• Biomolecules & Therapeutics
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• v.31 no.3
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• pp.350-358
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• 2023

Hand-foot-and-mouth disease (HFMD) is a viral infectious disease that occurs in children under 5 years of age. Its main causes are coxsackievirus (CV) and enterovirus (EV). Since there are no efficient therapeutics for HFMD, vaccines are effective in preventing the disease. To develop broad coverage against CV and EV, the development of a bivalent vaccine form is needed. The Mongolian gerbil is an efficient and suitable animal model of EV71 C4a and CVA16 infection used to investigate vaccine efficacy following direct immunization. In this study, Mongolian gerbils were immunized with a bivalent inactivated EV71 C4a and inactivated CVA16 vaccine to test their effectiveness against viral infection. Bivalent vaccine immunization resulted in increased Ag-specific IgG antibody production; specifically, EV71 C4a-specific IgG was increased with medium and high doses and CVA16-specific IgG was increased with all doses of immunization. When gene expression of T cell-biased cytokines was analysed, Th1, Th2, and Th17 responses were found to be highly activated in the high-dose immunization group. Moreover, bivalent vaccine immunization mitigated paralytic signs and increased the survival rate following lethal viral challenges. When the viral RNA content was determined from various organs, all three doses of bivalent vaccine immunization were found to significantly decrease viral amplification. Upon histologic examination, EV71 C4a and CVA16 induced tissue damage to the heart and muscle. However, bivalent vaccine immunization alleviated this in a dose-dependent manner. These results suggest that the bivalent inactivated EV71 C4a/CVA16 vaccine could be a safe and effective candidate HFMD vaccine.

• Journal of Korean Society of Disaster and Security
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• v.16 no.1
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• pp.1-11
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• 2023

The comprehensive natural disaster reduction plan, the highest plan in the disaster prevention field, was implemented by local governments. second plan is currently being formulated. In order to minimize human and property damage, structural and non-structural measures for each of the nine disaster types are established and implemented for 10 years. Structural measures are based on engineering and quantitative analysis, and the criteria for setting reduction measures are clear. Non-structural measures, however, currently lack the set criteria. the basic disaster and safety management law included the safety vulnerable class in 2018. Currently, the safety vulnerable class of the detailed establishment criteria of the comprehensive natural disaster reduction plan is being established, including children, the elderly, and the disabled. However, due to the lack of data securing and database construction by local governments, it is difficult to prepare a location map for establishing reduction measures for the safety vulnerable. Therefore, in this study, OPEN API data of the safety vulnerable class were collected and statistical information and GIS of SGIS information services were used. The distribution diagram of the safety vulnerable class in Samcheok, Gangwon-do, which is a sample area, and the distribution diagram of the safety vulnerable class in units of the output area (OA) in Geundeok-myeon were prepared.

• Journal of Korea Entertainment Industry Association
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• v.13 no.4
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• pp.107-117
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• 2019

This paper establishes and propagates the value of the play through the study of the transition process of the yesan play from 1920 to the present, presents an alternative through the unique theatricality of the region and aims to activate it. The theater divided the theater into Yecheon, Chungnam Theater Festival, and Youth Theater Festival, which are currently active, and focused on Yedang International Performing Arts Festival, which is the only one in Yesan. The details of the performance due to the loss of data were not specified as much as possible, but the contents of the yesan play before 1990 were reviewed using the eupji and Myeonji. It also starts with a lack of diversity in plays in the developing direction of Yesan. Children's plays should be dismissed for simple commercial purposes, or the value of traditional Korean plays should be compared to Western ones, to promote the development of local plays through the natural characteristics and the basis of traditional culture, and to sustain the continuity of extreme economic performance and performances through the development of repertoires. Infrastructure deployment can be cited. The in flow of specialized actors and the use of art administrators creates a stable theater environment and activates the reeducation of local actors to promote theatrical imagination. It is also an urgent task to develop a new theatrical form by introducing experimental theatrical methods of young artists in the overseas performance business of theater troupe Yechon. Finally, Yedang International Performing Arts Festival should be characterized and differentiated from other festivals.

• Journal of Naturopathy
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• v.12 no.1
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• pp.16-23
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• 2023

Background: There is a need for index research on music therapy activities for the elderly in Korea. Purposes: This study aims to suggest application standards in music therapy by surveying the elderly's preference for music therapy activities. Methods: A survey of music-related actions and musical instrument preferences was conducted with 91 older people in 4 nursing homes. The questionnaire consisted of information about music activities, genres of songs, types of instruments, methods of movement, and purpose of participation in activities. Results: The preference for musical activities was for playing musical instruments, followed by singing, music appreciation, flowing movements, and concert-oriented activities. Music genres appeared in the order of popular songs, folk songs, and children's songs. The instrument type preferred drums, followed by shakers and woodblocks. As a movement application method, movement using themes is preferred. Participating in music activities was leisure, followed by stress relief and emotional cultivation. Conclusion: When applying music therapy to the elderly, it predicted that the treatment effect would be high when the elderly focus on playing musical instruments and singing activities preferred by the elderly. Music genres selected from popular music and folk songs, and musical instruments are drums and shakers. Therefore, if you use it, you can expect a more significant effect.

• The Journal of KAIRB
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• v.5 no.1
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• pp.21-32
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• 2023

Purspose: The purpose of this study is to examine the meaning and definition of vulnerable subjects in clinical trials in light of domestic and international regulations and guidelines, to analyze the contents of standard operation procedures (SOPs) among advanced general hospitals in Korea that conduct clinical trials, and to examine deliberation procedures for operation plans. Methods: The study examined how vulnerable research subjects were defined and described in related regulations and the classification of vulnerable research subjects presented in the IRB/HRPP SOPs of 18 clinical trial institutions, including 11 AAHRPP-accreditated general hospitals in Korea, as well as the operation of the IRB deliberation. Results: Among all domestic and international regulations and guidelines, only the The Council for International Organization of Medical Sciences (CIOMS) guidelines explain why vulnerability is related to judgments on the severity of physical, psychological, and social harm, why individuals are vulnerable, and for what reasons. However, the classification of vulnerable subjects by institutions differed from the classification by the International Conference on Harmonization-Good Clinical Practice (ICH-GCP). A total of the 16 institutions classified children and minors as vulnerable research subjects. 14 institutions classified subjects who cannot consent freely were classified as vulnerable subjects. 15 institutions classified sujects who can be affected by the organizational hierarchy were classified as vulnerable subjects. Subjects in emergency situations were regarded as vulnerable research subjects in 8 of institutions, while people in wards, patients with incurable diseases, and the economically poor including the unemployed were categorized as vulnerable research subjects in 7, 4, and 4 of institutions, respectively. Additionally, some research subjects were not classified as vulnerable by ICH-GCP but were classified as vulnerable by domestic institutions 15 of the institutions classified pregnant women and fetuses as vulnerable, 11 classified the elderly as vulnerable, and 6 classified foreigners as vulnerable. Conclution: The regulations and institutional SOPs classify subjects differently, which may affect subject protection. There is a need to improve IRBs' classifications of vulnerable research subjects. It is also necessary to establish the standards according to the differences in deliberation processes. Further, it is recommended to maintain a consistent review of validity, assessment of risk/benefit, and a review using checklists and spokeperson. The review of IRB is to be carried out in a manner that respects human dignity by taking into account the physical, psychological, and social conditions of the subjects.

• Research in Community and Public Health Nursing
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• v.33 no.1
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• pp.13-31
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• 2022

Purpose: This study conducted a job analysis of visiting nurses in the process of change. Methods: Participants were the visiting nurses working for the Seoul Metropolitan city. On the basis of the Public Health Intervention Wheel model, two times of the focus group interview (FGI) with seven visiting nurses and one time of the Developing a Curriculum (DACUM) with 34 visiting nurses were performed. A questionnaire survey of 380 visiting nurses was conducted to examine the frequency, importance and difficulty levels of the tasks created by using the FGI and DACUM. Results: Visiting nurses' job was derived as the theme of present versus transitional roles. The present role was categorized as 'providing individual- and group-focused services' and 'conducting organization management', while the transitional role was categorized as 'providing district-focused services' and 'responding to new health issues'. The job generated 13 duties, 28 tasks, and 73task elements. The tasks showed the levels of frequency (3.65 scores), importance (4.27 scores), and difficulty (3.81 scores). All the tasks were determined as important, exceeding the average 4.00 scores. The group- and district-focused services of the tasks were recognized as more difficult but less frequent tasks. Conclusion: The visiting nurses exert both present and transitional roles. The transitional roles identified in the present study should be recognized as an extended role of visiting nurses in accordance with the current changing healthcare needs in South Korea. Finally, the educational curriculum for visiting nurses that reflects the transitional roles from the present study is needed.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.8 no.4
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• pp.517-531
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• 2018

This study was carried out for the purpose of investigating Uzbekistan students's adaptation to Korea college life. Qualitative interviews were conducted in regards to the motivation for college entrance and stresses incurred during college life for 10 Uzbekistan students who were studying at I college located in Incheon. Data from the interviews were analyzed using theme analysis method. Most of the participants in this study got information about Korean colleges through their overseas study exhibitions in their own countries and became Korea college. The results showed that the reasons for college enrollment were (1)preparation for future goals (2)the influence of family. In Uzbekistan, parents play a big role in determining their children's education. Therefore, their decision to study abroad and the role of their parents were significant. The stress they experienced in college life fell into five categories, namely, (1)financial stress (2)stress about studies (3) stress in regards to human relationships (4)stress in regards to their futures and getting a job. In addition, this study discussed how to solve such as problems experienced by Uzbekistan students. And also the role of college and the necessity of providing appropriate support programs were discussed. Finally, the implications of these findings were presented.

• Korean Journal of Culture and Social Issue
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• v.19 no.1
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• pp.19-44
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• 2013

The present study aimed at investigating how Korean housekeeper in midlife revaluate their lives. For this purpose, 14 housekeepers whose youngest child was at least older than high school students were interviewed in a semi-structured retrospective method. The interview was focused on relational, psychological, and economical aspects of the participants before and after marriage each. The interview usually continued one and a half to two hours. The phenomenological method describing personal meaning of experiences was referred to for data analyses by transforming retrospective life story of participants into key meaningful units. According to main retrospective contents of each stage of development, the participants' childhood and adolescence was characterized by familial circumstances, formation of personality and value, and career choice. Main themes of their early adulthood were spouse selection and marriage, marital adaptation, and family relationships. Their midlife focused on children, economic and emotional stability, family relationships, acceptance of their spouse and themselves, and health and religion. Life styles of the participants were analyzed in terms of turning events, meanings of current life, and cumulative effects of life events. These findings were discussed in terms of developmental pattern in relation to the established theory of development.

• Korean Journal of Culture and Social Issue
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• v.22 no.1
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• pp.65-85
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• 2016

In this study, we examined the longitudinal change of multicultural acceptability, peer relationship, and teacher relationship using latent growth curve modeling. This study used data from the second, third, and fourth waves of the middle school student cohort (N=2,178) of the Korean Children-Youth Panel Survey (KCYPS). The dependent variable was multicultural acceptability. The independent variables were peer relationship and teacher relationship. The major longitudinal findings of this study are as follows: First, peer relationships, teacher relationships and multicultural acceptability increased with time. Second, peer relationship showed a significant effect on the multicultural acceptability over time. Finally, the teacher relationship showed a significant effect on the multicultural acceptability over time. These results show differentiation with previous cross-sectional studies of multicultural acceptability. Furthermore, it is expected that this study will provide educational implications for the cultivation of multicultural acceptability.

• Korean Journal of Culture and Social Issue
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• v.14 no.1_spc
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• pp.63-109
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• 2008

This article examines psychological factors that contribute to educational achievement of Korean adolescents. By reviewing empirical research, three core areas are outlined. First, positive and negative roles that Korean society play on academic achievement are analyzed. Compared to other countries, Korean society places a high premium, pressure an investment on educational achievement. This has contributed to the rapid economic growth and development, but at the same time it has created numerous social problems. Second, psychological and relational dynamics of investing in and achieving success in education are delineated. Through indigenous psychological analysis, the role parents play in motivating and regulating their children to succeed academically is reviewed. In addition, the role of teachers and friends and the coordinated efforts of Korean society are outlined. Third, future directions and transformations in education that are needed in Korean society are discussed. Although Korean adolescents are high achievers in high school, this is not the case at the university level. Since Korean students are interested in entering a prestigious university, they have developed skills in doing well in standardized tests. Educational reforms need to take into consideration individuals' personal interests, skills and creativity to ensure that the knowledge that they acquired can be used to further their career and improve their subjective well-being. Educational transformation does not imply simply adopting Western models, but developing indigenous models that can maximize human and cultural potential and stimulate curiosity, diversity and creativity that are necessary in the global era.