• Journal of Microbiology and Biotechnology
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• 제32권8호
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• pp.1026-1033
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• 2022

This study presents a novel DNA part characterization technique that increases throughput by combinatorial DNA part assembly, solid plate-based quantitative fluorescence assay for phenotyping, and barcode tagging-based long-read sequencing for genotyping. We confirmed that the fluorescence intensities of colonies on plates were comparable to fluorescence at the single-cell level from a high-end, flow-cytometry device and developed a high-throughput image analysis pipeline. The barcode tagging-based long-read sequencing technique enabled rapid identification of all DNA parts and their combinations with a single sequencing experiment. Using our techniques, forty-four DNA parts (21 promoters and 23 RBSs) were successfully characterized in 72 h without any automated equipment. We anticipate that this high-throughput and easy-to-use part characterization technique will contribute to increasing part diversity and be useful for building genetic circuits and metabolic pathways in synthetic biology.

• 대한본초학회지
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• 제36권5호
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• pp.69-79
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• 2021

Objectives : In clinical practice, there are many cases of co-administration of herbal medicine and synthetic drugs. This study tried to identify whether the combined administration of herbal medicine and synthetic drugs including amoxicillin increases Helcicobacter pylori eradication rate compared to the single administration of synthetic drugs or the combined administration of synthetic drugs and placebo herbal medicine through systematic review. Methods : Relevant randomized controlled trials were searched in PubMED database. The risk of biases was assessed through the Cochrane Risk of Bias criteria. Three reviewers were extracted the characteristics and outcomes of each study. Meta-analysis of eradication rate and adverse event was conducted. Results : Four RCTs were selected. In meta-analysis, the combination of herbal medicine and synthetic drugs showed eradication effect, but it was not statistically significant (Odds Ratio [OR] 0.46; 95% confidence interval [CI] 0.17 to 1.24; p=0.13; I²=56%) than administration of synthetic medicine alone. Combination of herbal medicine and synthetic medicine did not increased the incidence of adverse event(OR 1.07; 95% CI 0.72 to 1.59; p=0.68, I²=0%) compared to single administration of synthetic medicine. Conclusion : Although no significant difference was observed between the two groups in the eradication rate and the incidence rate of adverse events, it was difficult to draw a clear conclusion due to the heterogeneity between studies and the low quality of reporting. A number of studies that have overcome these limitations in the future will lead to definite conclusions.

• 대한음성학회지:말소리
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• 제64호
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• pp.1-14
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• 2007

The purpose of this study was to examine the acoustic perception different by formants change for profoundly hearing impaired children with cochlear implants. The subjects were 10 children after 15 months of experience with the implant and mean of their chronological age was 8.4 years and Standard deviation was 2.9 years. The ability of auditory perception was assessed using acoustic-synthetic vowels. The acoustic-synthetic vowel was combined with F1, F2, and F3 into a vowel and produced 42 synthetic sound, using Speech GUI(Graphic User Interface) program. The data was deal with clustering analysis and on-line analytical processing for perception ability of acoustic synthetic vowel. The results showed that auditory perception scores of acoustic-synthetic vowels for cochlear implanted children were increased in F2 synthetic vowels compaire to those of F1. And it was found that they perceived the differences of vowels in terms of distance rates between F1 and F2 in specific vowel.

• 응용통계연구
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• 제36권4호
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• pp.279-294
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• 2023

재현자료를 생성할 때 순차회귀 다중대체(SRMI)를 이용하는 방식이 가장 널리 알려져 있으며, 이를 구현한 소프트웨어로 R-패키지 synthpop이 활용되고 있다. 본 논문에서는 확률적 주성분 분석(PPCA)을 이용하여 재현자료를 생성하는 방안을 제안하고 2개의 데이터 세트를 이용한 모의실험으로 SRMI 방식과 PPCA 방식을 비교하였다. 모의실험에서 PPCA 방식으로 생성한 재현자료는 쌍별 상관계수를 기준으로 원자료와의 유사성이 가장 우수함을 확인하였다. 향후 PPCA 방식을 이용하여 시계열 자료에 대한 재현자료 생성을 연구하고자 한다.

• 우주기술과 응용
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• 제1권2호
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• pp.268-281
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• 2021

합성 개구 레이다(SAR, synthetic aperture radar)는 주야간 및 기상 조건에 구애받지 않고 원하는 지점을 관측할 수 있다는 장점으로 인해 최근 그 수요가 점점 늘어나고 있다. SAR 위성으로 관측한 원시 데이터는 위성궤도보정, 방사보정, multi-looking, geocoding과 같은 전처리 과정이 필요하며, 사용자의 목적에 따라 물체 탐지, 변화탐지, DEM(Digital Elevation Model) 등 영상 활용을 하기 위해서는 추가적인 처리 과정이 요구된다. 이러한 전처리와 연산과정은 매우 복잡하며 많은 시간과 컴퓨팅 자원을 필요로 한다. 주로 SAR 영상을 활용하는 기관에서는 영상을 편리하고 쉽게 처리하기 위해 각 기관의 활용 목적에 맞는 분석도구를 개발하여 사용 및 외부 수요자들에게 제공하고 있다. 본 논문에서는 국내외에서 이용하고 있는 대표적인 SAR 분석도구들의 기능 및 특성에 대해 소개하고자 한다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1995년도 하계학술대회 논문집 B
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• pp.623-627
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• 1995

This paper describes analysis and optimization of Weil-Dobke synthetic testing circuit parameters, which is efficient and economical test method in high capacity AC circuit breaker. In this paper, analysis of synthetic short-circuit test circuit parameter proposed nondimensional factor that is reciprocal comparison value of circuit parameter and is not related to rated of circuit breaker, in particular, this study induce minimization of required energy of critical TRV generation specified in IEC 56 standards and present optimal design of synthetic short circuit testing facilities.

• 한국산학기술학회논문지
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• 제13권8호
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• pp.3352-3357
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• 2012

본 논문은 열매체(Synthetic Heat Transfer Fluid) 보일러의 화재원인을 분석하기 위하여 3차원 자동설계 프로그램인 CATIA를 활용하여 설계하였다. 또한 3차원 유한요소 코드인 ANSYS를 활용하여 설계된 열매체보일러에 대하여 구조해석을 실시하였다. 구조해석을 통하여 열매체보일러의 정상상태와 화재 후의 최대온도(maximum temperature), 최대응력(maximum stress), 최대변형율(maximum strain) 등을 구하였다.

• 품질경영학회지
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• 제33권1호
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• pp.1-10
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• 2005

This paper develops a new VSI $\={X}-CRL$ synthetic control chart that considers convenience of use in the field, and perception of change of process applying VSI techniques to synthetic control chart, simultaneously. We found the optimal sampling interval and various control limit factor of the suggested chart using markov chain. Comparison and analysis is carried out between synthetic VSI $\={X}-CRL$ chart and other chart in the statistical aspect; $\={X}$ control chart, VSI $\={X}$ chart, another synthetic chart. In case that the process follows normal distribution, the proposed VSI $\={X}-CRL$ synthetic control chart in detecting process mean shift showed the best performance in aspect of statistical performance, regardless of control limit L of CRL/S control chart.

• 대한의용생체공학회:의공학회지
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• 제26권1호
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• pp.31-35
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• 2005

A novel synthetic aperture method for real-time three-way dynamic focusing is proposed, which provides lateral beam patterns represented as the product of Fourier transforms of transmit subaperture, receive subaperture, and a synthetic window function. In the proposed method, all array elements are fired individually and for each firing echo signals are recorded from all elements of a receive subaperture moving along an array with the transmit element. The three-way dynamic focusing is then achieved by employing a synthetic aperture algorithm for two-way dynamic focusing and a synthetic focusing method for transmit dynamic focusing. Both theoretical analysis and computer simulation results show that the proposed method produces ultrasound beams with improved lateral resolution at all depths compared to the conventional phased array imaging and synthetic aperture focusing methods.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2022년도 추계학술대회
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• pp.19-21
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• 2022

자기 지도 학습을 이용한 이상 탐지는 일반적으로 합성 데이터를 생성해 정상과 이상을 학습하고, 실제 이상 데이터를 테스트 데이터로 사용하여 이상 탐지 성능을 측정한다. 정상 데이터와 유사한 합성 데이터를 생성하기 위해 기존 연구에서는 원본 이미지에서 특정 패치를 자르고 붙이는 식으로 합성 데이터를 생성한다. 이런 방식에서 정상 데이터와 유사한 정도는 패치 개수와 크기에 따라 달라지므로 이상 탐지 성능에 영향을 미칠 수 있다. 본 연구에서는 패치 크기 및 개수를 다르게 하여 합성 데이터를 생성한 뒤 사전 학습된 모델을 사용하여 정상 데이터와의 유사성 측정 및 분석을 진행하였고 모델을 학습시켜 이상 탐지 성능을 측정하여 보았다.