References
- Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155:1151-1164, 1995
- Fontenot JD, Gavin MA, Rudensky AY: Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells. Nat Immunol 4:330-336, 2003 https://doi.org/10.1038/ni904
- Blair PJ, Bultman SJ, Haas JC, Rouse BT, Wilkinson JE, Godfrey VL: CD4+ CD8 T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse. J Immunol 153:3764-3774, 1994
- Le Bras S, Geha RS: IPEX and the role of Foxp3 in the development and function of human Tregs. J Clin Invest 116:1473-1475, 2006 https://doi.org/10.1172/JCI28880
- Stephens GL, Shevach EM: Foxp3+ regulatory T cells: selfishness under scrutiny. Immunity 27:417-419, 2007 https://doi.org/10.1016/j.immuni.2007.08.008
- Rouse BT: Regulatory T cells in health and disease. J Intern Med 262:78-95, 2007 https://doi.org/10.1111/j.1365-2796.2007.01836.x
- Rouse BT, Suvas S: Regulatory T cells and immunity to pathogens. Expert Opin Biol Ther 7:1301-1309, 2007 https://doi.org/10.1517/14712598.7.9.1301
- Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL: CD4+ CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 420:502-507, 2002 https://doi.org/10.1038/nature01152
- Kinter AL, Horak R, Sion M, Riggin L, McNally J, Lin Y, Jackson R, O'Shea A, Roby G, Kovacs C, Connors M, Migueles SA, Fauci AS: CD25+ regulatory T cells isolated from HIV-infected individuals suppress the cytolytic and nonlytic antiviral activity of HIV-specific CD8+ T cells in vitro. AIDS Res Hum Retroviruses 23:438-450, 2007 https://doi.org/10.1089/aid.2006.0162
- Ralainirina N, Poli A, Michel T, Poos L, Andres E, Hentges F, Zimmer J: Control of NK cell functions by CD4+ CD25+ regulatory T cells. J Leukoc Biol 81:144-153, 2007 https://doi.org/10.1189/jlb.0606409
- Belkaid Y: Regulatory T cells and infection: a dangerous necessity. Nat Rev Immunol 7:875-888, 2007 https://doi.org/10.1038/nri2189
- Kobayashi N, Hiraoka N, Yamagami W, Ojima H, Kanai Y, Kosuge T, Nakajima A, Hirohashi S: FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis. Clin Cancer Res 13:902-911, 2007 https://doi.org/10.1158/1078-0432.CCR-06-2363
- Stoop JN, van der Molen RG, Kuipers EJ, Kusters JG, Janssen HL: Inhibition of viral replication reduces regulatory T cells and enhances the antiviral immune response in chronic hepatitis B. Virology 361:141-148, 2007 https://doi.org/10.1016/j.virol.2006.11.018
- Kinter AL, Hennessey M, Bell A, Kern S, Lin Y, Daucher M, Planta M, McGlaughlin M, Jackson R, Ziegler SF, Fauci AS: CD25(+) CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status. J Exp Med 200:331-343, 2004 https://doi.org/10.1084/jem.20032069
- Walther M, Tongren JE, Andrews L, Korbel D, King E, Fletcher H, Andersen RF, Bejon P, Thompson F, Dunachie SJ, Edele F, de Souza JB, Sinden RE, Gilbert SC, Riley EM, Hill AV: Upregulation of TGF-beta, FOXP3, and CD4+ CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection. Immunity 23:287-296, 2005 https://doi.org/10.1016/j.immuni.2005.08.006
- Suvas S, Kumaraguru U, Pack CD, Lee S, Rouse BT: CD4+ CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses. J Exp Med 198:889-901, 2003 https://doi.org/10.1084/jem.20030171
- Fernandez M, Wang YM, Stephen SL, Jones CA: Enhanced T regulatory cell activity contributes to the attenuated primary CD8+ and CD4 T cell responses to HSV-2 in neonatal mice. J Immunol (In press), 2007
- Hartigan-O'Connor DJ, Abel K, McCune JM: Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression. J Exp Med 204:2679-2692, 2007 https://doi.org/10.1084/jem.20071068
- Toka FN, Suvas S, Rouse BT: CD4+ CD25+ T cells regulate vaccine-generated primary and memory CD8+ T-cell responses against herpes simplex virus type 1. J Virol 78:13082-13089, 2004 https://doi.org/10.1128/JVI.78.23.13082-13089.2004
- Moore AC, Gallimore A, Draper SJ, Watkins KR, Gilbert SC, Hill AV: Anti-CD25 antibody enhancement of vaccineinduced immunogenicity: increased durable cellular immunity with reduced immunodominance. J Immunol 175:7264-7273, 2005 https://doi.org/10.4049/jimmunol.175.11.7264
- Litzinger MT, Fernando R, Curiel TJ, Grosenbach DW, Schlom J, Palena C: IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity. Blood 110:3192-3201, 2007 https://doi.org/10.1182/blood-2007-06-094615
- Suvas S, Azkur AK, Kim BS, Kumaraguru U, Rouse BT: CD4+ CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions. J Immunol 172:4123-4132, 2004 https://doi.org/10.4049/jimmunol.172.7.4123
- Eggena MP, Barugahare B, Jones N, Okello M, Mutalya S, Kityo C, Mugyenyi P, Cao H: Depletion of regulatory T cells in HIV infection is associated with immune activation. J Immunol 174:4407-4414, 2005 https://doi.org/10.4049/jimmunol.174.7.4407
- McCune JM: The dynamics of CD4+ T-cell depletion in HIV disease. Nature 410:974-979, 2001 https://doi.org/10.1038/35073648
- Kornfeld C, Ploquin MJ, Pandrea I, Faye A, Onanga R, Apetrei C, Poaty-Mavoungou V, Rouquet P, Estaquier J, Mortara L, Desoutter JF, Butor C, Le Grand R, Roques P, Simon F, Barre-Sinoussi F, Diop OM, Muller-Trutwin MC:Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS. J Clin Invest 115:1082-1091, 2005 https://doi.org/10.1172/JCI23006
- Coleman C, Muller-Trutwin MC, Apetrei C, Pandrea I: T regulatory cells: aid or hindrance in the clearance of disease? J Cell Mol Med 10.1111/j.1582-4934.2007. 00087.x, 2007
- Miyara M, Sakaguchi S: Natural regulatory T cells: mechanisms of suppression. Trends Mol Med 13:108-116, 2007 https://doi.org/10.1016/j.molmed.2007.01.003
- La Flamme AC, Ruddenklau K, Backstrom BT: Schistosomiasis decreases central nervous system inflammation and alters the progression of experimental autoimmune encephalomyelitis. Infect Immun 71:4996-5004, 2003 https://doi.org/10.1128/IAI.71.9.4996-5004.2003
- Wilson MS, Taylor MD, Balic A, Finney CA, Lamb JR, Maizels RM: Suppression of allergic airway inflammation by helminthinduced regulatory T cells. J Exp Med 202:1199-1212, 2005 https://doi.org/10.1084/jem.20042572
- Zaccone P, Fehervari Z, Jones FM, Sidobre S, Kronenberg M, Dunne DW, Cooke A: Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes. Eur J Immunol 33:1439-1449, 2003 https://doi.org/10.1002/eji.200323910
- Pacholczyk R, Kern J, Singh N, Iwashima M, Kraj P, Ignatowicz L: Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Immunity 27:493-504, 2007 https://doi.org/10.1016/j.immuni.2007.07.019
- Vahlenkamp TW, Tompkins MB, Tompkins WA: Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4+CD25+ T regulatory cells. J Immunol 172:4752-4761, 2004 https://doi.org/10.4049/jimmunol.172.8.4752
- Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM: Conversion of peripheral CD4+ CD25- naive T cells to CD4+ CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198:1875-1886, 2003 https://doi.org/10.1084/jem.20030152
- Jaeckel E, Kretschmer K, Apostolou I, von Boehmer H: Instruction of Treg commitment in peripheral T cells is suited to reverse autoimmunity. Semin Immunol 18:89-92, 2006 https://doi.org/10.1016/j.smim.2006.01.011
- Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK: Reciprocal developmental path ways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235-238, 2006 https://doi.org/10.1038/nature04753
- Pasare C, Medzhitov R: Toll pathway-dependent blockade of CD4+ CD25+ T cell-mediated suppression by dendritic cells. Science 299:1033-1036, 2003 https://doi.org/10.1126/science.1078231
- Fantini MC, Rizzo A, Fina D, Caruso R, Becker C, Neurath MF, Macdonald TT, Pallone F, Monteleone G: IL-21 regulates experimental colitis by modulating the balance between T(reg) and Th17 cells. Eur J Immunol 37:3155-3163, 2007 https://doi.org/10.1002/eji.200737766
- von Boehmer H: Oral tolerance: is it all retinoic acid? J Exp Med 204:1737-1739, 2007 https://doi.org/10.1084/jem.20071251
- Sun CM, Hall JA, Blank RB, Bouladoux N, Oukka M, Mora JR, Belkaid Y: Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 204:1775-1785, 2007 https://doi.org/10.1084/jem.20070602
- Coombes JL, Siddiqui KR, Arancibia-Carcamo CV, Hall J, Sun CM, Belkaid Y, Powrie F: A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 204:1757-1764, 2007 https://doi.org/10.1084/jem.20070590
- Kang S, Lim HW, Andrisani OM, Broxmeyer HE, Chang HK: Vitamin A metabolite Induce gut-homing Foxp3+ regulatory T cells. J Immunol 179:3724-3733, 2007 https://doi.org/10.4049/jimmunol.179.6.3724
-
Sehrawat S, Rouse BT: FTY720 treatment effectively induces antigen-specific
$Foxp3^+$ Regulatory T cells. J Immunol (Submitted), 2007