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http://dx.doi.org/10.4333/KPS.2008.38.2.119

Characterization and Controlled Release of Solid Dispersed Sibutramine  

Park, Jung-Soo (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Ku, Jeong (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Lee, Jun-Hee (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Kim, Yun-Tae (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Park, Jong-Hak (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Ahn, Sik-Il (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Mo, Jong-Hyun (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Lee, Hai-Bang (Nanobiomaterials Lab, Korea Research Institute of Chenmical Technology)
Khang, Gil-Son (BK-21 Polymer BIN Fusion Research Team, Chonbuk National University)
Publication Information
Journal of Pharmaceutical Investigation / v.38, no.2, 2008 , pp. 119-126 More about this Journal
Abstract
Solid dispersions of poorly water-soluble drug, sibutramine, were prepared with hydrophilic polymer, poly-N-vinylpyrrolidone (PVP), hydroxypropylmethylcellulose (HPMC) and organic acid, citric acid, to improve the solubility of drug. Physicochemical variation and shape of microsphere were characterized by scanning electron microscopy (SEM), differential scanning calorimeter (DSC) and Fourier-transform infrared spectroscopy (FT-IR). Microspheres containing additives showed more spherical shape than non additive microspheres. In vitro release behavior of microspheres presented at simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 6.8). The solid dispersion form transformed the drug into an amorphous state and dramatically improved its dissolution rate. These data suggest that the solid dispersion technique is an effective approach for developing the appetite depressant drug products and various pharmaceutical excipients are able to control the release behaviors.
Keywords
Sibutramine; Solid Dispersion; Spray Dryer; Controlled Release;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
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