• 제목/요약/키워드: ssanghwa

검색결과 42건 처리시간 0.028초

폴리페놀 및 항산화 관점에서의 쌍화탕 및 단미혼합쌍화탕의 동등성 (Equivalence of Traditional and Individual Preparation of Ssanghwa-tang in terms of Polyphenol Contents and Radical Scavenging Activity)

  • 김동선;엄영란;양민철;윤나영;이재훈;마진열
    • 한국한의학연구원논문집
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    • 제17권2호
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    • pp.169-172
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    • 2011
  • Traditional medicines usually use combinational formula that is prepared by mixing different varieties of medicinal herbs and boiling them in water to yield a decoction. In recent years a modified method has been proposed and practiced wherein the individual herbs are boiled with water separately and later these extracts are mixed together for use. This practice has lead to a constant controversy concerning the chemical and biological equivalence between the preparations arriving out of these two methodologies. In this research, we attempted to study the effects of traditional and individual preparation of Ssanghwa-tang (ST) to evaluate their equivalence in terms of its antioxidant activity and polyphenol content. The study results indicate that the polyphenol contents as well as the extraction yields of these two preparations were very similar to each other.

비결핵 항산균 폐질환 환자의 한의치료로 증상 호전에 대한 증례보고 (A Case Report of Symptom Improvement in a Patient Diagnosed with Nontuberculous Mycobacterial Lung Disease Treated with Korean Medicine)

  • 강성우;유창환;홍성은;김대영;김관일;이범준;정희재
    • 대한한방내과학회지
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    • 제41권5호
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    • pp.856-867
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    • 2020
  • Objectives: The purpose of this case study was to report the effect of Korean Medicine treatment on a patient diagnosed with nontuberculous mycobacterial lung disease. Methods: A 61-year-old female patient with nontuberculous mycobacterial lung disease was admitted to the clinic from October 15th, 2018 to November 7th, 2018. The patient was treated using Korean medical treatments of Jinhae-tang-gami, Ssanghwa-tang-gami, Haeyeol-tang, Jinhae-tang plus Ssanghwa-tang-gami, and Jinhae-tang plus Bojungikgi-tang-gami. We evaluated the improvement of symptoms by a numeric rating scale (NRS) score, C-reactive protein (CRP) levels, erythrocyte sedimentation rate (ESR), and body temperature. Results: After Korean medicine treatment, the patient's cough and sputum amounts were decreased as measured by the NRS score. CRP levels and ESR were also decreased and fever was relieved. Conclusion: This study suggested that Korean medicine treatment might be effective in treating patients diagnosed with nontuberculous mycobacterial lung disease.

Inhibitory effect of Ssanghwa-tang on bone loss in ovariectomized rats

  • Shim, Ki-Shuk;Lee, Ji-Hye;Ma, Choong-Je;Lee, Yoon-Hee;Choi, Sung-Up;Lee, Jae-Hoon;Ma, Jin-Yeul
    • Animal cells and systems
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    • 제14권4호
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    • pp.283-289
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    • 2010
  • Ssanghwa-tang (SHT) is a traditional Korean herbal medicine widely prescribed to decrease fatigue following an illness. The purpose of this study was to investigate the effects of SHT on osteoclast differentiation in vitro, and on bone loss in ovariectomized (OVX) rats in vivo. SHT significantly reduced the receptor activator for the nuclear factor ${\kappa}B$ (NF-${\kappa}B$) ligand (RANKL)-induced tartrate-resistant acid phosphatase (TRAP) activity, and multinucleated osteoclast formation in RAW264.7 cells without affecting cell viability. In addition, SHT significantly attenuated RANKL-induced mRNA expression levels of c-Src and cathepsin K. To examine the in vivo effect of SHT on OVX-induced bone loss in OVX rats, we administered SHT (0.6 g/kg BID) orally to OVX rats for 12 weeks. SHT administration significantly blocked OVX-induced decrease of femoral bone mineral density (BMD) and femoral trabeculae in OVX rats. In conclusion, these results suggest that SHT treatment effectively prevents OVX-induced bone loss, and this effect may result from its inhibitory effect on osteoclast differentiation.

Assessment of genotoxicity of Ssanghwa-tang, an herbal formula, by using bacterial reverse mutation, chromosome aberration, and in vivo micronucleus tests

  • Jang, Ji-Hye;Seo, Chang-Seob;Lee, Mee-Young;Shin, Hyeun-Kyoo;Han, Su-Cheol;Ha, Hyekyung
    • 대한한의학회지
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    • 제42권4호
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    • pp.25-39
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    • 2021
  • Objectives: Ssanghwa-tang (SHT) is a traditional herbal formula comprising nine medicinal herbs, and it is used for reducing fatigue in Korea. SHT exerts various effects such as anti-inflammatory, antioxidant, and anti-aging activities, and protection against acute hepatotoxicity. However, the genotoxicity of SHT has not yet been established. Methods: Ten components were identified in SHT water extract by using high-performance liquid chromatography analysis. We assessed the genotoxicity of SHT by using bacterial reverse mutation (Ames test), chromosome aberration, and in vivo micronucleus tests. Results: The contents of paeoniflorin, glycyrrhizin, and liquiritin apioside in SHT were 15.57, 6.94, and 3.48 mg/g extract, respectively. SHT did not increase the revertant colonies of Salmonella typhimurium and Escherichia coli strains in the presence or absence of metabolic activity. Although SHT did not induce structurally abnormal chromosomes in Chinese hamster lung (CHL) cells in the presence of metabolic activity, the number of structurally aberrated chromosomes increased dose-dependently in the absence of metabolic activity. In the in vivo micronucleus test, SHT did not affect the formation of micronuclei compared with the vehicle control. Conclusions: Genotoxicity of SHT was not observed in the Ames test and in vivo micronucleus test. However, based on the results of chromosome aberration test, it can be presumed that SHT has the potential to induce genotoxicity because it induced structurally abnormal chromosomes in the absence of metabolic activity.

쌍화탕 추출물이 항산화효소 및 항노화관련 효소 활성에 미치는 영향 (Effect of Ssanghwa-tang Extract on Antioxidant and Anti-aging Enzyme Activities)

  • 박지영;황재규;윤종국;한길환;도은주;김성옥;김미려
    • 대한본초학회지
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    • 제27권3호
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    • pp.67-74
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    • 2012
  • Objectives : The present study was designed to investigate effects of Ssanghwa-tang (Shu$\bar{a}$nghu$\bar{a}$-g$\bar{e}$ng) on oxidation/reduction reaction-related and aging-related enzymes $in$ $vitro$. Methods : We performed MTT assay, collagenase inhibition assay, elastase inhibition assay, tyrosinase inhibition assay, DPPH free radical scavenging assay, SOD-like activity and xanthine oxidase (XO) inhibition assay. Results : The 50% ethanol (EtOH) extract of Ssanghwa-tang (SHT) showed 55% inhibition of collagenase activity, and 42% inhibition of elastase activity at 1 mg/ml concentration. Also it's treatment showed 18% inhibition of tyrosinase activity, to relate whitening effect, at the same dose of 50% ethanol extract of SHT. Antioxidant activities were determined by DPPH radical scavenging, XO inhibiting activity and SOD-like activity. These scavenging, XO-inhibiting and SOD-like activities were measured in 80%, 75%, and 28% inhibitions, respectively, at a 1 mg/ml treated dose, compared to those of control. The inhibitory effects of 50% EtOH extract on aging and oxidation-related enzyme activities were higher than those of water extract and 95% EtOH extract. Conclusions : Taken together, our findings suggest that the SHT has potential and applicable benefits for development of cosmetics to have anti-aging (anti-wrinkle and whitening) and anti-oxidation functions.

가미쌍화탕과 양의공진단 투여로 호전된 양하지 속 상연축 환자 1례 (A Case Report of Benign fasciculation syndrome treated with Gami Ssanghwa-Tang and Yang Eui Gongjin-Dan.)

  • 김수경;여서원;이현중;이동혁;두경희;조승연;박성욱;고창남;박정미
    • 대한중풍순환신경학회지
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    • 제15권1호
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    • pp.66-71
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    • 2014
  • ■ Objectives This clinical study is to report the effect of Korean medicine on patient with chronic benign fasciculation syndrome on a both legs. ■ Methods A patient who suffered from involuntary fasciculation of Quadricepts femoris and Gastrocnemius was treated with herbal medicine Gami SSanghwa-Tang and Yang Eui Gongjin-dan, acupuncture and moxibustion. Degree of fasciculation and general condition was measured. ■ Results After taking Gami Ssanghwa-Tang and Yang Eui Gongjin-Dan, degree of fasciculation have reduced and patient's general condition improved. ■ Conclusion This clinical case study showed the effect of Korean medicine on symptom of fasciculation.

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뇌졸중 후유증으로 나타난 진전 증상 치험 3례 (Three Cases of Tremor in Stroke Sequela Patients)

  • 유현희;윤효진;윤지원;이성근;이기상;손지영
    • 동의생리병리학회지
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    • 제19권5호
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    • pp.1450-1455
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    • 2005
  • Tremor is an most common abnormal movements disease which is to-and-fro shaking. It is caused by problems -with the nerves supplying certain muscles. It can affect the whole body or just certain areas. Parkinson's disease, Brain disease like injury of Frontal lobe, Cerebellum and Brainstem, drug and alcohol caused this symptom. It could be occured by physiological and Essential cause. In this paper, authors report three cases who showed tremor after Cerebral infarction. And we suggest that 'Ssanghwa-Tang' should be helpful for tremor patients.

인삼제품(人蔘製品)의 품질안정성(品質安定性)에 관한 연구(硏究) -2. 인삼정분(人蓼精粉)과 시판다류제품(市販茶類製品)의 품질안정성(品質安定性) 비교(比較)- (Studies on Stability for the Quality of Ginseng Products -2. Comparative Study on Keeping Quality of Red Ginseng Extract Powders(RGEPs) and Commercial Dehydrated Tea Products-)

  • 최진호;변대석;노재일;박길동;성현순
    • 한국식품영양과학회지
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    • 제13권2호
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    • pp.209-214
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    • 1984
  • 유통과정(流通過程)중의 품질안정성(品質安定性) 유지(維持)가 항상 문제시되고 있는 홍삼정분(紅蓼精粉)(동결(凍結) 및 분무(噴霧))의 안정성(安定性)을 시판차류정품(市販茶類精品)과 비교(比較)하기 위하여 이들 제품(製品)의 흡습특성(吸濕特性)을 비교(比較)하였고 또 초기수분함량(初期水分含臺), 조지방함량(粗脂肪含量) 및 밀도(密度)와의 관계(關係)를 조사(調査)하여 홍삼정립(紅蓼精粒)의 안정성(安定性) 미치는 영향(影響)을 비교(比較)하였다. (1) 홍삼정분(紅蔘精粉) 및 시판차류제품(市販茶類製品)의 입도(粒度)는 100 mesh 이하였으며 동결건조제품(凍結乾燥製品)이 분무건조제품(噴霧乾燥製品)보다 입도(粒度)가 컸다. (2) 홍삼정분(紅蓼精粉)(동결(凍結) 및 분무(噴霧))이 3.85% 및 4.56% 로 초기수분함량(初期水分舍量)이 높은데 비해 커피(동결(凍結) 및 분무(噴霧))가 2.17% 및 3.52%로 낮았으며 홍삼정분(紅蔘精粉)이 커피 보다 1.3$\sim$l.8배의 높은 초기수분함량(初期水分含量)을 나타냈다. (3) 탱이나 쌍화차가 흡습율(吸濕率)이 가장 낮아 높은 안정성(安定性)을 나타냈는데 이는 탱과 쌍화차의 지방함량(脂肪含量) (4.12% 및 0.62%)이 높을 뿐만 아니라 밀도(密度)(0.89g/ml 및 0.59g/ml)도 다른 제품(製品)에 비해 훨씬 높기 때문으로 판단된다. (4) 커피의 흡습율(吸濕率)이 홍삼정분(紅參精粒)보다 컸으나 커피의 안정성(安定性)이 홍삼정분(紅蔘精紛)보다 더 높은 것은 커피의 초기수분함량(初期水分含量) (2.17${\sim}$3.52%)이 홍삼정분(紅蓼精粉) (3.85${\sim}$4.56%)보다 낮을 뿐만 아니라 커피의 지방함량(脂肪含量)(0.31${\sim}$0.38%)도 홍삼정분(紅蔘精粉)(0.12${\sim}$0.16%) 보다 훨신 높기 때문으로 판단된다. (5) 따라서 홍삼정분(紅蓼精粉)의 안정성(安定性)을 높이기 위해서는 현행 물추출방벙(抽出方法)을 용매추축(溶媒抽出)로의 전환(轉換)이나 지방피막(脂肪皮膜) 처리(處理)에 의한 흡습물성(吸濕物性)을 개선(改善)함이 바람직할 것으로 판단된다.

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홍삼 및 기능성 소재를 이용한 주류첨가용 액상제제 개발 (Development of Liquid Phase Product from Red Ginseng and Medicinal Herbs for Alcoholic Beverage)

  • 김도희;조양희;조재선;함태식;이종완;이철
    • Journal of Ginseng Research
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    • 제28권1호
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    • pp.45-51
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    • 2004
  • 본 연구에서는 홍삼 농축액의 crude saponin과 생약재의 물추출물이 ADH와 ALDH의 활성에 미치는 영향 및 이들 생약재를 이용한 주류첨가용 액상제제 개발을 위한 모델을 제시하였다. 재료자체의 비중이 커서 용매비율을 낮게 한 갈근의 경우, 추출에 따른 고형분의 함량이 매우 낮았고, 3시간이후 고형분의 함량에는 변화가 없었다. 갈화, 지구자, 상엽의 경우는 4시간이후 고형분 함량의 변화가 없었다. 홍삼의 crude saponin, 상엽, 갈화, 갈근, 지구자의 경우 적정농도에서 ADH의 상대활성을 104-114%까지 증가함을 보였고, 상엽, 지구자는 ALDH의 상대활성을 102∼106%까지 증가시켰다. 알코올 분해에 영향을 미치는 생약재를 원료로 액상제제를 제조하여 소주에 혼합한 후 1차 소비자 기호도 조사 결과, 경옥고향, 쌍화향, 칡향을 첨가한 세가지 시료 상호간에 유의적인 차이를 나타냈고, 쌍화향을 첨가한 시료가 가장 양호한 것으로 나타났다. 1차 기호도 조사결과 가장 양호한 것으로 나타난 쌍화향을 첨가한 시료와 향 무첨가 시료, 시판중인 K사제품간의 2차 기호도 조사 결과, 세가지 시료 상호간에 유의적인 차이를 보이지 않았다.

표준담배추출물과 Lipopolysaccharide로 유발한 만성폐쇄성폐질환 동물모델에서 쌍화탕의 폐손상 및 근감소 억제 효과 (Inhibitory Effects of Ssanghwa-tang on Lung Injury and Muscle Loss in a Cigarette Smoke Extract and Lipopolysaccharide-induced Chronic Obstructive Pulmonary Disease Mouse Model)

  • 최진관;양원경;이수원;우성천;김승형;박양춘
    • 대한한방내과학회지
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    • 제45권1호
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    • pp.11-30
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    • 2024
  • Objectives: This study evaluated the effects of Ssanghwa-tang (SHT) on lung injury and muscle loss in a COPD mouse model. Methods: C57BL/6 mice were challenged with cigarette smoke extract and lipopolysaccharide, and then treated with two concentrations of SHT (250 and 500 mg/kg). After sacrifice, the bronchoalveolar lavage fluid (BALF) or lung tissue was analyzed by cytospin, ELISA, real-time PCR, flow cytometry analysis, and H&E and Masson's trichrome staining. The grip strength of COPD mice was measured using a grip strength meter. The running time of COPD mice was measured by a treadmill test. Muscle tissue of the quadriceps was stained with H&E and Masson's trichrome staining. Results: SHT significantly inhibited the increase in neutrophil numbers in BALF and significantly decreased immune cell activity in BALF and lung tissue. It also significantly inhibited the increase in TNF-α, IL-17, and MIP2 in BALF. Real-time PCR analysis revealed that the mRNA expression of TNF-α, IL-17, MIP2, and TRPV1 in lung tissue showed a significant decrease compared with the control group. Lung tissue damage was significantly reduced in the histological analysis. The grip strength and running time of the COPD mice showed a significant decrease compared with the control group. In histological staining, SHT was found to reduce the damage to muscle tissue. Conclusions: This study indicates that SHT can be used as a therapeutic agent for COPD patients by inhibiting lung injury and muscle loss.