• 건축역사연구
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• 제11권3호
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• pp.21-34
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• 2002

This study is to analyse the transformation process of spatial structure of traditional small city structure in Jeollabuk-Do in the process of modern urbanization between 19th century and the year 2000. The small cities, IM-PI, YONG-AN, YEO-SAN, OK-GOO, GO-SAN, MU-JANG, GUM-MA, GO-BU, which have been local administrative center in CHO-SUN dynasty, have role of local administrative center of subdivision of country-myon, except OK-GOO. The method of this study is to investigate the transformation process of spatial structural elements of with the actual field surveys, the analysis of Gunhyun map made in 1872, land registration maps in 1910s and 2000, and various topological maps. The elements of analysis are the topological site and geographical situation conditions, the urbanized areas, the street systems, the function of streets, the focal points of urban land use, the land use systems, and the location of major facilities such as administration facilities, markets, bus terminals. The analytical point of view and the results are as follows. There is strong relationship between the transformation of internal matrix route system and the growth pattern of urbanized areas, Especially on the contrary to the matrix route with East-West direction which has the role of checking the growth of urbanized area, the South-North direction route acts as the leading line of the growth. The focal points structure of urban land use shows transformation process from the point of central space of administrative district in front of Nae-A, to the access point to administrative district or to the access point to housing and neighborhood commercial area. From the point of functional area structure and major facilities location, line-type commercial area is developed along the line of central axis route and access route to administrative district. Especially direction of the growth of commercial area is strongly connected with the interrelationship between the study area and its neighboring cities. Pattern of commercial district development is varied with the direction of matrix route. That is, commercial district, which shows one side development pattern along the East-West direction route, is developed on both sides of street along the South-North direction route.

• 한국초지조사료학회지
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• 제38권3호
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• pp.175-179
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• 2018

Humic substances that can be obtained from coal resources such as leonardite in a bulk scale have been employed as crop stimulators and soil conditioners. The polymeric organics containing a variety of aromatic and aliphatic structures are known to activate plants in a multifunctional way, thus resulting in enhanced germination rate and abiotic stress resistance concomitant with induction of numerous genes and proteins. Although detailed structural-functional relationship of humic substances for plant stimulations has not been deciphered yet, cutting-edge analytical tools have unraveled critical features of humic architectures that could be linked to the action mechanisms of their plant stimulations. In this review article, we introduce key findings of humic structures and related biological functions that boost plant growth and abiotic stress resistance. Oxygen-based functional groups and plant hormone-like structures combined with labile and recalcitrant carbon backbones are believed to be critical moieties to induce plant stimulations. Some proteins such as HIGH-AFFINITY $K^+$ TRANSPORTER 1, phospholipase A2 and $H^+$-ATPase have been also recognized as key players that could be critically involved in humic substance-driven changes in plant physiology.

• BMB Reports
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• 제35권3호
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• pp.291-296
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• 2002

Thanatin, a 21-residue peptide, is an inducible insect peptide with a broad range of activity against bacteria and fungi. It has a C-terminal disulfide loop, like the frog skin secretion antimicrobial peptides of the brevinin family. In this study, we tried to find the effect of a number of amino acids between the disulfide bond. Thanatin showed stronger antibacterial activity to Gram negative bacteria than other mutants, except Th1; whereas, the mutant peptides with deletion had higher activity to Gram positive bacteria than thanatin. An increase in the number of amino acid(s) using the alanine residue decreased the antibacterial activity in all of the bacteria. Th1 with deletion of threonine at position 15 ($Thr^{15}$) showed similar antibacterial activity against Gram-negative bacteria, but had higher activity against the Gram positive bacteria. In order to study the structure-function relationship, we measured liposome disruption by the peptides and CD spectra of the peptides. Th1 also showed the highest liposome leaking activity and α-helical propensity in the sodium dodecyl sulfate solution, compared with other peptides. Liposome disruption activity was closely correlated with the anti-Gram positive bacterial activity. All of the peptides showed no hemolytic activity. Th1 was considered to be useful as an antimicrobial peptide with broad spectrum without toxicity.

• 한국콘텐츠학회논문지
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• 제22권2호
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• pp.135-146
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• 2022

본 연구는 마을공동체미디어의 실천과 관련 누가, 왜 참여하고, 참여자들의 역할은 마을공동체미디어의 운영에 어떠한 연관성을 가지는지, 그리고 참여자들의 참여 요건은 무엇인지를 살펴보고자 했다. 이를 위해 농촌지역사회에서 실천되고 있는 마을신문을 민속지학적으로 접근하였고, 참여관찰, 심층인터뷰, 내용분석을 수행했다. 연구 결과는 조화로운 주민 참여가 마을신문 실천의 핵심이며, 주민 참여는 자발성, 개방성, 재능기부, 관계성이라는 요건을 바탕으로 하고 있음을 확인할 수 있었다. 자발성은 지역공동체의 구성원으로서 지역사회의 활성화에 대한 바램과 노력이 이어지는 것이다. 개방성은 주민 누구나 자유롭게 참여할 수 있는 마을신문의 운영 구조와 연관된다. 재능기부는 주민 참여의 구체적 실천 형태로서 각자의 경험, 지식, 전문성을 바탕으로 한다. 그리고 관계성은 자발성과 실천을 연결해주는 지역사회의 연결망이자 마을공동체미디어의 운영 구조이다. 이러한 주민참여의 요건들이 긍정적 협업으로 이어질 때 마을공동체미디어의 순기능이 발현되며, 지속가능성 역시 확보된다는 것을 마을신문의 사례를 통해 확인 할 수 있었다.

• 한국과학교육학회지
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• 제22권4호
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• pp.796-805
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• 2002

본 연구는 '식물의 구조와 기능' 단원의 학습 전 아동의 지식구조와 학습과정 및 학습 종료 7개월 후까지의 지식구조의 변화를 아동의 학습성향(유의미학습과 암기학습)과 관련지워 조사한 것이다. 연구단원과 관련된 기존의 지식구조를 알아보기 위하여 5학년 아동들에게 1차 개념도를 그리게 하고, 매 4차시 수업후 각각의 개념도를 그리게 했다. 그리고 지식구조의 지속효과를 알아보기 위하여 단원 학습이 종료된 직후와 3개월, 7개월 후에도 각각의 개념도를 그리게 했다. 학습과정 동안에는 기존의 개념도를 근거로 하여 개념도를 그리게 하였으며, 단원 학습 종료 후에는 기존의 개념도가 제시되지 않은 상태에서 개념도를 그리게 하였다. 아동들이 그린 각각의 개념도는 그 당시의 식물의 구조와 기능에 대한 이해 정도를 나타내었다. 초등학교 5학년 아동들은 '식물의 구조와 기능' 단원의 학습에 들어가기 전에 이와 관련된 여러 가지 개념들로 이루어진 사전 지식구조를 가지고 있으나 그 중 과학적으로 타당한 것은 개념도 상에서 2단계의 위계와 5개의 관계에 불과하였다. 한 단원의 학습이 진행되어감에 따라 아동들의 지식구조는 꾸준히 그리고 점진적으로 증가였다. 그러나 이러한 증가는 학습성향에 따라 차이를 보이며, 유의미 학습자가 암기 학습자보다 더 많이 증가하였다(관계, 연관, 예: p < .01, 위계: p < .05). 지식구조의 변화에 있어서 학습성향간에 다소 차이가 있으나 재구조화는 단원 학습의 초기에 높은 빈도로 일어났으며, 말기에는 전혀 일어나지 않았다. 조정은 유의미 학습자보다 암기 학습자에서 더 많이 일어나고 확장은 이와 반대로 유의미 학습자에서 더 많이 일어났다. 암기 학습자의 개념도 점수는 단원 학습을 마친 후 시간이 경과함에 따라 모든 범주에서 차츰 감소하였다. 그러나 유의미 학습자의 경우 단원 학습 후 3개월보다 7개월에서 오히려 소폭 증가했다. 그러므로 대체로 암기 학습자가 학습과정에서 새로이 구축하고자 하는 더 분화되고 정교한 지식구조가 유의미 학습자보다 불안정한 상태에 있으며, 지식구조의 분화 정도도 유의미 학습자에 비해 낮다고 할 수 있다.

• 한국실내디자인학회논문집
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• 제40호
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• pp.139-148
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• 2003

For lighting design in such diverse structures, we need lots of considerations, such as use and characteristics of the structure, harmony with its surroundings, and the function and type of lighting to be installed. The structural characteristics is determined by its shape and several vertical and horizontal factors based on the shape, which can be focused on at day time by shading, the surface structure, the quality of the surface and the color. On the other hand, they can be at night hidden in the darkness or enforced strongly by the effect of the lighting. In this paper, correlation between the ways of lighting and building facade types according to vocabularies for sensitivity is explored based upon an analysis of building facades for small-scale commerce which plays an important role in cityscape lighting design. It is considered that categorization of types of building facades, presented in this article, and the classification system of exterior lighting methods can be useful in planning lighting. And the process of the study is thought to be able to present a method about the exterior lighting planning. Furthermore, computer simulation on the bases of the correlation model of the lighting methods related to vocabularies for sensitivity about the building facade types is expected to be data and means which can be a great help for designers to predict various results quickly.

• Bulletin of the Korean Chemical Society
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• 제35권9호
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• pp.2655-2659
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• 2014

Dual specificity protein phosphatase 4 (DUSP4) has been considered a promising target for the development of therapeutics for various human cancers. Here, we report the first example for a successful application of the structure-based virtual screening to identify the novel small-molecule DUSP4 inhibitors. As a consequence of the virtual screening with the modified scoring function to include an effective molecular solvation free energy term, five micromolar DUSP4 inhibitors are found with the associated $IC_{50}$ values ranging from 3.5 to $10.8{\mu}M$. Because these newly identified inhibitors were also screened for having desirable physicochemical properties as a drug candidate, they may serve as a starting point of the structure-activity relationship study to optimize the medical efficacy. Structural features relevant to the stabilization of the new inhibitors in the active site of DUSP4 are discussed in detail.

• Steel and Composite Structures
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• 제19권1호
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• pp.237-262
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• 2015

In this study, we try to compare different intensity measures for evaluating nonlinear response of bridge structure. This paper presents seismic analytic fragility of a three-span concrete girder highway bridge. A complete detail of bridge modeling parameters and also its verification has been presented. Fragility function considers the relationship of intensities of the ground motion and probability of exceeding certain state of damage. Incremental dynamic analysis (IDA) has been subjected to the bridge from medium to strong ground motions. A suite of 20 earthquake ground motions with different range of PGAs are used in nonlinear dynamic analysis of the bridge. Complete sensitive analyses have been done on the response of bridge and also efficiency and practically of them are studied to obtain a proficient intensity measure for these types of structure by considering its sensitivity to the period of the bridge. Three dimensional finite element (FE) model of the bridge is developed and analyzed. The numerical results show that the bridge response is very sensitive to the earthquake ground motions when PGA and Sa (Ti, 5%) are used as intensity measure (IM) and also indicated that the failure probability of the bridge system is dominated by the bridge piers.

• Earthquakes and Structures
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• 제10권4호
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• pp.757-768
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• 2016

In the past decades, effect of near field earthquake on the historical monuments has attracted the attention of researchers. So, many analyses in this regard have been presented. Tunnels as vital arteries play an important role in management after the earthquake crisis. However, digging tunnels and seismic effects of earthquake on the historical monuments have always been a challenge between engineers and historical supporters. So, in a case study, effect of near field earthquake on the historical monument was investigated. For this research, Finite Element Analysis (FEM) in soil environment and soil-structure interaction was used. In Plaxis 2D software, different accelerograms of near field earthquake were applied to the geometric definition. Analysis validations were performed based on the previous numerical studies. Creating a nonlinear relationship with space parameter, time, angular and numerical model outputs was of practical and critical importance. Hence, artificial Neural Network (ANN) was used and two linear layers and Tansig function were considered. Accuracy of the results was approved by the appropriate statistical test. Results of the study showed that buildings near and far from the tunnel had a special seismic behavior. Scattering of seismic waves on the underground tunnels on the adjacent buildings was influenced by their distance from the tunnel. Finally, a static test expressed optimal convergence of neural network and Plaxis.

• BMB Reports
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• 제28권1호
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• pp.51-56
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• 1995

Thioredoxin is a small redox protein with an active-site disulfide/dithiol, and is ubiquitous in bacteria, plants, and animals. To investigate the structure-function relationship of thioredoxin, the genes encoding Escherichia coli thioredoxin and Corynebacterium nephridii thioredoxin C3 were fused via a common restriction site in the nucleotide sequence coding for the active site of the proteins to generate two chimeric thioredoxins, designated E-C3(N to C-terminal) and C3-E. The hybrid thioredoxin genes were put under the T7 promoter and their productions were confirmed. The two hybrid thioredoxins complemented phenotypes of a thioredoxin-deficient E. coli strain. A strain containing the C3-E hybrid thioredoxin supported growth of the T7 phage, whereas a strain expressing the E-C3 hybrid thioredoxin did not. However, both hybrids supported growth of M13 phages. The two hybrid thioredoxins were also characterized in other aspects. Differences in activity between the hybrid thioredoxins were attributed to altered interactions of the N- and C-terminal domains of the molecule, which produced changes in the three-dimensional structure of the active site region.