• Journal of the Korean Home Economics Association
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• v.51 no.2
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• pp.195-206
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• 2013

This study was conducted in order to investigate the variables that relate and affect the internalizing and externalizing problems of multicultural children. 159 multicultural children in the $3^{rd}{\sim}6^{th}$grade were selected from elementary schools in Gwangju and the Jeollanamdo area. The data was analyzed by using the frequency, Cronbach's ${\alpha}$, t-test, ANOVA, Pearson's correlation and hierarchical regression by SPSS 12.0 program. The results were as follows: first, the internalizing problems were different according to the socio-demographic variable: (gender, subjective economic level), multicultural characteristic variable: (mother's communication ability, likability of mother's nationality, etc.), parent-child relationship variable: (relationship with mother, relationship with father) and social support variable: (peer support, teacher support). Further, the externalizing problems were different according to the socio-demographic variable: (gender), multicultural characteristic variable: (mother's nationality, mother's communication ability, etc.), parent-child relationship variable: (relationship with mother, relationship with father) and social support variable: (peer support, teacher support). Second, the influential variables regarding the internalizing problems were children's stress from cultural adaptability and the likability of the mother's nationality of the multicultural characteristic variable group, peer support of the social support variable group and the subjective economic-level of the socio-demographic variable group. Moreover, the influential variable on the externalizing problems was children's stress from the cultural adaptability of the multicultural characteristic variable group. The most influential variable of such variables was children's stress from cultural adaptability of the multicultural characteristic variable group. The results of this study will provide information for the development of educational and therapeutic intervention program for multicultural children.

• BMB Reports
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• v.49 no.8
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• pp.405-413
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• 2016

Tau proteins, which stabilize the structure and regulate the dynamics of microtubules, also play important roles in axonal transport and signal transduction. Tau proteins are missorted, aggregated, and found as tau inclusions under many pathological conditions associated with neurodegenerative disorders, which are collectively known as tauopathies. In the adult human brain, tau protein can be expressed in six isoforms due to alternative splicing. The aberrant splicing of tau pre-mRNA has been consistently identified in a variety of tauopathies but is not restricted to these types of disorders as it is also present in patients with non-tau proteinopathies and RNAopathies. Tau mis-splicing results in isoform-specific impairments in normal physiological function and enhanced recruitment of excessive tau isoforms into the pathological process. A variety of factors are involved in the complex set of mechanisms underlying tau mis-splicing, but variation in the cis-element, methylation of the MAPT gene, genetic polymorphisms, the quantity and activity of spliceosomal proteins, and the patency of other RNA-binding proteins, are related to aberrant splicing. Currently, there is a lack of appropriate therapeutic strategies aimed at correcting the tau mis-splicing process in patients with neurodegenerative disorders. Thus, a more comprehensive understanding of the relationship between tau mis-splicing and neurodegenerative disorders will aid in the development of efficient therapeutic strategies for patients with a tauopathy or other, related neurodegenerative disorders.

• Molecules and Cells
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• v.38 no.3
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• pp.202-209
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• 2015

Hepatocellular carcinoma (HCC), a highly malignant disease and the third leading cause of all cancer mortalities worldwide, often responses poorly to current treatments and results in dismal outcomes due to frequent chemoresistance and tumor relapse. The heterogeneity of HCC is an important attribute of the disease. It is the outcome of many factors, including the cross-talk between tumor cells within the tumor microenvironment and the acquisition and accumulation of genetic and epigenetic alterations in tumor cells. In addition, there is accumulating evidence in recent years to show that the malignancy of HCC can be attributed partly to the presence of cancer stem cell (CSC). CSCs are capable to self-renew, differentiate and initiate tumor formation. The regulation of the stem cell-like properties by several important signaling pathways have been found to endow the tumor cells with an increased level of tumorigenicity, chemoresistance, and metastatic ability. In this review, we will discuss the recent findings on hepatic CSCs, with special emphasis on their putative origins, relationship with hepatitis viruses, regulatory signaling networks, tumor microenvironment, and how these factors control the stemness of hepatic CSCs. We will also discuss some novel therapeutic strategies targeted at hepatic CSCs for combating HCC and perspectives of future investigation.

• Journal of the Korean Home Economics Association
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• v.49 no.10
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• pp.91-101
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• 2011

The purpose of this study was to find a therapeutic intervention for a couple in the pre-divorce stage. We used data from the case study to examine the factors related to marital conflict and enhancements related to the family of origin. Our sample was the couple in pre-divorce stage who has been married for 3 years. The therapeutic intervention methods used were taken from Positive Psychology, Family Systems Theory, Communication Theory, and Solution-Focused Therapy. We counseled the couple once a week for 10 sessions from $5^{th}$ October to $7^{th}$ December in 2010. Our objective was to give a positive perspective on the couple who was in the pre-divorce stage. We also provided clear-cut, practical techniques for responding productively to inappropriate expressions of anger. The couple acquired strategies to make their relationship work more effectively. Finally, the couple set their family goals for adjustment instead of divorce.

• Journal of Microbiology and Biotechnology
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• v.28 no.8
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• pp.1299-1309
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• 2018

We previously reported on lactophoricin (LPcin), a cationic ${\alpha}-helical$ antimicrobial peptide derived from bovine milk, which has antimicrobial effects on Candida albicans as well as Gram-positive and Gram-negative bacteria. In this study, we designed the LPcin-YK3 peptide, a shorter analog of LPcin, and investigated its antimicrobial activity. This peptide, consisting of 15 amino acids with + 3 net charges, was an effective antimicrobial agent against the on the Gram-positive strain, Staphylococcus aureus (MIC: $0.62{\mu}g/ml$). In addition, the hemolytic activity assay revealed that the peptide was not toxic to mouse and human erythrocytes up to $40{\mu}g/ml$. We also used circular dichroism spectroscopy to confirm that peptide in the presence of lipid has ${\alpha}-helical$ structures and later provide an overview of the relationship between each structure and antimicrobial activity. This peptide is a member of a new class of antimicrobial agents that could potentially overcome the problem of bacterial resistance caused by overuse of conventional antibiotics. Therefore, it could be used as a therapeutic or natural additive, particularly in the cosmetics industry.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.11 no.3
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• pp.299-308
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• 2004

Purpose: This study was done to compare the perceived nursing needs as reported by admitted patients and nurses in a general hospital. Method: The participants were 194 patients and 183 nurses in a general hospital in Seoul. The instruments were constructed based on a prior study review and revised after a pilot study with 3 patients. The questionnaire for nursing needs included questions on physical, therapeutic, emotional, educational and socioeconomic domains. Data were collected between February 29 and March 26 for patients and between February 19 and 26, 2002 for nurses. The data were analyzed with frequencies, percentiles, means and t-test. Results: The results were as follow: 1. The total score for perceived nursing needs by nurses was higher than that reported by patients except for socioeconomic needs. 2. There were significant differences between patients and nurses only in the emotional domain (t=3.50, p=.001). 3. The highest score was for therapeutic needs and the next was for educational needs. 4. Relatively higher scored items were for comfort care, prevention of nosocomial infections, immediate treatment, monitoring health condition, kindness, and explanation of tests and treatments. Conclusion: Nurses generally understand patients' nursing needs but have to be more interested in patients' needs in order to prevent nosocomial infections, to provide care in a good relationship with the doctors and to encourage the patients.

• Journal of the Korea Society of Computer and Information
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• v.24 no.5
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• pp.171-177
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• 2019

In this paper, we analyze the current phenomenon of child abuse crimes based on the information gathered by the National Child Protection Agency. The purpose of this paper is to diagnose the seriousness of child abuse by biological parents based on the analyzed information and propose measures against it. Comprehensive and integrated measures are needed for child abuse committed by biological parents due to abuse concealment, continuity of damage, and inactive national intervention by considering punishment on attackers through national intervention, fundamental in-depth psychological counseling, therapeutic care, promoting recovery of victims, and ultimately continuous and regular management and monitoring as a long-terms measure. To do so, developing customized and individual educational programs and make them obligations can be first presented to identify child abuse in advance and build up preventive systems based on the principle of family preservation. In addition, problems should be addressed at a fundamental level by performing various and active therapeutic treatments such as psychological treatment, mental treatment, or drug treatment gradually and through phases for biological parents who commit child abuse and contributing to recovering the relationship. Furthermore, proper protection and treatment service should be provided to children victimized by abuse by extending professional children care facilities and adopting the professional family commission system as measures by separating family.

• Journal of Korean Academic Society of Home Health Care Nursing
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• v.27 no.3
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• pp.344-355
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• 2020

Purpose: Recovery has a growing influence on policy for individuals with mental illness and their families. This study was designed to examine the meaning of recovery from the perspectives of community-dwelling patients with mental illness and their families. Methods: Using a descriptive qualitative approach, in-depth, face-to-face interviews were conducted on 24 adults (14 patients with mental illness and 10 family members). All interviews were audiotaped, transcribed and analyzed using thematic analysis. Results: The findings showed that recovery for the patients with mental illness suggested gradual changes by individual will and self-awareness, the relationship with both their family and self-help group, and the support of a therapeutic environment. Seven primary themes emerged from the analysis: improving insight on illness, strong will toward hope, discovering changed myself, helping each other together, gradual influence of positivity, being oriented to a therapeutic setting, and recognizing of home as a calm place. Conclusion: The findings of this study revealed that based on the conceptual elements of recovery of the patients with mental illness and their families, we expect to improve the systematic, comprehensive, and quality mental health services.

• Journal of Microbiology and Biotechnology
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• v.32 no.9
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• pp.1086-1097
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• 2022

During the last decades, research and therapeutic methods in cancer treatment have been evolving. As the results, nowadays, cancer patients are receiving several types of treatments, ranging from chemotherapy and radiation therapy to surgery and immunotherapy. In fact, most cancer patients take a combination of current anti-cancer therapies to improve the efficacy of treatment. However, current strategies still cause some side effects to patients, such as pain and depression. Therefore, there is the need to discover better ways to eradicate cancer whilst minimizing side effects. Recently, immunotherapy, particularly immune checkpoint blockade, is rising as an effective anti-cancer treatment. Unlike chemotherapy or radiation therapy, immunotherapy has few side effects and a higher tumor cell removal efficacy depend on cellular immunological mechanisms. Moreover, recent studies suggest that tissue immune responses are regulated by their microbiome composition. Each tissue has their specific microenvironment, which makes their microbiome composition different, particularly in the context of different types of cancer, such as breast, colorectal, kidney, lung, and skin. Herein, we review the current understanding of the relationship of immune responses and tissue microbiome in cancer in both animal and human studies. Moreover, we discuss the cancer-microbiome-immune axis in the context of cancer development and treatment. Finally, we speculate on strategies to control tissue microbiome alterations that may synergistically affect the immune system and impact cancer treatment outcomes.

• Korean Journal of Radiology
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• v.23 no.6
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• pp.674-687
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• 2022

Patellofemoral instability (PFI) is common in pediatric knee injuries. PFI results from loss of balance in the dynamic relationship of the patella in the femoral trochlear groove. Patellar lateral dislocation, which is at the extreme of the PFI, results from medial stabilizer injury and leads to the patella hitting the lateral femoral condyle. Multiple contributing factors to PFI have been described, including anatomical variants and altered biomechanics. Femoral condyle dysplasia is a major risk factor for PFI. Medial stabilizer injury contributes to PFI by creating an imbalance in dynamic vectors of the patella. Increased Q angle, femoral anteversion, and lateral insertion of the patellar tendon are additional contributing factors that affect dynamic vectors on the patella. An imbalance in the dynamics results in patellofemoral malalignment, which can be recognized by the presence of patella alta, patellar lateral tilt, and lateral subluxation. Dynamic cross-sectional images are useful for in vivo tracking of the patella in patients with PFI. Therapeutic approaches aim to restore normal patellofemoral dynamics and prevent persistent PFI. In this article, the imaging findings of PFI, including risk factors and characteristic findings of acute lateral patellar dislocation, are reviewed. Non-surgical and surgical approaches to PFI in pediatric patients are discussed.