폴리머 (Polymer(Korea))

  • 제36권2호
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  • Pages.163-168
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  • 2012
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  • 0379-153X(pISSN)
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  • 2234-8077(eISSN)
한국고분자학회 (The Polymer Society of Korea)
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전기분사를 이용한 양성담관 협착 치료용 약물방출 스텐트 개발

Development of Drug Eluting Stent for the Treatment of Benign Biliary Stricture by Electro-spray Method

  • 신일균 ((주)엠아이텍 중재의학연구소) ;
  • 김동곤 ((주)엠아이텍 중재의학연구소) ;
  • 김한기 ((주)엠아이텍 중재의학연구소) ;
  • 김상호 ((주)엠아이텍 중재의학연구소) ;
  • 전동민 (가톨릭대학교 의공학교실) ;
  • 서태석 (가톨릭대학교 의공학교실) ;
  • 장홍석 (가톨릭대학교 의과대학 서울성모병원 방사선종양학과)
  • Shin, Il-Gyun (Institute of Interventional Medicine, M.I.Tech) ;
  • Kim, Dong-Gon (Institute of Interventional Medicine, M.I.Tech) ;
  • Kim, Han-Ki (Institute of Interventional Medicine, M.I.Tech) ;
  • Kim, Sang-Ho (Institute of Interventional Medicine, M.I.Tech) ;
  • Jeon, Dong-Min (Department of Biomedical Engineering, the Catholic University of Korea) ;
  • Suh, Tae-Seok (Department of Biomedical Engineering, the Catholic University of Korea) ;
  • Jang, Hong-Seok (Department of Radiation Oncology Seoul St.Mary's Hospital, the Catholic University of Korea)
  • 투고 : 2011.06.30
  • 심사 : 2011.10.04
  • 발행 : 2012.03.25
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초록

최근에 내시경 관련기술의 진보에 따라서 시술 편리성, 회복시간 단축, 환자 고통 경감 등의 장점으로 인해 스텐트 삽입술이 빠르게 진보하였다. 본 연구에서 양성담관 협착 치료를 목적으로 파클리탁셀을 이용한 약물방출 스텐트를 전기분사 방법에 의해 제조하였으며, 이 때 사용된 고분자는 polyether-based polyurethane(상표명 : PELLETHANE 2363-80AE$^{(R)}$)과 첨가제로서 Pluronic F127, 약물로서 파클리탁셀을 사용하여 금속스텐트 표면에 코팅하였다. 그 결과로서, 약물이 코팅된 고분자 필름의 물리적 특성은 SEM, FTIR, 접촉각 측정기, XRD에 의해 확인하였으며, 약물방출속도는 약물함량이 높을수록 감소하였음을 알 수 있었다.

Recently, along with technology development of endoscopic equipment, the stent technology has been developed for the convenience of operation, shortening of recovery times, and reduction of patient's pain. In this study, paclitaxel-eluting metal stents for treatment of biliary benign stenosis were developed through an electrospray-coating method. Polyether-based polyurethane (PELLETHANE 2363-80AE$^{(R)}$)) and paclitaxel were coated onto the surface of a metallic stent and Pluronic F127 was used as an additive. As a result, physicochemical characterization of paclitaxel via SEM, FTIR, contact angle and XRD techniques revealed the information of solid state of paclitaxel-loaded PU film. The in vitro release profile showed a slower release rate with a higher content of paclitaxel.

키워드

과제정보

연구 과제 주관 기관 : 보건복지부

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피인용 문헌

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