• 대한화학회지
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• 제52권3호
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• pp.257-265
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• 2008

새로운 다섯개의 tetrahydroquinazolines 의 합성과 구조 결정 및 생물학적 평가는 보고 되었다. 최초에 준비된 cyclohexanones는 목표분자를 얻기 위한 synthon으로 사용되어졌다. 이들은 치환된 벤즈알데히드와 결합되어졌고, 얻어진 chalcone은 구아니딘 염산염으로 처리했다. 모든 분자들은 인간세포에 무독하며 상당한 항균성을 보여줬다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 1997년도 춘계학술대회 논문집
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• pp.150-153
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• 1997

Langmuir-Blodgett(LB) technique is one of the ways of fabricating organic ultra-thin films. It is well known that It has the advantage to control the alignment and orientation of the molecules in the films. Metallo-phthalocyanines(MPcs) are sensitive to electron affinitive toxic gaseous molecules, such as NO$_2$, NO, SO$_2$. MPcs are thermal, optical, mechanical, chemical stable. Therefore, it is interesting to prepare phthalocyanine LB films containing copper as a chemical sensor for NO$_2$ and SO$_2$ gas and test their sensitivity to these toxic gases. In this study, thin films of Octa-dodecylosy copper-phthalocyanine were prepared by LB technique. $\pi$-A isotherm, transfer ratio, UV-VIS. spectroscopy of these films were investigated. Also current-voltage(I-V) characteristics of these was auto investigated.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.201-205
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• 2002

It is generally accepted that the immune system is one of the major target organs for many toxic chemicals. In addition, many toxic chemicals require metabolic activation by cytochrome P450s for their toxicity. Although the immune cells possess a limited amount of drug metabolizing capacity, metabolic activation of certain toxicants in liver and immune organs may have a significant role in immunosuppression. In the present studies, the possible role of metabolic activation by cytochrome P450s in chemical-induced immunosuppression was reviewed, with a particular emphasis on the methodological techniques to detect immunotoxicants requiring metabolic activation in vivo and in vitro. (omitted)

• Genomics & Informatics
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• 제4권3호
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• pp.129-132
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• 2006

Toxicogenomics has recently emerged in the field of toxicology and the DNA microarray technique has become common strategy for predictive toxicology which studies molecular mechanism caused by exposure of chemical or environmental stress. Although microarray experiment offers extensive genomic information to the researchers, yet high dimensional characteristic of the data often makes it hard to extract meaningful result. Therefore we developed toxicant enrichment analysis similar to the common enrichment approach. We also developed web-based system graPT to enable considerable prediction of toxic endpoints of experimental chemical.

• Bulletin of the Korean Chemical Society
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• 제30권4호
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• pp.825-828
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• 2009

Alum $(KAl(SO_4)_2{\cdot}12H_2O)$ is an inexpensive, efficient, non‐toxic and mild catalyst for the synthesis of bis(indolyl)methanes by the reaction of 1H-indole with various aldehydes/ketones under the influence of ultrasound irradiation in solvent‐free condition. The remarkable advantages of this method are the simple experimental procedures, shorter reaction times, high yields of product and green aspects by avoiding toxic catalysts and solvents.

• 대한화학회지
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• 제8권2호
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• pp.75-77
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• 1964

It was confirmed that korean scabby barley during the summer of 1963 was infected with Gibberella zeae. Feeding experiments showed that the diseased grain was toxic and induced emesis in pigs. The concentrated extracts which contained the emetic principle were prepared by refluxing the grain with methanol or water for 5 hours and then concentrating the filtrates and the washing in vacuum. Animal tests proved that methanol extraction for the emetic principle was more effective than extraction with water.

• 대한화학회지
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• 제8권2호
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• pp.82-84
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• 1964

It has been pointed out that various substances such as "toxoalbumin", glycoside, choline or readily hydrolysable choline derivatives, alkaloid, lysolecithine etc. are associated with the toxicity of the infected grain. But animal tests and analysis of paper chromatography by author's indicated that a basic substance present in the concentrated extracts from the grain may neither be acetylcholine, betaine, nor choline. This problem still have to be examine further.

• 한국산업보건학회지
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• 제22권1호
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• pp.20-25
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• 2012

Objectives: Hazard identification is the most important step in occupational health monitoring at the workplace. This paper reviewed the several related stuffs to the hazard identification in the semiconductor industry. Methods: I checked the MSDS system, chemical toxic informations, trade secrets and by-products by experience and the literature used in semiconductor industry. Results: I found and experienced as follows; (1) There are a few inventory and history of chemicals used in workplace. Toxic information of chemicals to be available is very limited. (2) There are many trade secrets in MSDS for chemical mixtures. It is difficult to identify the accurate information from MSDS. (3) By-products is necessary to identify that they will produce in workplace. Conclusions: It is necessary to regulate the obligations of employers which check the inventory and history of chemicals used in workplace. It is necessary to amend the trade secrets in MSDS system.

• 한국응용곤충학회지
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• 제31권3호
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• pp.304-313
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• 1992

The agricultural industry is beset by continuing demands to decrease the use of pest control agents which employ toxic modes of action. Although there are real problems of pesticide resistance, and sometimes overuse or redistribution in the environment, much criticism results from a lack of appreciation of how small is the risk involved. Whatever the background reasons, research and development for pesticide alternatives, particularly within Integrated Pest Management systems, is clearly of high priority. Currently available approaches, including use of natural products and molecular biology, are often regarded with naive optimism and require critical appraisal. For the future, methods of pest control based on chemicals with non-toxic modes of action (e.g. pheromones) continue to offer promise but, for widespread use, will require their integration with biological agents and development by means of plant molecular biology.

• 한국산학기술학회논문지
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• 제21권3호
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• pp.488-496
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• 2020

본 연구는 국내·외에서 질산화학사고를 바탕으로 사업장, 실험실, 병원, 용기파손, 화학물질 오 주입으로 이상반응으로 인한 유독가스가 발생하고, 여러 사례들을 바탕으로 질산의 위험성과 화학사고 발생 시 발생할 수 있는 상황과 안전성에 대한 사례검토를 통해서 5년간의(2014년부터 2018년까지) 질산 화학사고 사례 대상으로 각 연도별, 사고현황, 사고유형, 사고원인, 사고 장소 등의 사례를 분석하여 안전교육과 질산화학사고 발생 시 개선 방안을 검토하였다. 그 결과 36건의 질산 화학사고가 조사되었으며, 그중 16건의 작업자 부주의사고가 발생하였고, 8건의 운송사고와 12건의 시설괸리 부족과 같은 사고가 발생하였다. 질산화학사고는 지속적으로 발생하고 있으며, 이를 바탕으로 CARIS를 활용한 독성영향범위를 최악에 시나리오를 산정하여, 피해영향범위를 통해서 효과적인 사고대응 범위를 측정하였고, 질산화학사고 초기대응방법과 사고예방을 위해서 안전교육 강화와 비상조치계획과 상관관계식을 바탕으로 영향범위를 예측하여, 정량화된 자료를 파악하였다. 또한 주민대피 선정이 수월하게 할 수 있는 상관관계식을 바탕으로 영향범위의 신뢰성을 검토하고, 실제 사업장 사고 시나리오에 적용하여 사고 시 비상상황에 사고대응 효과와 예방대책을 제시하였다.