• Korean Journal of Psychosomatic Medicine
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• v.1 no.1
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• pp.98-100
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• 1993

To become an effective and successful consultation-liasion psychiatrist the psychiatrist should consider two aspects of consultation before he/she meets his/her patients. First the psychiatrist should understand the internal need and psychological state of patients who visited their physician before being refered to a psychiatrist So psychiatrists should be careful in the evaluation of the patient's intention whether they are willing to accept the psychiatric treatment approach or not Second the psychiatrist should understand the situation and the physician's internal need in the consultation. Psychiatrists should recognize whether there are any factors which interfere with the mutual understanding and cooperation between physicians and psychiatrist.

• IMMUNE NETWORK
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• v.7 no.4
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• pp.167-172
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• 2007

Various cell types that express regulatory function may influence the pathogenesis of most and perhaps all infections. Some regulatory cells are present at the time of infection whereas others are induced or activated in response to infection. The actual mechanisms by which different types of infections signal regulatory cell responses remain poorly understood. However a most likely mechanism is the creation of a microenvironment that permits the conversion of conventional T cells into cells with the same antigen specificity that have regulatory function. Some possible means by which this can occur are discussed. The relationship between regulatory cells and infections is complex especially with chronic situations. The outcome can either be of benefit to the host or damage the disease control process or in rare instances appears to be a component of a finely balanced relationship between the host and the infecting agent. Manipulating the regulatory cell responses to achieve a favorable outcome of infection remains an unfulfilled objective of therapeutic immunology.

• Biomolecules & Therapeutics
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• v.31 no.3
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• pp.241-252
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• 2023

The era of innovative RNA therapies using antisense oligonucleotides (ASOs), siRNAs, and mRNAs is beginning. Since the emergence of the concept of ASOs in 1978, it took more than 20 years before they were developed into drugs for commercial use. Nine ASO drugs have been approved to date. However, they target only rare genetic diseases, and the number of chemistries and mechanisms of action of ASOs are limited. Nevertheless, ASOs are accepted as a powerful modality for next-generation medicines as they can theoretically target all disease-related RNAs, including (undruggable) protein-coding RNAs and non-coding RNAs. In addition, ASOs can not only downregulate but also upregulate gene expression through diverse mechanisms of action. This review summarizes the achievements in medicinal chemistry that enabled the translation of the ASO concept into real drugs, the molecular mechanisms of action of ASOs, the structure-activity relationship of ASO-protein binding, and the pharmacology, pharmacokinetics, and toxicology of ASOs. In addition, it discusses recent advances in medicinal chemistry in improving the therapeutic potential of ASOs by reducing their toxicity and enhancing their cellular uptake.

• International journal of advanced smart convergence
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• v.13 no.2
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• pp.214-221
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• 2024

This study explores the relationship between childhood abuse experiences and subsequent mental disorders in adults, with a particular focus on the moderating role of spiritual well-being. Using self-reported data from 210 graduate students in the Daejeon and Chungcheong regions, the findings demonstrate that spiritual well-being significantly moderate how childhood abuse impacts adult mental health. Specifically, individuals with lower levels of spiritual well-being experience a greater exacerbation of metnal disorders related to past abuse, while those with higher levels show a buffering effect. These results suggest that enhancing spiritual well-being could be a vital component of therapeutic interventions aimed at preventing mental disorders in adults who have experienced childhood abuse. We highlight the potential benefits of incorporating spiritual well-being into mental health strategies and call for additional research to substantiate these findings across broader populations. This unique contribution underscores the importance of considering spiritual factors int the therpeutic process, offering a new and valuable perspective in the field of mental health research.

• Radiation Oncology Journal
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• v.18 no.2
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• pp.127-132
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• 2000

Purpose : To determine if the tumor intersitial fluid pressure (TIFP) and/or its change in patients with metastatic Iymph node in head and neck area can predict radiotherapy outcome. Materials and Methods : In 26 biopsy Proven metastatic Iymph node Patients in head and neck area with accessible by direct inspection and palpation, and of sufficient thickness (>1 cm) to permit accurate needle placement, we measured TIFP at cervical Iymph node before and during radiotherapy. Tumor size was measured clinically and radiologically. Results : The mean preradiotherapy TIFP was 24.7 mmHg. Preradiotherapy TIFP had marginally significant relationship with tumor size (p=0.06). Preradiotherapy TIFP significantly decreased when tumor size decreased (p=0.009). Preradiotherapy TIFP was not different between complete response group and group with partial or less response (p=0.75). Radiotherapy outcome was not different between group with above and group with below than average TIFP (p=0.229). TIFP decreased 36mmHg in complete response group and 29.7 mmHg in group with partial or less response. Conclusion :The mean TIFP was elevated with 24.7 mmHg. Preradiotherapy TIFP had marginally significant relationship with tumor size (p=0.06). TIFP decreased 36 mmHg in complete response group and 29.7 mmHg in group with partial or less respone but there was no statistically significant relationship in two groups.

• Journal of Korean Academy of Nursing
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• v.36 no.6
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• pp.1002-1011
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• 2006

Purpose: The purpose of this study was to determine characteristics of nursing science and identify expected outcomes from baccalaureate graduates, and to develop accreditation standards and criteria reflecting the characteristics of the nursing profession. Methods: A methodological research design was utilized in this study. Related literature reviews and the nursing education program goals and objectives of the 99 nursing schools in Korea were analyzed. A cross-sectional survey research design was utilized to test the validity of the developed characteristics of the nursing profession and their accreditation criteria and standards. The face validity was from the advisory committee and public committee hearing. Results: The characteristics of nursing science were defined with five concepts including humanity, scientific knowledge, professionalism, therapeutic relationship, and facilitating well-being. The expected outcomes from graduates were identified as providing holistic nursing, critical thinking, establishing professionalism and leadership, construction of a therapeutic relationship, and skilled nursing practice. Finally6 standards and 14 criteria reflecting the unique characteristics of the nursing profession were developed for accreditation. These proposed accreditation standards and criteria are a challenge to promote the quality of nursing science.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.4 no.1
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• pp.142-163
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• 1993

A 8 year old boy with problems of hyperactivity, impulsivity received playpsychotherapy. Through the detailed examination of their contents and group supervision of play therapy session, common mistakes novice therapist make frequently and tasks in the initial phase of play psychotherapy are illustrated. Therapist's personality and anxiety frequently interferes therapeutic processes. Common mistakes therapist makes during initial phase of play therapy are ; therapist's over-enthusiasm, overinvolvement or non-responsiveness, premature or inappropriate interpretation and direct connection of play theme to reality. It is utmost important for the therapist to make positive and trusting relationship with the patient in the initial phase of the therapy. In order to do so therapist must accept the patient as he is, permit the patient takes his leads. And as a result, the Patient can go through corrected developmental experience. In conclusion, it is a therapist's main task to establish relationship.

• Journal of Korean Physical Therapy Science
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• v.30 no.4
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• pp.17-28
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• 2023

Background: The purpose of this study is to examine the multiple-parallel mediation effects of self-esteem and body-image on the relationship between peer attachment and happiness in children with chronic diseases. In addition, this study aims to provide a basis for supporting psychological services alongside therapeutic services as a way to increase the overall happiness of children with chronic diseases. Design: This study utilized data from the 2020 Panel Study on Korean Children. Methods: The survey method was conducted as a survey by investigators, and the number of cases used in the study was 363. Results: First, children's peer attachment is associated with higher levels of overall happiness. Second, it can see that peer attachment not only increases self-esteem, but also leads to a positive perception of one's own body-image. Third, it can be seen that peer attachment, high self-esteem, and positive perception of body-image increase children's overall happiness. Finally, it can be seen that peer attachment can increase children's happiness through self-esteem and body-image Conclusion: It is thought that a more positive prognosis can be expected when psychological support is provided together with therapeutic treatment in providing medical services for children with chronic diseases.

• Journal of the Korea Fashion and Costume Design Association
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• v.15 no.2
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• pp.123-133
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• 2013

The purpose of this study is to find out how female immigrants are interested in beauty and how fashion affects their fashion management behavior. First, the correlation between interest in beauty and fashion behaviors showed that every factor has a positive relationship with each other. Self-interest, which is one of the two sub-factors of interest in beauty, showed a particularly strong correlation with interest in orientation towards fashion. Interest in appearance education, which is one of the two sub-factors of interest in fashion, showed a strong relationship with interest in orientation towards fashion, proving that the more one is interested in appearance-related education, the more she follows fashion trends. This suggests that caring for appearance and fashion trends have a strong relationship. Second, looking into the effect of interest in beauty and fashion on fashion behaviors, it turned out that only personal interest, out of the two sub-factors of interest in beauty, affected pursuit of fashion sense, out of the two sub-factors of fashion behaviors; interest in appearance education rather than interest in orientation towards fashion affected pursuit of fashion sense; interest in orientation towards fashion affected caring for one's appearance.

• Korean Journal of Childcare and Education
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• v.17 no.6
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• pp.93-108
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• 2021

Objective: This study examined the mediating effect of adolescents' self-esteem on the relationship between their childhood abuse experiences and school rule-breaking behavior. Methods: The research participants consisted of 1,748 adolescents aged from 15 to 16. Adolescents' school rule-breaking behavior and self-esteem were measured in 2016, whereas their childhood abuse experiences were measured in 2010. Panel data collected by the National Youth Policy Institute were analyzed using the bootstrapping technique and PROCESS Macro for SPSS. Results: The results of the study are as follows. First, the adolescents' childhood abuse experiences affected their school rule-breaking behavior. That is, the adolescents who were abused by their parents were at higher risk of breaking school rules later in life. Second, the adolescents' self-esteem mediated the relationship between their childhood abuse experiences and school rule-breaking behavior. The adolescents who were abused by their parents tend to have low levels of self-esteem and thereby break school rules. Conclusion/Implications: The present study shows the possibility that childhood abuse experiences lead to adolescents' problematic behaviors, such as school rule violation. It also indicates that it is necessary to provide counseling and therapeutic interventions for enhancing the self-esteem of adolescents of the at-risk group with childhood abuse experiences.