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http://dx.doi.org/10.7317/pk.2012.36.2.163

Development of Drug Eluting Stent for the Treatment of Benign Biliary Stricture by Electro-spray Method  

Shin, Il-Gyun (Institute of Interventional Medicine, M.I.Tech)
Kim, Dong-Gon (Institute of Interventional Medicine, M.I.Tech)
Kim, Han-Ki (Institute of Interventional Medicine, M.I.Tech)
Kim, Sang-Ho (Institute of Interventional Medicine, M.I.Tech)
Jeon, Dong-Min (Department of Biomedical Engineering, the Catholic University of Korea)
Suh, Tae-Seok (Department of Biomedical Engineering, the Catholic University of Korea)
Jang, Hong-Seok (Department of Radiation Oncology Seoul St.Mary's Hospital, the Catholic University of Korea)
Publication Information
Polymer(Korea) / v.36, no.2, 2012 , pp. 163-168 More about this Journal
Abstract
Recently, along with technology development of endoscopic equipment, the stent technology has been developed for the convenience of operation, shortening of recovery times, and reduction of patient's pain. In this study, paclitaxel-eluting metal stents for treatment of biliary benign stenosis were developed through an electrospray-coating method. Polyether-based polyurethane (PELLETHANE 2363-80AE$^{(R)}$)) and paclitaxel were coated onto the surface of a metallic stent and Pluronic F127 was used as an additive. As a result, physicochemical characterization of paclitaxel via SEM, FTIR, contact angle and XRD techniques revealed the information of solid state of paclitaxel-loaded PU film. The in vitro release profile showed a slower release rate with a higher content of paclitaxel.
Keywords
stent; electrospray; pellethane; paclitaxel; drug release;
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