• Journal of Genetic Medicine
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• 제6권2호
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• pp.131-145
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• 2009

착상전 유전진단은 유전질환이 이환될 가능성이 있는 부부들을 대상으로 산전진단을 통한 임신중절의 위험성 없이 정상적인 아이를 가질 수 있게 도와주는 보조생식술의 한 방법으로 확립되었다. 단일 할구를 대상으로 하는 분자생물학 및 분자생물학적 기술의 발전은 착상전 유전진단의 정확성을 높은 수준에 이르게 하였고 whole genome amplification 방법을 이용함으로써 단일세포로부터 여러 가지 다양한 진단을 동시에 수행 가능케 하였으며 단일 유전자 질환에 대한 착상전 유전진단에서의 오진을 감소시킬 수 있었다. 따라서 PCR을 이용한 단일 유전자 질환에 대한 착상전 유전진단의 적용가능 유전질환은 더욱 확대될 것이며 건강한 아이의 출산을 원하는 더 많은 부부들에게 기회를 제공해 줄 것이다. 본 종설에서는 현재 단일유전자 질환에 대한 착상전 유전진단을 시행하는 대부분의 센터에서 시행하고 있는 생검 방법과 multiplex PCR, PCR 후 진단 방법, 그리고 multiple displacement amplification 등의 분자생물학적 방법과 단일 세포 분석에서의 문제점 등을 포함한 단일 유전자 질환에 대한 착상전 유전진단 전반에 관하여 논의할 것이다.

• Nuclear Engineering and Technology
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• 제45권6호
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• pp.731-744
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• 2013

Energy security is a topic of high importance to many countries throughout the world. Countries with access to vast energy supplies enjoy all of the economic and political benefits that come with controlling a highly sought after commodity. Given the desire to diversify away from fossil fuels due to rising environmental and economic concerns, there are limited technology options available for baseload electricity generation. Further complicating this issue is the desire for energy sources to be sustainable and globally scalable in addition to being economic and environmentally benign. Nuclear energy in its current form meets many but not all of these attributes. In order to address these limitations, TerraPower, LLC has developed the Traveling Wave Reactor (TWR) which is a near-term deployable and truly sustainable energy solution that is globally scalable for the indefinite future. The fast neutron spectrum allows up to a ~30-fold gain in fuel utilization efficiency when compared to conventional light water reactors utilizing enriched fuel. When compared to other fast reactors, TWRs represent the lowest cost alternative to enjoy the energy security benefits of an advanced nuclear fuel cycle without the associated proliferation concerns of chemical reprocessing. On a country level, this represents a significant savings in the energy generation infrastructure for several reasons 1) no reprocessing plants need to be built, 2) a reduced number of enrichment plants need to be built, 3) reduced waste production results in a lower repository capacity requirement and reduced waste transportation costs and 4) less uranium ore needs to be mined or purchased since natural or depleted uranium can be used directly as fuel. With advanced technological development and added cost, TWRs are also capable of reusing both their own used fuel and used fuel from LWRs, thereby eliminating the need for enrichment in the longer term and reducing the overall societal waste burden. This paper describes the origins and current status of the TWR development program at TerraPower, LLC. Some of the areas covered include the key TWR design challenges and brief descriptions of TWR-Prototype (TWR-P) reactor. Selected information on the TWR-P core designs are also provided in the areas of neutronic, thermal hydraulic and fuel performance. The TWR-P plant design is also described in such areas as; system design descriptions, mechanical design, and safety performance.

• 한국정보시스템학회지:정보시스템연구
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• 제17권4호
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• pp.233-260
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• 2008

Universities have recognized e-Learning Systems as the critical IT resources which contribute to improving the competitiveness of the universities as well as the quality of the traditional class-based lectures. Instructors deliver the main contents in the class. Other supplementary activities like online discussions, sharing of teaching-learning materials, submission of homeworks, communication among the learners and between the instructors and the learners, and so on can be efficiently facilitated using e-Learning Systems. In other words, e-Learning Systems enable a blended learning combined class-based lectures and e-learning in a variety of ways. Nonetheless, compared to the level of implementation of e-Learning Systems, the usage of both the instructors and the learners is not high. Accordingly, this study examines the determinants to affect on the usage of e-Learning Systems from the learners perspective. To draw the key determinants, we review the IS literatures related to adoption or use of the IS like Media Richness Theory (MRT), Technology Acceptance Model (TAM), Social Influence Model (SIM), and Self-efficacy Model. The variables are drawn out to be expected on the usage of e-Learning like Media Richness, Ease of Use from MRT, TAM and Instructor's Influence, Co-learner's Influence from SIM, and Self-efficacy. To test our model and hypotheses, we have collected data in the class-based lectures using e-Learning System complementary. The results of the test with 192 data are as follows: Firstly, it shows that the Instructor's Influence and the Media Richness are the influential determinants to affect on the Perception of Usefulness of e-Learning Systems. Additionally, the Co-learner's Influence and Ease of Use in order is significant to the Perception of Usefulness. Secondly, as to the degree of use of the e-Learning Systems, the Co-leaner's Influence, the Media Richness, and the Ease of Use are, in that order, the significant determinants. The Perception of Usefulness, also, founded a key factor on increasing the use of e-Learning Systems. On the other hand, the Instructor's Influence is not significant to the use of e-Learning Systems. Finally, it has been found that Self-efficacy is significant to the Perception of Media Richness, Ease of Use, but not significant to the Perception of Usefulness.

• 유통과학연구
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• 제14권3호
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• pp.73-83
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• 2016

Purpose - The parcel delivery service(courier) industry all over the world has been expanding its market so far, but its growth has been declining in recent years. In this situation, most parcel delivery companies are having trouble with managing themselves because of the pressure from the customer to increase service level and decrease the rate. The purpose of this study is to provide ways to improve competitive advantages of the parcel delivery service industry by evaluating the multi-period operating efficiency of Korea, Japan and global service providers. Research design, data, and methodology - The data for the period of 2011 to 2014 were collected from the annual reports published by parcel delivery companies. In this study, we analyze the marketability (revenue), profitability (operating profits), and management conditions (net profits) of parcel service companies by combining information on human resources (number of employees) and material resources (total assets and equity). Therefore, the number of employees, total assets, and equity are selected as input variables, and revenue, operating profits, and net profits as the output variables. In this study, DEA (Data Envelopment Analysis) is used to measure the comparative efficiency and MPI (Malmquist Productivity Index) is used to analyze the trend of change of the efficiency for a multi-year period. Results - The operational efficiency scores of medium-sized parcel delivery companies in Korea are higher than other larger competitors such as Korean, Japan and Global larger companies. As of 2014, Logen(1.878) was found to be the most efficient parcel delivery enterprise, followed by KGB (1.224), and Kyoungdong(1.002). Otherwise, Hanjin(0.235), CJ(0.262), Hyundai Logistics(0.657), DHL(0.611), UPS(0.766), FedEx(0.498), TNT(0.350), Yamato(0.762) and Sagawa(0.520), larger sized companies, were done inefficiently. The productivity of parcel delivery companies is influenced by endogenous factors as well as exogenous ones such as changes in business environment and technological advances. Conclusions - Korean medium-sized companies have relatively high efficiency scores in operation. That is why they still survive the competitive market in Korea where market restructuring on the industry has been expected to be conducted for many years. The reason why medium-sized couriers had higher efficient scores than larger couriers is that most of couriers spend more operating expenses versus unit price of delivery which is the amount of money that is needed in order to send a package by parcel service. So the delivery unit price must be taken into account by all the expenses associated with the cost of fuel, labor and maintenance expenses for facilities, etc. therefore, the unit price must be increased to strengthen business competitive power. In order for the industry to have more competitive advantage, the companies need to make profits by increasing demand volume and raising the delivery rate to provide high-quality delivery service to customers. And both endogenous and exogenous change must take precedence in order to strengthen their competitiveness.

• 유통과학연구
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• 제13권6호
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• pp.87-96
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• 2015

Purpose - Several domestic telecommunication companies have made a considerable effort to continuously grow and survive, and they have strived to thrive in the midst of mature market competition. To overcome this challenging situation and to grow continuously, while still meeting customer needs that are becoming more diverse and complicated with the passage of time, extensive support for internal marketing is essential. Without such internal support, companies face serious limitations and market roadblocks. The communication industry is a high-level service industry and a basic communications industry characteristic is its significant dependence on the employees delivering the services. Therefore, entrepreneurs in the information/communications industry, as well as existing competitors, should look to satisfy external customers through critical investment in internal customers (employees). Therefore, it is important for research to examine how internal factors influence technology innovation and service quality, which are the key drivers for companies that are seeking leading market positions. Research design, data, and methodology - The purpose of this study is to analyze the relationship of technology innovation and perceived service quality with the internal marketing factors in the communication industry and to offer suitable and effective internal marketing suggestions. The independent variables of this study are internal communication, education and training, the support of the executives, reward systems, and empowerment. The dependent variables are technology innovation and perceived service quality. Utilizing these, this paper studies the influence of internal marketing factors on technology innovation and perceived service quality. Results - The study results revealed the following. First, the identified internal marketing factors have a positive effect on technology innovation. Among the five internal marketing factors, three had a significant effect on product innovation, empowerment, the support of executives, and education and training, in this order. Second, the internal marketing factors also had a positive effect on the process innovation of technology innovation. The marketing factors, the support of executives, empowerment, internal communication, and education and training, in this order, significantly affect process innovation. Third, technology innovation had a positive effect on perceived service quality. All of the five service quality factors, namely, tangibles, reliability, assurance, responsibility, and empathy, in this order, significantly affect product innovation. Additionally, tangibles, reliability, responsibility, empathy, and assurance, in this order, significantly affect process innovation. Fourth, product and process innovation significantly affect tangibles and reliability in technology innovation. To enhance tangibles and reliability, process innovation should first be enhanced. Fifth, product and process innovation significantly affect responsibility and empathy in technology innovation. To enhance the responsibility and empathy, process innovation should first be enhanced. Sixth, product and process innovation significantly affect assurance in technology innovation. To enhance the assurance, product innovation should first be enhanced. Conclusions - According to the results, a company's internal marketing factors have a positive and significant effect on technology innovation and, further, product and process innovation have a positive and significant effect on the perceived serviced quality.

• 만화애니메이션 연구
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• 통권48호
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• pp.1-22
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• 2017

독립 단편애니메이션은 창의적이며 진보적인 표현을 중심으로 젊은 애니메이션 창작자들을 위한 표현 방식이었으며 애니메이션의 탄생이후 애니메이션의 질적인 발전과 다양화를 가져오는 원동력이 되어왔다. 이것은 애니메이션의 발전과정과 함께 하며 실험성과 도전성을 강조하는 많은 작품을 세상에 등장시켰고 프랑스, 일본, 캐나다 등 애니메이션 자원이 풍부한 나라에서는 그 중요성을 인식하고 가치를 이어가기 위해 젊은 창작자들을 지원하고 있다. 하지만 한국 애니메이션 작품들은 어린이들로부터의 인기로 작품의 질을 평가받고 작품의 완성도 보다는 완구를 비롯한 제품개발과 판매에 주력하는 기업과 그것을 당연하게 수용하는 대중적 인식이 산업 전반에 형성되어 있다. 이런 점들로 인해 한국의 젊은 애니메이션 창작자들은 미래를 위한 창의적인 시각과 철학적인 문제의식을 표현하지 못하고 상업 애니메이션 시장의 한계에 갇혀 벗어나지 못하고 있다. 유아용 애니메이션으로 포화상태에 이른 한국 애니메이션 산업의 재도약과 확장을 위해서는 좋은 기획과 스토리 개발, 기술혁신을 통한 상업적 목표달성과 더불어 도전적이고 실험적인 성격의 독립 단편애니메이션 대한 가치를 재정립하고 다양화를 중심으로 하는 창작환경과 지원제도의 변화가 필요하다. 이를 위해 본 논문은 한국 독립 단편애니메이션의 제작 및 상영, 배급, 정부지원 등의 현황을 분석하고 구조적 문제점과 해결을 위한 방법을 알아본다.

• Asia pacific journal of information systems
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• 제21권2호
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• pp.59-87
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• 2011

These days, firms are focusing on the improvement of relationships with business partners. The supply chain integrations are taking critical role in improving the relationships with business partners. In accordance with the development of the IT technology, it became possible for firms not only to integrate inner parts of the organization, but also to integrate the company with other organizations in the supply chain. Therefore, in e-Biz environments, it is imperative for firms to strengthen the core capacity through the supply chain, and to precisely determine the components of the determinants of e-Business integration which impact the firm performance. This study analyzed determinants that have impacts on e-business integration in e-business capacity perspectives in competitive environments. This study based on the premise that the resources and capacities that Grant(1991) and Hart(1995) emphasized do not directly influence the corporate performance. This study focused on the fact that corporate must create core competencies based on these capacities to establish competitive edge. Therefore, this study model analyzed to find out which e-Biz competencies are needed to integrate e-Biz according to competitive environment elements. This study designed to empirically analyze the impact of the e-Biz competencies to the e-Biz integration and to the corporate performance. Independent variables of this study-IT management, partner management, e-Biz knowledge, e-Biz establishment and proliferation, process innovation-are selected based on precedent studies on e-Biz competencies. We selected intermediate variables to verify that e-Biz competencies do not have direct impact on the corporate performance, but have impact on the e-Biz integration, which is intermediate effect. That is to verify that if the components of supply chain improve the integration level using e-Biz competencies, the overall supply chain performances will improve. Dependent variables are selected to verify that e-Biz integration has impacts on corporate performances. This study used factor analysis, path analysis, moderating effect analysis as statistical tests. First, we used exploratory factor analysis and confirmatory factor analysis to analyze reliability and validity. Because e-Biz competencies are presented variously by preceding studies, we used SPSS16.0 to verify if survey questionnaire used by theoretical backgrounds is properly composed. Second, we tested the property of structure model by AMOS. We did path analysis using AMOS16.0 to test structure that is composed of e-Biz competencies and e-Biz integration. Last, we tested moderating effects of measure factors. We analyzed 163 domestic companies to find out many significant suggestive points. First, relationship improvement capacity, e-business knowledge sharing capacity with business partners, and process innovation capacity are adopted as determinants of differentiation and competitive edges against competing firms. Second, e-business knowledge sharing capacity, and process innovation capacity are analyzed as the determinants of e-business integration in the firm which demand fluctuation in the market is high. On the other hand, among the determinants that require capturing ideas on new products, and strengthening the technological power, process innovation capacity are adopted as the determinants. These results provide us the foundation that the determinants that we have analyzed can impact the supply chain integration strategies which take into account the competitive environments.

• 한국진공학회:학술대회논문집
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• 한국진공학회 1998년도 제14회 학술발표회 논문개요집
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• pp.120-120
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• 1998

Boron nitride (BN) films have attracted a growing interest for a variety of t technological applications due to their excellent characteristics, namely hardness, c chemical inertness, and dielectrical behavior, etc. There are two crystalline phases 1551; of BN that are analogous to phases of carbon. Hexagonal boron nitride (h-BN) has a a layered s$\sigma$ucture which is spz-bonded structure similar to that of graphite, and is t the stable ordered phase at ambient conditions. Cubic boron nitride (c-BN) has a z zinc blende structure with sp3-bonding like as diamond, 따ld is the metastable phase a at ambient conditions. Among of their prototypes, especially 삼Ie c-BN is an i interesting material because it has almost the same hardness and thermal c conductivity as di없nond. C Conventionally, significant progress has been made in the experimental t techniques for synthesizing BN films using various of the physical vapor deposition 밍ld chemical vapor deposition. But, the major disadvantage of c-BN films is that t they are much more difficult to synthesize than h-BN films due to its narrow s stability phase region, high compression stress, and problem of nitrogen source c control. Recent studies of the metalorganic chemical vapor deposition (MOCVD) of I III - V compound have established that a molecular level understanding of the d deposition process is mandatory in controlling the selectivity parameters. This led t to the concept of using a single source organometallic precursor, having the c constituent elements in stoichiometric ratio, for MOCVD growth of 삼Ie required b binary compound. I In this study, therefore, we have been carried out the growth of h-BN thin f films on silicon substrates using a single source precursors. Polycrystalline h-BN t thin films were deposited on silicon in the temperature range of $\alpha$)() - 900 $^{\circ}$C from t the organometallic precursors of Boron-Triethylamine complex, (CZHs)3N:BRJ, and T Tris(dimethylamino)Borane, [CH3}zNhB, by supersonic molecular jet and remote p plasma assisted MOCVD. Hydrogen was used as carrier gas, and additional nitrogen w was supplied by either aDlIDonia through a nozzle, or nitrogen via a remote plasma. T The as-grown films were characterized by Fourier transform infrared spectroscopy, x x-ray pthotoelectron spectroscopy, Auger electron spectroscopy, x-ray diffraction, t transmission electron diffraction, optical transmission, and atomic force microscopy.roscopy.

• 기술혁신연구
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• 제19권2호
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• pp.99-128
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• 2011

본 논문은 대학 교수의 스핀오프에 영향을 미치는 요인들을 탐색하고 이를 실증적으로 분석하는데 초점을 맞춘 연구이다. 대학스핀오프는 공공연구기관에서 창출된 기술을 사업화하는 여러 가지 방법 중에서 가장 직접적이고 가시적인 방법이다. 또한, 개인 연구자에게 내재되어 있는 암묵적인 지식을 효과적으로 이전 할 수 있는 장점을 가진 유용한 기술사업화 방법이기 때문에 다각도의 분석이 필요하다. 그러나 기존의 대학스핀오프에 대한 연구는 대학이나 정부의 정책 등과 같은 거시적 관점의 연구가 주류를 이루고 있고 교수 등 개별 연구자에 대한 연구는 부족한 실정이다. 이에 본 연구는 대학 교수의 대학스핀오프 형성을 촉진 하는 요인들을 자원기반관점을 중심으로 파악하고 그 영향력을 실증적으로 분석하였다. 실증 분석을 위해 2005년에서 2010년 사이 대학스핀오프를 형성한 국내 전국 25개 대학 교수 149명의 데이터 확보하였다. 연구를 위해 각 대학의 산학협력단에서 스핀오프 형성 현황을 확보하고, 한국연구업적통합정보에서 수집한 개별 교수 데이터를 활용했다는 점에서 기존의 연구들과 차별화를 이룬다. 수집한 자료를 활용해 교수의 자원을 기술적 연구역량, 학문적 연구역량, 연구비 수혜로 나누어 대학스핀오프 형성에 미치는 영향을 분석하였다. 콕스비례위험회귀모형으로 분석한 결과, 교수의 연구역량과 연구비 수혜가 스핀오프 형성을 촉진 한다는 것이 검증되었다. 본 연구의 결과는 교수의 대학스핀오프 의사결정에 도움을 줄 수 있으며, 스핀오프 지원정책의 개선에 도움을 줄 수 있을 것으로 기대한다.

• 기술혁신연구
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• 제22권2호
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• pp.1-30
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• 2014

우리나라는 1980년대 초 절충교역 제도를 도입하여 국가 경제발전 및 국방 전력증강의 수단으로 활용하고 있으며 2010년까지 백억 달러가 넘는 가치를 절충교역으로 획득하였다. 그러나 한편으로 그간 절충교역 제도의 실효성에 대해 지속적으로 의문이 제기되어온 것이 사실이다. 현실적으로 절충교역을 통해 획득한 기술의 성과를 객관적으로 분석, 산출한다는 것은 매우 어려운 과제이며 이에 따라 정량적인 성과분석은 매우 제한적으로 이루어지고 있는 실정이다. 따라서 본 연구에서는 보다 깊이 있는 성과분석을 통하여 절충교역활용 현황을 파악하고 이를 기반으로 향후 절충교역 제도의 발전방향을 제안하였다. 먼저, 기존 성과분석 관련 문헌조사를 통해 절충교역 성과분석을 위한 조사지표를 도출하여 설문서를 작성하였으며, 각 수혜기관, 업체를 대상으로 조사를 실시하였다. 또한 각 군, 정부기관 및 연구소, 업체 소속 절충교역 분야 전문가를 대상으로는 정성적인 측면에서 제도의 성과, 실효성에 대한 설문을 실시하여 그 결과를 분석하였다. 그리고 최근 3개년 동안의 사업에서 획득한 기술들을 대상으로 DEA 기법을 활용하여 성과 창출의 효율성을 살펴보았다. 성과분석 및 설문조사 결과, 공통적으로 기술적 측면에서는 긍정적인 성과가 있었으나 경제적인 부분에서는 성과가 상대적으로 저조했으며 설문결과도 이와 동일한 것으로 나타났다. 이를 토대로 절충교역 제도는 신정부의 정책방향에 발맞춰 기존 핵심기술 획득 위주의 정책에서 대 중소기업 상생, 방위산업 활성화를 통한 국가경제 기여를 위해 그 추진방향의 전환이 필요한 것으로 판단된다.