• Archives of Pharmacal Research
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• v.23 no.5
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• pp.507-512
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• 2000

This study set out to improve the physical and pharmaceutical characteristics of the present formulation using an appropriate experimental design. The work described here concerns the formulation of the dispersible tablet applying direct compression method containing roxithromycin in the form of coated granules. In this study $2^3$ factorial design was used as screening test model and Central Composite Design (CCC) associated with response surface methodology was used as optimization study model to develop and to optimize the proper formulation of roxithromycin dispersible tablet. The three independent variables investigated were functional excipients like binder (X1), disintegrant (X2) and lubricant (X3). The effects of these variables were investigated on the following responses: hardness (Y1), friability (Y2) and disintegration time (Y3) of tablet. Three replicates at the center levels of the each design were used to independently calculate the experimental error and to detect any curvature in the response surface. This enabled the best formulations to be selected objectively. The effect order of each term to all response variable was X3> X2> Xl> X1＊X2> X2＊X2> X2＊X3> X3＊X3> Xl＊X3> Xl＊Xl and model equations on each response variables were generated. Optimized compositions of formula were accordingly computed using those model equations and confirmed by following demonstration study. As a result, this study has demonstrated the efficiency and effectiveness of using a systematic formulation optimization process to develop the tablet formulation of roxithromycin dispersible tablet with limited experiment.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.40 no.5
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• pp.341-349
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• 2003

A real time interactive controller (spectrometer) for magnetic resonance imaging (MRI) system has been developed using high speed digital signal processors (DSP). The controller generates radio frequency (rf) waveforms and audio frequency gradient waveforms and controls multiple receivers for data acquisition. By employing DSPs having high computational power (e.g., TMS320C670l) real time generation of complicated gradient waveforms and interactive control of selection planes are possible, which are important features in real-time imaging of moving organs, e.g., cardiac imaging. The spectrometer was successfully implemented at a 1.5 Tesla whole body MRI system for clinical application. Performance of the spectrometer is verified by various experiments including high- speed imaging such as fast spin echo (FSE) and echo planar imaging (EPI). These high-speed imaging techniques reduce measurement time, however, usually intensify artifact if there is any systematic phase error or jitter in the synchronization between the transmitter, receiver, and gradients.

• Journal of The Korean Association For Science Education
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• v.33 no.5
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• pp.881-892
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• 2013

It has been recently emphasized that comprehensive understanding of students' cognitive activities in the process of writing as well as final product is needed in order to develop an effective strategy for science writing. In this study, we investigated the characteristics of writing process in the situation that students wrote a composition in solving the application problem on a science topic. Seven eighth graders selected in the consideration of their science achievement and communication skills were asked to write a composition using think-aloud method. They were also interviewed after their writing work. The analyses of the results indicated that students' writing processes consisted of six distinctive components: generating, organizing, setting, translating, evaluating, and revising. It was also found that the patterns of process components for each student were different in terms of the frequency and the sequence. The patterns of process components were categorized into four types: systematic, tacit planning, trial and error, and random strategies. Educational implications were also discussed.

• Journal of Korean Academy of Nursing
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• v.43 no.1
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• pp.50-58
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• 2013

Purpose: The purpose of this study was to evaluate measurement properties of self-report questionnaires for studies published in Korean nursing journals. Methods: Of 424 Korean nursing articles initially identified, 168 articles met the inclusion criteria. The methodological quality of the measurements used in the studies and interpretability were assessed using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist. It consists of items on internal consistency, reliability, measurement error, content validity, construct validity including structural validity, hypothesis testing, cross-cultural validity, and criterion validity, and responsiveness. For each item of the COSMIN checklist, measurement properties are rated on a four-point scale: excellent, good, fair, and poor. Each measurement property is scored with worst score counts. Results: All articles used the classical test theory for measurement properties. Internal consistency (72.6%), construct validity (56.5%), and content validity (38.2%) were most frequently reported properties being rated as 'excellent' by COSMIN checklist, whereas other measurement properties were rarely reported. Conclusion: A systematic review of measurement properties including interpretability of most instruments warrants further research and nursing-focused checklists assessing measurement properties should be developed to facilitate intervention outcomes across Korean studies.

• Proceedings of the Korea Water Resources Association Conference
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• 2010.05a
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• pp.1784-1788
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• 2010

APEC 기후센터(APEC Climate Center, APCC)에서 제공하는 다중모형앙상블(Multi-model Ensemble, MME) 형태의 계절예측정보를 이용하여 3개월 가뭄전망을 수행하였다. APCC MME는 기후예측모형이 가지는 불확실성을 최소화하기 위한 방법으로, 아시아 태평양 지역 내 9개 회원국 16개 기관 21개 기후모형의 계절예측정보를 활용하여, 개별 모형이 가지는 계통오차(Systematic error)를 앙상블 기법을 통하여 상쇄함으로써 최적의 예측자료를 도출한다. 또한, 기후예측 모형이 예측한 대기순환장은 관측 지점변수와 경험적 통계적 관련성을 가지므로, 이를 바탕으로 상세지역의 이상기후에 대한 정보를 도출할 수 있다. 본 연구에서는 가뭄 관리 및 전망을 위한 입력 자료로서, 기상전문 기관인 APEC 기후센터 (APEC Climate Center, APCC)에서 제공하는 전구 규모의 기온 및 강수 전망자료를 기상청 산하 59개 지점의 전망자료로 통계적 규모 축소화 기법을 통해 3개월 예보를 실시하였다. APCC 계절예측자료를 가뭄모니터링시스템의 자료입력 포맷에 따라 적절히 가공한 뒤, 가뭄 관리 및 전망을 위하여 SPI(Standard Precipitation Index) 및 PDSI(Palmer Drought Severity Index)지수의 입력자료로 사용하여 SPI 및 PDSI 지수를 산정하였다. 또한 분위사상법(Quantile Mapping)을 이용하여 총 59개 지점의 과거 월평균 관측값과 최근 2009년에 대한 모의값의 누적확률분포값을 계산하고 모의값의 확률분포를 관측값의 확률분포에 사상시켜 가뭄 전망을 위한 기상변수의 오차를 보정하고자 하였다. 이러한 계절예측정보를 이용하여 가뭄 전망에 대한 신뢰도가 높아진다면, 사전예방 및 피해완화로 가뭄상황에 대한 신속한 대처 및 피해의 경감이 이루어질 수 있을 것이다.

• Applied Microscopy
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• v.29 no.1
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• pp.75-81
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• 1999

Optimum conditions for making the Au and Al internal standards for TEM have been determined experimentally. The Au internal standard was produced by sputter coating at 9mA for 100 seconds in low vacuum $(\leq1\times10^{-3})$. The Al internal standard was produced by evaporation coating at 7kV for 10 minutes in high vacuum $(\leq1\times10^{-5})$. Measurements of the lattice parameters of andalusite and albite feldspars with this Au internal standard resulted in errors of (a) $ \leq1.2%$ in precion and $\leq0.3%$ in accuracy for andalusite: (b) $\leq0.5%$ in precision and $\leq1.1%$ in accuracy for albite feldspars. The most significant error occurred from the measuring processes of distances and angles of electron diffraction patterns. By employing systematic procedures of measurement with high precision devices, this lattice parameter determination method utilizing the internal standard should be a good alternative to the conventional powder XRD method or the sophisticated CBED method for special samples.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.16 no.3
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• pp.84-92
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• 2002

A size of low-voltage conductor cables is determined by the voltage drop of a system the cable impedance and the cable ampacity based on temperature correction factor in accordance with the condition of cable installation. Therefore, the proper temperation correction factor according to the condition of cable installation should be applied to determining the cable ampacity and also the skin effect and proximity effect, along with the kind and size of conductor and the condition of cable installation, should be properly considered to analyze the proper value of resistance and the reactance of the conductors. This paper addresses the systematic design flow for determining the size of low voltage level con여ctor cables in calculating the voltage drop of a power system and proposes a new improved the calculating formula what error should be minimized in comparison with the general formula and which can be applied in design work for determining the size of conductor cables.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.10
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• pp.486-492
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• 2019

The system-based approach is needed to select an optimal mix of weapon systems and ship platform among a variety of design alternatives with the uncertainties of the initial required operational capability. In the early-phase design, which included a feasibility study and concept design, it is possible to cause problems when a review of the operational concept, database development, and systematic design are not done, thereby producing uncertain and unstable requirements. To select the best solution without trial-and-error, the U.S. navy has applied the set-based method for the early-phase design of a new ship-to-shore connector. The ship synthesis model plays an important role in applying the set-based method, but only a few countries possess this model and have prohibited this model from being transferred to other countries. This paper suggests a set-based method using a genetic algorithm and decision-making theory through benchmarking existing ship data. The algorithm was verified using the DDG-51 class ship synthesis model to optimize the weapon system design, which has been released for research purposes.

• Nuclear Engineering and Technology
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• v.49 no.5
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• pp.989-995
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• 2017

Distributed Control System (DCS) communication networks, which use Fast Ethernet with redundant networks for the transmission of information, have been installed in digitalized nuclear power plants. Normally, failover tests are performed to verify the reliability of redundant networks during design and manufacturing phases; however, systematic integrity tests of DCS networks cannot be fully performed during these phases because all relevant equipment is not installed completely during these two phases. In additions, practical verification tests are insufficient, and there is a need to test the actual failover function of DCS redundant networks in the target environment. The purpose of this study is to verify that the failover functions works correctly in certain abnormal conditions during installation and commissioning phase and identify the influence of network failover on the entire DCS. To quantify the effects of network failover in the DCS, the packets (Protocol Data Units) must be collected and resource usage of the system has to be monitored and analyzed. This study introduces the use of a new methodology for verification of DCS network failover during the installation and commissioning phases. This study is expected to provide insight into verification methodology and the failover effects from DCS redundant networks. It also provides test results of network performance from DCS network failover in digitalized domestic nuclear power plants (NPPs).

• Atmosphere
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• v.31 no.1
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• pp.85-100
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• 2021

The necessity of accurate high-resolution meteorological forecasts becomes increasing in socio-economical applications and disaster risk management. The Korea Meteorological Administration Post-Processing (KMAPP) system has been operated to provide high-resolution meteorological forecasts of 100 m over the South Korea region. This study evaluates and improves the KMAPP performance in simulating wind speeds over complex terrain areas using the ICE-POP 2018 field campaign measurements. The mountainous measurements give a unique opportunity to evaluate the operational wind speed forecasts over the complex terrain area. The one-month wintertime forecasts revealed that the operational Local Data Assimilation and Prediction System (LDAPS) has systematic errors over the complex mountainous area, especially in deep valley areas, due to the orographic smoothing effect. The KMAPP reproduced the orographic height variation over the complex terrain area but failed to reduce the wind speed forecast errors of the LDAPS model. It even showed unreasonable values (~0.1 m s-1) for deep valley sites due to topographic overcorrection. The model's static parameters have been revised and applied to the KMAPP-Wind system, developed newly in this study, to represent the local topographic characteristics better over the region. Besides, sensitivity tests were conducted to investigate the effects of the model's physical correction methods. The KMAPP-Wind system showed better performance in predicting near-surface wind speed during the ICE-POP period than the original KMAPP version, reducing the forecast error by 21.2%. It suggests that a realistic representation of the topographic parameters is a prerequisite for the physical downscaling of near-ground wind speed over complex terrain areas.