• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.31 no.3
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• pp.219-227
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• 2005

Purpose: Abnormalities in the p53 gene are regarded as the most consistent genetic abnormalities detected in head and neck squamous cell carcinogenesis. Two new members of the p53 gene family, p73 and p63 have recently been identified. They share considerable sequence homology with p53 in the transactivation, DNA binding, and oligomerization domains, indicating possible involvement in carcinogenesis. Disruption of the homeostatic balance between proliferation and apoptosis is widely believed to contribute to human oral carcinogenesis. The aim of this study was to analyze expression of p63 in squamous cell carcinogenesis and to compare with immunochemical markers representing cell proliferation and apoptosis. Materials and Methods: Using the Syrian hamster oral cancer model, the fraction of apoptotic (apoptotic index-AI), proliferating (mitotic index-MI) and p63 expressing keratinocytes were examined at normal, dysplastic and malignant oral epithelium using the TUNEL assay, PCNA and p63 immunostaining. Results: p63 significantly increased between normal and dysplastic epithelium and between dysplastic and malignant epithelium. PCNA significantly increased between normal and dysplastic epithelium and between normal and malignant epithelium. However, increase between dysplastic and malignant epithelium, though still increasing, was not statistically significant. The percentage of TUNEL positive cells increased from normal to dysplastic epithelium and returned to normal keratinocyte level in the malignant epithelium. However, differences between tissue types were not significant. The ratio of MI:AI increased significantly only in the dysplastic-malignant epithelial transition. The increase of p63 expression closely reflected the change in the MI:AI ratio during oral carcinogenesis. Conclusion: The p63 may be associated with the regulation of epithelial proliferation and apoptosis in DMBA-induced hamster buccal pouch squamous cell carcinogenesis. Further study is required to investigate which p63 isoforms are involved in hamster buccal pouch carcinogenesis.

• Journal of Korean Society of Environmental Engineers
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• v.32 no.7
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• pp.690-698
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• 2010

Contamination of groundwater resources by organic chemicals has become an issue of increasing environmental concern. Surfactant-enhanced aquifer remediation (SEAR) is widely recognized as one of the most promising techniques to remediate organic contaminations in-situ. Solutions of surfactant or surfactant with polymer are used to dramatically expedite the process, which in turn, may reduce the treatment time of a site compared to use of water alone. In the design of surfactant-based technologies for remediation of organic contaminated aquifers, it is very important to have a considerable analysis using extensive numerical simulations prior to full-scale implementation. This study investigated the formation and flow of microemulsions during SEAR of organic-contaminated aquifer using the finite difference model UTCHEM, a three-dimensional, multicomponent, multiphase, compositional model. The remediation process variables considered in this study were the sequence of injection fluids, the injection and extraction rate, the concentrations of polymer in surfactant slug and chase water, and the duration of surfactant injection. For each variable, temporal changes in injection and production wells and spatial distributions of relative saturations in the organic phase were compared. Cleanup time and cumulative organic recovery were also quantified. The study would provide useful information to design strategies for the remediation of nonaqueous phase liquid-contaminated aquifers.

• The Journal of the Korea Contents Association
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• v.15 no.10
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• pp.626-635
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• 2015

Along with the social interests and needs for health, the U-Healthcare Service as a new model to control individual dietary life and to prevent chronic diseases is now drawing the public attention. In this study, the characteristics of the requirement of U-Healthcare Service were investigated from subjects aged over 50 years old. As parts of the expectation to the U-Healthcare service, the customized clinical care & control (37.7%) and the systematic understanding of individual health state (21.4%) appeared significantly. And for the application of the U-Healthcare Service to the field of healthcare, the control of dietotherapy (43.9%) appeared higher than anything else and thus the customized service for individual dietotherapy seemed to be needed. Regarding the field of searching for health information, the disease control (35.6%), food materials (28.6%), and recipe for health foods (22.7%) appeared in sequence and revealed that the majority over 50% of subjects were interested in foods. The requirements for the information of dietary formula were also investigated through 5 points scaled questionnaires on respective topics of nutritive components, menus customized for corresponding health states (diseases), and the results obtained from surveys on respective topics all showed the needs for all information by representing each point value exceeded 3.9. Through the results obtained from this study, the provision of customized information enabling the nutritional control in accordance with individual states of health or disease was estimated to be needed for the popularization of U-Healthcare Service providing contents for dietary life of clients especially those of aged over 50 years.

• The KIPS Transactions:PartC
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• v.11C no.6 s.95
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• pp.835-842
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• 2004

In this paper, we have analyzed the MC-DS/CDMA system with input signal synchronized completely through adjustment of the gain in the PLL loop, by using the hybrid SC/MRC-(2/3) technique, which is said to one of the optimal diversity techniques under the multi-path fading environment, assuming that phase error is defined to the phase difference between the received signal from the multi-path and the reference signal in the PLL of the receiver. Also, assuming that the regarded radio channel model for the mobile communication is subject to the Nakagami-m fading channel, we have developed the expressions and performed the simulation under the consideration of various factor, in the MC/DS-CDMA system with the hybrid SC.MRC-(2/3) diversity method, such as the Nakagami fading index(m), $the\;number\;of\;paths\;(L_p),$ the number of hybrid SC.MRC-(2/3) $diversity\;branches\;(L,\;L_c),$ the number of users (K), the number of subcarriers (U), and the gain in the PLL loop. As a result of the simulation, it has been confirmed that the performance improvement of the system can be achieved by adjusting properly the PLL loop in order for the MC/DS-CDMA system with the hybrid SC/MRC-(2/3) diversity method to receive a fully synchronized signal. And the value of the gain in the PLL loop should exceed 7dB in order for the system to receive the signal with prefect synchronization, even though there might be a slight difference according to the values of the fading index and the spread processing gain of the subcarrier.

• Geophysics and Geophysical Exploration
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• v.7 no.3
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• pp.207-212
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• 2004

This article reviews recent developments in three-dimensional (3-D) magntotelluric (MT) imaging. The inversion of MT data is fundamentally ill-posed, and therefore the resultant solution is non-unique. A regularizing scheme must be involved to reduce the non-uniqueness while retaining certain a priori information in the solution. The standard approach to nonlinear inversion in geophysis has been the Gauss-Newton method, which solves a sequence of linearized inverse problems. When running to convergence, the algorithm minimizes an objective function over the space of models and in the sense produces an optimal solution of the inverse problem. The general usefulness of iterative, linearized inversion algorithms, however is greatly limited in 3-D MT applications by the requirement of computing the Jacobian(partial derivative, sensitivity) matrix of the forward problem. The difficulty may be relaxed using conjugate gradients(CG) methods. A linear CG technique is used to solve each step of Gauss-Newton iterations incompletely, while the method of nonlinear CG is applied directly to the minimization of the objective function. These CG techniques replace computation of jacobian matrix and solution of a large linear system with computations equivalent to only three forward problems per inversion iteration. Consequently, the algorithms are efficient in computational speed and memory requirement, making 3-D inversion feasible.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.30 no.5
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• pp.782-793
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• 1997

To study the physiological adaptation (shift-up) of phytoplankton under the simulated upwelling conditions, nitrate uptake capacity of Dunaliella tertiolecta batch culture was measured in the laboratory using the stable isotope $^{15}N-KNO_3$. Contrary to the expected, there was no significant relationship between the maximum $V_{NO3}$ (nitrogen specific nitrate uptake rate) and the initial nitrate concentration. However, there was a strong relationship between the maximum $\rho_{NO3}$ (nitrate transport rate) and the initial nitrate concentration of $<25\;{\mu}M$, which was also influenced by the physiological status of the culture. The increase in $V_{NO3}$ was mainly due to the increase in PON (particulate organic nitrogen) concentration and partly due to the increase in $V_{NO3}$. When the phytoplankton population was severely shifted-down, the physiological adaptation of nitrate uptake was significantly inhibited at high initial nitrate concentrations. The timing of the maximum $V_{NO3}$ or $\rho_{NO3}$ was related to the initial nitrate concentration. At higher initial nitrate concentrations, maxima in $V_{NO3}$ and $\rho_{NO3}$ occurred 1 or 2 days later than at lower nitrate concentrations. This relationship was the opposite to the prediction from the shift-up model of Zimmerman et al. (1987), The shift-up process is apparently controlled by an internal time sequence and the initial nitrate concentration, but the magnitude of $V_{NO3}$ was affected little by changes in nitrate concentration.

• Journal of Korean Society of Transportation
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• v.27 no.5
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• pp.97-111
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• 2009

Image-based traffic information collection systems have entered widespread adoption and use in many countries since these systems are not only capable of replacing existing loop-based detectors which have limitations in management and administration, but are also capable of providing and managing a wide variety of traffic related information. In addition, these systems are expanding rapidly in terms of purpose and scope of use. Currently, the utilization of image processing technology in the field of traffic accident management is limited to installing surveillance cameras on locations where traffic accidents are expected to occur and digitalizing of recorded data. Accurately recording the sequence of situations around a traffic accident in a signal intersection and then objectively and clearly analyzing how such accident occurred is more urgent and important than anything else in resolving a traffic accident. Therefore, in this research, we intend to present a technology capable of overcoming problems in which advanced existing technologies exhibited limitations in handling real-time due to large data capacity such as object separation of vehicles and tracking, which pose difficulties due to environmental diversities and changes at a signal intersection with complex traffic situations, as pointed out by many past researches while presenting and implementing an active and environmentally adaptive methodology capable of effectively reducing false detection situations which frequently occur even with the Gaussian complex model analytical method which has been considered the best among well-known environmental obstacle reduction methods. To prove that the technology developed by this research has performance advantage over existing automatic traffic accident recording systems, a test was performed by entering image data from an actually operating crossroad online in real-time. The test results were compared with the performance of other existing technologies.

• Journal of Internet Computing and Services
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• v.22 no.2
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• pp.77-87
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• 2021

With the development of the Internet and personal computers, various and complex attacks begin to emerge. As the attacks become more complex, signature-based detection become difficult. It leads to the research on behavior-based log anomaly detection. Recent work utilizes deep learning to learn the order and it shows good performance. Despite its good performance, it does not provide any explanation for prediction. The lack of explanation can occur difficulty of finding contamination of data or the vulnerability of the model itself. As a result, the users lose their reliability of the model. To address this problem, this work proposes an explainable log anomaly detection system. In this study, log parsing is the first to proceed. Afterward, sequential rules are extracted by Bayesian posterior probability. As a result, the "If condition then results, post-probability" type rule set is extracted. If the sample is matched to the ruleset, it is normal, otherwise, it is an anomaly. We utilize HDFS datasets for the experiment, resulting in F1score 92.7% in test dataset.

• Journal of Life Science
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• v.31 no.1
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• pp.83-89
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• 2021

Uu-ilys, an i-type lysozyme from spoon worm (Urechis unicinctus), is an innate immune factor that plays an important role in the defense against pathogens. It also possesses non-enzymatic antibacterial activity. Thus, there is a possibility to develop an antimicrobial model peptide from Uu-ilys. In this study, we report the design, production, and antibacterial activity of an Uu-ilys analog that exhibits antibacterial activity. The Uu-ilys structure was fragmented according to its secondary structures to predict the regions with antimicrobial activity using antimicrobial peptide (AMP) prediction tools from different AMP databases. A peptide containing the C-terminal fragment was predicted to exert antimicrobial activity. The chosen fragment was designated as an Uu-ilys analog containing the C-terminal fragment, Uu-ilys-CF. To examine the possibility of developing an AMP using the sequence of Uu-ilys-CF, recombinant fusion protein (TrxA-Uu-ilys-CF) was produced in an expression system that was heterologous. The produced fusion protein was cleaved after methionine leaving Uu-ilys-CF free from the fusion protein. This was then isolated through high performance liquid chromatography and reverse phase column, CapCell-Pak C18. The antibacterial activity of Uu-ilys-CF against different microbial strains (four gram-positive, six gram-negative, and one fungal strain) were assessed through the ultrasensitive radial diffusion assay (URDA). Among the bacterial strains tested, Salmonella enterica was the most susceptible. While the fungal strain tested was not susceptible to Uu-ilys-CF, broad spectrum antibacterial activity was observed.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.34 no.1
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• pp.43-50
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• 2021

A Leg Mating Unit (LMU) is a device utilized during the float-over installation of offshore structures that include hyperelastic pads and mating part. The hyperelastic pads absorb the loads, whereas the mating part works as guidance between topside and supporting structures during the mating sequence of float-over installation. In this study, the design optimization of an LMU for the float-over installation of floating-type offshore structures is conducted to enhance the performance and to satisfy the requirements defined by classification society regulations. The initial dimensions of the LMU are referred to the dimensions of those used in fixed-type float-over installation because only the location and the number of LMUs are known. The two-parameter Mooney-Rivlin model is adopted to describe the hyperelastic pads under given material parameters. Geometric variables, such as the thickness, height, and width of members, as well as configuration variables, such as the angle and number of members, are defined as design variables and are parameterized. A sampling-based design sensitivity analysis based on latin hypercube sampling method is performed to filter the important design variables. The design optimization problem is formulated to minimize the total mass of the LMU under maximum von Mises stress and reaction force constraints.