• Asian-Australasian Journal of Animal Sciences
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• v.31 no.12
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• pp.1852-1862
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• 2018

Objective: The purpose of this study was to investigate a single step genome-wide association study (ssGWAS) for identifying genomic regions affecting reproductive traits in Landrace and Large White pigs. Methods: The traits included the number of pigs weaned per sow per year (PWSY), the number of litters per sow per year (LSY), pigs weaned per litters (PWL), born alive per litters (BAL), non-productive day (NPD) and wean to conception interval per litters (W2CL). A total of 321 animals (140 Landrace and 181 Large White pigs) were genotyped with the Illumina Porcine SNP 60k BeadChip, containing 61,177 single nucleotide polymorphisms (SNPs), while multiple traits single-step genomic BLUP method was used to calculate variances of 5 SNP windows for 11,048 Landrace and 13,985 Large White data records. Results: The outcome of ssGWAS on the reproductive traits identified twenty-five and twenty-two SNPs associated with reproductive traits in Landrace and Large White, respectively. Three known genes were identified to be candidate genes in Landrace pigs including retinol binding protein 7, and ubiquitination factor E4B genes for PWL, BAL, W2CL, and PWSY and one gene, solute carrier organic anion transporter family member 6A1, for LSY and NPD. Meanwhile, five genes were identified to be candidate genes in Large White, two of which, aldehyde dehydrogenase 1 family member A3 and leucine rich repeat kinase 1, associated with all of six reproduction traits and three genes; retrotransposon Gag like 4, transient receptor potential cation channel subfamily C member 5, and LHFPL tetraspan subfamily member 1 for five traits except W2CL. Conclusion: The genomic regions identified in this study provided a start-up point for marker assisted selection and estimating genomic breeding values for improving reproductive traits in commercial pig populations.

• 제어로봇시스템학회:학술대회논문집
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• 1987.10b
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• pp.566-569
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• 1987

The primary difficulties encountered in the use of step motors are underdamped response when stopping at a specified position and dynamic instability during high-speed slewing. This paper proposes a speed and position detection scheme using the back EMF generated by the rotating permanent magnet field of a two-phase 1.8.deg. hybrid step motor, and presents its application to the state-variable feedback control of the hybrid step motor. All simulation results in a single step response show that the hybrid step motor performances such as peak overshoot and settling time are greatly improved.

• Proceedings of the KIEE Conference
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• 1994.11a
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• pp.15-17
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• 1994

The economic operation in power systems has long been in keen interests for power system engineers. The classical equal incremental fuel cost rule is still the basis for it, even though more elaborate tools such as optimal power flow have been developed already. The classical method requires usually many iterations, while the optimal power flow shows often some difficulties. This paper suggests a single step solution based on the classical method revisited. The concept is shown graphically. Three sample systems are compared. The proposed approach has shown a single step solution regardless system sizes, while the conventional methods require many iterations.

• Genomics & Informatics
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• v.20 no.1
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• pp.2.1-2.11
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• 2022

The method of single-cell RNA sequencing has been rapidly developed, and numerous experiments have been conducted over the past decade. Their results allow us to recognize various subpopulations and rare cell states in tissues, tumors, and immune systems that are previously unidentified, and guide us to understand fundamental biological processes that determine cell identity based on single-cell gene expression profiles. However, it is still challenging to understand the principle of comprehensive gene regulation that determines the cell fate only with transcriptome, a consequential output of the gene expression program. To elucidate the mechanisms related to the origin and maintenance of comprehensive single-cell transcriptome, we require a corresponding single-cell epigenome, which is a differentiated information of each cell with an identical genome. This review deals with the current development of single-cell epigenomic library construction methods, including multi-omics tools with crucial factors and additional requirements in the future focusing on DNA methylation, chromatin accessibility, and histone post-translational modifications. The study of cellular differentiation and the disease occurrence at a single-cell level has taken the first step with single-cell transcriptome and is now taking the next step with single-cell epigenome.

• JSTS:Journal of Semiconductor Technology and Science
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• v.15 no.1
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• pp.22-28
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• 2015

This paper proposes column-parallel three step Single Slope Analog-to-Digital Converter (SS-ADC) for high frame rate VGA CMOS Image Sensors (CISs). The proposed three step SS-ADC improves the sampling rate while maintaining the architecture of the conventional SS-ADC for high frame rate CIS. The sampling rate of the three-step ADC is increased by a factor of 39 compared with the conventional SS-ADC. The proposed three-step SS-ADC has a 12-bit resolution and 200 kS/s at 25 MHz clock frequency. The VGA CIS using three step SS-ADC has the maximum frame rate of 200 frames/s. The total power consumption is 76 mW with 3.3 V supply voltage without ramp generator buffer. A prototype chip was fabricated in a $0.13{\mu}m$ CMOS process.

• 한국초전도학회:학술대회논문집
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• v.10
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• pp.146-150
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• 2000

Two methods have been investigated to fabricate good quality step-edge Josephson junctions on STO, MgO, and LAO single crystal substrates. One is the annealing of substrates at 1050$^{\circ}$C in 1 atmospheric oxygen after Ar-ion milling. The other is the cleaning of step-edge by using Ar ion milling. The step-edge is characterized with atomic force microscope (AFM) images. And YBCO thin films are deposited by using pulsed laser. The I-V properties of step-edge junctions are characterized. The yield rate of step-edge junction is increased by new fabrication methods.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.12C
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• pp.1133-1143
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• 2005

In this paper, we propose an enhanced two-step search scheme for rapid and reliable signal acquisition in UWB systems under multipath channels. The proposed TSS-LS (Two-Step Search scheme with the Linear search based Second step) achieves rapid acquisition performance comparable to the conventional TSS-BS (Two-Step Search scheme with the Bit reversal search based Second step) already proposed by the authors, based on the single-dwell search with two-step thresholds and search windows. However, unlike the TSS-BS which employs the bit reversal search in the second step, the proposed TSS-LS utilizes the linear search in the second step to improve the reliability of signal acquisition. Simulation results with multipath channel models by IEEE 802.15.3a show that the two-step search schemes for the UWB signal acquisition can achieve sig nificant reduction of the required mean acquisition time as compared to general search schemes. In addition, we observe that the proposed TSS-LS achieves quite good bit error rate performance for large signal-to-noise ratios, which is favorably comparable to the case of ideal perfect timing.

• Physical Therapy Korea
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• v.15 no.3
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• pp.35-43
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• 2008

The purpose of this study was to compare spatio-temporal parameters during walking between patients with idiopathic Parkinson's disease and a control group matched for age, height, and weight. Thirty-three subjects were included in this study. Fifteen normal subjects (age, $63.3{\pm}5.8$ yrs; height, $164.1{\pm}8.7$ cm; weight, $60.7{\pm}17.5$ kg) and eighteen patients (age, $64.0{\pm}7.7$ yrs; height, $164.7{\pm}7.3$ cm; weight, $63.6{\pm}7.7$ kg) participated in the study. The Vicon 512 Motion analysis system was used for gait analysis in each group during walking, with and without an obstacle. The measured spatio-temporal parameters were cadence, walking speed, stride time, step time, single limb support time, double limb support time, stride length, and step length. Results in stride length and step length, when walking without an obstacle, showed a significantly greater decrease in the patient group compared to the control group. During walking with an obstacle, the patient group showed a significantly greater decrease in the step length as compared to the control group. For the control group, there were significant decreases in parameters of cadence and walking speed and increases in parameters of stride time, step time, and single limb support time when walking with an obstacle. The patient group had lower cadence and walking speed and higher stride time, step time, and single limb support time during walking with an obstacle than in walking without an obstacle. These results suggest that patients with Parkinson's disease who walk over an obstacle can decrease cadence, stride length, and step length. Further study is needed, performed with more obstacles and combined with other external cues, such as visual or acoustic guides.

• Journal of Power Electronics
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• v.15 no.6
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• pp.1468-1479
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• 2015

Renewable energy resources such as wind and photovoltaic power generation systems demand a high step-up DC-DC converters to convert the low voltage to commercial grid voltage. However, the high step-up converter using a transformer has limitations of high voltage stresses of switches and diodes when the transformer winding ratio increases. Accordingly, conventional studies have been applied to series-connect multioutput converters such as forward-flyback and switched-capacitor flyback to reduce the transformer winding ratio. This paper proposes new single-ended converter topologies of an isolation type and a non-isolation type to improve power efficiency, cost-effectiveness, and output ripple. The first proposal is an isolation-type charge-pump switched-capacitor flyback converter that includes an extreme-ratio isolation switched-capacitor cell with a chargepump circuit. It reduces the transformer winding number and the output ripple, and further improves power efficiency without any cost increase. The next proposal is a non-isolation charge-pump switched-capacitor-flyback tapped-inductor boost converter, which adds a charge-pump-connected flyback circuit to the conventional switched-capacitor boost converter to improve the power efficiency and to reduce the efficiency degradation from the input variation. In this paper, the operation principle of the proposed scheme is presented with the experimental results of the 100 W DC-DC converter for verification.

• Physical Therapy Korea
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• v.19 no.4
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• pp.16-23
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• 2012

This study examined the effects of custom-made foot orthotics on the temporal-spatial gait parameters in children with cerebral palsy. Twenty spastic bilateral cerebral palsy (spastic CP) children (11 boys and 9 girls) participated in this study. GAITRite was used to examine the velocity, cadence, step length differential, step length, stride length, stance time, single support time, double support time, base of support, and toe angle while walking with and without foot orthotics. The differences in temporal-spatial parameters were analyzed using paired t-test. The significance level was set at .05. The velocity, cadence, both step lengths, both stride lengths, both bases of support and right toe angle significantly increased when the children with spastic CP with foot orthotics compared to without foot orthotics (p<.05). The step length differential between the two extremities, left stance time and left single support time, significantly decreased with foot orthotics (p<.05). Right stance time, right single support time, both double support times and left toe angle showed little change (p>.05). This study demonstrated that foot orthotics were beneficial for children with spastic CP as a gait assistance tool.