• Journal of Environmental Health Sciences
• /
• v.39 no.2
• /
• pp.130-137
• /
• 2013

Objectives: The OECD QSAR Application Toolbox was developed by the Organisation for Economic Cooperation and Development (OECD) to facilitate the practical use of QSAR approaches in regulatory contexts as well as to reduce the need for additional animal testing. In this study, human health and the ecotoxicity of chemicals were predicted by applying the OECD QSAR Application Toolbox and the results were compared with experimental data in order to evaluate the applicability of this program. Methods: Read-across, trend analysis, and QSAR of OECD QSAR Application Toolbox were used for the prediction of toxicity. Results: The toxicity prediction was conducted on 6,354 chemicals for which toxicity data have been produced on the six endpoints of skin sensitization, skin irritation, eye irritation, mutagenicity, and acute toxicities of fish and Daphnia. From the total of 6,354, we obtained prediction results for 1,621 chemicals (25.5%). Conclusions: The predicted properties of mutagenicity, skin sensitization, and acute aquatic toxicities were reasonably good when compared with experimental data, but other endpoints were not due to the limitation of applicable chemical groups.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.30 no.3 s.47
• /
• pp.389-392
• /
• 2004

We screened several materials to stimulate IGF-1 promoter activity using luciferase reporter assay and found that Amomi Semen extract (ASE) among them is the most powerful stimulator We also studied about the anti-wrinkle effect of ethanolic extract of Amoni Semen in vitro and in vivo. Semi-quantitative RT-PCR showed that the extract elevated the presence level of IGF-1 mRNA. And $[^3H]$ proline incorporation and semi-quantitative RT-PCR showed that the extract increased the expression of type-I collagen compared with vehicle in vitro and in vivo, respectively. Significant inhibition of MMP-1 expression was determined by ELISA and Western blot. Finally, topical treatment of the extract on hairless mouse's dorsal skin expanded the volume of collagen and dermal thickness. These results suggest that Amomi Semen may be a good candidate for improving extracellular matrix through the increase of collagen expression and inhibition of MMP-1 expression. Moreover, this study enables us to guess that IGF-1 stimulated by the extract may be involved in the mechanism of anti-wrinkle effect of it.

• 한국생물공학회:학술대회논문집
• /
• 2003.10a
• /
• pp.794-798
• /
• 2003

The reactive oxygen species (or free radicals) generated by ultraviolet radiation cause damage on cellular components and pigment of skin. The aim of this study was to investigate the skin-whitenig effect of Okyong-san. Inhibitory effects of okyong-san extracts on melanin synthesis were studied. Namely, UV-absorbing ability, free radical scavenging activity and tyrosinase inhibitory activity of okyong-san extracts were investigated. As a result, the extracts of okyong-san were found to inhibit the activity of tyrosinase and they showed an absorbance in the UV-B region and UV-C region. We also observed that extracts of okyong-san had free radical scavenging activity.

• The Journal of Industrial Distribution & Business
• /
• v.10 no.12
• /
• pp.15-23
• /
• 2019

Purpose : We will develop the distribution method of wide oil extract technology to develop repellent using this technology and study mosquito repellent persistence. Research design, data and methodology : A positive control group containing purified water, ethanol and picaridin was prepared, and the experimental control group was prepared in the same proportion as the positive control group, and 0.6% of broad oil was added. The results were summarized using the calculation method according to the avoidance effect and statistically tested by t-test using the excel statistics program. Results : Experiments on skin surface area and voice control of participants showed that men had 8.9% wider skin surface area than women, and voice control tests showed that women were bitten by mosquitoes five times more than men. Both the positive and the experimental control groups had a valid duration of up to three hours, but from the time of five hours, the positive control group had 77% and the experimental control had 90%, indicating a difference of 14.4% over the positive control group. Conclusions : The mosquito repellents developed in this study on the basis of safety and continuity are cost-effective in terms of mosquito repellent, and in addition fragrance, odor removal, perfume, ink, skin care and massage effect.

• Journal of the Korean Applied Science and Technology
• /
• v.15 no.4
• /
• pp.71-78
• /
• 1998

Gum is known as natural polymer. Biodegradable films were prepared by solution blend method in the weight ratio of natural gums(Xanthan, Locust bean, Guar) for the purpose of useful bioimplants. The possibility of bioimplants, which prepared from natural gums as a skin substitute was evaluated by measuring biodegradability. This biodegradable films were inserted in the back of rats and their of biodegradability were investigated by hematological change evaluation as a function of time to the biotransformation. Rats implantation test results showed that Guar induced increments of monocyte and basophil after 48 hours of implantation. And Locust bean showed increase of monocyte and neutrophile counts after 48 hours of implantation. And Xanthan induced decrease of monocyte and neutrophile at 24 hours after implantation. Guar and Locust showed high hemoglobin contents and hematocrit after 48 hours of implantation. Guar and Locust induced some suspects of incompatibility in the tissue after 48 hours, but three were little effects to the skin inflammation at 24 hours. These values of biodegradable films, which prepared from prepared from natural gums measured in this were some satisfiable results at short period with those of ideal skin bioimplants.

• Journal of Environmental Science International
• /
• v.20 no.2
• /
• pp.175-183
• /
• 2011

This study was conducted to survey the subjective symptoms of workers and users in selected 5 public facility groups(offices, performance halls, private crammers, wedding halls and indoor sports facilities), located in Seoul, Daejeon and Chungnam Province. Overall as subjective symptoms that were worse at public facilities than those usual, following responses appeared: I have a headache, My eyes are dry or feel irritated or itching, I feel eyestrain or my eyes are bloodshot, My nose was stuffy, I have a cough, I feel dry in the throat or inflammation happens, I feel oppressed in the breast or sometimes have difficulty in breathing, My skin gets dry, My skin is itching or has some spots, I feel like vomiting, I feel easily tired or sleep, I lose my concentration and I feel my memory is falling, I feel dizzy, I feel depressed, I feel being sharp and feel tension, I feel muscular pain or stiffness on shoulders, back and neck. Also, we compare with normal subjective symptoms scores and subjective symptoms scores in public facilities. The highest subjective symptoms score in at normal was my skin gets dry(2.35 points) and subjective symptoms score in public facilities was I feel eyestrain or my eyes are bloodshot(2.61 points).

• Women's Health Nursing
• /
• v.6 no.2
• /
• pp.305-315
• /
• 2000

The purpose of this study was to explore the psychoneuroimmunologic effect of aromatherapy massage and to compare the effect with that of massage. This study is designed as a nonequivalent control group pretest-posttest quasi-experimental study and each twenty postpartum mothers volunteered the experimental group and control group. For experimental group, researcher used massage with 2% Jojova oil mixed with Lavender and Rosemary oil (Bush Boake Allen Inc., USA) for 20 minutes, whereas for control group Jojova oil was used as luburicant for massage. Skin temperature was measured with YSI Tele-thermometer(Simpson electric Co., USA) and the concentration of IgA in salivary was analyzed by immunoturbididimetric assay(Cobas INTEGRA, Roche, Swiss) at pre and post test. Also at this time fatigue were measured by Rhoten Fatigue Scale through self-report. The data were analyzed using SAS and hypothesis was tested with unpaired t-test. The results were as follows : 1) Score of fatigue decreased significantly after use of aromatherapy massage. 2) Skin temperature increased significantly after use of aromatherapy massage. 3) Concentration of salivary IgA increased significantly after use of aromatherapy massage. In conclusion, from the standpoint of psychoneuroimmunologic view, the results suggest that aromatherapy massage have greater effect compared with massage and can be effective nursing intervention to enhance relaxation of mind and body in the postpartum mothers.

• Women's Health Nursing
• /
• v.14 no.3
• /
• pp.173-180
• /
• 2008

Purpose: This study was to explore the perception about menstruation and discomforts of using disposable menstrual pads in menstruating women. Method: A survey was conducted of 132 menstrual women recruited by convenience sampling. Data were collected by a face-to-face interview and a study questionnaire, and analyzed by frequency and $X^2$-test. Result: More than half of the subjects expressed a negative perception about menstruation, while 25% expressed a mixed perception and 24.2% expressed a positive perception. Women who perceived their menstruation negatively had more menstrual pain than the others (p<.001). The most frequently experienced discomforts of using disposable pads were an unpleasant smell (18.9%), leakage (18.9%), and discomfort (16.6%). Adverse effects of using disposable pads were reported as an itching sense (23.1%). skin rash (20.2%), and skin irritation (10.6%). Alternate materials were reported with tampons, alternate washable pads, and maternity pads. Conclusion: The results indicate that disposable menstrual pads cause several discomforts and common adverse effects such as skin problems. To decrease these discomforts and relieve adverse effects, planned nursing education including women's personal hygiene methods and information about an alternate pad may be helpful.

• Journal of agricultural medicine and community health
• /
• v.21 no.1
• /
• pp.13-20
• /
• 1996

Paederus dermatitis caused by the contact of staphylinid beetles(Paederus fuscipes) body fluid(pederin) is characterized by linear erythematous vesicopustular lesions. An outbreak of dermatitis occurred at apartments located at the river side after rainy season in summer 1994. Authors surveyed 189 cases(94 males and 95 females) from 103 households reported at the apartment office in Kimcheon on September 1994. The results are as follows; 1. The causative agent of skin diseases was identified as Paederus fuscipes. 2. The attack rate of paederus dermatitis was 52.6% by households, and the residents in the middle floors of the apartments were attacked more frequently than those in other floors. All ages were affected. 3. The skin lesions developed by paederus were distributed on face(38.2%), neck(18.5%), shoulder and trunk(11.0%), arm and leg(10.3%), and back(6.6%). In 21 cases(15.4%), skin lesions were developed in multiple sites. 4. The apartments attacked by paederus was located near the sand and damp soil along the bank of the river. The fodder cultivating farm was located near the upper reaches of river, and a rice field and grape garden in the backyard of the apartment.

• Preventive Nutrition and Food Science
• /
• v.21 no.2
• /
• pp.85-89
• /
• 2016

Omega-3 rich fish oils are extremely labile, thus requiring control of oxidation and off flavor development. A recently proposed emulsification method, layer-by-layer (LbL) deposition, was found to be a plausible method to enhance the characteristics of bioactive ingredients, especially lipids. The present work was designed to test the possibility of enhancing the uptake and utilization of omega-3 fatty acids present in fish oil. The bioavailability of nano-emulsified fish oil was monitored in terms of intestinal absorption as well as skin permeability by using the everted intestinal sac model and Franz cell model. The skin permeability and intestinal absorption characteristics was significantly improved by LbL emulsification with lecithin/chitosan/low methoxypectin. Multilayer encapsulation along with nano-emulsification can be a useful method to deliver biologically active lipids and related components, such as fish oil. The protective effect of this tool from lipid oxidation still needs to be verified.