• Journal of the Korean Child Neurology Society
• /
• v.26 no.4
• /
• pp.284-287
• /
• 2018

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutation of one of two genes, TSC1 (encoding hamartin, 9q34) and TSC2 (encoding tuberin, 16p13). It invades the central nervous system and various parts of the body, causing various symptoms. Crohn's disease (CD) is a chronic immune-mediated disease that has not been clearly elucidated. It is thought to be caused by an excessive immune response of the body to bacteria that normally exist in the digestive tract with genetic factors. No cases have been reported in which both of the above-mentioned diseases occurred simultaneously. We report a case of CD in a patient with TSC. A 12-year-old boy was brought to our hospital because of abdominal pain. Skin lesions were observed in the TSC. Fundus examination revealed a hamartoma in the right retina. Brain magnetic resonance imaging revealed a subendothelial giant cell astrocytoma (SEGA). On the basis of these findings, he was diagnosed as having TSC. Blood test results showed increased levels of inflammatory markers. On abdominal ultrasonography, his colon walls were observed to be thickened with increased vascularity of the proximal ascending colon, ileocecal valve, and terminal ileum. Colonoscopy revealed discontinuous ulcerations and inflammations of the ileum, IC valve, and cecum, similar to those found in CD. Everolimus was administered orally for the SEGA but was discontinued frequently owing to the exacerbation of CD. The possibility of CD should be kept in mind in patients with TSC considering to undergo treatment for SEGA.

• Journal of Environmental Health Sciences
• /
• v.47 no.5
• /
• pp.384-397
• /
• 2021

Background: With volatile organic compounds (VOCs) containing aromatic and halogenated hydrocarbons such as benzene, toluene, and xylene that can adversely affect the respiratory and cardiovascular systems when a certain concentration is reached, it is important to accurately evaluate the source and the corresponding health risk effects. Objectives: The purpose of this study is to provide scientific evidence for the city of Seoul's VOC reduction measures by confirming the risk of each VOC emission source. Methods: In 2020, 56 VOCs were measured and analyzed at one-hour intervals using an online flame ionization detector system (GC-FID) at two measuring stations in Seoul (Gangseo: GS, Bukhansan: BHS). The dominant emission source was identified using the Positive Matrix Factorization (PMF) model, and health risk assessment was performed on the main components of VOCs related to the emission source. Results: Gasoline vapor and vehicle combustion gas are the main sources of emissions in GS, a residential area in the city center, and the main sources are solvent usage and aged VOCs in BHS, a greenbelt area. The risk index ranged from 0.01 to 0.02, which is lower than the standard of 1 for both GS and BHS, and was an acceptable level of 5.71×10^-7 to 2.58×10^-6 for carcinogenic risk. Conclusions: In order to reduce the level of carcinogenic risk to an acceptable safe level, it is necessary to improve and reduce the emission sources of vehicle combustion and solvent usage, and eco-car policies are judged to contribute to the reduction of combustion gas as well as providing a response to climate change.

• Journal of the Computational Structural Engineering Institute of Korea
• /
• v.34 no.5
• /
• pp.279-286
• /
• 2021

In this study, we investigated the behavior characteristics of the L-type flange bolt connection, which is used to connect upper and lower flanges having L-type ring sections, by bolts. This connection is mainly used in domestic wind turbine structures, wherein it is a vital component as any imperfection could cause the collapse of the entire structural system. Therefore, understanding the behavior characteristics of the L-type flange bolt connection is imperative. In this study, the connection's response to external force was simulated using finite element (FE) analysis and the FE model was idealized to behave as a single L-type bolt flange. The variation in the bolt tension and the L-type flange stress were analyzed to understand the behavior characteristics of the connection. Moreover, the bolt-load function models proposed by Petersen, Schmidt/Neuper and VDI 2230, theoretically expressing a relation between bolt tension and external force, were compared to evaluate the suitability of the FE analysis and analyze the significant behavior characteristics of the connection. Furthermore, the changes in the bolt-load curve due to the variations in the partial dimensions of the L-type flange bolt connection were analyzed.

• The Journal of the Korea Contents Association
• /
• v.21 no.9
• /
• pp.580-594
• /
• 2021

The purpose of this paper is to investigate the impact on self-reliance and satisfaction of participants participating in the self-sufficiency business program of the Ulsan Metropolitan Regional Self-Sufficiency Center. A self-filled questionnaire was surveyed on self-sufficiency participants in five Borough and Country in Ulsan for 4 weeks from September 1 to 30, 2020, and final 233 copies were used in the actual analysis. As a result of the study, first, the percentage of positive responses of the participants was found to be good at 71.7%, for questions on the degree of support to the government, local governments, and administrative welfare centers. Second, in response to a system or service that would like to be supported or needed in the future, support for living expenses and support for health and medical expenses appeared and as a result of gender difference analysis, it was confirmed that there was a significant difference between support for children's education expenses and support for housing funds. Among the factors of the participant's psychological self-reliance(self-control, confidence, and willingness to work), the factor of self-control was the most significant factor, followed by confidence and willingness to work. Overall satisfaction with work was the highest among 9 satisfaction items such as salary and working hours.

• Journal of the Korean Society of Marine Environment & Safety
• /
• v.27 no.2
• /
• pp.377-386
• /
• 2021

The A60 class deck penetration piece is a fire-resistant system installed on a horizontal compartment to prevent flame spreading and protect lives in fire accidents in ships and offshore plants. This study deals with approximate optimization using discrete variables for the fire resistance design of an A60 class deck penetration piece using different surrogate models and a genetic algorithm. Transient heat transfer analysis was performed to evaluate the fire resistance design of the A60 class deck penetration piece. For the approximate optimization of the piece, the length, diameter, material type, and insulation density were applied to discrete design variables, and temperature, productivity, and cost constraints were considered. The approximate optimum design problem based on the surrogate models was formulated such that the discrete design variables were determined by minimizing the weight of the piece subjected to the constraints. The surrogate models used in the approximate optimization were the response surface model, Kriging model, and radial basis function-based neural network. The approximate optimization results were compared with the actual analysis results in terms of approximate accuracy. The radial basis function-based neural network showed the most accurate optimum design results for the fire resistance design of the A60 class deck penetration piece.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.22 no.4
• /
• pp.281-286
• /
• 2021

The International Maritime Organization recently proposed a policy to establish a preemptive response strategy for exhaust gas pollution on board ships according to the recent strengthening of the sulfur content regulations. Discussions on improving the fuel oil quality and reducing emissions are also ongoing. Fuel oil quality information, which is one of the main concerns internationally, is increasing as the sulfur content standard is being applied from the current 3.5% to 0.5% by 2020. From the perspective of shipping companies and recipients, the essential quality of fuel oil is also requested for domestic and international fuel oil information, basic properties, correlation information between characteristics for application of solid ships and ships. The current standard for the basic quality of fuel oil is generally used, but the nature and composition of the fuel oil are very complex, and the interpretation of the basic quality is complicated because there are many cases outside the scope of the basic standard. Various factors were analyzed for the basic quality of fuel oil in terms of the basic quality of fuel oil, optimization of operation in ships, and fuel efficiency in ships. Moreover, the possibility of applying the standard according to the dilution was suggested.

• Land and Housing Review
• /
• v.12 no.2
• /
• pp.1-12
• /
• 2021

The purpose of this study is to provide implications for the demonstration and the spread of smart cities. For this, the European Lighthouse project, a well-known smart city initiative, is analyzed. This article investigates agendas, applied solutions, stakeholders and cooperation, and expansion strategies in the 18 Lighthouse projects implemented by the EIP-SCC Smart City Demonstration Project. Four implications are discussed for Korean smart city projects. First, in promoting smart cities, clear philosophies and principles should be established in response to global issues such as climate change. Second, smart cities should be understood as the approaches for problem-solving rather than simply applying advanced technology. Third, a business system should be established in a way to meet the needs of the actors participating in the smart city demonstration project. Finally, an evaluation framework should be established to verify the performance of the project. High-performing best-practice projects should be supported by articulating their standards for their lessons to be spread into other cities. The implications presented here can contribute to developing smart city models along with follow-up studies.

• Ocean policy research
• /
• v.33 no.2
• /
• pp.83-119
• /
• 2018

Under the Korean Marine Environment Management Act (hereunder, the KMEMA), the duty to arrange spill clean-up equipments, including spill clean-up vessels, required by the article 67 of the KMEMA is in essence the provision of public goods since it is a precautionary or preventive measure for the efficient performance of oil spill cleaning up. Also the obligation to control marine pollution and the duty to arrange of anti-pollution measures imposed on polluters is the obligation imposed by the public law in accordance with "the Polluter-Pays Principle". Therefore, the execution of such obligations shall be accompanied by the minimum legal and institutional arrangements. On the other hand, judging whether to form the roles of the public and private sectors in providing public goods is basically a matter of policy decision. However, even if the private sector is allowed to participate in the provision of public goods, it is imperative that a minimum requirement be provided to secure the public interest. Although major countries allows polluters to conclude a preliminary contract with a civil anti-pollution management company, these civilian institutions are in principle constituted by the owners of oil storage facilities. Additionally it is worth noting that it operates as a non-profit organization. In particular, if the practitioner performs pollution control for commercial purposes, their profitability may depend on the size of the pollution, the period spent on pollution control, the size of the equipment and manpower mobilized in the pollution control, and so on. Considering the above problems, caution should be taken to allow marine environmental management companies to be un-limitedly entrusted with the responsibility of arranging measures such as pollution control. In order to allow the marine environmental management contractor to be entrusted for the assignment of duty to protect the marine environment, the marine environment management business should be expanded so that the marine pollutant management capacity satisfies the statutory control capacity. For this purpose, it is necessary to manage and supervise the maintenance and improvement of the control capability of the marine environment management business. It is also necessary to discuss the introduction of the grading system for the control ability of the civil control companies alike in major countries.

• Genes and Genomics
• /
• v.40 no.12
• /
• pp.1351-1361
• /
• 2018

A new cold tolerant germplasm resource named glutinous rice 89-1 (Gr89-1, Oryza sativa L.) can overwinter using axillary buds, with these buds being ratooned the following year. The overwintering seedling rate (OSR) is an important factor for evaluating cold tolerance. Many quantitative trait loci (QTLs) controlling cold tolerance at different growth stages in rice have been identified, with some of these QTLs being successfully cloned. However, no QTLs conferring to the OSR trait have been located in the perennial O. sativa L. To identify QTLs associated with OSR and to evaluate cold tolerance. 286 $F_{12}$ recombinant inbred lines (RILs) derived from a cross between the cold tolerant variety Gr89-1 and cold sensitive variety Shuhui527 (SH527) were used. A total of 198 polymorphic simple sequence repeat (SSR) markers that were distributed uniformly on 12 chromosomes were used to construct the linkage map. The gene ontology (GO) annotation of the major QTL was performed through the rice genome annotation project system. Three main-effect QTLs (qOSR2, qOSR3, and qOSR8) were detected and mapped on chromosomes 2, 3, and 8, respectively. These QTLs were located in the interval of RM14208 (35,160,202 base pairs (bp))-RM208 (35,520,147 bp), RM218 (8,375,236 bp)-RM232 (9,755,778 bp), and RM5891 (24,626,930 bp)-RM23608 (25,355,519 bp), and explained 19.6%, 9.3%, and 11.8% of the phenotypic variations, respectively. The qOSR2 QTL displayed the largest effect, with a logarithm of odds score (LOD) of 5.5. A total of 47 candidate genes on the qOSR2 locus were associated with 219 GO terms. Among these candidate genes, 11 were related to cell membrane, 7 were associated with cold stress, and 3 were involved in response to stress and biotic stimulus. OsPIP1;3 was the only one candidate gene related to stress, biotic stimulus, cold stress, and encoding a cell membrane protein. After QTL mapping, a total of three main-effect QTLs-qOSR2, qOSR3, and qOSR8-were detected on chromosomes 2, 3, and 8, respectively. Among these, qOSR2 explained the highest phenotypic variance. All the QTLs elite traits come from the cold resistance parent Gr89-1. OsPIP1;3 might be a candidate gene of qOSR2.

• Korean Journal of Construction Engineering and Management
• /
• v.20 no.2
• /
• pp.3-12
• /
• 2019

Despite the importance and function of productivity information, in the Korean construction industry, the method of collecting and analyzing productivity data has not been organized. Also, in most cases, productivity management is reliant on the experience and intuitions of field managers, and productivity data are rarely being utilized in planning and management. Accordingly, this study intends to develop a prediction model for interior finishes of apartment using deep learning techniques, so as to provide a foundation for analyzing the productivity impacting factors and predicting productivity. The result of the study, productivity prediction model for interior finishes of apartment using deep learning techniques, can be a basic module of apartment project management system by applying deep learning to reliable productivity data and developing as data is accumulated in the future. It can also be used in project engineering processes such as estimating work, calculating work days for process planning, and calculating input labor based on productivity data from similar projects in the past. Further, when productivity diverging from predicted productivity is discovered during construction, it is expected that it will be possible to analyze the cause(s) thereof and implement prompt response and preventive measures.