• Journal of Pharmaceutical Investigation
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• 제41권6호
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• pp.347-354
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• 2011

Repeated oral administration of loxoprofen can induce many side effects such as gastric disturbances and acidosis. Therefore, we considered alternative routes of administration for loxoprofen to avoid such adverse effects. The aim of this study was to develop an ethylene-vinyl acetate (EVA) matrix system containing a permeation enhancer for enhanced transdermal delivery of loxoprofen. The EVA matrix containing loxoprofen was fabricated and the effects of drug concentration, temperature, enhancer and plasticizer on drug release were studied from the loxoprofen-EVA matrix. The solubility of loxoprofen was highest at 40% (v/v) PEG 400. The release rate of drug from drug-EVA matrix increased with increased loading dose and temperature. The release rate was proportional to the square root of loading dose. The activation energy (Ea), which was measured from the slope of log P versus 1000/T, was 5.67 kcal/mol for a 2.0% loaded drug dose from the EVA matrix. Among the plasticizer used, diethyl phthalate showed the highest release rate of loxoprofen. Among the enhancers used, polyoxyethylene 2-oleyl ether showed the greatest enhancing effect. In conclusion, for the enhanced controlled transdermal delivery of loxoprofen, the application of the EVA matrix containing plasticizer and penetration enhancer could be useful in the development of a controlled drug delivery system.

• 대한기계학회논문집A
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• 제21권11호
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• pp.1896-1911
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• 1997

Effects of fiber-matrix interphases on the micro-and macro-mechanical behaviors of unidirectionally fiber-reinforced composites subjected to transverse shear loading at remote distance have been studied. The interphases between fibers and matrix have been modeled by the spring-layer which accounts for continuity of tractions, but allows radial and circumferential displacement jumps across the interphase that are linearly related to the normal and tangential tractions. Numerical calculations for basic cells of the composites have been carried out using the boundary element method. For an undamaged composite the micro-level stresses at the matrix side of the interphase and effective shear stiffness have been computed as functions of fiber volume ratio $V_f$ and interphase stiffness k. Results are presented for various interphase stiffnesses from the perfect bonding to the case of total debonding. For a square array composite the results show that for a high interphase stiffness k>10, an increase of $V_f$ increases the effective transverse shear modulus G over bar of the composite. For a relatively low interphase stiffness k<1, it is shwon that an increase of $V_f$ slightly decreases the effective transverse shear modulus. For the perfect bonding case, G over bar for a hexagonal array composite is slightly larger than that for a square array composite. Also for a damaged composite partially debonded at the interphase, local stress fields and effective shear modulus are calculated and a decrease in G over bar has been observed.

• 대한전자공학회논문지TC
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• 제44권7호통권361호
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• pp.47-52
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• 2007

본 논문은 다중 셀 환경에서 MMSE 수신기를 가지는 MIMO MC-CDMA시스템의 출력 SINR을 점근적으로 분석한다. 단일 셀에서의 점근적 성능 분석이 다중셀 환경으로 확장 적용된다. 점근적 분석을 위한 Haar 유니터리 코드의 사용은 다른 셀로부터의 간섭성분이 대각성분들의 값이 다른 대각행렬로 나타나게 한다. 본 논문에서는 다른 셀의 코드 간섭 성분을 mean square측면에서 간섭의 전력으로 수렴함을 보이고, 셀간 간섭 성분이 주어질 때 점근적으로 특정 SINR값을 찾는다. 다중 셀에서의 거리에 따른 느린 페이딩을 로그노말 분포를 가정하여 구한 이론적인 비트오차 확률과 실험을 비교하여 비슷함을 보이고, 점근적 성능에 의한 데이터 전송 수율의 셀 반경에 따른 성능을 보인다.

• Journal of the Korean Statistical Society
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• 제21권1호
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• pp.59-69
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• 1992

A measure is proposed to represent the degree of residuals from the symmetry model for square contingency tables with nominal categories. The measure is derivedby modifying the sum of squared singular values for a skew symmetric matrix of the residuals from the symmetry model. The proposed measure would be useful for comparing the degree of residuals from the symmetry model in several tables.

• The Journal of the Acoustical Society of Korea
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• 제23권4E호
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• pp.103-107
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• 2004

In this Paper, we propose an algorithm called partitioned recursive least square (PRLS) that involves a procedure that partitions a large data matrix into small matrices, applies RLS scheme in each of the small sub matrices and assembles the whole size estimation vector by concatenation of the sub-vectors from RLS output of sub matrices. Thus, the algorithm should be less complex than the conventional RLS and maintain an almost compatible estimation performance.

• 대한수학회논문집
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• 제32권3호
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• pp.715-724
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• 2017

We study the Gauss map G of helicoidal surfaces in the 3-dimensional Euclidean space ${\mathbb{E}}^3$ with respect to the so called Cheng-Yau operator ${\square}$ acting on the functions defined on the surfaces. As a result, we completely classify the helicoidal surfaces with Gauss map G satisfying ${\square}G=AG$ for some $3{\times}3$ matrix A.

• 한국수학교육학회지시리즈E:수학교육논문집
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• 제6권
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• pp.371-381
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• 1997

Let p be an odd prime number. We introduce simple and useful decoding algorithm for orthogonal Latin square codes of order p. Let H be the parity check matrix of orthogonal Latin square code. For any x ${\in}$ GF(p)$^{n}$, we call xH$^{T}$ the syndrome of x. This method is based on the syndrome decoding for linear codes. In L$_{p}$, we need to find the first and the second coordinates of codeword in order to correct the errored received vector.

• 한국수학교육학회지시리즈B:순수및응용수학
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• 제14권3호
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• pp.197-201
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• 2007

In this paper, when n = 6, we will determine the minimum permanent and minimizing matrices on the face of ${\Omega}_{n}$ which contains exactly two square zero-submatrices.

• The Journal of the Acoustical Society of Korea
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• 제26권2E호
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• pp.63-68
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• 2007

Using the neural network model for oriented principal component analysis (OPCA), we propose a solution to the data least squares (DLS) problem, in which the error is assumed to lie in the data matrix only. In this paper, we applied this neural network model to channel equalization. Simulations show that the neural network based DLS outperforms ordinary least squares in channel equalization problems.

• 대한수학회보
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• 제54권4호
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• pp.1421-1441
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• 2017

We compute explicitly the matrix represented by the Toeplitz operator on the Hardy space over a smoothly finitely connected bounded domain in the plane with respect to special orthonormal bases consisting of the classical kernel functions for the space of square integrable functions and for the Hardy space. The Fourier coefficients of the symbol of the Toeplitz operator are obtained from zeroth row vectors and zeroth column vectors of the matrix. And we also find some condition for the product of two Toeplitz operators to be a Toeplitz operator in terms of matrices.