Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Mixed Extract for Elimination of Hangover on Ethanol Pharmacokinetics in Rats

랫드에서 한방 혼합 추출물이 Ethanol의 약물동태학적 거동에 미치는 영향

  • Jeon Tae Won (Efficacy and Safety Research Center for Traditional Oriental Medicines. Life Resources Center of Oriental Medicine. Kyungsan University Kyongbuk Technopark) ;
  • Lee Eun Sil (Efficacy and Safety Research Center for Traditional Oriental Medicines. Life Resources Center of Oriental Medicine. Kyungsan University Kyongbuk Technopark) ;
  • Lee Young Sun (Efficacy and Safety Research Center for Traditional Oriental Medicines. Life Resources Center of Oriental Medicine. Kyungsan University Kyongbuk Technopark) ;
  • Han Ok Kyung (Efficacy and Safety Research Center for Traditional Oriental Medicines. Life Resources Center of Oriental Medicine. Kyungsan University Kyongbuk Technopark) ;
  • Kim Hyun Young (CycloGen Co., LTD.) ;
  • Kim Kwang Joong (College of Oriental Medicine, Kyungsan University) ;
  • Kim Hyo Jung (Efficacy and Safety Research Center for Traditional Oriental Medicines. Life Resources Center of Oriental Medicine. Kyungsan University Kyongbuk Technopark, College of Oriental Medicine, Kyungsan University)
  • 전태원 ((재)경북테크노파크 경산대학교 한방생명자원특화센터 효능검증원) ;
  • 이은실 ((재)경북테크노파크 경산대학교 한방생명자원특화센터 효능검증원) ;
  • 이영선 ((재)경북테크노파크 경산대학교 한방생명자원특화센터 효능검증원) ;
  • 한옥경 ((재)경북테크노파크 경산대학교 한방생명자원특화센터 효능검증원) ;
  • 김현영 ((주)싸이클로젠) ;
  • 김광중 (경산대학교 한의과대학) ;
  • 김효정 ((재)경북테크노파크 경산대학교 한방생명자원특화센터 효능검증원, 경산대학교 한의과대학)
  • Published : 2002.06.01
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Abstract

To investigate an efficacy of mixed extract with Ginseng radix, Puerariae lobata, Puerariae radix, Rubi pructus, Gomi pructus, Hoelen, Dried orange peel and Parvum comus cervi etc., on the hangover elimination, 12 hr-fasted male Sprague-Dawley rats weighing 150-200 g were given mixed extract (5 mL/kg, p.o.) and administered ethanol at a dose of 3 g/kg bw (25% in distilled water) orally 30 min postdosing. Blood was collected from caudal artery at 0.25, 0.5, 1, 2, 4, 6, 8, 10, and 12hr and then the animals were sacrificed at 24hr after the ethanol treatment. In these experiments, liver function indices, such as alanine aminotransferase and alkaline phosphatase activities, showed unaltered results in all treated groups compared with the normal group. The pharmacokinetics of ethanol after oral administration of mixed extract were also evaluated. From 0 min to 12hr, the administration of mixed extract showed 14% reduction of the area under the serum concentrations-versus-time curves (AUC) compared with the control group. The activities of alcohol dehydrogenase and aldehyde dehydrogenase measured at 24hr postdosing were also not altered by the administration of mixed extract compared with the control group. These studies demonstrate that oral administration of mixed extract, prepared by traditional prescription, decreases the ethanol concentration in serum and reduces AUC, suggesting that the mixed extract is effective for elimination of ethanol-induced hangover.

Keywords

References

  1. 국세통계자료연보 국세청
  2. 국세통계연보 국세청
  3. 음주문화의 변화 조선일보
  4. Alcohol Health Res. World v.22 Alcohol hangover, mechanisms and mediators Swift, R.;Davidson, D.
  5. Life Sci. v.15 no.4 Speculations on the biochemical pharmacology of ethanol Rahwan, R. G.
  6. Fed. Proc. v.44 no.1 Metabolic effects of alcohol Mezey, E.
  7. Yakhak Hoeji v.37 no.5 Effect of glumate on the blood concentrations of ethanol in healthy adults Kim, Y. C.;Park, S. H.;Lee, M. G.
  8. 한국농화학회지 v.38 no.6 갈화(Puerariae flos) 추출물이 rat 혈중 ethanol 농도에 미치는 영향 김정한;민선식;김성훈;홍희도;김종수;김수언
  9. Kor. J. Pharmacogn. v.26 no.2 Studies on the effect of Aloe spp. on ethanol metabolism (Ⅰ) Shin, K. H.;Woo, W. S.;Song, Y. J.;Chung, H. S.;Lee, J. M.;Shim, C. S.
  10. 黃帝內經 牛兵占
  11. 醫方類聚 浙江省中醫硏究所 湖州中醫院(校)
  12. 丹溪心法 朱震亨
  13. Chem. Pharm. Bull.(Tokyo) v.37 no.1 Effect of water extracts of aloe and some herbs in decreasing blood ethanol concentration in rats. Ⅱ Sakai, K.;Saitoh, Y.;Ikawa, C.;Nishihata, T.
  14. Biochem. Pharmacol. v.34 Liver microsomal drug metabolism in ethanol-treated hamsters Fujii, M.;Ohmachi, T.;Sagami, I.;Watanabe, M.
  15. Methods of enzymatic analysis(2nd ed.) Bergmeyer, H. U.
  16. Biochem. Biophys. Acta. v.397 Different forms of rat liver aldehyde dehydrogenase and their subcellular distribution Koivula, T.;Koivusolo, M.
  17. J. Biol. Chem. v.193 Protein measurement with the folin phenol reagent Lowry, O. H.;Rosenbrough, N. J.;Farr, A. L.;Randall, R. J.
  18. 식품산업과 영양 v.4 no.1 숙취의 원인과 결과 김초일
  19. Pathological basis of disease Robbins, L. S.;Cotran, R. S.
  20. Digest. Dis. v.23 Alcoholic liver disease presenting with marked elevation of serum alkaline phosphatase Perrillo, R. P.;Grifin, R.;Kecskemeto, K. D.;Launder, J. J.;Zuckerman, G. R.
  21. Alcohol v.13 no.1 Influence of long-term ethanol treatment on rat liver aniline and p-nitrophenol hydroxylation Wirkner, K.;Poelchen, W.
  22. Alcohol Alcohol v.35 Cytochrome P-450 2E1 activity and oxidative stress in alcoholic patients Bendenez, I. D. P.;Simon, F. B. B.;Bardow, L. G.;Lucas, D.
  23. Am. J. Clin. Nutr. v.33 Alcoholic liver disease; Roles of alcohol and malnutrition Mezey, E.
  24. Arch. Pharm. Res. v.20 no.5 Inhibition of ethanol absorption by Rhodiola sachalinensis in rats Kim, M. H.;Park, C. K.
  25. Quart. J. Stud. Alcohol v.34 Alcohol-induced hangover: A double-blind comparison of pyritinol and placebo in preventing hangover symptoms Khan, M. A.;Jensen, K.;Krogh, H. J.
  26. Eur. J. Clin. Invest. v.6 Effects of fructose and glucose on ethanol-induced metabolic changes and on the intensity of alcohol intoxication and hangover Ylikahri, R. H.;Leino, T.;Huttunen, M. O.;Eriksson, C. J. P.;Nikkila, E. A.
  27. Alcohol Alcohol. v.22 Differing effects of carbohydrate, fat and protein on the rate of ethanol metabolism Rogers, J.;Smith, J.;Starmer, G. A.;Whitfield, J. B.
  28. Hepatology v.4 Alcohol and the liver: 1984 update Lieber, C. S.
  29. Acta. Med. Scand. v.703 no.Suppl. Alcohol and the liver: Metabolism of ethanol, metabolic effects and pathogenesis of injury Lieber, C. S.
  30. Acta. Chem. Scand. v.5 Studies on liver alcohol dehydrogenase. Ⅰ. Equilibria and initial reaction velocities Theorell, H. S.;Bonnichsen, R.
  31. Biochem. J. v.127 Intracellular localization of aldehyde dehydrogenase in rat liver Marjanen, L.
  32. Hepatology(3rd ed.) v.3 Alcoholic liver disease Nanji, A. A.;Zakim, D.;Zakim, D.;Boyer, T.(eds.)