Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Prevalence of Hyperhomocysteinemia and Related Factors in a Community-based Health Examination Survey: A Cross-sectional Study

경기도 일개 지역사회 대표집단에서 고호모시스테인혈증의 유병률 및 관련요인에 대한 단면조사연구

  • Kim, Soo-Jeong (Institute of Human Genomic Study, Korea University Medical Center Ansan Hospital, Management for Health Promotion) ;
  • Lim, Kyung-Sook (Korea Institute for Health and Social Affairs) ;
  • Song, Mi-Sook (College of Nursing, Ajou University) ;
  • Kang, Yeon-Ji (Department of Preventive Medicine, Ajou University School of Medicine) ;
  • Lee, Soon-Young (Department of Preventive Medicine, Ajou University School of Medicine)
  • 김수정 (고려대학교 의료원 안산병원 인간유전체연구소) ;
  • 임경숙 (한국보건사회연구원 건강증진사업지원단) ;
  • 송미숙 (아주대학교 간호학과) ;
  • 강연지 (아주대학교 의과대학 예방의학교실) ;
  • 이순영 (아주대학교 의과대학 예방의학교실)
  • Published : 2009.09.30
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Abstract

Background : Many previous studies have shown that elevated homocysteine in the serum is a well known risk factor for cardiovascular disease and this is associated with other risk factors for cardiovascular disease, but any Korean data on this is limited. Objectives : This study aimed to calculate the prevalence of hyperhomocysteinemia and to analyze the relation between elevated homocysteine and the lifestyle factors of Korean adults. Methods : We conducted a cross-sectional survey that included 650 men and 743 women (age range, 20 to 79 years) who were residents of Gwangju City in Gyeonggi-do. These subjects participated in the health interview and examination survey from November to December 2005. The total homocysteine, total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride in the serum were measured. All the participants had their body composition measured such as height and weight, and we obtained health-related behavioral information through the self-entry questionnaire. Results : Very right-handed skewed distributions of homocysteine were shown in men and women. The prevalence of hyperhomocysteinemia was 22.6% in men and 13.7% in women in Gwangju city. On the multiple logistic regression analysis, hyperhomocysteinemia was associated with age (OR=1.02, 95% CI=1.01-1.04), male gender (OR=1.60, 95% CI=1.02-2.52), severe general physical activity (OR=0.32, 95% CI=0.15-0.69) and nutrient consumption (OR=0.49, 95% CI=0.31-0.76). Conclusions : There is a great prevalence of hyperhomocysteinemia in adults of Gwangju City, Korea and it was associated with both genetic factors and lifestyle risk factors. This study can suggest that comprehensive lifestyle modification is needed in order to diminish the prevalence of hyperhomocysteinemia and to prevent CVD.

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