• Biomolecules & Therapeutics
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• v.22 no.4
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• pp.355-362
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• 2014

We have developed a fully automated high throughput drug screening (HTDS) system based on the microfluidic cell culture array to perform combinational chemotherapy. This system has 64 individually addressable cell culture chambers where the sequential combinatorial concentrations of two different drugs can be generated by two microfluidic diffusive mixers. Each diffusive mixer has two integrated micropumps connected to the media and the drug reservoirs respectively for generating the desired combination without the need for any extra equipment to perfuse the solution such as syringe pumps. The cell array is periodically exposed to the drug combination with the programmed LabVIEW system during a couple of days without extra handling after seeding the cells into the microfluidic device and also, this device does not require the continuous generation of solutions compared to the previous systems. Therefore, the total amount of drug being consumed per experiment is less than a few hundred micro liters in each reservoir. The utility of this system is demonstrated through investigating the viability of the prostate cancer PC3 cell line with the combinational treatments of curcumin and tumor necrosis factor-alpha related apoptosis inducing ligand (TRAIL). Our results suggest that the system can be used for screening and optimizing drug combination with a small amount of reagent for combinatorial chemotherapy against cancer cells.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.7
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• pp.3370-3392
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• 2017

Next Generation Beyond 4G/5G systems will rely on the deployment of small cells over conventional macrocells for achieving high spectral efficiency and improved coverage performance, especially for indoor and hotspot environments. In such heterogeneous networks, the expected performance gains can only be derived with the use of efficient interference coordination schemes, such as Fractional Frequency Reuse (FFR), which is very attractive for its simplicity and effectiveness. In this work, femtocells are deployed according to a spatial Poisson Point Process (PPP) over hexagonally shaped, 6-sector macro base stations (MeNBs) in an uncoordinated manner, operating in hybrid mode. A newly introduced intermediary region prevents cross-tier, cross-boundary interference and improves user equipment (UE) performance at the boundary of cell center and cell edge. With tools of stochastic geometry, an analytical framework for the signal-to-interference-plus-noise-ratio (SINR) distribution is developed to evaluate the performance of all UEs in different spatial locations, with consideration to both co-tier and cross-tier interference. Using the SINR distribution framework, average network throughput per tier is derived together with a newly proposed harmonic mean, which ensures fairness in resource allocation amongst all UEs. Finally, the FFR network parameters are optimized for maximizing average network throughput, and the harmonic mean using a fair resource assignment constraint. Numerical results verify the proposed analytical framework, and provide insights into design trade-offs between maximizing throughput and user fairness by appropriately adjusting the spatial partitioning thresholds, the spectrum allocation factor, and the femtocell density.

• Proceedings of the IEEK Conference
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• 2000.11a
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• pp.221-224
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• 2000

The issue of supporting TCP traffic over ATM networks is currently one of the most important issues in the field of data networks. One important part of this issue is congestion control. In general, congestion control uses method such as packet drop to relieve network resource when the network is congested so as to maintain high throughput and low delay. In addition, congestion control is required to ensure fair sharing of resources among all users during congestion. In this paper we propose a new congestion control method using WRED & per-VC accounting mechanism. This packet discard scheme is proposed with the goal to provide both good performance in terms of throughput and fairness in terms of bandwidth exploitation of the output link among all virtual circuits.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.25 no.10A
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• pp.1529-1539
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• 2000

The contact procedure of access channel necessary to set up the originating call has a close relation with the performance and capacity of the base station system in CDMA cellular network. This paper investigates the structure and the operation of the backward channel of IS-95 CDMA standard and explains the related system parameters. We can derive the throughput of the CDMA access channel depending on the arrivals of the access probes per access channel slot, given the system parameters such as cell radius, the maximum number of retransmission, and the error rates of the access and paging channel. It shows that the performance in throughput is much better in the CDMA IS-95 access channel than in the slotted aloha channel. It also gives the reasonable number of the trafic channels in a cell with the given blocking probability.

• International Journal of Oral Biology
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• v.37 no.2
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• pp.43-50
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• 2012

The use of high throughput screening (HTS) in drug development is principally for the selection new drug candidates or screening of chemical toxicants. This system minimizes the experimental environment and allows for the screening of candidates at the same time. Umbilical cord-derived stem cells have some of the characteristics of fetal stem cell and have several advantages such as the ease with which they can be obtained and lack of ethical issues. To establish a HTS system, optimized conditions that mimic typical cell culture conditions in a minimal space such as 96 well plates are needed for stem cell growth. We have thus established a novel HTS system using human umbilical cord derived-mesenchymal stem cells (hUC-MSCs). To determine the optimal cell number, hUC-MSCs were serially diluted and seeded at 750, 500, 200 and 100 cells per well on 96 well plates. The maintenance efficiencies of these dilutions were compared for 3, 7, 9, and 14 days. The fetal bovine serum (FBS) concentration (20, 10, 5 and 1%) and the cell numbers (750, 500 and 200 cells/well) were compared for 3, 5 and 7 days. In addition, we evaluated the optimal conditions for cell cycle block. These four independent optimization experiments were conducted using an MTT assay. In the results, the optimal conditions for a HTS system using hUC-MSCs were determined to be 300 cell/well cultured for 8 days with 1 or 5% FBS. In addition, we demonstrated that the optimal conditions for a cell cycle block in this culture system are 48 hours in the absence of FBS. In addition, we selected four types of novel small molecule candidates using our HTS system which demonstrates the feasibility if using hUC-MSCs for this type of screen. Moreover, the four candidate compounds can be tested for stem cell research application.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.22 no.1
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• pp.109-116
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• 2018

This paper describes an area-efficient design of SHA-256 hash function that is widely used in various security protocols including digital signature, authentication code, key generation. The SHA-256 hash processor includes a padder block for padding and parsing input message, so that it can operate without software for preprocessing. Round function was designed with a 16-bit data-path that processed 64 round computations in 128 clock cycles, resulting in an optimized area per throughput (APT) performance as well as small area implementation. The SHA-256 hash processor was verified by FPGA implementation using Virtex5 device, and it was estimated that the throughput was 337 Mbps at maximum clock frequency of 116 MHz. The synthesis for ASIC implementation using a $0.18-{\mu}m$ CMOS cell library shows that it has 13,251 gate equivalents (GEs) and it can operate up to 200 MHz clock frequency.

• Journal of Digital Contents Society
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• v.8 no.3
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• pp.323-328
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• 2007

Communication systems beyond 3G should provide more than 100 Mbps for wireless access. In addition to smart antennas, wireless multi-hop networks are proposed to increase the cell size and throughput. For example, Zigbee technology is expected to provide low cost and low power connectivity and can be implemented in wireless mesh networks larger than is possible with Bluetooth. Also, home embedded system using wireless mesh network is one of the key market areas for Zigbee applications. If the line-of-sight path is shadowed by home obstacles, a direct connection between the access point (AP) and the node is not possible at high frequencies. Therefore, by using multi-hop relay scheme the end node can be reached to AP. In this paper, the relaying of data between the AP and the end node is investigated and the throughput and PER(Packet Error Rate) are evaluated in multi-hop wireless mesh networks by using DSSS/BPSK system.

• Journal of Advanced Navigation Technology
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• v.16 no.3
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• pp.471-479
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• 2012

In cellular femto systems, femto Base stations(f-BSs) can be installed unnecessarily and overcrowded in small areas. This will cause an interference problem and it can impact on the capacity, blocking probability, and coverage of femtocells in the shared channel systems. In this paper, we propose a load distribution scheme by using forced handover and probabilistic subchannel scheduling policy to resolve the problem. The proposed scheme operates in distributed manner though communication with neighboring f-BSs, and includes self-detection of overcrowded area and radio resource management based on measurements. We evaluate the performance of the proposed scheme in terms of average cell throughput and average throughput per users.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.42 no.5 s.335
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• pp.55-62
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• 2005

In this paper, we propose an efficient symbol detection algorithm for space-frequency OFDM (SF-OFDM) transmit diversity scheme and present the implementation results of the SF-OFDM WLAN baseband processor with the proposed algorithm. When the number of sub-carriers in SF-OFDM scheme is small, the interference between adjacent sub-carriers may be generated. The proposed algorithm eliminates this interference in a parallel manner and obtains a considerable performance improvement over the conventional detection algorithm. The bit error rate (BER) performance of the proposed detection algorithm is evaluated by the simulation. In the case of 2 transmit and 2 receive antennas, at $BER=10^{-4}$ the proposed algorithm obtains about 3 dB gain over the conventional detection algorithm. The packet error rate (PER), link throughput, and coverage performance of the SF-OFDM WLAN with the proposed detection algorithm are also estimated. For the target throughput at $80\%$ of the peak data rate, the SF-OFDM WLAN achieves the average SNR gain of about 5.95 dB and the average coverage gain of 3.98 meter. The SF-OFDM WLAN baseband processor with the proposed algorithm was designed in a hardware description language and synthesized to gate-level circuits using 0.18um 1.8V CMOS standard cell library. With the division-free architecture, the total logic gate count for the processor is 945K. The real-time operation is verified and evaluated using a FPGA test system.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39C no.10
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• pp.937-945
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• 2014

As various services requiring high data rate are supported by introducing LTE/LTE-adv., mobile traffic increases rapidly. To cope with the continuous growth of traffic demand, small cell technology is considered as one of the most promising one. Small cell can increase system capacity by increasing the number of base stations with reduced cell radius. In this paper, we analyze the effect of cell densification with small cells in terms of SINR and average UE throughput considering cell split and the number of UE per unit area. As the cell becomes smaller, SINR degradation arises from high ICI(Inter Cell Interference) and we evaluate the effect of interference mitigation scheme in small cell environment where the proper interference mitigation technique is applied.