Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지
DOI QR코드

DOI QR Code

Review on Korean Herbal Medicine Complex Prescriptions and Single Herbal Medicines for Osteoporosis - Focused on Domestic Research Published Since 2013

골다공증의 한방 복합 처방 및 단일 본초에 대한 국내 연구 고찰 - 2013년 이후 발표된 국내 연구를 중심으로

  • Lee, Jung Min (Department of Korean Medicine Rehabilitation, College of Korean Medicine) ;
  • Kim, Nam Hoon (Department of Korean Medicine Rehabilitation, College of Korean Medicine) ;
  • Lee, Eun-Jung (Department of Korean Medicine Rehabilitation, College of Korean Medicine)
  • 이정민 (대전대학교 한의과대학 한방재활의학과교실) ;
  • 김남훈 (대전대학교 한의과대학 한방재활의학과교실) ;
  • 이은정 (대전대학교 한의과대학 한방재활의학과교실)
  • Received : 2021.04.19
  • Accepted : 2021.06.24
  • Published : 2021.06.25
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study was to investigate the effect of single herbal medicines and Korean herbal medicine complex prescriptions for osteoporosis in Korea. We targeted studies published in domestic journals from January 1, 2013 to April 1, 2021. For domestic databases, RISS, NDSL, OASIS, DBpia, KISS, KISTI, and Korean Traditional Knowledge Portal were used. Words such as "osteoporosis", "herbal medicine", "herbal combination prescription" and "herbal" were combined and searched. A total of 32 studies were selected. Among them, 8 studies were conducted exclusively for animal studies, 18 studies were conducted on cell experiments, and 6 studies were conducted on both animal and cell experiments. There were 18 studies using a single herb and 14 studies using a combination of Herbal medicine. As a result of the investigation of a single herb, it was found that 補陽藥 was most widely used, and it was found that it was mainly used in the herbal combination prescription, mainly for 補陽藥, 補氣藥, and 補陰藥. Studies in animal experiments revealed significant results mainly in bone mineral density, serological indicators, and morphological indicators of bone tissue. In the study of cell experiments, the effects were found in factors related to the differentiation of osteoclasts and inhibitors of inflammation. Through the results of this study, we are able to confirm the effective single herbal medicines and herbal medicine complex prescriptions for the treatment of osteoporosis, and it is expected that they will contribute to clinical treatment.

Keywords

Acknowledgement

This study was supported by the Ministry of Education, Science and Technology (NRF-2021R1A2C2013483).

References

  1. Shin HK, Lee JW, Song SC. Perioperative Medical Treatment to Improve Surgical Outcomes: Management of Osteoporosis. J Korean Orthop Assoc. 2019;54(1):18-23. https://doi.org/10.4055/jkoa.2019.54.1.18
  2. The Korean Orthopaedic Association. Orthopaedics. The 7th Edition; Seoul: Choi Shin, 2013.
  3. Health Insurance Review & Assessment Service [Internet]. 2020 December [cited 2020 December 1). Available from: http://opendata.hira.or.kr/op/opc/olapMfrnIntrsIlnsInfo.do.
  4. Ahn, JH, Cho YE, Kim JH, Lee SH, Kang JW, LEE JD. Patients' Perceptions of Korean Medicine Treatment for Osteoporosis in a Clinical Trial of an Osteoporosis Herbal Medicine Drug: A Qualitative Study. J. Int. Korean Med. 2017;38(2):201-16. https://doi.org/10.22246/jikm.2017.38.2.201
  5. Oh HK. Medical Treatment of Osteoporosis/Prevention of Falls. J Korean Fract Soc. 2018;31(4):165-71. https://doi.org/10.12671/jkfs.2018.31.4.165
  6. Chun SW. Pharmacological treatment of osteoporosis. J Korean Med Assoc. 2019;62(10):542-50. https://doi.org/10.5124/jkma.2019.62.10.542
  7. Choi HS. Management of Osteoporosis in the Elderly. Korean J Clin Geri. 2019;20(2):46-51. https://doi.org/10.15656/kjcg.2019.20.2.46
  8. Kim MB, Kim SS, Chung SH. A Literature Review of Herbal Medicines on Osteoporosis Studies - Reviewing Articles Published after Year 2000. 2010;20(1):91-107.
  9. Seo MS, Kim HC, Choo WJ et al. The Review on the Study of Osteoporosis in Korean Medicine Journals. The Journal of Korean CHUNA Manual Medicine for Spine & Nerves. 2013;8(2):67-78.
  10. Kim JM, Choi SM, An HD. Effects of the Pharmacopuncture in Animal Models for Treatment of Osteoporosis: A Review of Animal Study Reports Published in Korea. 2016;26(2):75-83. https://doi.org/10.18325/jkmr.2016.26.2.75
  11. Im KJ, Choi KH, Jung EH, Yoo DY. The Effect of Dried Roots of Rehmannia glutinoss Extract on Osteoblast in Rat Fetus Calvarial Cells. J Korean Obstet Gynecol. 2013;26(3):33-43. https://doi.org/10.15204/jkobgy.2013.26.3.033
  12. Baek JM, Kim JY, Lee MS, Jeung WJ, Moon SY, Jeon BH, Oh JM, Choi MK. Inhibition Effect of Taxilli Ramulus Extract on Osteoclast Differentiation and Bone Resorption. Korean J. Oriental Physiology & Pathology 2013;27(4):431-6.
  13. Baek JM, Park JH, Song JH, Park SN, Jeong WJ, Moon SY, Lee CH, Choi MK, Kim JJ, Oh JM, Jang SJ. The Effects of Phlomis umbrosa turcz on Osteoclast Differentiation. Korean Association of Physical Anthropologists. 2013;26(3):115-23. https://doi.org/10.11637/kjpa.2013.26.3.115
  14. Je YM, Yoo DY. Effects of Dokhwalgisaengtang-gami Water Extract on Osteoclast Differentiation and Osteoblast Function in RANKL-induced RAW 264.7 cell. J Korean Obstet Gynecol. 2013;26(2):1-16. https://doi.org/10.15204/jkobgy.2013.26.2.001
  15. Jang HJ, Hwang DS, Lee JM, Lee CH, Lee KS, Jang JB. Osteoclast Differentation of Polygoni Cuspidati Radix Extracts Effects and Mechanism of Inhibition Studies. 2014;27(1):17-27 https://doi.org/10.15204/jkobgy2014.27.1.017
  16. Choi KH, Yoo DY. The Effect of Guibi-tang Water Extract on Osteoclast Differentiation and Osteoblast Proliferation. J Korean Obstet Gynecol. 2014;27(3):12-27. https://doi.org/10.15204/JKOBGY.2014.27.3.012
  17. Yoon KH, Baek JM, Kim JY, Kwak SC, Cheon YH, Jeon BH, Lee CH, Choi MK, Oh JM, Lee MS, Kim JJ. Inhibitory Effect on RANKL-Induced Osteoclast Differentiation by Water Extract of Zizyphus Jujuba Mill. Korean J. Oriental Physiology & Pathology. 2014;28(1):29-34.
  18. Jung GE, Kim JY, Kim JH, Han SY, Kim YK. Effect of Co-administration of Aconiti Lateralis Preparata Radix and Cinnamomi Cortex on Osteoclast Differentation. Kor. J. Herbology 2014;29(2):61-7. https://doi.org/10.6116/kjh.2014.29.2.61
  19. Kum CJ, Cho CY, Lim JM, Song DU, Kim JH, Lee BN, Jung HS. Effects of Yoohyangheukho-dan on Osteoporosis Induced by Ovariectomy in Rats. Journal of Korean Medicine Rehabilitation. 2014;24(3):29-37.
  20. Kim JH, Kim JS. Effects of Lycii Fructus and Lycii Folium Extracts on Osteoporosis in Ovariectomized Rats. J Korean Soc Food Sci Nutr. 2014;43(1):24-9. https://doi.org/10.3746/JKFN.2014.43.1.024
  21. Ju IH, Lee EK, Hwang GS, Chong MS. Journal of Society of Preventive Korean Medicine. 2015;19(2):135-44.
  22. Lee JJ, Jo SH, Park MC, Jo EH. Inhibitory Effects of Yongbu-tang on Osteoclast Differentiation and Bone Resorption. The Acupuncture. 2015;32(3):27-40. https://doi.org/10.13045/acupunct.2015036
  23. Kim SJ, Lee JJ, Kim JH, Jo SH, Park MC, Jo EH. Inhibitory of Ssangbohwan on Osteoclast Differentiation and Bone Resorption. The Acupuncture. 2015;32(3):69-81.
  24. Jung EH, Yoo DY. Effects of Kanghwalsokdan-tang Gamibang Water Extract on Osteoclast Differentiation and Osteoblast Proliferation. J Korean Obstet Gynecol. 2016;29(2):66-82. https://doi.org/10.15204/jkobgy.2016.29.2.066
  25. Lee MJ, An BK, Jung HK, Lee KH, Kim AH, Lee HJ, Jang JH, Sim MO, Kim TM, Kim MS, Seong TG, Woo KW, Cho JH, Kim JC, Cho HW. The Anti-osteoporosis Effects of Cassia tora L. Seed Ethanol Extract in Ovariectomized Rats. 2016;47(4):333-42.
  26. Cho CY, Kim EY, Kim DH, Kim MB, Kim SB, Yang KJ, Sohn YG, Jung HS. Effects of Bia-hwan on the Ovariectomized Rat Model of Osteoporosis. Journal of Korean Meidicine Rehabilitation. 2017;27(2):19-27.
  27. Lee SH, Kim DC. Aqueous Extracts of Jibaekjihwang-tang Ameliorate Ovariectomy-induced Climacterium Symptoms in Mouse. 2017;30(2):16-36. https://doi.org/10.15204/jkobgy.2017.30.2.016
  28. Choi YK, Hwang GS. Effects of Gardeniae Jasminoides on RANKL-induced Osteoclastogenesis and Bone Resorption. J. Int. Korean Med. 2017;38(6):1035-48. https://doi.org/10.22246/jikm.2017.38.6.1035
  29. Jang SB, Yoo DY, Yoo JE. Effects of Hyeolbuchugeo-tang on Osteoclast Differentiation and bone Resorption. J Korean Obstet Gynecol. 2017;30(4):1-17. https://doi.org/10.15204/jkobgy.2017.30.4.001
  30. Ahn MY, Lim HH. Effect of Sochungryong-tang Extract on Osteoclast Differentiation and Bone-pit Formation. J Korean Med. 2017;38(3):59-72. https://doi.org/10.13048/jkm.17025
  31. Cho SY, Kim DC. Ani-osteoporotic Activity of Gojineumja Aqueous Extracts on the Ovariectomized Mice. J Korean Obstet Gynecol. 2018;31(4):16-38. https://doi.org/10.15204/JKOBGY.2018.31.4.016
  32. Jung JI, Lee HS, Kim HJ, Kim YM, Kim SH, Yoo DJ, Kim EJ. Anti-osteoporotic Activity of Mixed Herbal Extract Involving Platycodon Grandiflorum Root in Osteoblastic MC3T3-E1 and Osteoclastic RAW 264.7 cells. J Korean Obstet Gynecol. 2018;31(4):1-15. https://doi.org/10.15204/JKOBGY.2018.31.4.001
  33. Park HI, Lee KH. Comparison of the Effects of Deer Antler, Old Antler, and Antler Glue on Osteoporosis in Ovariectomized Rats. J Acupunct Res. 2018;35(1):21-7. https://doi.org/10.13045/jar.2018.00031
  34. Park JS, Lim HH. Effects of Pyrola japonica Extracts on Osteoclast Differentiation and Boen Resorption. Journal of Korean meidicine Rehabilitation. 2019;29(2):135-47.
  35. Kim HH, Ahn SH, Park SY. Effects of Bombycis Corpus on Male Osteoporosis. J Physiol & Pathol Korean Med. 2019;33(1):56-62. https://doi.org/10.15188/kjopp.2019.02.33.1.56
  36. Eom JW, Kim JH, Kim MS, Kim SW, Shin HJ, Jung HS, Sohn YJ. Forsythiae Fructus Extract Inhibits RANKL-Induced Osteoclast Differentiation and Prevent Bone Loss in OVX-Induced Osteoporosis Rat. Korean Journal of Acupuncture. 2019;36(2):115-26. https://doi.org/10.14406/acu.2019.008
  37. Kim HJ, Ahn SH, Park SY. The Effects of Alpiniae Oxyphyllae Fructus on Osteoporosis and Muscle Dystrophy of Male Mice. J. Int. Korean Med. 2019;40(1):1-12.
  38. An TEB, Kim DC. Selection of the Fittest Anti-osteoporotic Mixed Compositions Consist of Morindae Radix and Cistanchis Herba Aqueous Extracts on Ovariectomized Mice. J Korean Obstet Gynecol. 2019;32(3):1-19. https://doi.org/10.15204/JKOBGY.2019.32.3.001
  39. Jang SS, Ryu HS, Jeon CY, Hwang GS. Effects of Hansu-Daebowon on RANKL-induced Osteoclast Differentiation and Bone Loss in Mammal Model. J. Int. Korean Med. 2019;40(1):58-69. https://doi.org/10.22246/jikm.2019.40.1.58
  40. Cho HS, Lee BY, Lee WK, Lee JH, Park DJ, Choi CI, Jin MH, Roh SS, Ju YS. The effects of a Mixture of puerariae Flos Extract and Citri Unshius Pericarpium Extract on Estrogenic Activities and Osteoclastogenesis. Kor. J. Herbol. 2020;35(3):1-8. https://doi.org/10.6116/KJH.2020.35.3.1
  41. Yang KJ, Kim JH, Kim MS, Ryu GH, Moon JH, Lee HI, Jung HS, Sohn YJ. Gentianae Macrophyllae Radix Water Extract Inhibits RANKL-Induced Osteoclastogenesis and Osteoclast Specific Genes. Korean Journal fo Acupuncture. 2020;37(2):63-75. https://doi.org/10.14406/acu.2020.002
  42. Yun GW, Lee H. Effect of Cheongawongagam Extract on the Ovariectomized Rat Model of Osteoporosis. J Physiol & Pathol Korean Med. 2020;34(1):14-23. https://doi.org/10.15188/kjopp.2020.02.34.1.14
  43. Herbology Editorial Committee of Korean Medicine schools. Boncho-hak. Seoul : Publication Younglimsa. 2004.
  44. The Korean Orthopaedic Association. Orthopaedics. The 7th Edition. Seoul:Choi Shin. 2013:251-68.
  45. Korean Society for Bone and Mineral Research. Osteoporosis and Osteoporotic Fracture Fact Sheet 2019, 1st ed. Seoul: Korean Society for Bone and Mineral Research, 2019; 5-6.
  46. Jeong JH, Shin JY. Treatment Patterns of Osteoporosis and Factors Affecting the Prescribing of Bone-forming Agents: From a National Health Insurance Calims Database. Korean J Clin Pharm. 2021;31(1):27-34. https://doi.org/10.24304/kjcp.2021.31.1.27