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http://dx.doi.org/10.5012/jkcs.2008.52.3.257

Synthesis, Characterization and Bioevaluation of New Tetrahydroquinazolines  

Murthy, Y.L.N. (Dept. of Organic Chemistry, Andhra University)
Acharyulu, P.V.N. (Dept. of Organic Chemistry, Andhra University)
Dubey, P.K. (Dept. of Chemistry, J.N.T.University)
Sundari, T. Tirunala (NFMC, Bharatidasan University)
Publication Information
Journal of the Korean Chemical Society / v.52, no.3, 2008 , pp. 257-265 More about this Journal
Abstract
The synthesis, characterization and bioevaluation of five new tetrahydroquinazolines was reported. Initially cyclohexanones were prepared and they were used as synthons to get the target molecules. These were condensed with substituted benzaldehydes and the resulting chalcones were treated with guanidine hydrochloride . All the molecules were non-toxic to human cells and showed significant antibacterial activity.
Keywords
Tetrahydroquinazolines; Cyclohexanones; Non-toxic Antibacterial Agents
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