• Polymer(Korea)
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• v.36 no.2
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• pp.163-168
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• 2012

Recently, along with technology development of endoscopic equipment, the stent technology has been developed for the convenience of operation, shortening of recovery times, and reduction of patient's pain. In this study, paclitaxel-eluting metal stents for treatment of biliary benign stenosis were developed through an electrospray-coating method. Polyether-based polyurethane (PELLETHANE 2363-80AE$^{(R)}$)) and paclitaxel were coated onto the surface of a metallic stent and Pluronic F127 was used as an additive. As a result, physicochemical characterization of paclitaxel via SEM, FTIR, contact angle and XRD techniques revealed the information of solid state of paclitaxel-loaded PU film. The in vitro release profile showed a slower release rate with a higher content of paclitaxel.

• Journal of Pharmaceutical Investigation
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• v.38 no.2
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• pp.119-126
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• 2008

Solid dispersions of poorly water-soluble drug, sibutramine, were prepared with hydrophilic polymer, poly-N-vinylpyrrolidone (PVP), hydroxypropylmethylcellulose (HPMC) and organic acid, citric acid, to improve the solubility of drug. Physicochemical variation and shape of microsphere were characterized by scanning electron microscopy (SEM), differential scanning calorimeter (DSC) and Fourier-transform infrared spectroscopy (FT-IR). Microspheres containing additives showed more spherical shape than non additive microspheres. In vitro release behavior of microspheres presented at simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 6.8). The solid dispersion form transformed the drug into an amorphous state and dramatically improved its dissolution rate. These data suggest that the solid dispersion technique is an effective approach for developing the appetite depressant drug products and various pharmaceutical excipients are able to control the release behaviors.

• Journal of Biosystems Engineering
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• v.25 no.3
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• pp.187-194
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• 2000

One of effective utilization technique of rice husk is known to carbonize it for using as the culture materials. A series of study on the production of carbonized rice husk by a cyclone combustor shows that the carbonized rice husk produced have a strong alkalinity. Therefore, carbonized rice husk produced by a cyclone combustor is required to neutralize with proper normality. This work is the third part of a series on the production of carbonized rice husk by a cyclone combustor. In this work, the development of neutralization process was carried out in the range of experimental conditions recommended in the previous study. Those include the preheat temperature of combustion chamber of T1b=1273∼1373K, equivalence ratio =1.68∼2.17, auxiliary gas flow rates Qg=5.15∼6.43$\ell$/min. The injection technique of dilute acid was employed for neutralization. At the lower position of the outside of combustor, a dilute nitric acid selected as neutralization liquid was injected to the carbonized rice husk exhausted from the combustion chamber. The normalities of dilute nitric acid were varied to 0.01, 0.03 and 0.05N, respectively. The injection flow rates of the solution were changes from 1.7∼4$\ell$/min. The required carbonized and neutralized rice husk could be obtained at the dilute nitric acid with normality of 0.3N and flow rate of dilute nitric acid of 2∼3.5$\ell$/min. However, the carbonized and neutralized rice husks of about 10∼20% were destroyed by spray with high injection pressure.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.37 no.2
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• pp.175-180
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• 2009

In this article, we fabricated polytetrafluoroethylene(PTFE) nozzle treated by ion beam, in order to fabricate polymer based electrospray micro thruster with super hydrophobic nozzle. To obtain the super hydrophobic surface, PTFE surface is treated by argon and oxygen plasma treatment process. The optimal condition is investigated argon and oxygen flow rate as well as the paalied energy level for the treatment process. Fabricated nozzle was evaluated by measuring contact angle, and the surface morphology was examined by using scanning electron microscope(SEM) and atomic force microscope(AFM). We observe that jetting becomes more stable and repeatable on the treated nozzle. And to evaluate performance of fabricated nozzle, we measure micro scale thrust using a cantilever and a nozzle treated by ion beam laser displacement sensor.

• Polymer(Korea)
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• v.26 no.5
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• pp.670-679
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• 2002

1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, carmustine) is one of the effective chemotherapeutic agents which has been used clinically for treating malignant glioma. Poly(D,L-lactide-co-glycolide) (PLGA, molecular weight: 20000 g/mole. mole ratio of lactide to glycolide 75 : 15) is a well known biodegradable polymer used as a drug carrier for drug delivery system. In this study, we investigated the BCNU release behaviour of BCNU-loaded PLGA wafers containing poly (N-vinylpyrrolidone) (PVP) or polyethyleneoxide (PEO) and the effect of hydrophilic polymers incoporated in the wafers. BCNU-loaded PLGA microparticles with or without hydrophilic polymers were prepared by a spray drying method and fabricated into wafers by direct compression. Encapsulation efficiency of BCNU-loaded PLGA microparticles containing PVP and PEO was 85 ∼ 97% and crystallinity of BCNU encapsulated in PLGA decreased significantly initial release amount and release rate of BCNU increased with the increasing PVP or PEO amount. Morphological change and mass loss of wafers during the release test were confirmed that hydration and degradation of PLGA would be facilitated with an increase of hydrophilic polymers.

• Korean Journal of Poultry Science
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• v.27 no.2
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• pp.109-114
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• 2000

The objective of these experiments was to develop an attenuated thermostable Newcastle disease virus(NDV), CBP-1 strain isolated from infected pheasants. Safety, pathogenicity and protective effects against velogenic NDV were also investigated to evaluate if the attenuated NDV, CBP-1 strain could be a candidate for a new NDV vaccine strain. CBP-1 strain was passaged up to the 173 times by nine days old embryonated eggs and chicken embryo fibroblast(CEF) cell cultures. Its sensitivitly to lipid solvents and low pH, thermostability, mean death time(MDT), intracerebral pathogenicity index(ICPI) of one day old chicks and intravenous pathogenicity index(IVPI) of four weeks old chicks were examined. Safety, boosting and protective effects were tested by chicks mortality. CBP-1 NDV strain had significant thermostability at 56$\^{C}$ for 30 minutes. by hemagglutinin activity and egg infectivity test, but was not resistant to lipid solvent. It showed possibility to use as a feed or water vaccine because of the resistance to low pH. MDT, ICPI and IVPI of CBP-1 were attenuated from 51.5, 1.96, 2.60 to 112.4, 1.12, 1.45. These results implied that the 173rd passages in embryonated egg and CEF cell cultures induced a substantial attenuation of the pathogenicity of the parent virus, changing the virulence from velogenic to intermediate between mesogenic and lentogenic. After vaccination with CBP-1 at one day old by drinking water mortality was 17.5%. However, spray vaccination with B1 at one day old, CBP-1 at two weeks ild and challenge with velogenic Kyojeongwon strain at four weeks old showed 93.5% survival rate. Mortality of chicks, vaccination with 173rd passaged CBP-1 strain at one day old, two weeks old and challenge with Kyokeongwon strain at four weeks old, was 20.0%. The results of these studies indicated that partial attenuated CBP-1 strain tended to be a low safety for ND of broiler chicks and would need to be more successive attenuation.

• Applied Chemistry for Engineering
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• v.16 no.2
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• pp.212-216
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• 2005

Benzotriazole which is used as a corrosion inhibitor for the zinc coated steel was intercalated into Na-MMT. X-ray diffraction experiments on intercalant/silicate composite samples demonstrated that the intercalation of intercalant leads to an increase in the spacing between silicate layers. Water soluble poly(ethylene-co-acrylic acid) (PEA) nanocomposites, to use as a coating agent, were prepared with these modified MMT. We found that mono-layered silicates were dispersed in PEA matrix and those resultants were exfoliated nanocomposites. From the result of salt spray test, we found that this coating agent prepared with water soluble poly(ethylene-co-acrylic acid) (PEA) nanocomposite provided good corrosion protection. These results were caused by decreasing the rate of oxygen permeation from silicate layers dispersed homogeneously in PEA matrix and the effect of corrosion inhibitor from benzotriazole.

• Journal of the Korean Society of Hazard Mitigation
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• v.9 no.1
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• pp.99-105
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• 2009

The main purpose of this work is to analyse damages caused by debris flows during the heavy rainfalls at Inje of Kangwon Province, Korea. A series of site investigations have been carried out to survey the characteristics of debris flows occurred during the summer season of 2006. It has been found that major losses in human life and property are caused by discharge of soil and rock fragments from landslides. During the rainfall high precipitation rate of 113.5 mm/hour and 355 mm/day was recorded, which could happen at 80-500 year period. Comparing the rainfall record with the time of landslides being occurred, occurrence of the landslides is directly related to heavy rainfalls. At present, several debris barriers have been built at the valleys and natural slopes have been protected by the seed spray method. It is intended to propose an alternative of restoration of landslide damages and maintenance based on findings from the current study.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.4
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• pp.711-717
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• 2017

Startability and harmful emissions are the main issues in diesel engine development under cold conditions. The characteristics of combustion with multiple injection were investigated under cold start conditions. For quantitative analysis, the in-chamber pressure profile was measured and combustion visualization using direct imaging was accomplished. With multiple injection, the peak in-chamber pressure and heat release rate were increased compared to single injection. In addition, the period of flame luminosity detection was shortened using multiple injection. Combustion by main injection was improved with an increase in heat released by pilot combustion when the pilot injection quantity was increased. Finally, an increase in injection pressure also showed the possibility of combustion improvement. On the other hand, an increase of in the pilot injection quantity and injection pressure can cause an increase in harmful emissions, such as HC and CO due to wall wetting. Therefore, more sensitive calibration will be needed when applying a multiple injection strategy under cold start conditions.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.20 no.10
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• pp.19-26
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• 2021

In fine-particle injection processing, hard fine particles, such as silicon carbide or aluminum oxide, are injected - using high-pressure air, and a small amount of material is removed by applying an impact to the workpiece by spraying at high speeds. In this study, a two-axis stage device capable of sequence control was developed to spray various shapes, such as circles and squares, on the surface during the micro-particle jetting process to understand the surface-shape micro-particle-processing characteristics. In the experimental device, two stepper motors were used for the linear movement of the two degree-of-freedom mechanism. The signal output from the microcontroller is - converted into a signal with a current sufficient to drive the stepper motor. The stepper motor rotates precisely in synchronization with the pulse-signal input from the outside, eliminating the need for a separate rotation-angle sensor. The major factors of the processing conditions are fine particles (silicon carbide, aluminum oxide), injection pressure, nozzle diameter, feed rate, and number of injection cycles. They were identified using the ANOVA technique on the design of the experimental method. Based on this, the surface roughness of the spraying surface, surface depth of the spraying surface, and radius of the corner of the spraying surface were measured, and depending on the characteristics, the required spraying conditions were studied.