• Journal of Ginseng Research
• /
• v.37 no.2
• /
• pp.201-209
• /
• 2013

Ginsenoside, one of the active ingredients of Panax ginseng, has a variety of physiologic and pharmacologic effects. The purpose of this study was to explore the effects of ginsenoside Rd (G-Rd) on melastatin type transient receptor potential 7 (TRPM7) channels with respect to the proliferation and survival of AGS and MCF-7 cells (a gastric and a breast cancer cell line, respectively). AGS and MCF-7 cells were treated with different concentrations of G-Rd, and caspase-3 activities, mitochondrial depolarizations, and sub-G1 fractions were analyzed to determine if cell death occurred by apoptosis. In addition, human embryonic kidney (HEK) 293 cells overexpressing TRPM7 channels were used to confirm the role of TRPM7 channels. G-Rd inhibited the proliferation and survival of AGS and MCF-7 cells and enhanced caspase-3 activity, mitochondrial depolarization, and sub-G1 populations. In addition, G-Rd inhibited TRPM7-like currents in AGS and MCF-7 cells and in TRPM7 channel overexpressing HEK 293 cells, as determined by whole cell voltage-clamp recordings. Furthermore, TRPM7 overexpression in HEK 293 cells promoted G-Rd induced cell death. These findings suggest that G-Rd inhibits the proliferation and survival of gastric and breast cancer cells by inhibiting TRPM7 channel activity.

• Journal of KIISE:Computer Systems and Theory
• /
• v.30 no.10
• /
• pp.523-532
• /
• 2003

Video on Demand(VOD) services cause high resource consumption in a video seuer, because multimedia are characterized by continuous playback, a high bandwidth requirement, and long playback duration. Patching has been proposed to save the network I/O bandwidth of a video server. To achieve true VOD, patching uses multicasting to share video streams, thereby providing immediate VOD services to users without any service latency. A communication channel is used to either multicast the entire video as a regular channel or multicast only the leading portion of a video as a Patching channel. This paper Proposes a buffering patching technique that divides regular channels, as used in patching, into sub-regular channels and regular channels to shorten the holding time of the channels. In the proposed technique, the last portion of video data, corresponding to the size of the buffering window, is not transferred by sub-regular channels, but rather downloaded and buffered in the user buffer from the latest regular channel. When simulations were performed to compare the performance of the proposed technique with that of conventional patching, the results indicated that the proposed technique was superior in terms of the defection rate, average service latency, and fairness, although the amount of video data buffered at each user station was higher than that with patching.

• International Journal of Computer Science & Network Security
• /
• v.23 no.10
• /
• pp.1-10
• /
• 2023

This paper proposes a method to extend Inter-Carrier Interference (ICI) canceling Orthogonal Frequency Division Multiplexing (OFDM) receivers for 5G mobile systems to spatial multiplexing 2×2 MIMO (Multiple Input Multiple Output) systems to support high-speed ground transportation services by linear motor cars traveling at 500 km/h. In Japan, linear-motor high-speed ground transportation service is scheduled to begin in 2027. To expand the coverage area of base stations, 5G mobile systems in high-speed moving trains will have multiple base station antennas transmitting the same downlink (DL) signal, forming an expanded cell size along the train rails. 5G terminals in a fast-moving train can cause the forward and backward antenna signals to be Doppler-shifted in opposite directions, so the receiver in the train may have trouble estimating the exact channel transfer function (CTF) for demodulation. A receiver in such high-speed train sees the transmission channel which is composed of multiple Doppler-shifted propagation paths. Then, a loss of sub-carrier orthogonality due to Doppler-spread channels causes ICI. The ICI Canceller is realized by the following three steps. First, using the Demodulation Reference Symbol (DMRS) pilot signals, it analyzes three parameters such as attenuation, relative delay, and Doppler-shift of each multi-path component. Secondly, based on the sets of three parameters, Channel Transfer Function (CTF) of sender sub-carrier number n to receiver sub-carrier number l is generated. In case of n≠l, the CTF corresponds to ICI factor. Thirdly, since ICI factor is obtained, by applying ICI reverse operation by Multi-Tap Equalizer, ICI canceling can be realized. ICI canceling performance has been simulated assuming severe channel condition such as 500 km/h, 8 path reverse Doppler Shift for QPSK, 16QAM, 64QAM and 256QAM modulations. In particular, 2×2MIMO QPSK and 16QAM modulation schemes, BER (Bit Error Rate) improvement was observed when the number of taps in the multi-tap equalizer was set to 31 or more taps, at a moving speed of 500 km/h and in an 8-pass reverse doppler shift environment.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 1991.10a
• /
• pp.29-32
• /
• 1991

Non-volatile SNOSFET memory devices using CMOS 1Mbit design rule(1.2$\mu\textrm{m}$), whose channel width and length are 15${\times}$1.5$\mu\textrm{m}$, 15${\times}$1.5$\mu\textrm{m}$, 2.0${\times}$15$\mu\textrm{m}$ and length are 15${\times}$1.7$\mu\textrm{m}$, respectivley, were fabricated. And the transfer, Id-Vd and switching characteristics of the devices were investigated. As a result, the 15${\times}$1.5$\mu\textrm{m}$ device was good in the transfer characteristics and the switching characteristics were favourable, which had $\Delta$V$\sub$TH/=6.3V by appling pulse voltage of V$\sub$w/=+34V, Tw=50msec.

• JSTS:Journal of Semiconductor Technology and Science
• /
• v.17 no.1
• /
• pp.94-100
• /
• 2017

Stress drain bias dependent current model is proposed for sub-70-nm p-channel metal-oxide semiconductor field-effect transistors (pMOSFETs) under drain-avalanche-hot-carrier (DAHC-) mechanism. The proposed model describes the both on-current and off-current degradation by using two device parameters: channel length variation (${\Delta}L_{ch}$) and threshold voltage shift (${\Delta}V_{th}$). Also, it is a simple and effective model of predicting reliable circuit operation and standby power consumption.

• Proceedings of the Korea Contents Association Conference
• /
• 2005.11a
• /
• pp.340-344
• /
• 2005

For the next generation wireless systems, multimedia services will be highly demanded and needed to transmit the cost-efficient packet data. With this regard, the adaptive resource management methods are preferable to optimally control the various traffic classes in OFDMA (WiBro) systems. We have developed a sub-channel state prediction method based on the past sub-channel state dependency. Using the method, we are developed a scheduling algorithm that can efficiently control multimedia traffic downlink transmissions.

• ETRI Journal
• /
• v.29 no.1
• /
• pp.79-88
• /
• 2007

This paper proposes a novel concept of adjusting the hardware size in a multi-carrier code division multiple access (MC-CDMA) receiver in real time as per the channel parameters such as delay spread, signal-to-noise ratio, transmission rate, and Doppler frequency. The fast Fourier transform (FFT) or inverse FFT (IFFT) size in orthogonal frequency division multiplexing (OFDM)/MC-CDMA transceivers varies from 1024 points to 16 points. Two low-power reconfigurable radix-4 256-point FFT processor architectures are proposed that can also be dynamically configured as 64-point and 16-point as per the channel parameters to prove the concept. By tailoring the clock of the higher FFT stages for longer FFTs and switching to shorter FFTs from longer FFTs, significant power saving is achieved. In addition, two 256 sub-carrier MC-CDMA receiver architectures are proposed which can also be configured for 64 sub-carriers in real time to prove the feasibility of the concept over the whole receiver.

• Bulletin of the Korean Chemical Society
• /
• v.32 no.1
• /
• pp.89-94
• /
• 2011

The mechanism of the cycloaddition reaction of forming germanic bis-heterocyclic compound between singlet dimethylgermylene carbene and acetone has been investigated with CCSD(T)//B3LYP/6-$31G^*$ method. From the potential energy profile, it can be predicted that, this reaction has one dominant channel. The presented rule of this dominant channel is that the two reactants firstly form a four-membered ring carbene (RC4) through the [2+2] cycloaddition reaction. Due to $sp^2$ hybridization of carbene C atom in RC4, RC4 further combines with acetone to form a reactant complexe (RC5). Due to the further $sp^3$ hybridization of carbene C atom in RC4, RC5 isomerizes to a germanic bisheterocyclic compound (P6) via the transition state (TS5).

• The Transactions of the Korean Institute of Electrical Engineers P
• /
• v.62 no.4
• /
• pp.164-168
• /
• 2013

Recently, in the elevator of the buildings, such as apartment and office building, the visitor monitoring cameras for surveillance, advertising LCD to provide a variety of information, emergency call devices, and safe driving information sensors are installed. A variety of multimedia data from these devices to the central control office, management office, or to guard room are transmitted in real-time. Each sub-systems in the elevator are installed with a separate lines and operated independently and use different management principals, so integrated management for each sub-systems are very difficult. In this study, we develop a new IP-based multi-channel video surveillance system which is integrated surveillance camera, emergency call devices, communications devices, various sensors in the elevator, DVR, ODM, and can manage all devices by two-way communication and integrated interface. And we evaluated the performance of the developed system.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.10 no.10
• /
• pp.5035-5048
• /
• 2016

Nano scale networks are futuristic networks deemed as enablers for the Internet of Nano Things, Body area nano networks, target tracking, anomaly/ abnormality detection at molecular level and neuronal therapy / drug delivery applications. Molecular communication is considered the most compatible communication technology for nano devices. However, connectivity in such networks is very low due to inter-symbol interference (ISI). Few research papers have addressed the issue of ISI mitigation in molecular communication. However, many of these methods are not adaptive to dynamic environmental conditions. This paper presents an enhancement over original Memory-1 ISI cancellation scheme using maximum likelihood estimation of a channel parameter (λ) to make it adaptable to variable channel conditions. Results of the Monte Carlo simulation show that, the connectivity (P_conn) improves by 28% for given simulation parameters and environmental conditions by using enhanced Memory-1 cancellation method. Moreover, this ISI mitigation method allows reduction in symbol time (Ts) up to 50 seconds i.e. an improvement of 75% is achieved.