• Journal of Microbiology
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• 제39권1호
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• pp.67-73
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• 2001

A validation study was conducted to evaluate the efficacy and mechanism of the cryo-precipitation, monoclonal anti-FVIIIc antibody (mAb) chromatography, Q-Sepharose chromatography, and lyophilization steps involved in the manufacture of high purity factor VIII (GreenMono) from human plasma, in the removal and/or inactivation of hepatitis A virus (HAV). Samples from the relevant stages of the production process were spiked with HAV and subjected to scale-down processes mimicking the manufacture of the high purity factor VIII concentrate. Samples were collected at each step and immediately titrated using a 50% tissue culture infectious dose (TCID$\_$50/) and then the virus reduction factors were evaluated. HAV was effectively partitioned from factor VⅢ during cryo-precipitation with the log reduction factor of 3.2. The mAb chromatography was the most effective step far removal of HAV with the log reduction factor of $\geq$4.3. HAV infectivity was not detected in the fraction of factor VⅢ, while most of HAV infectivity was recovered in the fractions of flow through and wash during mAb chromatography. Q-Sepharose chromatography showed the lowest efficacy for partitioning HAV with the log reduction factor of 0.7. Lyophilization was an effective step in inactivating HAV with the log reduction factor of 2.3. The cumulative lag reduction factor, $\geq$10.5, achieved for tile entire manufacturing process was several magnitudes greater than the potential HAV load of current plasma pools.

• Composites Research
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• 제13권2호
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• pp.61-71
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• 2000

오늘날 항공기의 경량화를 위해 복합재료를 사용하는 것은 필수적인 설계 및 제작 요건이 되고 있다. 복합재료로 제작된 날개는 적층각에 따라 구조적 특성이 심하게 변화될 수 있기 때문에 설계시 최적의 적층각을 결정하는 것이 매우 중요한 문제이다. 따라서, 본 연구에서는 복합재료 날개의 적층각에 대한 정적 공탄성 최적화 연구를 수행하였다. 이를 위해 공력하중에 대한 복합재료 날개의 구조 평형상태를 구할 수 있는 정적 공탄성(하중재분포) 해석시스템을 개발하였으며, 유전자 알고리즘을 활용한 최적화 프로그램이 통합 개발되었다. 후퇴각이 있는 복합재료날개에 대하여 적층각 변화가 정적 공탄성 변형에 미치는 영향을 고찰하였으며, 구조 변형이 최소가 되는 경우의 최적 적층각 조건을 구하였다. 이를 토대로 실제 제작에 실용적인 적층각 조합에 대하여 정적 공탄성 특성을 최대화 할 수 있는 최적 적층각 조건이 제시되었다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2003년도 춘계학술대회 논문집
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• pp.246-250
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• 2003

In this study, two new types of micro-grippers in which micro-fingers are actuated by piezoelectric multi-layer benders and stacks are introduced for the manipulation of micrometer-sized objects. First, we constructed a 3-chopstick-mechanism tungsten gripper, which is composed of three chopsticks: two are designed to grip micro-objects, and tile third is used to help grasp and release the objects through overcoming especially electrostatic force among some surface effects including electrostatic, van der Waals forces and surface tension. Second, a 2-chopstick-mechanism silicon micro-gripper that uses an integrated force sensor to control the gripping force was developed. The micro-gripper is composed of a piezoelectric multilayer bender for actuating the gripper fingers, silicon fingertips fabricated by use of silicon-based micromachining, and supplementary supports. The micro-gripper is referred to as a hybrid-type micro-gripper because it is composed of two main components; micro-fingertips fabricated using micromachining technology to integrate a very sensitive force sensor for measuring the gripping force, and piezoelectric gripper finger actuators that are capable of large gripping forces and moving strokes. The gripping force signal was found to have a sensitivity of 667 N/V. To the design of each of components of both of the grippers. a systematic design approach was applied, which made it possible to establish the functional requirements and design parameters of the micro-grippers. The micro-grippers were installed on a manual manipulator to assess its performance in tasks such as moving micro-objects from one position to a desired position. The experiment showed that the micro-grippers function effectively.

• 한국세라믹학회지
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• 제46권6호
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• pp.602-608
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• 2009

The yield is increasing as the manufacturing technology of ceramics progresses, however, there are many ceramics of poor quality due to variables upon producing ceramics. Some of those waste ceramics are recycled by sanitary ware or tile manufacturers, but most of them are filled in making environmental problem. Therefore, a research begins to recycle waste ceramic ware as alternative to some imported ceramic ware materials and to reduce environmental pollution. This study, succeeding last study which applied waste white ware as ceramic body material, aimed to solve problems of environment and materials by recycling waste ceradon generated in specially formed areas for ceramic in Gyeonggi-do such as Icheon, Yeoju and Gwangju as the ceramic body material. Consequently, the addition of waste ceramic ware into the ceramic body was judged to have limit up to 30% according to plasticity measurement. As we added shredded waste ceramic ware as much as 30% into basic ceramic body and checked its features, the pore rate and absorption rate were good to be average 4% and 3% respectively. In addition, it showed strength more than 720 kgf/$cm^2$ which is higher than existing ceradon body on the market with good sinter state; so it is judged to be available or developed as new ceramic body.

• 보건행정학회지
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• 제10권4호
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• pp.116-143
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• 2000

Considerable attention has been devoted in the accounting literature to identify the factors that cause or drive the costs of overhead activities. This paper extends recent cost driver research to the health care provider. In various case studies, it has been suggested that overhead costs are driven by volume and complexity variables. This paper investigates the significance of these variables in determining hospital overhead costs, how they are structurally related and how the cost impacts of these variables can be estimated in practice. This paper analyzes the determinants of hospital costs using the sample of South Korea hospitals for seven year during the period 1952－1997. The paper focuses on the extent to which hospital overhead costs depend on complexity, efficiency in addition to depending on more conventional volume based measures of hospital activity. The results of regression analysis suggest that volume and complexity factors positively and significantly affect overhead costs in the hospital industry. The results show that the complexity-related cost drivers strongly affected on the overhead costs in tile health care provider industry more than manufacturing industry which is mainly affected by volume-related cost drivers. That means each Industry may have different cost structures. Therefore it Is Important to find their proper cost structures and cost drivers and use them. Futhermore identification of overhead or indirect cost drivers is likely to be particularly useful in heath care. The identification of cost drivers can be of benefit to all health care stakeholders because these facilitates more efficient management of the national resources devoted to health care. While this study has documented that the level of service complexity is a significant determinant of hospital overhead costs, caution should be exercised in interpreting this as supportive of the cost accounting procedures associated with ABC. It is an open question whether even a well-designed ABC system will provide suitable proxies for marginal costs for decision making purposes.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 1999년도 IFSCC . ASCS 학술대회 발표 논문
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• pp.97-110
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• 1999

The new stick make-up product was studied by using a gel, which is a viscous complex formed with clay minerals, vitamins A and I and fluorinated liquid polymer with a 1500 molecular weight. The gel cannot be obtained with any random combination of clay minerals and the ingredients described above. It takes the sequential manufacturing method as follows to get this kind of gel. Firstly, clay minerals and liquid polymers have ·to be pre-mixed in order to saturate the liquid polymers with the clay minerals. Then tile on-processed gel has to be finely crystallized. The clay minerals, which are the core elements for this gel, were used as a function of Binder & Buffer and liquid polymer was mixed together for the deterioration of the surface tension of each component and to from a functional film in the gel. This liquid polymer was combined with clay minerals because it is not miscible with most oils and solvents. Waxes have a function of keeping a solid status in the stick. We reduced the usage of waxes by putting clay minerals as buffer in the proportion of 0.5 : 1 with oil phase. Ceramide takes care of the skin when used regularly and maintains the skin’s moisture. Vitamins A and I contribute to preventing skin’aging by the activation of skin cells. We could get the stable viscous gel, which has about 80% oil phase using clay minerals and liquid polymer, The crystal 1 me structures of gel were surface-chemical1y-analyzed using SEM and Image Analyzer and were thermodynamically analyzed using DSC, Surface tension test and softness were done by Rheometer. In the end, these characteristics were verified by consumer panel tests in Seoul, Baegeon and Pusan in Korea and Hokkaido, Oska and Miyazaki in Japan with correlation to the climate.

• 비파괴검사학회지
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• 제20권6호
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• pp.555-561
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• 2000

다양한 기계가공 결함을 유기한 공칭 외경 100mm의 덕타일 주철관을 대상으로 원거리장 와전류 검사를 수행하였다. 상수도 배수관으로 사용되는 주철관은 제조 단계의 큰 허용 오차 때문에 두께가 일정하지 않고 단면이 비대칭적인 특징을 지니므로, 원거리장 와전류 탐상 신호에는 배관 축방향에 걸친 장범위 잡음이 존재하게 된다. 본 논문에서는 장범위에 걸친 배경잡음을 효과적으로 제거하기 위하여 이동구간 평균법을 응용하였고, 결함의 깊이와 원주방향 정도를 정량적으로 평가하기 위하여 voltage plane 극좌표 (VPPP) 방법을 활용하였다. 이동구간 평균처리로서 신호비를 일차적으로 향상시킨 다음 VPPP 기법을 이용하여 결함신호를 얻은 결과, 결함신호가 VPPP상의 기준점에서 x 축과 이루는 각이 결함 깊이와 직선적인 상관 관계가 있음을 확인하였다. 따라서 배관과 동축으로 놓인 탐촉코일을 이용한 원거리장 와전류 검사로서 매설 상수도 배관 내 외부에 존재하는 부식결함을 비파괴 정량평가할 수 있는 기반을 구축하였다.

• 한국건축시공학회지
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• 제21권4호
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• pp.281-291
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• 2021

건설산업의 환경부하를 최소화하기 위해서는 건축 자재의 친환경성을 강화하고 내구수명을 연장하여 신축 및 철거를 최소화의 필요성이 있다. 따라서 이러한 문제점을 개선하기 위해 많은 한옥의 지붕마감 공법이 제안되었지만 현재는 경제성, 무게, 내구성 등의 문제점으로 기존공법을 사용하는 추세이다. 한옥 건물의 지붕재로 사용되는 점토기와의 제조방법에 경주에서 생산된 기와용 점토와 고령토와 S사의 재활용 FNS(Ferro Nickel Slag) 활용하여 문제를 해결하고자 연구를 진행하여 한국전통 점토기와의 개발 특성과 재료를 연구하고 관련 기초자료를 제시한다.

• 헤리티지:역사와 과학
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• 제53권1호
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• pp.34-51
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• 2020

성남 고등동 회곽묘는 한 지역에서 다른 시기에 제작된 6기의 회곽묘가 발굴되었으며, 회곽묘 조성에 사용된 삼물회의 다양한 제작 기법이 확인되었다. 삼물회의 제작 기법을 규명하기 위하여 고문헌 기록을 바탕으로 석회 원료와 제작 기법 및 배합 방법을 고찰하였다. 조선시대 고문헌에는 석회의 원료 중 저품위 석회석을 사용한 기록과 배합 재료로 황토와 백토, 기와 가루 등과 같은 석회의 강도를 향상시킬 수 있는 포졸란 물질 사용에 대한 기록이 남아있다. 또한 삼물회의 다양한 배합 방법이 기록되어 있어 이에 대한 재현 실험을 바탕으로 석회 원료, 배합 재료, 배합 비율에 따른 삼물회 제작 기법 분석이 요구되었다. 조선시대 전기에는 석회를 다방면으로 사용하였으나 공급이 적고 기술적인 미숙함으로 지속적인 문제가 발생하였으며, 조선시대 후기에 이르러 대량 생산됨과 함께 석회 제작 기술이 발달하였다. 16세기와 18세기 회곽묘 삼물회의 제작 기법 분석을 바탕으로 고문헌에 기록된 배합비와 배합 방법들이 적용된 것을 알 수 있었으며, 회곽묘 삼물회는 시기에 따라 석회의 품질이 변화하였고 배합 재료 또한 변화됨에 따라 배합 비율이 다르게 나타나는 것으로 판단된다. 회곽묘 삼물회의 배합 비율은 시기에 따라서 변화하였으며, 주례와 가례를 기준으로 정해진 배합 방법으로 제작되었기 때문에 회곽묘 삼물회의 제작 기법에 대한 과학적 분석 자료가 지속적으로 구축된다면 회곽묘 편년 연구에 도움이 될 것으로 기대된다.

• 기술사
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• 제20권3호
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• pp.15-25
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• 1987

Statistical control charts are useful tools to monitor and control the manufacturing processes and are widely used in most Korean industries. Many Korean companies, however, do not always obtain desired results from the traditional control charts by Shewhart such as the X-chart, X-chart, X-chart, etc. This is partly because the quality charterstics of the process are not distributed normally but are skewed due to the intermittent production, small lot size, etc. In Shewhart X-chart, which is the most widely used one in Korea, such skewed distributions make the plots to be inclined below or above the central line or outside the control limits although no assignable causes can be found. To overcome such shortcomings in nonnormally distributed processes, a distribution-free type of confidence interval can be used, which should be based on order statistics. This thesis is concerned with the design of control chart based on a sample median which is easy to use in practical situation and therefore properties for nonnormal distributions may be easily analyzed. Control limits and central lines are given for tile more famous nonnormal distributions, such as Gamma, Beta, Lognormal, Weibull, Pareto, Truncated-normal distributions. Robustness of the proposed median control chart is compared with that of the X-chart, the former tends to be superior to the latter as the probability distribution of the process becomes more skewed. The average run length to detect the assignable cause is also compared when the process has a Normal or a Gamma distribution for which the properties of X are easy to verify, the proposed chart is slightly worse than the X-chart for the normally distributed product but much better for Gamma-distributed products. Average Run Lengths of the other distributions are also computed. To use the proposed control chart, the probability distribution of the process should be known or estimated. If it is not possible, the results of comparison of the robustness force us to use the proposed median control chart based on a normal distribution. To estimate the distribution of the process, Sturge's formula is used to graph the histogram and the method of probability plotting, $X^2$-goodness of fit test and Kolmogorov-Smirnov test, are discussed with real case examples. A comparison of the propose4 median chart and the X chart was also performed with these examples and the median chart turned out to be superior to the X-chart.