• 대한수학회지
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• 제33권3호
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• pp.527-539
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• 1996

• 대한수학회보
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• 제34권1호
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• pp.51-61
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• 1997

• The Korean Journal of Physiology and Pharmacology
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• 제19권2호
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• pp.111-118
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• 2015

Osteoprotegerin (OPG), receptor activator of NF-${\kappa}B$ ligand (RANKL)/receptor activator of NF-${\kappa}B$ (RANK) axis, and TNF-related apoptosis-inducing ligand (TRAIL) participate in vascular calcification process including atherosclerosis, but their contributions under high glucose (HG) and phosphate (HP) condition for a long-term period (more than 2 weeks) have not been fully determined. In this study, we evaluated the effects of HG and HP levels over 2 or 4 weeks on the progression of vascular calcification in rat vascular smooth muscle cells (VSMCs). Calcium deposition in VSMCs was increased in medium containing HG (30 mmol/L D-glucose) with ${\beta}$-glycerophosphate (${\beta}$-GP, 12 mmol/L) after 2 weeks and increased further after 4 weeks. OPG mRNA and protein expressions were unchanged in HG group with or without ${\beta}$-GP after 2 weeks. However, after 4 weeks, OPG mRNA and protein expressions were significantly lower in HG group with ${\beta}$-GP. No significant expression changes were observed in RANKL, RANK, or TRAIL during the experiment. After 4 weeks of treatment in HG group containing ${\beta}$-GP and rhBMP-7, an inhibitor of vascular calcification, OPG expressions were maintained. Furthermore, mRNA expression of alkaline phosphatase (ALP), a marker of vascular mineralization, was lower in the presence of rhBMP-7. These results suggest that low OPG levels after long term HG and phosphate stimulation might reduce the binding of OPG to RANKL and TRAIL, and these changes could increase osteo-inductive VSMC differentiation, especially vascular mineralization reflected by increased ALP activity during vascular calcification.

• 한국농공학회:학술대회논문집
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• 한국농공학회 2003년도 학술발표논문집
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• pp.99-102
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• 2003

The purpose of this study is the making of standard which is optimal region selection for the creation of the naturally favorable waterfront area. We surveyed data of twenty two site in Korea where are managed KARICO(Korea Rural Infrastructure Corporation). Three different evaluation methods, simple score give method, subjective evaluation method, and check-list method were used. We were divided into "the highest priority area in consolidation rank", "the priority area in consolidation rank", the other area in consolidation rank". Thus, the object areas for consolidation of environment friendly canals will be chosen as in an objective manner and they will be good use of the long-term plan for consolidation of environment friendly canals.

• Journal of applied mathematics & informatics
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• 제22권1_2호
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• pp.193-208
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• 2006

A modified BFGS algorithm for solving the unconstrained optimization, whose Hessian matrix at the minimum point of the convex function is of rank defects, is presented in this paper. The main idea of the algorithm is first to add a modified term to the convex function for obtain an equivalent model, then simply the model to get the modified BFGS algorithm. The superlinear convergence property of the algorithm is proved in this paper. To compared with the Tensor algorithms presented by R. B. Schnabel (seing [4],[5]), this method is more efficient for solving singular unconstrained optimization in computing amount and complication.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1998년도 가을 학술발표대회 논문집(III)
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• pp.656-661
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• 1998

This paper presents a method of statistical analysis and sensitivity analysis of creep and shrinkage effects in PSC box girder bridges. The statistical and sensitivity analyses are performed by using the numerical simulation of Latin Hypercube sampling. For each sample, the time-dependent structural analysis is performed to produce response data, which are then statistically analyzed. The probabilistic prediction of the confidence limits on long-term effects of creep and shrinkage is then expressed. Three measures are examined to quantify the sensitivity of the outputs to each of the input variables. These are rank correlation coefficient(RCC), partial rank correlation coefficient(PRCC) and standardized rank regression coefficient(SRRC) computed on the ranks of the observations. Probability band widens with time, which indicates an increase of prediction uncertainty with time. The creep model uncertainty factor and the relative humidity appear as the most dominant factors with regard to the model output uncertainty.

• 응용통계연구
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• 제28권2호
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• pp.241-250
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• 2015

경시적 자료 연구의 중요한 주제 중의 하나는 시간이 지남에 따라 개인의 건강 상태가 어떻게 변하는지를 추적하는 확률이다. 질병의 상태를 시간의 흐름에 따라 추적하는 것은 장기간에 걸친 임상적 관찰 연구의 계획과 분석, 그리고 질병의 예방과 치료에 중요한 의미를 지닌다. 본 논문에서는 두 다른 시점에서 각 개인의 건강 상태에 대한 조건부 확률을 추정해내는 순위 추적 확률에 대하여 연구하였다. 순위 추적 확률과 순위 추적 확률비를 추정하기 위하여 선형 혼합 효과 모형을 고려하였다. 본 논문의 방법은 아동을 대상으로 심혈관계 질환의 위험요인을 연구하는 역학 자료에 적용되었다.

• 운동영양학회지
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• 제23권1호
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• pp.13-20
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• 2019

[Purpose] The OPG/RANK/RANKL signaling is a new family of bone metabolism biomarkers belonging to the immune system. However, the bone metabolism response to long-term exercise in the RANKL/RANK/OPG signaling is less evident. The purpose of this study was to examine these biomarkers in healthy college females after 12-weeks combined exercise intervention. [Methods] Participants (N=22, 22.4±1.3yrs) were randomly divided in two different group: 12 in the control group and 10 in the exercise group performing combined exercise program that interventions was conducted 3 times per week for 12 weeks. The outcome measures included serum concentrations of RANKL, OPG and bone metabolic cytokines such as TNF-α and IL-6, and mRNA expressions of same variables from PBMC. VO_2max and bone mineral density (BMD) were measured at before and after exercise intervention. [Results] There were no significant differences in the serum RANKL, OPG concentrations and all RANKL/RANK/OPG signaling mRNA expression on interaction effect between group and time (NS). Also no significant differences were found in the serum TNF-α and IL-6 concentrations and mRNA expression (NS). The IL-6 mRNA expression only showed significant difference in the main effect of groups (p<.05). There were also no significant differences in the VO_2max and BMD on interaction effect between group and time (NS). [Conclusion] These results suggested that there were no effects on bone mineral density and RANKL/RANK/OPG signaling without the effect of 8-weeks combined exercise on cardiovascular endurance fitness.

• 풍력에너지저널
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• 제5권2호
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• pp.45-50
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• 2014

Reviewing the capacity and timing of Southwest sea offshore wind farms, additional farms developing, and potential farms, we devised the long-term plan of domestic offshore wind farms development. In order to rank many wind farms, we determined evaluation indicators and weights of priority. We applied economic and preliminary factors such as wind grade, depth of water, distance from substations, farms scale, MOU signed, and feasibility studies. After deciding the ranking of wind farms by the scores, we planed domestic long-term scenarios of offshore wind farms development to meet national energy policy objectives.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권2호
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• pp.522-541
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• 2016

Network virtualization provides an effective way to overcome the Internet ossification problem. As one of the main challenges in network virtualization, virtual network embedding refers to mapping multiple virtual networks onto a shared substrate network. However, existing heuristic embedding algorithms evaluate the embedding potential of the nodes simply by the product of different resource attributes, which would result in an unbalanced embedding. Furthermore, ignoring the hops of substrate paths that the virtual links would be mapped onto may restrict the ability of the substrate network to accept additional virtual network requests, and lead to low utilization rate of resource. In this paper, we introduce and extend five node attributes that quantify the embedding potential of the nodes from both the local and global views, and adopt the technique for order preference by similarity ideal solution (TOPSIS) to rank the nodes, aiming at balancing different node attributes to increase the utilization rate of resource. Moreover, we propose a novel two-stage virtual network embedding algorithm, which maps the virtual nodes onto the substrate nodes according to the node ranks, and adopts a shortest path-based algorithm to map the virtual links. Simulation results show that the new algorithm significantly increases the long-term average revenue, the long-term revenue to cost ratio and the acceptance ratio.