의 경험식을 제안하였다. 개수로에서의 마찰계수 분포도 원형판에서의 완난류 마찰계수 분포와 유사함을 고려하여 대부분의 관측자료는 완난류 구간에 드는 것으로 판단하였으며, 원형관 완난류 마찰계수 산정식을 수정하여 사각형 개수로 완난류 마찰계수 산정식을 개발하였다. 또한 차원의 일치를 이룬 새로운 형태의 경험식들을 포함하여 이들 산정식을 Bazin의 실험자료에 적용하여 비교 검토하였다.

• 한국정보통신학회논문지
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• 제8권8호
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• pp.1790-1795
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• 2004

본 논문에서는 다중 사용자가 컴퓨터 시스템을 이용하려는 사용자의 적법성을 확인하는 방법을 개선하기 위하여 타인의 관찰로부터 노출되기 쉬운 패스워드의 약점들을 보안하고, 시스템의 안전성을 높이기 위한 SPS(Secure Password System)라는 패스워드 시스템을 제안하였다. SPS는 쉬운 구현과 낮은 비용을 포함한 전통적 패스워드 시스템의 대부분의 이점들을 받아들였고, 또한 전통적 패스워드 시스템에 쉽게 이식될 수 있다. 제안한 SPS는 실험 결과 침입자의 온라인 사전적 공격과, 클라이언트에서의 패스워드 노출에 대해 높은 안전성을 보였다