• Environmental Mutagens and Carcinogens
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• v.19 no.1
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• pp.46-55
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• 1999

To develop a chemopreventive strategy based on the different stages of premalignant lesions, we hypothesized that the inhibitory effect of chemopreventive agents is influenced by different promotion stages during carcinogenesis. DMBA-TPA-induced skin carcinogenesis was used with ICR mice and chlorophyllin (CHL) was applied as a chemopreventive agent. In vitro assay was performed with Salmonella typhi. TA100 to observe any anti-mutagenic activity of CHL against DMBA. Pre-initiation and pre-promotion effects of CHL were observed by CHL treatment before initiation and before promotion. To evaluate the inhibitory effect at different promotion stages, each group was divided into three subgroups after TPA promotion for 6, 18 and 24 weeks, respectively ; the first subgroup was immediately sacrificed after termination of TPA, the second subgroup was treated with CHL, and the third subgroup was sacrificed 8 weeks after termination of TPA without CHL treatment. The degrees of epithelial dysplasia, papilloma formation, and invasive carcinoma were observed histologically, and GST-Pi expression was observed immunohistochemically. ODC mRNA level was analyzed by reverse transcriptase-polymerase chain reaction. Results showed : CHL dose-dependently inhibited the mutation of Salmonella typhi. TA100; the incidence of epithelial dysplasia and papilloma formation was lower in pre-initiation and pre-promotion CHL-treated mice than DMBA-TPA-treated mice; no invasive carcinoma developed in pre-initiation CHL-treated groups, while 67% of DMBA-TPA treated mice had carcinomas; GST-Pi expression decreased when CHL was treated before initiation and before promotion; and when CHL was treated after termination of TPA application at 18 and 24- week-TPA promotion stages, respectively, the incidence of epithelial dysplasia and papilloma was markedly reduced compared to non-treated groups. When comparing the incidence of epithelial dysplasia and papilloma between the immediately-sacrificed subgroup and the non-treated group with a waiting period, we speculated that the 18-week-TPA promotion stage might belong to the promoter-independent progression stage. At the 18-week-TPA promotion stage, the level of ODC mRNA in the CHL-treated group was clearly reduced to the level of normal tissue. Taking these results together, CHL showed both anti-initiation and anti-promotion effects, while the inhibitory effect of CHL was prominent in the 18-week-TPA promotion stage. However, CHL seems to be incapable of completely blocking the progression in the 24-week-TPA promotion stage.

• Journal of the Korea Society of Computer and Information
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• v.16 no.9
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• pp.11-18
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• 2011

This paper proposes a novel planning method for computer generated forces (CGFs) in war games that plans the behaviors of CGFs according to a given mission and situations. CGFs which are received their missions first plan their tasks for accomplishing the mission and then plan their behaviors for accomplishing each task. After that, they execute their planned behaviors considering the conditions of environments (in other words situations). The tasks and behaviors are hierarchically composed and include start conditions for beginning those and termination conditions for stopping those. CGFs first check whether the start condition of the planned behavior for accomplishing a task is satisfied or not in some degree and perform the behavior if satisfied continuously until the termination condition of the behavior will be met. If the termination condition is satisfied, then they check the start condition of the next planned behavior. This process will be repeated for accomplishing the mission. If the situations of CGFs are different by changing the environments from those of planning time, it may cause the start condition of the planned behavior to be dissatisfied. In this case, CGFs can decide a new behavior using fuzzy rule base. We realized our planning system and tested CGFs with a scenario. Experimental results showed that our system worked well and actively coped with situation changes. It will be possible to make CGFs that can do more autonomous behaviors if we continually develop our method.

• Journal of Broadcast Engineering
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• v.18 no.5
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• pp.691-701
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• 2013

In this paper, an early termination algorithm for merge process is proposed to reduce the computational complexity in High Efficiency Video Coding (HEVC) encoder. In the HEVC, the same candidate modes from merge candidate list (MCL) are shared to predict a merge or merge SKIP mode. This search process is performed by the number of the obtained candidates for the both of the merge and SKIP modes. This may cause some redundant search operations. To reduce this redundant search operation, we employ the neighboring blocks which have been encoded in prior, to check on the contextual information. In this study, the spatial, temporal and depth neighboring blocks have been considered to compute a correlation information. With this correlation information, an early termination algorithm for merge process is suggested. When all modes of neighboring blocks are SKIP modes, then the merge process performs only SKIP mode. Otherwise, usual merge process of HEVC is performed Through experimental results, the proposed method achieves a time-saving factor of about 21.25% on average with small loss of BD-rate, when comparing to the original HM 10.0 encoder.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.8
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• pp.1183-1196
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• 2018

Objective: This study ascertained effects of roughage quality, period of day at meal termination and time lapse after feeding on digesta load in the rumen. Methods: Veld hay was untreated (poor roughage quality, PRQ), improved (improved roughage quality, IRQ) by treating with urea or semi-improved by spraying with urea (semi-improved roughage quality, SIRQ). Experiment 1a used four rumen fistulated sheep to determine in-sacco degradability. Twelve sheep ($56.3{\pm}4.59kg$) were blocked by weight and randomly allocated to IRQ (n = 6) and PRQ (n = 6) to determine solid and liquid passage rates. In experiment 1b, nine sheep ($37.6{\pm}9.34kg$) were blocked by weight and randomly allocated to IRQ (n = 4) and PRQ (n = 5) to determine digestibility. Sixteen sheep ($36.47{\pm}9.46kg$) were blocked by body weight and randomly allocated to IRQ (n = 8) and PRQ (n = 8). Two sheep were slaughtered for each sampling time in each treatment (IRQ and PRQ) at 0, 6, 12, and 24 h after feeding to determine rumen load. In experiment 2, eighteen goats ($25.4{\pm}9.08kg$) were blocked by weight and randomly allocated to IRQ (n = 6), SIRQ (n = 6), and PRQ (n = 6). Then all 18 goats were slaughtered soon after meal termination in the morning; afternoon and evening to determine the effect of period of day on rumen fill. Results: Rate of degradation and effective degradability were enhanced by improvement of roughage quality. Roughage quality had no effect on digestibility, but digestibility was higher in goats than sheep. Fractional passage rate of particles was higher for IRQ than PRQ, but similar for liquids. Digesta fractional clearance rates at 24 h after feeding were 0.018/h (IRQ) and 0.006/h (PRQ). Period of day had an influence on rumen load. Neutral detergent fibre load for goats were above 2.03 kg/100 kg body weight for all diet treatments. Conclusion: Following starvation, passage rate had negligible effects on emptying of rumen load.

• Restorative Dentistry and Endodontics
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• v.23 no.1
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• pp.328-338
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• 1998

Porphyromonas endodontalis, an anaerobic Gram negative cocobacillus which was known to be associated with the infected root canals and periapical lesions, is very difficult to culture and to detect by the traditional method in that it requires much time to induce the specific black pigmentation, and it is very sensitive to oxygen and the antibiotics added in the culture medium. In this study, the nucleotide sequences of the 'probe h' (0.73kb), one of the specific DNA probes top. endodontalis (ATCC 35406) which had been developed by our department, was determined and then a pair of primers for PCR amplification was fabricated to identify P. endodontalis. The plasmids containing 'probe h' were purified by $Wizard^{TM}$ Midipreps DNA Purification System (Promega Corp.), and the nucleotide sequences of the 'probe h' were determined by the dideoxy chain termination method using TaqTrack Sequencing System (Promega Corp.) and detected by fluorescent labelling method. The sense/antisense PCR primers were designed with computer software (Lasergene, DNASTAR Ind. PCR was done with a programmable GeneAmp PCR System 2400 (Perkin Elmer-Cetus Co.). Each sample containing the whole genomic DNA of P. endodontalis and other black-pigmented Bacteroides was itailly denatured at $94^{\circ}C$ for 5 min and then subjected to 30 cycles, each of them consisting of 60s at $94^{\circ}C$, 60s at $60^{\circ}C$, and 90s. at $72^{\circ}C$. The amplified DNA was resolved electrophoretically in a 1.0 % agarose gel in 1X TAE buffer, stained with EtBr, and photographed on a UV transilluminator. The results were as follows : 1. The nucleotide sequences of 'probe h' (743 base pairs) were obtained by dideoxy chain termination method, and from that results the specific primers to P. endodontalis (ATCC 35406), 'Primer H1/ Primer H2', were designed. 2. It has been found that 'Primer H1/H2' could detect P. endodontalis (ATCC 35406) using PCR. 3. The PCR system with this primers may be a powerful technique to amplify the specific sequences of 'probe h' of P. endodontalis (ATCC 35406) that produce distinct identification of it from other black-pigmented Bacteroides, and this could help us to determine the nature of periapical disease.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.42 no.6
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• pp.869-877
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• 2022

This study aims to analyze the factors affecting the re-subscription period upon initial termination of the reverse mortgage subscription. The study utilized the Korea Housing Finance Corporation's database to extract the information regarding re-subscribers of the reverse mortgage from July 2007 to June 2021. The ordered logit model was employed and found that a set of user (subscriber) characteristics are influential towards the re-subscription period. Among the individual characteristics, changes in age group, marital status from married to single-living, maintaining single-living, and the initial subscription period were found statistically significant, highlighting that the increase in the initial subscription period decreased the re-subscription period. Among the housing (home equity) characteristics, changes in housing price and ownership type (single and partial ownership) were statistically significant, indicating that the change in ownership type decreases the re-subscription period. Lastly, the variables related to loan terms were found significant, revealing that changes in payout method and schedule were both increasing factors of the re-subscription period. Based on the findings, necessary policy implications can be considered to secure the returning subscribers of the reverse mortgage effectively.

• Korean Journal of Mineralogy and Petrology
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• v.35 no.3
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• pp.235-258
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• 2022

We interpreted the evolutionary history of the southwestern part of the Pohang Basin, the largest Miocene basin in the southeastern part of the Korean Peninsula, based on the detailed geological mapping and analysis of the geological structures. The southwestern part of the Pohang Basin can be divided into the Bomun Domain in the west and Ocheon Domain in the east by an NNE-trending horst-in-graben. These two domains have different geometries and deformation histories. The Bomun Domain was rarely deformed after the incipient extension of the basin, whereas the Ocheon Domain is an area where continued and overlapped deformations occurred after the basin fill deposition. Therefore, the Bomun Domain provides critical information on the initial extension mode of the Pohang Basin. The subsidence of the Bomun Domain was led by the zigzag-shaped western border fault that consists of NNE-striking normal and NNW-striking dextral strike-slip fault segments. This border fault is connected to the Yeonil Tectonic Line (YTL), a regional dextral principal displacement zone and the westernmost limit of Miocene crustal deformation in SE Korea. Therefore, it is interpreted that the Pohang Basin was initially extended in WNW-ESE direction as a transtensional fault-termination basin resulting from the movement of NNE-striking normal and/or oblique-slip faults formed as right-stepover in the northern termination of the YTL activated since approximately 17-16.5 Ma. As a result, an NNE-trending asymmetric graben or half-graben exhibiting an westward deepening of basin depth was formed in the Bomun Domain. Afterward, crustal extension and deformation were migrated to the east, including the Ocheon Domain.

• Journal of the military operations research society of Korea
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• v.29 no.2
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• pp.1-12
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• 2003

Knowing the characteristic of battle duration is important for commanders and logicians in the analysis of combat realization. Analytic solutions for mean and standard deviation can be found in small sized battles. Stochastic combat simulation model is utilized to study a probabilistic behavior of the combat duration. Output data is fitted to a certain probability distribution and some moments such as skewness and kurtosis are investigated. Fire allocation strategies, reselect options, interfiring time random variables, and kill rates are considered to investigate how they affect the battle termination time.

• Proceedings of the Korea Institute of Applied Superconductivity and Cryogenics Conference
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• 2002.02a
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• pp.35-36
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• 2002

High temperature super conducting(HTS) cable system for power transmission are under development that will be cooled by sub-cooled liquid nitrogen to provide cooling of the cable and termination. The target of the development during the first 3-years stage is 22.9kV/50MVA class and 30m length cold dielectric type 3-phase power cable. The essential features of the HTS cable cryogenic system and performance conditions for the design of power cable will be discussed.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.3
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• pp.416-420
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• 2008

This paper proposes a new method to improve signal characteristics at branches frequently met in system-level routing. We also introduce the numerical formula which can estimate the time delay due to branches and the simple design guideline for system-level routing. Finally, we propose the routing method which can eliminate the signal reflection for the case of one driver and two receivers (multi-drop topology).