• Mass Spectrometry Letters
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• v.8 no.3
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• pp.49-52
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• 2017

Ibuprofen is one of the most popular analgesic and antipyretic drugs. An isotope dilution mass spectrometry method based on LC/MS was developed as a candidate reference method for the accurate determination of ibuprofen in pharmaceutical tablets. Isotope labelled ibuprofen, $ibuprofen-d_3$, was added as an internal standard into sample extracts. Ibuprofen and $ibuprofen-d_3$, was analysed by LC/MS in a selected ion monitoring (SIM) mode to detect ions at m/z 205 and 208, respectively. The repeatability and reproducibility of the developed ID-LC/MS method were tested for the validation and assessment of metrological quality of the method.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.8 no.6
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• pp.2186-2196
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• 2014

Spam mail is one of the most general mail dysfunctions, which may cause psychological damage to internet users. As internet usage increases, the amount of spam mail has also gradually increased. Indiscriminate sending, in particular, occurs when spam mail is sent using smart phones or tablets connected to wireless networks. Spam mail consists of approximately 68% of mail traffic; however, it is believed that the true percentage of spam mail is at a much more severe level. In order to analyze and detect spam mail, we introduce a technique based on spam mail characteristics and text mining; in particular, spam mail is detected by extracting the linguistic analysis and language processing. Existing spam mail is analyzed, and hidden spam signatures are extracted using text clustering. Our proposed method utilizes a text mining system to improve the detection and error detection rates for existing spam mail and to respond to new spam mail types.

• Journal of The Korean Society of Clinical Toxicology
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• v.5 no.2
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• pp.138-141
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• 2007

Because of the ready availability of aspirin, salicylate poisoning remains a common problem in many countries. Another potential source of salicylate poisoning is medicated oil containing methyl salicylate (oil of wintergreen). Methyl salicylate poses a much greater safety threat than aspirin tablets because of its liquid, concentrated form and high lipid solubility. Because of this danger, the toxic potential of medicated oil containing methyl salicylate should be fully appreciated both by physicians and by the general public. We encountered two cases of salicylate poisoning resulting from accidental ingestion of Chinese medicated oil. We report these cases along with a review of the literature.

• YAKHAK HOEJI
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• v.39 no.3
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• pp.337-345
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• 1995

The effects of ginkgolides(natural mixture of ginkgolides, ginkgolide B, ginkgolide C) and flavonoids(quercetin, kaempferol, myricetin), extracted from Ginkgo biloba, on ADP and PAF-induced platelet aggregation in vitro and ex vivo were investigated. In these experiments, both of ginkgolides and ginkgoflavonoids did not affect the ADP(5 $\mu{M}$) induced platelet aggregation in vitro. The IC$_{50}$ value on PAF (0.3 $\mu{M}$) induced platelet aggregation were 2.52 $\mu{M}$ (ginkgolide B) and 6.35 $\mu{M}$ (natural mixture of ginkgolides) and 2.80 $\mu{M}$ (mixture of ginkgolide B and quercetin). Oral administration of ginkgolide B (1 and 3 mg/kg) and quercetin (3 and 9 mg/kg) to rabbits inhibited ex vivo PAF induced platelet aggregation in a dose-dependent manner. Ginkomin-F tablets administered to the diabetic patients showed inhibitory activities on the ADP and PAF induced platelet aggregation in a dose and time dependent manner.

• Bulletin of the Korean Chemical Society
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• v.31 no.6
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• pp.1535-1542
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• 2010

Spectrophotometric micro determination of allopurinol (ALP) via charge-transfer formation is described. This includes the utility of some $\pi$-acceptors such as 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and 3,6-dichloro-2,5-dihydroxy-p-benzoquinone (p-CLA) for estimation of ALP drug (act as $\grave{e}$-donor). These reactions are applied for determination of ALP in its pharmaceutical preparations coming from different companies. Elucidation of the chemical structure of the solid CT complexes formed via reaction between drugs under study and $\pi$-acceptors, using elemental analyses (C, H, N), I. R., $^1H$ NMR and mass spectrometry.

• Information and Communications Magazine
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• v.31 no.3
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• pp.103-116
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• 2014

This paper proposes the design of Vehicular Cyber-Physical Systems (called VCPS) based on vehicular cloud for smart road networks. Our VCPS realizes mobile cloud computing services where vehicles themselves or mobile devices (e.g., smartphones and tablets of drivers or passengers in vehicles) play a role of both cloud server and cloud client in the vehicular cloud. First, this paper describes the architecture of vehicular networks for VCPS and the delay modeling for the event prediction and data delivery, such as a mobile node's travel delay along its navigation path and the packet delivery delay in vehicular networks. Second, the paper explains two VCPS applications as smart road services for the driving efficiency and safety through the vehicular cloud, such as interactive navigation and pedestrian protection. Last, the paper discusses further research issues for VCPS for smart road networks.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.9 no.4
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• pp.153-159
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• 2009

In this paper, we deal with the coordinate estimate algorithm of the wired tablet device. In order to got the position of the electric pen on the tablet, electromagnetic induction effect is used. Most electric tablets have used the electromagnetic induction effect. Tracking the position of the pen on a tablet that is directly related with the performance of the device is very important. In this research, a new real time coordinate estimate algorithm is introduced. To estimate the position of the pen, the electromagnetic induced signals og the wired tablet are used.

• YAKHAK HOEJI
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• v.47 no.5
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• pp.261-265
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• 2003

Near-infrared (NIR) system was used to determine rapidly and simply indomethacin in buffer solution for a dissolution test of tablets and capsules. Indomethacin standards were prepared ranging from 10 to 50 ppm using the mixture of phosphate buffer (pH 7.2) and water (1 : 4). The near-infrared (NIR) transmittance spectra of indomethacin standard solutions were collected by using a quartz cell in 1 mm and 2 mm pathlength. Partial least square regression (PLSR) was explored to develop calibration models over the spectral range 1100∼1700 nm. The model using 1 mm quartz cell was better than that using 2 mm quartz cell. The PLSR models developed gave standard error of prediction (SEP) of 0.858 ppm. In order to validate the developed calibration model, routine analysis was performed using another standard solutions. The NIR routine analysis showed good correlation with actual values. Standard error of prediction (SEP) is 1.414 ppm for 7 indomethacin samples in routine analysis and its error was permeable in the regulation of Korean Pharmacopoeia (VII). These results show the potential use of the real time monitoring for indomethacin during a dissolution test.

• The Proceeding of the Korean Institute of Electromagnetic Engineering and Science
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• v.24 no.2
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• pp.23-34
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• 2013

Over the past several decades in the microelectronics industry, devices have gotten smaller, thinner, and lighter, without any accompanying degradation in quality, performance, and reliability. One permanent and deniable trend in packaging as well as wafer fabrication industry is system integration. The proliferating options for system integration, recently, are driving change across the overall semiconductor industry, requiring more investment in developing, ramping and supporting new die-, wafer- and board-level solution. The trend toward 3D system integration and miniaturization in a small form factor has accelerated even more with the introduction of smartphones and tablets. In this paper, the key issues and state of the art for system integration in the packaging process are introduced, especially, focusing on ease transition to next generation packaging technologies like through silicon via (TSV), 3D wafer-level fan-out (WLFO), and chip-on-chip interconnection. In addition, effective solutions like fine pitch copper pillar and MEMS packaing of both advanced and legacy products are described with several examples.

• Carbon letters
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• v.27
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• pp.50-63
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• 2018

An imprinted potentiometric sensor was developed for direct and selective determination of gabapentin. Sensor is based on carbon paste electrode adapted by graphene oxide that is decorated with silver nanoparticles and mixed with molecularly imprinted polymers nanoparticles using gabapentin as a template molecule. The synthesized nanoparticles were characterized by Fourier transmission infrared spectroscopy, transmission electron microscopy and X-ray diffraction. Under optimal experimental conditions, the studied sensor exhibited high selectivity and sensitivity with LOD of $4.8{\times}10^{-11}mol\;L^{-1}$. It provided a wide linearity range from $1{\times}10^{-10}$ to $1{\times}10^{-3}mol\;L^{-1}$ and high stability for more than 3 mo. The sensor was effectively used for the determination of gabapentin in pharmaceutical tablets and spiked plasma samples.