Browse > Article

Effects of Natural Extracts on UVB-induced Pigmentation and Inflammation in C57BL/6 Mouse Skin  

Choi, Wook-Hee (Department of Health Science, Dongduk Women's University)
Ann, Hyoung-Soo (College of Pharmacology, Dongduk Women's University)
Choi, Tae-Youn (Department of Clinical Pathology, College of Medicine, Soonchunhyang University)
Jin, So-Young (Department of Clinical Pathology, College of Medicine, Soonchunhyang University)
Ahn, Ryoung-Me (Department of Health Science, Dongduk Women's University)
Publication Information
Journal of Environmental Health Sciences / v.32, no.5, 2006 , pp. 492-498 More about this Journal
Abstract
Ultraviolet(UV) radiation causes a variety of biological effects on the skin, including inflammation, pigmentation, photoaging and cancer. Free radicals are involved in inflammatory skin reactions induced by UVB radiation. In this study, we investigated the effects of antioxidants(Tea, Korean red ginseng, Ginkgo biloba extract) on UVB-induced skin damage. Tea, KRG and EGb 761 were topically treated to dorsal skin of ICR mouse. The mice were also treated soon after IMED ($1.4KJ/m^{2}$) of UVB irradiation. Skin pigmentation of irradiated mouse was observed by a chromameter after 2 weeks. Topical application of Tea, KRG and EGb 761 for 2 weeks decreased skin pigmentation compared to DVB control group(p<.05). Tea, KRG and EGb 761 also reduced UVB-induced infiltration of inflammatory cells. These results showed that Tea, KRG and EGb 761 as a topical application may have preventive effect against UVB-induced skin damage.
Keywords
UVB radiation; Korean red ginseng(KRG); Ginkgo biloba extract(EGb 761); tea;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Kazuhisa, M. and Masato, H. : Involvement of photooxidation of melanogenic precursors in prolonged pigmentation induced by ultraviolet A. The Journal of Investigative Dermatology, 122, 503-509, 2004   DOI   ScienceOn
2 Koch, W. H. and Chedekel, M. R. : Photochemistry and phorobiology of melanogenic metabolites:Formation of free radicals. Photochemistry and Photobiology, 46, 229-238, 1987   DOI   ScienceOn
3 Yamakoshi, J., Otsuka, F., Sano, A., Tokutake, S., Saito, M., Kikuchi, M. and Kubota, Y. : Lightening effect on ultraviolet-induced pigmentation of guinea pig skin by oral administration of a proanthocyanidin-rich extract from grape seeds. Pigment Cell Research, Dec., 16(6), 629-38, 2003   DOI   ScienceOn
4 성금수, 전 철, 권용훈, 김경현, 장재철 : 홍삼 추출물 투여가 생쥐간에서 항산화 효소 활성과 지질과산화에 미치는 효과. 고려인삼학회지, 24(1), 29-34, 2000
5 최욱희, 안령미 : 자외선 B 조사로 유도되는 염증 반응과 지질과산화에 대한 EGb 761의 억제효과. 동덕여자대학교 생활과학회지, 10, 42-49, 2005
6 Katiyar, S. K. and Elmets, C. A. : Green tea polyphenolic antioxidants and skin photoprotection(review). International Journal of Oncology, Jun., 18(6), 1307-13, 2001
7 이은희, 이종권, 홍진태, 정경미, 외 4인 : 녹차추출물 성분 catechin이 자외선에 의해 손상된 피부에 미치는 영향. Journal of Food Hygiene and Safety 16(2), 117-124, 2001
8 Choi, S. Y., Kim, S. H., Hwang, J. S., Lee, B. G., Kim, H. C. and Kim, S. Y. : Benzylamide derivative compound attenuates the ultraviolet B-induced hyperpigmentation in the brownish guinea pig skin. Biochemical Pharmacology, 67, 707-715, 2004   DOI   ScienceOn
9 박수남 : 피부노화와 항산화제. 대한화장품학회지, 23(1), 75-132, 1997
10 Mahadik, S . P. a nd Mu kherjee, S . : Free r adical pathology and antioxidant defense in schizophrenia(review). Schizophrenia Research, Mar., 19(1), 1-17, 1996   DOI   ScienceOn
11 이상화 : 멜라닌 생성과 그 조절. 대한화장품학회지, 4차 심포지움, 22-32, 1996
12 이민경, 이세윤, 안형수, 안령미 : 자외선 B파로 유도된 Hairless mouse의 과산화지질 및 항산화효소활성도와 탄닌의 효과. 한국환경위생학회지, 22(4), 102-108, 1996
13 이은희, 이종권, 홍진태, 정경미 외 4인 : 녹차추출물 성분 catechin이 자외선에 의해 손상된 피부에 미치는 영향. Journal of Food Hygiene and Safety, 16(2), 117-124, 2001
14 Ozkur, M. K., Bozkurt, M. S., Balabanli, B., Aricioglu, A., Ilter, N., Gurer, M. A. and Inaloz, H. S. : The effects of EGb 761 on lipid peroxide levels and superoxide dismutase activity in sunburn. Photodermatology, Photoimmunology & Photomedicine, Jun., 18(3), 117-120, 2002   DOI   ScienceOn
15 Fazekas, Z., Gao, D., Saladi, R. N., Lu, Y., Lebwohl, M. and Wei, H. : Protective effects of lycopene against ultraviolet B-induced photodamage. Nutrition and Cancer, 47(2), 181-7, 2003   DOI   ScienceOn
16 최욱희, 김덕성, 안형수, 이영미, 안령미 : UV-B 조사로 유도된 접촉 과민반응에 대한 홍삼과 홍삼 + EGb761 혼합물의 억제 효과 비교. 한국환경독성학회지, 20(2), June, 2005
17 Nita, A. and Antony, R. Y. : Melanogenesis:a photoprotective response to DNA damage? (review). Mutation Research, 1-12, 2005
18 Alison, W., Takeshi, K., Katsuhiko, T., Kazunori, U., Pilar, A., Koichiro, K. and Vincent, J. H. : The tyrosinase gene family-interactions of melanogenic protein to regulate melanogenesis. Cellular and Molecular Biology Reearch, 40(7/8), 613-626, 1994
19 Koga, S., Nakano, M. and Tero Kubota, S. : Generation of superoxide during the enzymatic action of tyrosinase. Archives of Biochemistry and Biophysics, 292, 570-575, 1991   DOI   ScienceOn
20 최욱희, 안형수, 안령미 : ICR mou se에 있어 UVB 조사로 유도된 접촉 과민반응에 대한 EGb 761의 억제 효과. 한국환경보건학회지, 31(1), 7-14, 2005   과학기술학회마을
21 Deng, H. L. and Zhang, J. T. : Anti-lipid peroxilative effect of ginsenoside Rb1 and Rg1. Chinese Medical Journal, May, 104(5), 395-8, 1991
22 Halliday, G. M. : Inflammation, gene mutation and photoimmunosuppression in response to UVRinduced oxidative damage contributes to photocarcinogenesis. Mutation Research, Elsevier, Paris, 1-14, 2005
23 Lee, C. K., Han, S. S., Shin, Y. K., Chung, M. H., Park, Y. I., Lee, S. K. and Kim, Y. S. : Prevention of ultraviolet radiation-induced suppression of contact hypersensitivity by Aloe vera gel components. International Journal of Immunopharmacology, 21, 303-310, 1999   DOI   ScienceOn
24 김영곤 : Antioxidants, 여문각, 2004
25 Jeener, P. and Olanow, C. W. : Oxidative stress and the pathogenesis of Parkinson's disease. Neurology. Dec., 47(6), 161-70, 1996   DOI
26 Runa, S., Diane, E . H., Thomas, M. M ., Y and, J ., William, J. M. and Jeffrey, D. L. : UVB light suppresses nitric oxide production by murine keratinocytes and macrophages. Biochemical Pharmacology, 64, 1469-1481, 2002   DOI   ScienceOn