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http://dx.doi.org/10.5012/bkcs.2010.31.6.1535

Spectrophotometric Determination of Allopurinol Drug in Tablets: Spectroscopic Characterization of the Solid CT Complexes  

Refat, Moamen S. (Department of Chemistry, Faculty of Science, Port Said 42111, Suez Canal University)
Mohamed, Gehad G. (Chemistry Department, Faculty of Science, Cairo University)
Fathi, Ahmed (Chemistry Department, Faculty of Science, Cairo University)
Publication Information
Bulletin of the Korean Chemical Society / v.31, no.6, 2010 , pp. 1535-1542 More about this Journal
Abstract
Spectrophotometric micro determination of allopurinol (ALP) via charge-transfer formation is described. This includes the utility of some $\pi$-acceptors such as 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and 3,6-dichloro-2,5-dihydroxy-p-benzoquinone (p-CLA) for estimation of ALP drug (act as $\grave{e}$-donor). These reactions are applied for determination of ALP in its pharmaceutical preparations coming from different companies. Elucidation of the chemical structure of the solid CT complexes formed via reaction between drugs under study and $\pi$-acceptors, using elemental analyses (C, H, N), I. R., $^1H$ NMR and mass spectrometry.
Keywords
Allopurinol; DDQ; p-CLA; Spectrophotometry; Charge transfer complexes;
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