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Quality of Anticoagulation and Treatment Satisfaction in Patients with Non-Valvular Atrial Fibrillation Treated with Vitamin K Antagonist: Result from the KORean Atrial Fibrillation Investigation II

  • Oh, Seil;Kim, June-Soo;Oh, Yong-Seog;Shin, Dong-Gu;Pak, Hui-Nam;Hwang, Gyo-Seung;Choi, Kee-Joon;Kim, Jin-Bae;Lee, Man-Young;Park, Hyung-Wook;Kim, Dae-Kyeong;Jin, Eun-Sun;Park, Jaeseok;Oh, Il-Young;Shin, Dae-Hee;Park, Hyoung-Seob;Kim, Jun Hyung;Kim, Nam-Ho;Ahn, Min-Soo;Seo, Bo-Jeong;Kim, Young-Joo;Kang, Seongsik;Lee, Juneyoung;Kim, Young-Hoon
    • Journal of Korean Medical Science
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    • v.33 no.49
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    • pp.323.1-323.12
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    • 2018
  • Background: Vitamin K antagonist (VKA) to prevent thromboembolism in non-valvular atrial fibrillation (NVAF) patients has limitations such as drug interaction. This study investigated the clinical characteristics of Korean patients treated with VKA for stroke prevention and assessed quality of VKA therapy and treatment satisfaction. Methods: We conducted a multicenter, prospective, non-interventional study. Patients with $CHADS_2{\geq}1$ and treated with VKA (started within the last 3 months) were enrolled from April 2013 to March 2014. Demographic and clinical features including risk factors of stroke and VKA treatment information was collected at baseline. Treatment patterns and international normalized ratio (INR) level were evaluated during follow-up. Time in therapeutic range (TTR) > 60% indicated well-controlled INR. Treatment satisfaction on the VKA use was measured by Treatment Satisfaction Questionnaire for Medication (TSQM) after 3 months of follow-up. Results: A total of 877 patients (age, 67; male, 60%) were enrolled and followed up for one year. More than half of patients (56%) had $CHADS_2{\geq}2$ and 83.6% had $CHA_2DS_2-VASc{\geq}2$. A total of 852 patients had one or more INR measurement during their follow-up period. Among those patients, 25.5% discontinued VKA treatment during follow-up. Of all patients, 626 patients (73%) had poor-controlled INR (TTR < 60%) measure. Patients' treatment satisfaction measured with TSQM was 55.6 in global satisfaction domain. Conclusion: INR was poorly controlled in Korean NVAF patients treated with VKA. VKA users also showed low treatment satisfaction.

Design and Implementation of an Efficient Web Services Data Processing Using Hadoop-Based Big Data Processing Technique (하둡 기반 빅 데이터 기법을 이용한 웹 서비스 데이터 처리 설계 및 구현)

  • Kim, Hyun-Joo
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.1
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    • pp.726-734
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    • 2015
  • Relational databases used by structuralizing data are the most widely used in data management at present. However, in relational databases, service becomes slower as the amount of data increases because of constraints in the reading and writing operations to save or query data. Furthermore, when a new task is added, the database grows and, consequently, requires additional infrastructure, such as parallel configuration of hardware, CPU, memory, and network, to support smooth operation. In this paper, in order to improve the web information services that are slowing down due to increase of data in the relational databases, we implemented a model to extract a large amount of data quickly and safely for users by processing Hadoop Distributed File System (HDFS) files after sending data to HDFSs and unifying and reconstructing the data. We implemented our model in a Web-based civil affairs system that stores image files, which is irregular data processing. Our proposed system's data processing was found to be 0.4 sec faster than that of a relational database system. Thus, we found that it is possible to support Web information services with a Hadoop-based big data processing technique in order to process a large amount of data, as in conventional relational databases. Furthermore, since Hadoop is open source, our model has the advantage of reducing software costs. The proposed system is expected to be used as a model for Web services that provide fast information processing for organizations that require efficient processing of big data because of the increase in the size of conventional relational databases.

Establishing a Research Framework for Ecological Aesthetics: A Methodological Review (생태미학 연구의 개념화 및 방법론 탐구)

  • Lee, Jong-Seon
    • Journal of the Korean Institute of Landscape Architecture
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    • v.45 no.4
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    • pp.71-80
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    • 2017
  • Landscape design pursues a balance among different values in our society, but aesthetic value and ecological value in landscapes must bring complex relationships into harmony. Ecological aesthetics can be defined as a domain of study that manages the relationship between landscape ecology and landscape aesthetics to create aesthetically attractive and ecologically beneficial landscapes. Despite the importance of the research area, there has been limited empirical research addressing ecological aesthetics. This article aspires to connect and expand the conceptual framework to the research methodologies of ecological aesthetics. First, this study suggests a conceptual framework that examines the relationship between landscape and perceptual process in the context of ecological aesthetics. This framework stresses the importance of information and design intervention as moderators in this relationship. From this framework, three key topics in ecological aesthetics arise: (1) correlation between ecological integrity and aesthetic preference, (2) "compromised" design and management intervention principles that enhance aesthetic pleasure and still have biodiversity, and (3) the impact of information intervention in aesthetic experience. The framework indicated three domains affect each other; thus, when one domain is studied, the other two need to be considered. Secondly, several theoretical and empirical studies on ecological aesthetics will be reviewed from a methodological point of view. This will help to consider ecological aesthetics research, which has primarily been limited to theoretical discourse in empirical research.

Dynamic Decision Making using Social Context based on Ontology (상황 온톨로지를 이용한 동적 의사결정시스템)

  • Kim, Hyun-Woo;Sohn, M.-Ye;Lee, Hyun-Jung
    • Journal of Intelligence and Information Systems
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    • v.17 no.3
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    • pp.43-61
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    • 2011
  • In this research, we propose a dynamic decision making using social context based on ontology. Dynamic adaptation is adopted for the high qualified decision making, which is defined as creation of proper information using contexts depending on decision maker's state of affairs in ubiquitous computing environment. Thereby, the context for the dynamic adaptation is classified as a static, dynamic and social context. Static context contains personal explicit information like demographic data. Dynamic context like weather or traffic information is provided by external information service provider. Finally, social context implies much more implicit knowledge such as social relationship than the other two-type context, but it is not easy to extract any implied tacit knowledge as well as generalized rules from the information. So, it was not easy for the social context to apply into dynamic adaptation. In this light, we tried the social context into the dynamic adaptation to generate context-appropriate personalized information. It is necessary to build modeling methodology to adopt dynamic adaptation using the context. The proposed context modeling used ontology and cases which are best to represent tacit and unstructured knowledge such as social context. Case-based reasoning and constraint satisfaction problem is applied into the dynamic decision making system for the dynamic adaption. Case-based reasoning is used case to represent the context including social, dynamic and static and to extract personalized knowledge from the personalized case-base. Constraint satisfaction problem is used when the selected case through the case-based reasoning needs dynamic adaptation, since it is usual to adapt the selected case because context can be changed timely according to environment status. The case-base reasoning adopts problem context for effective representation of static, dynamic and social context, which use a case structure with index and solution and problem ontology of decision maker. The case is stored in case-base as a repository of a decision maker's personal experience and knowledge. The constraint satisfaction problem use solution ontology which is extracted from collective intelligence which is generalized from solutions of decision makers. The solution ontology is retrieved to find proper solution depending on the decision maker's context when it is necessary. At the same time, dynamic adaptation is applied to adapt the selected case using solution ontology. The decision making process is comprised of following steps. First, whenever the system aware new context, the system converses the context into problem context ontology with case structure. Any context is defined by a case with a formal knowledge representation structure. Thereby, social context as implicit knowledge is also represented a formal form like a case. In addition, for the context modeling, ontology is also adopted. Second, we select a proper case as a decision making solution from decision maker's personal case-base. We convince that the selected case should be the best case depending on context related to decision maker's current status as well as decision maker's requirements. However, it is possible to change the environment and context around the decision maker and it is necessary to adapt the selected case. Third, if the selected case is not available or the decision maker doesn't satisfy according to the newly arrived context, then constraint satisfaction problem and solution ontology is applied to derive new solution for the decision maker. The constraint satisfaction problem uses to the previously selected case to adopt and solution ontology. The verification of the proposed methodology is processed by searching a meeting place according to the decision maker's requirements and context, the extracted solution shows the satisfaction depending on meeting purpose.

Prevalence of Hyperhomocysteinemia and Related Factors in a Community-based Health Examination Survey: A Cross-sectional Study (경기도 일개 지역사회 대표집단에서 고호모시스테인혈증의 유병률 및 관련요인에 대한 단면조사연구)

  • Kim, Soo-Jeong;Lim, Kyung-Sook;Song, Mi-Sook;Kang, Yeon-Ji;Lee, Soon-Young
    • Journal of Preventive Medicine and Public Health
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    • v.42 no.5
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    • pp.337-342
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    • 2009
  • Background : Many previous studies have shown that elevated homocysteine in the serum is a well known risk factor for cardiovascular disease and this is associated with other risk factors for cardiovascular disease, but any Korean data on this is limited. Objectives : This study aimed to calculate the prevalence of hyperhomocysteinemia and to analyze the relation between elevated homocysteine and the lifestyle factors of Korean adults. Methods : We conducted a cross-sectional survey that included 650 men and 743 women (age range, 20 to 79 years) who were residents of Gwangju City in Gyeonggi-do. These subjects participated in the health interview and examination survey from November to December 2005. The total homocysteine, total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride in the serum were measured. All the participants had their body composition measured such as height and weight, and we obtained health-related behavioral information through the self-entry questionnaire. Results : Very right-handed skewed distributions of homocysteine were shown in men and women. The prevalence of hyperhomocysteinemia was 22.6% in men and 13.7% in women in Gwangju city. On the multiple logistic regression analysis, hyperhomocysteinemia was associated with age (OR=1.02, 95% CI=1.01-1.04), male gender (OR=1.60, 95% CI=1.02-2.52), severe general physical activity (OR=0.32, 95% CI=0.15-0.69) and nutrient consumption (OR=0.49, 95% CI=0.31-0.76). Conclusions : There is a great prevalence of hyperhomocysteinemia in adults of Gwangju City, Korea and it was associated with both genetic factors and lifestyle risk factors. This study can suggest that comprehensive lifestyle modification is needed in order to diminish the prevalence of hyperhomocysteinemia and to prevent CVD.

Study on the Introducing of the Certificates for the Business Incubating Managers (BI 전문자격증 제도 개발 및 운영방안)

  • Kim, Hong;Chang, Seog-Ju;Ha, Kyu-Soo;Yoon, Byung-Seop
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.2 no.2
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    • pp.121-155
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    • 2007
  • This paper was based on the answers of the BI(Business Incubating) managers who had been working in the business incubating field. The main purpose of this research was to figure out working conditions of those managers and to find out proper solutions. The result of the research was as follows. Overall economic rewards for those managers were relatively low level, job conditions for those managers were short-time contract-basis and those managers' ages were relatively young, 20s or 30s, and majority of the managers' working experience was usually less than 3years. Also some of the full-time managers were spending much of their working time in administration affairs rather than practical business incubating or business incubating consulting service. Therefore, the satisfaction level for their salary and working condition was quite unsatisfactory and they didn't have positive vision for their job and for their business consulting service. As a result to resolve those negative affects and to promote overall working for those BI managers, authorized certificates are necessary for those BI managers. Then they can specialize BI managing works and can improve their working conditions by blocking non -certified workers and can advance the quality of their consulting service.

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Analysis on contents and types of Web-based Multimeida Learning Materials for Environmental Education (웹 기반 멀티미디어 환경 교육 교수·학습 자료의 내용 및 유형 분석)

  • Cha, Min-Jung;So, Keum-Hyun;Shim, Kew-Cheol;Yeau, Sung-Hee
    • Journal of Science Education
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    • v.34 no.1
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    • pp.84-92
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    • 2010
  • We analyzed learning materials from web sites of the Ministry of Environments, the Ministry of Land, Transport and Maritime Affairs and Korea Energy Management Corporation to help people to develop and utilize web-based multimedia teaching materials. The contents of web-based multimedia teaching materials for environmental educations were generally concentrated in 304 cases of natural environments (22.1%), 250 cases of environmental contaminations (16.5%) and 187 cases of environmental preservation plans (12.4%). It did not significantly deviate from traditional teaching-learning contents being conducted focusing on environmental pollutions of the past. The types of web-based multimedia teaching materials for environmental educations were 934 cases of teaching plans (61.8%), 156 cases of documentaries (10.3%) and 128 cases of e-text information (8.5%). The web-based multimedia teaching materials by school-levels showed that there were 796 for primary schools (35.3%), 588 for middle schools (26.1%) and 320 for high schools (14.2%). It also showed that environmental education with similar contents were provided even in advanced schools. Therefore, it is believed that there needs development of various types of teaching materials while the fields of environmental education contents are covered with connectivity according to school-levels.

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Analysis of Characteristics of Scientific Inquiry Problem Finding Process in Small Group Free Inquiry (소집단 자유 탐구에서 과학적 탐구 문제 발견 과정의 특징 분석)

  • Cheon, Myeongki;Lee, Bongwoo
    • Journal of The Korean Association For Science Education
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    • v.38 no.6
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    • pp.865-874
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    • 2018
  • The purpose of this study is to explore the process of inquiry problem finding in high school students' small group free-inquiry. For this purpose, 91 second grade high school students took part in small group free-inquiry. We conducted interviews with students (48 students in 15 groups) who were relatively successful in the inquiry performed for one semester (about 4 months). Based on the results of the interviews, we analyzed the characteristics of the inquiry problem finding through the steps and strategies in the inquiry problem finding process. The main results are as follows: First, in the inquiry problem finding process, steps such as selecting keyword, presenting an inconvenience, presenting a question, and finding an inquiry problem were found, and in particular, the process of selecting the keyword that correspond to the subject of inquiry, such as the material and situation of inquiry, is very important step in inquiry problem finding. Second, the strategies that students used in the process of finding inquiry problem included searching information, review of prior research, sharing of knowledge and experience, linking and extension of knowledge and experience, environmental awareness, expert consultation, discussion of suitability, elaboration, etc. Third, finding an inquiry problem was relatively easy in the inquiry for finding out problems (i.e. inconvenience) in everyday life and investigating ways to solve them. Fourth, the review of prior researches through the internet was useful in the process of selecting keyword and elaboration. Fifth, the factors that students consider when selecting one of several candidate inquiry problems are feasibility, real-life applicability, and economic condition. Sixth, the current affairs had a positive impact on the inquiry problem finding. Based on the above results, we discussed some ways to increase students' inquiry problem finding ability.

The Study of Documentaries' 'Rhetoric' as a Statement on Social Issues: Focused on EBS-TV (사회적 쟁점에 대한 발언으로서 다큐멘터리의 수사학 연구: EBS-TV <지식채널(e)>를 중심으로)

  • Kim, Nam-Il;Lee, Gyu-Jeong
    • Korean journal of communication and information
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    • v.53
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    • pp.53-72
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    • 2011
  • has become the representative program of EBS after first airing in 2004. After seeing as a media text, this study was fulfilled on the basis of Bill Nichols' "Rhetoric" discussion, in order to analyze the structural method and social meaning of the program. As a result of the study, we were first able to see that was taking form as a documentary to make a constructive statement on current affairs related to Korean society, by mobilizing 'knowledge' related to these issues. Second, the "rhetoric" plays an important role in the program's process to generate meaning, and despite the text being relatively short, the rhetorical process undergone for the generation of meaning has been fully reflected. Moreover, the program was successfully structuring a new method of generating meaning by enthusiastically raising questions and choosing a unique method of vision mix. Third, by looking at the study's results in-depth, we can see that was creating a ideological place for open discussion, which was providing viewers with the satisfaction of overcoming our society's dominating ideology and forming new ones. In that sense, the easily accessible 'knowledge'that surrounds us holds somewhat of a political meaning. On top of that, it can be seen that the program especially, is a media text that holds a cultural political meaning, which is an important factor to consider in the Korean broadcasting industry. In conclusion, we found out that this program uses 'knowledge' to see the possibility of 'knowledge'journalism by making constructive statements through a 'rhetorical' process.

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Legal issues of obtaining informed consent in pharmaceutical clinical trial as human material research : Focusing on the use of statutory form (인체유래물연구에 해당되는 의약품임상시험에서 동의 획득 기준의 법적 문제: <인체유래물연구동의서> 법정 서식의 사용을 중심으로)

  • Yoo, Sujung;Kim, Eunae
    • The Journal of KAIRB
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    • v.1 no.2
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    • pp.30-42
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    • 2019
  • In pharmaceutical clinical trials as human material research, the collection, use, storage and provision of human materials must be in accordance with the criteria stipulated in 「Bioethics and Safety Act」, except in the case that some criteria about it is in the law related to clinical trials such as 「Pharmaceutical Affairs Act」 and 「Enforcement Rule on Safety of Drugs, etc.」 so these take precedence over. Under 「Bioethics and Safety Act」, the core aspect of the legal standard for obtaining informed consent is the use of statutory form . The use of statutory form ensure that both those who obtain informed consent and those who give it can know the contents contained this form as well as recognize its importance. Thus, the person who has the right to informed consent can sign the statutory form after correct understanding of the contents. In reality, however, some researchers and IRB members determine that only the main informed consent form is to be used because most of contents on statutory from are included in the main informed consent form. Some other researchers and IRB members judge that the use of statutory form is not needed if human materials may only be used for laboratory testing and the rest will not be stored and provided for future use. Most of these determination and judgement is based on the interpretation of the Korea National Institute for Bioethics Policy(hereafter, KoNIBP) on IRB Information Portal Site. But, it is questionable whether the KoNIBP's interpretation is legally valid and the KoNIBP is the legal entity having authority to interpret existing statute. In some cased not only using the main informed consent form including enough information about the collection, use, storage and provision of human materials but also collecting necessary minimum human materials, and discarding the rest, unusing the statutory form may not cause the problem to respect and protect the research participant's rights. Therefore, the provision stipulating the criteria about the use of statutory form as the legal standard of obtaining informed consent that applies all human material research without exception should review to revise. At least, straighten out the confusion surrounding whether or not the statutory form is to be used, before the revision of related provision, considering the logical opinions of some researchers and IRB Members, the Ministry of Health and Welfare as the legal entity having authority to interpret existing statute should represent its opinion about permission of the acceptable exceptions.

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