• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.3
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• pp.87-96
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• 2021

The purpose of this study was to investigate the effect of single herbal medicines and Korean herbal medicine complex prescriptions for osteoporosis in Korea. We targeted studies published in domestic journals from January 1, 2013 to April 1, 2021. For domestic databases, RISS, NDSL, OASIS, DBpia, KISS, KISTI, and Korean Traditional Knowledge Portal were used. Words such as "osteoporosis", "herbal medicine", "herbal combination prescription" and "herbal" were combined and searched. A total of 32 studies were selected. Among them, 8 studies were conducted exclusively for animal studies, 18 studies were conducted on cell experiments, and 6 studies were conducted on both animal and cell experiments. There were 18 studies using a single herb and 14 studies using a combination of Herbal medicine. As a result of the investigation of a single herb, it was found that 補陽藥 was most widely used, and it was found that it was mainly used in the herbal combination prescription, mainly for 補陽藥, 補氣藥, and 補陰藥. Studies in animal experiments revealed significant results mainly in bone mineral density, serological indicators, and morphological indicators of bone tissue. In the study of cell experiments, the effects were found in factors related to the differentiation of osteoclasts and inhibitors of inflammation. Through the results of this study, we are able to confirm the effective single herbal medicines and herbal medicine complex prescriptions for the treatment of osteoporosis, and it is expected that they will contribute to clinical treatment.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.3
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• pp.547-552
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• 2002

To investigate an efficacy of mixed extract with Ginseng radix, Puerariae lobata, Puerariae radix, Rubi pructus, Gomi pructus, Hoelen, Dried orange peel and Parvum comus cervi etc., on the hangover elimination, 12 hr-fasted male Sprague-Dawley rats weighing 150-200 g were given mixed extract (5 mL/kg, p.o.) and administered ethanol at a dose of 3 g/kg bw (25% in distilled water) orally 30 min postdosing. Blood was collected from caudal artery at 0.25, 0.5, 1, 2, 4, 6, 8, 10, and 12hr and then the animals were sacrificed at 24hr after the ethanol treatment. In these experiments, liver function indices, such as alanine aminotransferase and alkaline phosphatase activities, showed unaltered results in all treated groups compared with the normal group. The pharmacokinetics of ethanol after oral administration of mixed extract were also evaluated. From 0 min to 12hr, the administration of mixed extract showed 14% reduction of the area under the serum concentrations-versus-time curves (AUC) compared with the control group. The activities of alcohol dehydrogenase and aldehyde dehydrogenase measured at 24hr postdosing were also not altered by the administration of mixed extract compared with the control group. These studies demonstrate that oral administration of mixed extract, prepared by traditional prescription, decreases the ethanol concentration in serum and reduces AUC, suggesting that the mixed extract is effective for elimination of ethanol-induced hangover.

• Journal of Life Science
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• v.32 no.7
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• pp.550-566
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• 2022

Stroke is among the leading causes of death and long-term physical and cognitive disabilities worldwide, affecting an estimated 15 million people annually. The pathophysiological process of stroke is complicated by multiple and coordinated events. The breakdown of the blood-brain barrier (BBB) in people with stroke can significantly contribute to the development of ischemic brain injury. Therefore, BBB disruption is recognized as a hallmark of stroke; thus, it is important to develop novel therapeutic strategies that can protect against BBB dysfunction in ischemic stroke. Traditional medicines are composed of natural products, which represent a promising source of new ingredients for the development of conventional medicines. Indeed, several studies have shown the effectiveness of Korean medicine on stroke, highlighting the value of Korean medicinal treatment for ischemic stroke. This review summarizes the current information and underlying mechanisms regarding the ameliorating effects of the formula, decoction, herbs, and active components of traditional Korean medicine on cerebral ischemia-induced BBB disruption. These traditional medicines were shown to have protective effects on the BBB in many cellular and animal ischemia models of stroke, and experiments in various animal species, such as mice and rats. In addition, they showed brain-protective effects by protecting the BBB through the regulation of tight junction proteins and matrix metalloproteinase-9, reducing edema, neuroinflammation, and neuronal cell death. We hope that this review will help promote further investigation into the neuroprotective effects of traditional Korean medicines and stimulate the performance of clinical trials on Korean herbal medicine-derived drugs in patients with stroke.

• Journal of Microbiology
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• v.37 no.2
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• pp.80-85
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• 1999

The purification system of glucoamylase (glucan 1,4-${\alpha}$-glucosidase, EC 3. 2. 1. 3), some characteristics of the purified enzyme and hydrolysis rate of various raw starch were investigated through several experiments. The enzyme was produced on a solid, uncooked wheat bran medium of Aspergillus oryzae NR 3-6 isolated from traditional Korean Nuruk. The enzyme was homogeneously purified 6.8-fold with an overall yield of 28.3% by the criteria of disc- and SDS-polyacrylamide gel electrophoresis. The molecular weight was estimated to be 48 kDa by SDS-PAGE. The optimum temperature and pH were 55$^{\circ}C$ and 4.0, respectively. The enzyme was stable at a pH range of 3.0∼10.0 and below 45$^{\circ}C$. Enzyme activity was inhibited about 27% by 1mM Hg2+. The hydrolysis rate of raw wheat starch was shown to be 17.5-fold faster than the hydrolysis rate of soluble starch. The purified enzyme was identified as glucoamylase because the product of soluble starch by the purified enzyme was mainly glucose by thin layer chromatography.

• Journal of the Korea Society of Computer and Information
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• v.21 no.5
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• pp.1-10
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• 2016

Magnetic disks have been used for decades in auxiliary storage devices of computer systems. In recent years, the use of NAND flash memory, which is called SSD, is increased as auxiliary storage devices. However, NAND flash memory, unlike traditional magnetic disks, necessarily performs the erase operation before the write operation in order to overwrite data and this leads to degrade the system lifetime and performance of overall NAND flash memory system. Moreover, NAND flash memory has the lower endurance, compared to traditional magnetic disks. To overcome this problem, this paper proposes EPET (Enhanced Prediction and Elapsed Time) wear leveling technique, which is especially efficient to portable devices. EPET wear leveling uses the advantage of PET (Prediction of Elapsed Time) wear leveling and solves long-term system failure time problem. Moreover, EPET wear leveling further improves space efficiency. In our experiments, EPET wear leveling prolonged the first bad time up to 328.9% and prolonged the system lifetime up to 305.9%, compared to other techniques.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.3
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• pp.1231-1245
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• 2015

People have transferred their business model from traditional commerce to e-commerce in recent decades. Both shopping and payment can be completed through the Internet and bring convenience to consumers and business opportunities to industry. These trade techniques are mostly set up based on the Secure Sockets Layer (SSL). SSL provides the security for transaction information and is easy to set up, which makes it is widely accepted by individuals. Although attackers cannot obtain the real content even when the transferred information is intercepted, still there is risk for online trade. For example, it is impossible to prevent credit card information from being stolen by virtual merchant. Therefore, we propose a new mechanism to solve such security problem. We make use of the disposable dynamic security code (DSC) to replace traditional card security code. So even attackers get DSC for that round of transaction, they cannot use it for the next time. Besides, we apply visual secret sharing techniques to transfer the DSC, so that interceptors cannot retrieve the real DSC even for one round of trade. This way, we can improve security of credit card transaction and reliability of online business. The experiments results validate the applicability and efficiency of the proposed mechanism.

• The Journal of Information Systems
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• v.21 no.3
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• pp.137-161
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• 2012

The increasing interest in big data analysis using various data mining techniques indicates that many commercial data mining tools now need to be equipped with fundamental text analysis modules. The most essential prerequisite for accurate analysis of text documents is an understanding of the exact semantics of each term in a document. The main difficulties in understanding the exact semantics of terms are mainly attributable to homonym and synonym problems, which is a traditional problem in the natural language processing field. Some major text mining tools provide a thesaurus to solve these problems, but a thesaurus cannot be used to resolve complex synonym problems. Furthermore, the use of a thesaurus is irrelevant to the issue of homonym problems and hence cannot solve them. In this paper, we propose a semantic text mining methodology that uses ontologies to improve the quality of text mining results by resolving the semantic ambiguity caused by homonym and synonym problems. We evaluate the practical applicability of the proposed methodology by performing a classification analysis to predict customer churn using real transactional data and Q&A articles from the "S" online shopping mall in Korea. The experiments revealed that the prediction model produced by our proposed semantic text mining method outperformed the model produced by traditional text mining in terms of prediction accuracy such as the response, captured response, and lift.

• Journal of the Korean Society for Nondestructive Testing
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• v.31 no.2
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• pp.134-138
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• 2011

Fault detection for dynamic loading conditions of rotational machineries was considered from the contactless, non-destructive infrared thermographic method, rather than the traditional diagnosis method. In this paper, by applying a rotating deep-grooved ball bearing, passive thermographic experiment was performed as an alternative way proceeding the traditional fault monitoring. In addition, the thermographic experiments were compared with the vibration spectrum analysis to evaluate the efficiency of the proposed method. Based on the results, it was concluded the temperature characteristics of the ball bearing under dynamic loading conditions were analyzed thoroughly.

• Water for future
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• v.28 no.2
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• pp.155-168
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• 1995

The present paper discusses the traditional empirical equations of friction factor or cross-sectional mean velocity of open channel flow and suggests the new form of friction factor equation. Dimensional analysis is conducted for the possible forms of traditional empirical equations in order to satisfy the dimensional equality, and new forms of empirical equations are presented with introducing equivalent roughness height. Considering the distribution of friction factor against Reynolds number which has a similar characteristics to that of smooth turbulent flow in circular pipe, the friction factor equation of rectangular open channel flow is developed by modifying the friction factor equation of circular pipe flow for the region of smooth turbulent flow. The equations including the dimensionally-corrected empirical equations are tested against Bazin's laboratory experiments.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.8 no.8
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• pp.1790-1795
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• 2004

In this paper, the new password system called SPS(Secure Password System) in order to enhance the security of the system as well as to improve the weakness of the password which is very easy to be disclosed by other people, improving the methods which is identifying the users' legality using the computer system in the multi-users computer. SPS is adopting several strong points such as Easy Embodiment, Low Cost, and most of the good points of the traditional password system. In addition, it makes an easy introduction from the traditional password system. Above SPS has the high stable security in the practical experiments about both the literal attack of the online intruders and the exposure of Clients' password.