• Molecules and Cells
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• 제26권2호
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• pp.200-205
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• 2008

The mitogen-activated protein kinase (MAPK) signaling pathway is activated in response to extracellular stimuli and regulates various activities in eukaryotic cells. Following exposure to stimuli, MAPK is known to be activated via dual phosphorylation at a conserved TxY motif in the activation loop; both threonine and tyrosine residues are phosphorylated by an upstream kinase. However, the mechanism underlying dual phosphorylation is not clearly understood. In the budding yeast Saccharomyces cerevisiae, the Hog1 MAPK mediates the high-osmolarity glycerol (HOG) signaling pathway. Tandem mass spectrometry and phosphospecific immunoblotting were performed to quantitatively monitor the dynamic changes occurring in the phosphorylation status of the TxY motif of Hog1 on exposure to osmotic stress. The results of our study suggest that the tyrosine residue is preferentially and dynamically phosphorylated following stimulation, and this in turn leads to the dual phosphorylation. The tyrosine residue was hyperphosphorylated in the absence of a threonine residue; this result suggests that the threonine residue is critical for the control of signaling noise and adaptation to osmotic stress.

• 한국도로학회논문집
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• 제17권4호
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• pp.117-126
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• 2015

PURPOSES : This study aims to investigate the direct and indirect influence areas from incidents on urban interrupted roadways and to develop traffic management strategies for each influence area. METHODS : Based on a literature review, various traffic management strategies for certain incidents were collected. In addition, the relationship between the measure of effectiveness and the characteristics of incidents was explored using an extensive simulation study. RESULTS : From the simulation studies, traffic delays increased as the number of lane closures increased, and the impact of lane closures was reduced to the direction upstream from the incident site. However, the magnitude of the delay change depended on the degree of saturation. Using these characteristics, the direct and indirect influence areas resulting from incidents were defined, and traffic management strategies were established for each direct and indirect influence area and for each level of incident. CONCLUSIONS: The results of this study will contribute to the improvement of national traffic safety by preventing secondary incidents and by effective adaptation to incident events.

• Interdisciplinary Bio Central
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• 제6권1호
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• pp.1.1-1.6
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• 2014

A growing body of evidence shows that most psychological traits are polygenic, that is they involve the action of many genes with small effects. However, the study of selection has disproportionately been on one or a few genes and their associated sweep signals (rapid and large changes in frequency). If our goal is to study the evolution of psychological variables, such as intelligence, we need a model that explains the evolution of phenotypes governed by many common genetic variants. This study illustrates simple statistical tools to detect signals of recent polygenic selection: a) ANOVA can be used to reveal significant deviation from random distribution of allele frequencies across racial groups. b) Principal component analysis can be used as a tool for finding a factor that represents the strength of recent selection on a phenotype and the underlying genetic variation. c) Method of correlated vectors: the correlation between genetic frequencies and the average phenotypes of different populations is computed; then, the resulting correlation coefficients are correlated with the corresponding alleles' genome-wide significance. This provides a measure of how selection acted on genes with higher signal to noise ratio. Another related test is that alleles with large frequency differences between populations should have a higher genome-wide significance value than alleles with small frequency differences. This paper fruitfully employs these tools and shows that common genetic variants exhibit subtle frequency shifts and that these shifts predict phenotypic differences across populations.

• 한국소음진동공학회논문집
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• 제18권3호
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• pp.284-292
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• 2008

The active control technique mostly uses the least-mean-square(LMS) algorithm, because the LMS algorithm can easily obtain the complex transfer function in real-time, particularly when the Filtered-X LMS(FXLMS) algorithm is applied to an active noise control(ANC) system. However, FXLMS algorithm has the demerit that stability of the control is decreased when the step size become larger but the convergence speed is faster because the step size of FXLMS algorithm is fixed. As a result, the system has higher probability which the divergence occurs. Thus the Co-FXLMS algorithm was developed to solve this problem. The Co-FXLMS algorithm is realized by using an estimate of the cross correlation between the adaptation error and the filtered input signal to control the step size. In this paper, the performance of the Co-FXLMS algorithm is presented in comparison with the FXLMS algorithm. Simulation and experimental results show that active noise control using Co-FXLMS is effective in reducing the noise in duct system.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2007년도 추계학술대회논문집
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• pp.737-742
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• 2007

The method of the reducing duct noise can be classified by passive and active control techniques. However, passive control has a limited effect of noise reduction at low frequencies (below 500Hz) and is limited by the space. On the other hand, active control can overcome these passive control limitations. The active control technique mostly uses the Least-Mean-Square (LMS) algorithm, because the LMS algorithm can easily obtain the complex transfer function in real-time particularly when the Filtered-X LMS (FXLMS) algorithm is applied to an active noise control (ANC) system. However, the convergence performance of the LMS algorithm decreases slightly so it may delay the convergence time when the FXLMS algorithm is applied to the active control of duct noise. Thus the Co-FXLMS algorithm was developed to improve the control performance in order to solve this problem. The Co-FXLMS algorithm is realized by using an estimate of the cross correlation between the adaptation error and the filtered input signal to control the step size. In this paper, the performance of the Co-FXLMS algorithm is presented in comparison with the FXLMS algorithm. Simulation results show that active noise control using Co-FXLMS is effective in reducing duct noise.

• 제어로봇시스템학회논문지
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• 제2권4호
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• pp.306-311
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• 1996

This paper discusses the maintenance of the water level of steam generators at its programmed value. The process, the water level of a steam generator, has the nonminimum phase property. So, it causes a reverse dynamics called a swell and shrink phenomenon. This phenomenon is severe in a low power condition below 15 %, in turn makes the start-up of the power plant too difficult. The control algorithm used here incorporates a pole-assignment scheme into the minimum variance strategy and we use a parallel adaptation algorithm for the parameter estimation, which is robust to noises. As a result, the total control system can keep the water level constant during full power by locating closed-loop poles appropriately, although the process has the characteristics of high complexity and nonlinearity. Also, the extra perturbation signals are added to the input signal such that the control system guarantee persistently exciting. In order to confirm the control performance of a proposed pole-assignment self-tuning controller we perform a computer simulation in full power range.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2007년도 춘계학술대회논문집
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• pp.598-603
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• 2007

The active control technique mostly uses the Least-Mean-Square (LMS) algorithm, because the LMS algorithm can easily obtain the complex transfer function in real-time, particularly when the Filtered-X LMS (FXLMS) algorithm is applied to an active noise control (ANC) system. However, FXLMS algorithm has the demerit that stability of the control is decreased when the step size become larger but the convergence speed is faster because the step size of FXLMS algorithm is fixed. As a result, the system has higher probability which the divergence occurs. Thus the Co-FXLMS algorithm was developed to solve this problem. The Co-FXLMS algorithm is realized by using an estimate of the cross correlation between the adaptation error and the filtered input signal to control the step size. In this paper, the performance of the Co-FXLMS algorithm is presented in comparison with the FXLMS algorithm. Simulation results show that active noise control using Co-FXLMS is effective in reducing the noise in duct system.

• 한국산업융합학회 논문집
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• 제19권1호
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• pp.18-30
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• 2016

In this paper, we propose a new technique to the design and real-time control of an adaptive controller for robotic manipulator based on digital signal processors. The Texas Instruments DSPs(TMS320C80) chips are used in implementing real-time adaptive control algorithms to provide enhanced motion control performance for dual-arm robotic manipulators. In the proposed scheme, adaptation laws are derived from model reference adaptive control principle based on the improved Lyapunov second method. The proposed adaptive controller consists of an adaptive feed-forward and feedback controller and time-varying auxiliary controller elements. The proposed control scheme is simple in structure, fast in computation, and suitable for real-time control. Moreover, this scheme does not require any accurate dynamic modeling, nor values of manipulator parameters and payload. Performance of the proposed adaptive controller is illustrated by simulation and experimental results for a dual arm robot manipulator with eight joints. joint space and cartesian space.

• 한국음향학회지
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• 제7권4호
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• pp.77-85
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• 1988

各種의 Conditioning Monitoring 技術이 硏究되고 있는데 本 硏究에서는 Cepstrum 解析法에 Adaptive Noise Cancelling (ANC) 법을 利用하여 回轉機械要素의 하나인 베어링의 缺陷을 管理하는 手段으로써의 可能性을 檢討하였으며 ANC의 物理的 意味를 正確히 把握하고자 컴퓨터 시뮬레이션을 行하였다. 컴퓨터 시뮬레이션에 衣해 Adaptive filter 에서의 最適한 適應利得을 推定하였으며 信號對雜音比에 따른 ANC의 性能과 LMS알고리즘의 收劍性을 考察하였다. 또한 ANC法을 Cepstrum 解析法에 利用한 베어링의 異常診斷은 旣存의 Cepstrum解析法보다 有效함을 알았다.

• 한국통신학회논문지
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• 제19권4호
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• pp.597-604
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• 1994

본 논문은 “Stop-and-go"알고리듬을 부분응답시스템에 응용한 것이다. ”Stop-and-Go"알고리듬은 결정한 심볼에 관한 에러신호가 충분히 믿을만 한가를 판단하여 등화기에 간단한 깃발로 알려주어 등화 적응 과정을 멈추는 성질을 이용하는 것이다. 부분응답신호는 현재 수신되는 신호 레벨이 바로 전에 들어온 이웃 신호 레벨에 의해 가능한 레벨이 정해지는 레벨 천이 특성을 가지고 있다. 이 레벨 천이 특성을 이용하여 부분응답신호에 적합한 새로운 비선형 예측기를 제안하고, 컴퓨터 시뮬레이션을 통하여 제안한 비선형 예측기의 우수한 성능을 보인다.한 성능을 보인다.