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Effect of Hydrophilic Polymers on the Release of BCNU from BCNU-loaded PLGA Wafer  

안태군 (전북대학교 유기신물질공학과)
강희정 (전북대학교 유기신물질공학과)
문대식 (전북대학교 유기신물질공학과)
이진수 (전북대학교 유기신물질공학과)
성하수 (한국화학연구원 생체고분자연구실)
Publication Information
Polymer(Korea) / v.26, no.5, 2002 , pp. 670-679 More about this Journal
Abstract
1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, carmustine) is one of the effective chemotherapeutic agents which has been used clinically for treating malignant glioma. Poly(D,L-lactide-co-glycolide) (PLGA, molecular weight: 20000 g/mole. mole ratio of lactide to glycolide 75 : 15) is a well known biodegradable polymer used as a drug carrier for drug delivery system. In this study, we investigated the BCNU release behaviour of BCNU-loaded PLGA wafers containing poly (N-vinylpyrrolidone) (PVP) or polyethyleneoxide (PEO) and the effect of hydrophilic polymers incoporated in the wafers. BCNU-loaded PLGA microparticles with or without hydrophilic polymers were prepared by a spray drying method and fabricated into wafers by direct compression. Encapsulation efficiency of BCNU-loaded PLGA microparticles containing PVP and PEO was 85 ∼ 97% and crystallinity of BCNU encapsulated in PLGA decreased significantly initial release amount and release rate of BCNU increased with the increasing PVP or PEO amount. Morphological change and mass loss of wafers during the release test were confirmed that hydration and degradation of PLGA would be facilitated with an increase of hydrophilic polymers.
Keywords
brain tumor; BCNU; hydrophilic polymers; PLGA; microparticles; wafers;
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