• Journal of Korean Physical Therapy Science
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• v.3 no.3
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• pp.25-34
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• 1996

The purpose of this experimental study was conducted to examine the most effective modality between two methods of cold application(ice pack and cold spray), the most effective length of time for the application and the continuing effect after each type of cold application. Sixty students were assigned randomly to each of two cold application methods; (a) ice pack, (2) cold spray. Each methods was applied to the posterior surface of right forearm with subject in the sitting position. Skin temperature and the electrical stimulation induced pain threshold were measured before each application and every five degree ($^{\circ}C$) decline point after ice pack application. They were also measured point of minimum skin temperature after cold spray application. The results of this study are as follows; 1. Skin temperatures according to the cold spray application decreased to a range of $4.2^{\circ}C{\sim}9.2^{\circ}C$(male, p<0.001), $3.6^{\circ}C{\sim}7.6^{\circ}C$(female, p<0.001). 2. Pain threshold according to the cold spray application increased to a range of $0.6mA{\sim}1.9mA$(male, p<0.01), $1.2mA{\sim}3.86mA$(female, p>0.05).

• Journal of Environmental Health Sciences
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• v.32 no.5 s.92
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• pp.492-498
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• 2006

Ultraviolet(UV) radiation causes a variety of biological effects on the skin, including inflammation, pigmentation, photoaging and cancer. Free radicals are involved in inflammatory skin reactions induced by UVB radiation. In this study, we investigated the effects of antioxidants(Tea, Korean red ginseng, Ginkgo biloba extract) on UVB-induced skin damage. Tea, KRG and EGb 761 were topically treated to dorsal skin of ICR mouse. The mice were also treated soon after IMED ($1.4KJ/m^{2}$) of UVB irradiation. Skin pigmentation of irradiated mouse was observed by a chromameter after 2 weeks. Topical application of Tea, KRG and EGb 761 for 2 weeks decreased skin pigmentation compared to DVB control group(p<.05). Tea, KRG and EGb 761 also reduced UVB-induced infiltration of inflammatory cells. These results showed that Tea, KRG and EGb 761 as a topical application may have preventive effect against UVB-induced skin damage.

• Archives of Plastic Surgery
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• v.42 no.3
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• pp.341-345
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• 2015

Background A tie-over dressing is the accepted method to secure skin grafts in order to prevent haematoma or seroma formation. We describe the novel application of a barbed suture tie-over for skin graft dressing. The barbs act as anchors in the skin so constant tensioning of the suture is not required. Methods From January 2014 to August 2014 we used the technique in 30 patients with skin defects requiring split-thickness or full-thickness grafts. Patient demographics, clinicopathological details and graft outcome were collected prospectively. Results The majority of cases were carried out for split-thickness skin grafts (n=19) used on the lower limb (n=20). The results of this novel technique were excellent with complete (100%) graft take in all patients. Conclusions Our results demonstrate the clinical application of a barbed device for securing skin grafts with excellent results. We find the technique quick to perform and the barbed device easy to handle, which can be applied without the need for an assistant.

• Archives of Plastic Surgery
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• v.44 no.6
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• pp.509-515
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• 2017

Background Skin flap necrosis is a common complication after mastectomy and breast reconstruction. It has been proven that nitroglycerin ointment, as a topical vasodilator, can decrease the rate of skin flap necrosis after mastectomy and breast reconstruction. However, nitroglycerin can cause several side effects, including headache, dizziness, and hypotension. The purpose of this study was to evaluate whether the application of a low dose of nitroglycerin ointment reduced the rate of skin flap necrosis in breast reconstruction after skin-sparing or nipple-sparing mastectomy. Methods A total of 73 cases of breast reconstruction after nipple-sparing and skin-sparing mastectomy at our institution from March 2012 to January 2017 were retrospectively studied. Of these patients, 52 received nitroglycerin ointment (4.5 mg) application to the skin around the nipple-areolar complex from August 2015 to January 2017, while 21 received fusidic acid ointment from March 2012 to August 2015. The number of patients who experienced necrosis of the breast skin flap was counted in both groups. Results Skin flap necrosis developed in 2 (3.8%) patients who were treated with nitroglycerin ointment and 5 (23.8%) patients who did not receive nitroglycerin ointment treatment. Patients who did not receive nitroglycerin ointment treatment had a significantly higher risk of mastectomy skin flap necrosis than patients who did (odds ratio=7.81; 95% confidence interval, 1.38 to 44.23; P=0.02). Conclusions Low-dose nitroglycerin ointment administration significantly decreased the rate of skin flap necrosis in patients who underwent breast reconstruction after skin-sparing or nipple-sparing mastectomy, without increasing the incidence of the side effects of nitroglycerin.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.3 s.47
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• pp.385-388
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• 2004

Recently, along with the remarkable increase in interest in natural products, the application of phytoestrogens in anti-aging products has become very important. In the focus, we developed Pueraria mirifica (PM), in this in vivo study on skin elasticity and wrinkles, and investigated the anti-aging properties. Thirty healthy women volunteers, between the ages of 30 and 60, applied the cream formula with $4\% Pueraria mirifica or placebo, on the face area twice a day for 16 weeks. The evaluation was made by silicon replica analysis, Cutometer SEM 575 and Comeometer followed by statistical treatment using the student's t-test. Results of skin elasticity measurement showed that topical application on the skin increased the total surface of skin elasticity in comparison with placebo group (p<0.05). However, PM cream does not have prominent effect on the depth of wrinkles and skin moisturization. This in vivo study demonstrates that, PM exhibits a significant effect on skin elasticity therefore, is of great interest in anti-aging and firmness skin care products.

• ETRI Journal
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• v.38 no.4
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• pp.776-786
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• 2016

The fairly recent standard of equipping mobile devices with advanced imaging sensors has opened the possibility of conveniently diagnosing skin conditions, anywhere, anytime. For this application, we attempted to estimate skin conditions from a skin image taken by a mobile handheld camera. To estimate the skin conditions, we specifically identified three skin features (pigmentation, pores, and roughness) that can be measured quantitatively from a skin image. The experimental data indicate that the existing thresholding methods are inappropriate for extracting the pigmentation and pore skin features. Thus, we propose a new line-fitting based thresholding method for skin feature detection. We thoroughly evaluated our proposed skin condition estimation method using our skin image database. The experimental results show that our proposed thresholding method can better determine the threshold leading to the most visually plausible detection, when compared to existing methods. We also confirmed that skin conditions can be feasibly estimated using a common mobile handheld camera (for example, a smartphone).

• Journal of Multimedia Information System
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• v.1 no.1
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• pp.77-85
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• 2014

Usually, the skin pigmentation detection and diagnosis are made by clinicians. In this process it is subjective and non-quantitative. We develop an approach to detect and measure the different pigmentation lesions base on computer vision technology. In the paper we study several usually used skin-detecting color space like HSV, YCbCr and normalized RGB. We compare their performance with illumination influence for detecting the pigmentation lesions better. Base on a relatively stable color space, we propose an approach which is RGB channels vector difference characteristic for the detection. After the object region detection, we also use the difference to measure the difference between the lesion and the surrounding normal skin. From the experiment results, our approach can effectively detect the pigmentation lesion, and perform robustness with different illumination.

• Journal of Environmental Health Sciences
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• v.32 no.6
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• pp.566-570
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• 2006

Exposure to ultraviolet B(UVB) radiation causes skin inflammation such as pigmentation and the induction of cyclooxygenase-2(COX-2) gene expression. In this study, we investigated the effect of natural extracts from Tea, EGb 761 and Korean red ginseng(KRG), on the pigmentation and expression of COX-1 and COX-2 mRNA in UVB-irradiated C57BL/6 mice. Before UVB irradiation, the skin color was significantly showed the lightening effect by topical application of natural compounds (p<.05). In the case of UVB irradiated mice, we observed a decrease in pigmentation by compounds (p<.05). In irradiated skin, COX-1 mRNA expression is not changed following UVB irradiation, but COX-2 gene increases. Also, natural compounds lowered mRNA levels of COX-2. Therefore, these results suggest that COX-2 mRNA increases by UVB irradiation. Also, Tea, EGb 761 and KRG as a topical application may inhibit skin pigmentation and modulate COX-2 mRNA level.

• Biomolecules & Therapeutics
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• v.23 no.5
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• pp.391-399
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• 2015

As a major component of the epidermal tissue, a primary keratinocyte has served as an essential tool not only for the study of pathogenesis of skin-related diseases but also for the assessment of potential toxicities of various chemicals used in cosmetics. However, its short lifespan in ex vivo setting has been a great hurdle for many practical applications. Therefore, a number of immortalization attempts have been made with success to overcome this limitation. In order to understand the immortalization process of a primary keratinocyte, several key biological phenomena governing its lifespan will be reviewed first. Then, various immortalization methods for the establishment of stable keratinocyte cell lines will be explained. Finally, its application to a three-dimensional skin culture system will be described.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2018.11a
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• pp.145-146
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• 2018

This study was performed to develop the lifting pallets for the application of smart skin system when remodeling the balcony of apartment house. For this purpose, the smart skin system based on IoT, combining window, BIPV, ESS, air purifier applied in this study was examined. The study developed and presented a foldable double pallet considering the load (about 2Ton) and specification (width 7m × height 2.6m × width 1.3m) of the smart skin system. In future research, it is necessary to verify the application of the foldable pallet in this study.