• 정신신체의학
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• 제1권1호
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• pp.98-100
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• 1993

To become an effective and successful consultation-liasion psychiatrist the psychiatrist should consider two aspects of consultation before he/she meets his/her patients. First the psychiatrist should understand the internal need and psychological state of patients who visited their physician before being refered to a psychiatrist So psychiatrists should be careful in the evaluation of the patient's intention whether they are willing to accept the psychiatric treatment approach or not Second the psychiatrist should understand the situation and the physician's internal need in the consultation. Psychiatrists should recognize whether there are any factors which interfere with the mutual understanding and cooperation between physicians and psychiatrist.

• IMMUNE NETWORK
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• 제7권4호
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• pp.167-172
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• 2007

Various cell types that express regulatory function may influence the pathogenesis of most and perhaps all infections. Some regulatory cells are present at the time of infection whereas others are induced or activated in response to infection. The actual mechanisms by which different types of infections signal regulatory cell responses remain poorly understood. However a most likely mechanism is the creation of a microenvironment that permits the conversion of conventional T cells into cells with the same antigen specificity that have regulatory function. Some possible means by which this can occur are discussed. The relationship between regulatory cells and infections is complex especially with chronic situations. The outcome can either be of benefit to the host or damage the disease control process or in rare instances appears to be a component of a finely balanced relationship between the host and the infecting agent. Manipulating the regulatory cell responses to achieve a favorable outcome of infection remains an unfulfilled objective of therapeutic immunology.

• Biomolecules & Therapeutics
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• 제31권3호
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• pp.241-252
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• 2023

The era of innovative RNA therapies using antisense oligonucleotides (ASOs), siRNAs, and mRNAs is beginning. Since the emergence of the concept of ASOs in 1978, it took more than 20 years before they were developed into drugs for commercial use. Nine ASO drugs have been approved to date. However, they target only rare genetic diseases, and the number of chemistries and mechanisms of action of ASOs are limited. Nevertheless, ASOs are accepted as a powerful modality for next-generation medicines as they can theoretically target all disease-related RNAs, including (undruggable) protein-coding RNAs and non-coding RNAs. In addition, ASOs can not only downregulate but also upregulate gene expression through diverse mechanisms of action. This review summarizes the achievements in medicinal chemistry that enabled the translation of the ASO concept into real drugs, the molecular mechanisms of action of ASOs, the structure-activity relationship of ASO-protein binding, and the pharmacology, pharmacokinetics, and toxicology of ASOs. In addition, it discusses recent advances in medicinal chemistry in improving the therapeutic potential of ASOs by reducing their toxicity and enhancing their cellular uptake.

• International journal of advanced smart convergence
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• 제13권2호
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• pp.214-221
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• 2024

This study explores the relationship between childhood abuse experiences and subsequent mental disorders in adults, with a particular focus on the moderating role of spiritual well-being. Using self-reported data from 210 graduate students in the Daejeon and Chungcheong regions, the findings demonstrate that spiritual well-being significantly moderate how childhood abuse impacts adult mental health. Specifically, individuals with lower levels of spiritual well-being experience a greater exacerbation of metnal disorders related to past abuse, while those with higher levels show a buffering effect. These results suggest that enhancing spiritual well-being could be a vital component of therapeutic interventions aimed at preventing mental disorders in adults who have experienced childhood abuse. We highlight the potential benefits of incorporating spiritual well-being into mental health strategies and call for additional research to substantiate these findings across broader populations. This unique contribution underscores the importance of considering spiritual factors int the therpeutic process, offering a new and valuable perspective in the field of mental health research.

• Radiation Oncology Journal
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• 제18권2호
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• pp.127-132
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• 2000

목적 : 두경부 악성 림파절 환자에서 방사선치료중 종양내 간질액 압력을 측정하여 종양내 간질액 압력 및 이의 변화가 갖는 임상적 의의를 밝히고자 하였다. 방법 : 조직학적으로 확진된 26명의 전이성 두경부 악성 림파절 환자를 대상으로 육안적으로 확인 가능하며 접근이 가능한 부위에 위치하고 주사침 끝이 적절히 위치할 수 있도록 적어도 1 cm 이상의 충분한 두께를 갖는 경부 림프절에서 방사선치료 직전 및 방사선치료 중에 종양내 간질액 압력을 측정하였다. 종양의 크기는 촉지하여 임상적으로 측정하고 방사선과적 검사로 측정을 확인하였다. 결과 : 방사선치료 전 TIFP는 25명에서 측정이 가능하였으며 평균치는 24.7 mmHg였다. 방사선치료 전종양의 크기가 클수록 치료 전 TIFP가 높았으며 통계적으로 marginal한 상관관계를 보였고(p=0.06), 치료 전 종양 크기가 크면 치료 후 TIFP의 감소가 큰 경향을 보였으나 통계적인 유의성은 없었다(p=0.43). 방사선치료 중 9명에서 TIFP의 측정이 가능하였으며, 이들의 방사선치료 전과 치료 후 TIFP변화는 평균 12.5 mmHg로 감소하였으며 통계적으로 유의한 결과를 보였다(p=0.009). 치료 전 TIFP가 평균치 이상인 환자군과 이하인 환자군 사이에 방사선치료 결과의 차이가 관찰되지 않았다(p=0.229). 방사선 치료 후 완전 관해를 보인 환자군과 부분관해 이하의 치료 결과를 보인 군 사이에 치료 전 TIFP의 차이는 관찰되지 않았다(p=0.75). 방사선치료 후 완전 관해를 보인 환자군의 TIFP의 치료 전과 치료 중 비교시 평균 36 mmHg 감소하였으며 부분관해 이하의 치료 결과를 보인 군은 29.7 mmHg 감소하여 현재까지는 두 환자군 사이에 유의한 차이는 관찰되지 않았다(p=0.75) 결론 : 방사선치료 전 TIFP의 평균치는 24.7 mmHg였으며 종양의 크기가 클수록 치료 전 TIFP가 높았으며 통계적으로 marginal하게 유의하였다(p=0.06). 방사선치료 후 부분 관해 이하의 치료 결과를 보인 환자군의 치료 전과 치료 중 TIFP를 비교시 평균 29.7 mmHg로 감소하였으나 완전관해를 보인 군은 36mmHg의 더 큰 감소를 보였으나 현재까지는 두 군간의 차이는 유의하지는 않았다.(p=0.75)

• 대한간호학회지
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• 제36권6호
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• pp.1002-1011
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• 2006

Purpose: The purpose of this study was to determine characteristics of nursing science and identify expected outcomes from baccalaureate graduates, and to develop accreditation standards and criteria reflecting the characteristics of the nursing profession. Methods: A methodological research design was utilized in this study. Related literature reviews and the nursing education program goals and objectives of the 99 nursing schools in Korea were analyzed. A cross-sectional survey research design was utilized to test the validity of the developed characteristics of the nursing profession and their accreditation criteria and standards. The face validity was from the advisory committee and public committee hearing. Results: The characteristics of nursing science were defined with five concepts including humanity, scientific knowledge, professionalism, therapeutic relationship, and facilitating well-being. The expected outcomes from graduates were identified as providing holistic nursing, critical thinking, establishing professionalism and leadership, construction of a therapeutic relationship, and skilled nursing practice. Finally6 standards and 14 criteria reflecting the unique characteristics of the nursing profession were developed for accreditation. These proposed accreditation standards and criteria are a challenge to promote the quality of nursing science.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제4권1호
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• pp.142-163
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• 1993

정서적인 문제로 갑자기 산만하고 공격적인 문제를 보였던 8세된 국민학교 남아의 놀이치료 내용과 이에 대한 집단 지도 ${\cdot} 감독(supervision)을 자세히 기술함으로써 놀이치료 초심자가 초기 놀이치료에서 경험할 수 있는 여러 가지 문제점과 과제에 대해 살펴보았다. 놀이치료 초기에 초심치료자가 흔히 범하는 잘못은 치료자 자신의 불안이나 성격적 특성 때문에 놀이를 환아가 선택하는 방향으로 보다는 자신에게 의미있는 내용으로 이끌려하고, 너무 적극적이거나 무반응, 과잉간섭, 과잉 및 부적절한 해석, 현실과의 직접적 인계시도이다. 놀이치료 초기의 가장 중요한 과제는 치료자가 환아의 긍정적이고 신뢰할 수 있는 관계를 형성하는 것임으로 그리기 위해서는 환아를 있는 그대로 수용하며, 환아가 이끄는 방향으로 놀이가 일어날 수 있도록 허용하며, 치료자와의 관계를 통해 수정된 발달경험을 함으로써 문제와 갈등이 해결될 수 있다는 확신을 전해주어야 한다. 치료자는 놀이치료의 초기에는 모든 노력을 관계형성을 이루는데 촛점을 맞추어야 한다.

• 대한물리치료과학회지
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• 제30권4호
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• pp.17-28
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• 2023

Background: The purpose of this study is to examine the multiple-parallel mediation effects of self-esteem and body-image on the relationship between peer attachment and happiness in children with chronic diseases. In addition, this study aims to provide a basis for supporting psychological services alongside therapeutic services as a way to increase the overall happiness of children with chronic diseases. Design: This study utilized data from the 2020 Panel Study on Korean Children. Methods: The survey method was conducted as a survey by investigators, and the number of cases used in the study was 363. Results: First, children's peer attachment is associated with higher levels of overall happiness. Second, it can see that peer attachment not only increases self-esteem, but also leads to a positive perception of one's own body-image. Third, it can be seen that peer attachment, high self-esteem, and positive perception of body-image increase children's overall happiness. Finally, it can be seen that peer attachment can increase children's happiness through self-esteem and body-image Conclusion: It is thought that a more positive prognosis can be expected when psychological support is provided together with therapeutic treatment in providing medical services for children with chronic diseases.

• 한국의상디자인학회지
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• 제15권2호
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• pp.123-133
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• 2013

The purpose of this study is to find out how female immigrants are interested in beauty and how fashion affects their fashion management behavior. First, the correlation between interest in beauty and fashion behaviors showed that every factor has a positive relationship with each other. Self-interest, which is one of the two sub-factors of interest in beauty, showed a particularly strong correlation with interest in orientation towards fashion. Interest in appearance education, which is one of the two sub-factors of interest in fashion, showed a strong relationship with interest in orientation towards fashion, proving that the more one is interested in appearance-related education, the more she follows fashion trends. This suggests that caring for appearance and fashion trends have a strong relationship. Second, looking into the effect of interest in beauty and fashion on fashion behaviors, it turned out that only personal interest, out of the two sub-factors of interest in beauty, affected pursuit of fashion sense, out of the two sub-factors of fashion behaviors; interest in appearance education rather than interest in orientation towards fashion affected pursuit of fashion sense; interest in orientation towards fashion affected caring for one's appearance.

• 한국보육지원학회지
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• 제17권6호
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• pp.93-108
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• 2021

Objective: This study examined the mediating effect of adolescents' self-esteem on the relationship between their childhood abuse experiences and school rule-breaking behavior. Methods: The research participants consisted of 1,748 adolescents aged from 15 to 16. Adolescents' school rule-breaking behavior and self-esteem were measured in 2016, whereas their childhood abuse experiences were measured in 2010. Panel data collected by the National Youth Policy Institute were analyzed using the bootstrapping technique and PROCESS Macro for SPSS. Results: The results of the study are as follows. First, the adolescents' childhood abuse experiences affected their school rule-breaking behavior. That is, the adolescents who were abused by their parents were at higher risk of breaking school rules later in life. Second, the adolescents' self-esteem mediated the relationship between their childhood abuse experiences and school rule-breaking behavior. The adolescents who were abused by their parents tend to have low levels of self-esteem and thereby break school rules. Conclusion/Implications: The present study shows the possibility that childhood abuse experiences lead to adolescents' problematic behaviors, such as school rule violation. It also indicates that it is necessary to provide counseling and therapeutic interventions for enhancing the self-esteem of adolescents of the at-risk group with childhood abuse experiences.