• Nutrition Research and Practice
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• v.13 no.5
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• pp.399-409
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• 2019

BACKGROUND/OBJECTIVES: This study was designed to provide scientific evidence on the effectiveness of worksite-based dietary intervention to reduce obesity among overweight/obese employees. MATERIALS/METHODS: Electronic search was performed using Ovid Medline, Embase, Cochrane Library, and CINAHL databases. The keywords used were "obesity," "nutrition therapy," and "worksite." The internal validity of the randomized controlled trials (RCTs) was assessed using the Cochrane's Risk of Bias. Meta-analysis of selected studies was performed using Review Manager 5.3. RESULTS: A total of seven RCTs with 2,854 participants were identified. The effectiveness of dietary interventions was analyzed in terms of changes in weight, body mass index (BMI), total cholesterol, and blood pressure. The results showed that weight decreased with weighted mean difference (WMD) of -4.37 (95% confidence interval (CI): -6.54 to -2.20), but the effectiveness was statistically significant only in short-term programs < 6 months (P = 0.001). BMI also decreased with WMD of -1.26 (95% CI: -1.98 to -0.55), but the effectiveness was statistically significant only in short-term programs < 6 months (P = 0.001). Total cholesterol decreased with WMD of -5.57 (95% CI: -9.07 to -2.07) mg/dL, demonstrating significant effectiveness (P = 0.002). Both systolic (WMD: -4.90 mmHg) and diastolic (WMD: -2.88 mmHg) blood pressure decreased, demonstrating effectiveness, but with no statistical significance. CONCLUSIONS: The worksite-based dietary interventions for overweight/obese employees showed modest short-term effects. These interventions can be considered successful because weight loss was below approximately 5-10 kg of the initial body weight, which is the threshold for the management of obesity recommended by the Scottish Intercollegiate Guideline Network (SIGN).

• Journal of the Korea Institute of Information Security & Cryptology
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• v.17 no.6
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• pp.29-39
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• 2007

RSA is one of the most popular public-key crypto-system in various applications. This paper addresses a high-speed RSA crypto-processor with modified radix-4 modular multiplication algorithm and Chinese Remainder Theorem(CRT) using Carry Save Adder(CSA). Our design takes 0.84M clock cycles for a 1024-bit modular exponentiation and 0.25M cycles for a 512-bit exponentiations. With 0.18um standard cell library, the processor achieves 365Kbps for a 1024-bit exponentiation and 1,233Kbps for two 512-bit exponentiations at a 300MHz clock rate.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.23 no.12
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• pp.1609-1617
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• 2019

Described in this paper is a design of hardware accelerator for implementing public-key cryptographic protocols (PKCPs) based on Elliptic Curve Cryptography (ECC) and RSA. It supports five elliptic curves (ECs) over GF(p) and three key lengths of RSA that are defined by NIST standard. It was designed to support four point operations over ECs and six modular arithmetic operations, making it suitable for hardware implementation of ECC- and RSA-based PKCPs. In order to achieve small-area implementation, a finite field arithmetic circuit was designed with 32-bit data-path, and it adopted word-based Montgomery multiplication algorithm, the Jacobian coordinate system for EC point operations, and the Fermat's little theorem for modular multiplicative inverse. The hardware operation was verified with FPGA device by implementing EC-DH key exchange protocol and RSA operations. It occupied 20,800 gate equivalents and 28 kbits of RAM at 50 MHz clock frequency with 180-nm CMOS cell library, and 1,503 slices and 2 BRAMs in Virtex-5 FPGA device.

• Journal of the Korean Society for information Management
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• v.39 no.4
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• pp.1-21
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• 2022

The aim of this study is to identify the research topics and suggest an information literacy curriculum by analyzing research articles on information literacy. For this purpose, we applied the topic modeling technique to 97 scientific articles and identified the core contents of information literacy education, such as media literacy, information literacy instruction, and the use of information resources. Based on the analysis results, we suggested an information literacy curriculum by considering the Big 6 model, information literacy standards of American Association of School Library, and Association of College and Research Libraries's information literacy competencies. This study is significant in that it considered 'use of information resources' and 'information ethics' to suggest information literacy education.

• Restorative Dentistry and Endodontics
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• v.47 no.2
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• pp.15.1-15.18
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• 2022

This review aimed to characterize the effect of direct restorative material types and adhesive protocols on marginal adaptation and the bond strength of the interface between the material and the proximal dentin/cementum. An electronic search of 3 databases (the National Library of Medicine [MEDLINE/PubMed], Scopus, and ScienceDirect) was conducted. Studies were included if they evaluated marginal adaptation or bond strength tests for proximal restorations under the cementoenamel junction. Only 16 studies met the inclusion criteria and were included in this review. These studies presented a high degree of heterogeneity in terms of the materials used and the methodologies and evaluation criteria of each test; therefore, only a descriptive analysis could be conducted. The included studies were individually evaluated for the risk of bias following predetermined criteria. To summarize the results of the included studies, the type of restorative material affected the test results, whereas the use of different adhesive protocols had an insignificant effect on the results. It could be concluded that various categories of resin-based composites could be a suitable choice for clinicians to elevate proximal dentin/cementum margins, rather than the open sandwich technique with resin-modified glass ionomers. Despite challenges in bonding to proximal dentin/cementum margins, different adhesive protocols provided comparable outcomes.

• Biomolecules & Therapeutics
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• v.32 no.3
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• pp.390-398
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• 2024

FoxO1, a member of the Forkhead transcription factor family subgroup O (FoxO), is expressed in a range of cell types and is crucial for various pathophysiological processes, such as apoptosis and inflammation. While FoxO1's roles in multiple diseases have been recognized, the target has remained largely unexplored due to the absence of cost-effective and efficient inhibitors. Therefore, there is a need for natural FoxO1 inhibitors with minimal adverse effects. In this study, docking, MMGBSA, and ADMET analyses were performed to identify natural compounds that exhibit strong binding affinity to FoxO1. The top candidates were then subjected to molecular dynamics (MD) simulations. A natural product library was screened for interaction with FoxO1 (PDB ID-3CO6) using the Glide module of the Schrödinger suite. In silico ADMET profiling was conducted using SwissADME and pkCSM web servers. Binding free energies of the selected compounds were assessed with the Prime-MMGBSA module, while the dynamics of the top hits were analyzed using the Desmond module of the Schrödinger suite. Several natural products demonstrated high docking scores with FoxO1, indicating their potential as FoxO1 inhibitors. Specifically, the docking scores of neochlorogenic acid and fraxin were both below -6.0. These compounds also exhibit favorable drug-like properties, and a 25 ns MD study revealed a stable interaction between fraxin and FoxO1. Our findings highlight the potential of various natural products, particularly fraxin, as effective FoxO1 inhibitors with strong binding affinity, dynamic stability, and suitable ADMET profiles.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.17 no.3
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• pp.160-180
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• 2012

We have studied the eukaryotic plankton species diversity to compare the community structure of fresh and brackish waters in the lower reaches of the Nakdong River using metagenomic methods. We constructed 18S rDNA clone libraries of total DNAs extracted from environmental water samples collected at Mulgeum (MG100929, fresh) and Eulsukdo bridge (ES, brackish). Through the steps of colony PCR, PCR-RFLP, sequencing and similarity analysis, we discovered the diverse species composition of eukaryotic plankton. Total 338 clones (170 at MG100929 and 168 at ES) were analyzed, and then we found 74 phylotypes (49 for MG100929 and 25 for ES). From the phylogenetic analysis, we confirmed various eukaryotic plankton of broad range of taxonomic groups, including Stramenopiles, Cryptophyta, Viridiplantae, Alveolata, Rhizaria, Metazoa, and Fungi. We also found several unreported species in Korea and candidates of new taxonomic entities at levels higher than genus. Especially, the cryptic species diversity including unreported phylotypes of Pirsonia (Stramenopiles) and Perkinsea (Alveolata) suggests that the molecular monitoring method can produce new informative biological data in monitoring the changes in the Nakdong River Mouth ecosystem.

• The Korean Journal of Archival Studies
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• no.7
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• pp.37-74
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• 2003

An Old document(Diploma) is a historical and unique record, so it must be collected, arranged, and preserved for research as soon as possible. Especially, for the effective use of the Old Document(Diploma), it is needed to arrange and describe the material systematically on the ground of modern archival theory. The Kyujanggak Archives in the Seoul National University has published 23 volumes of Old document(Diploma) material Old Document(Diploma). But they seem to cause the readers inconvenience, because the materials are classified and gathered only by genre, the titles or the orders of the materials are not standardized, and there is no description about the content of each Old document(Diploma). Jangseo-gak Library in The Academy of Korean Studies has also published the series of Old document(Diploma) material Old Document(Diploma) Collection. However the case is not different, since they are all mixed up with materials classified and gathered by genre, family, academy, or local school. And a great part of the materials have no titles and no description about the content of each Old document(Diploma), either. About the arrangement and description of the records, European and American archival science has established the theory of l)the principle of provenance, 2)the principle of original order, 3)levels of control, 4)collective description. These theories are valuable for the effective use of Old document(Diploma). On the viewpoint of the principle of provenance, Old document(Diploma) materials should not be classified by subject and genre, but by family and person. Then, the Old document(Diploma) materials, after collected by the unit of family or person on the viewpoint of the principle of provenance, should be arranged in their original order for more detailed arrangement and furthermore, for the work to find their relationship. This is so called the principle of original order. The hierarchical management of the Old document(Diploma) materials, for example, classifying by record group, sub-group, series, item and so on, is the concept of the levels of control, and comprehensive description of the each hierarchical structure is the concept of the collective description. Let's apply these archival theories to 34 pieces of the Chung, Man-Seok's material in the series of Old document(Diploma) material Old Document(Diploma). First, collect the Old document(Diploma) materials into Chung, Man-Seok's collection(the principle of provenance), which were scattered in the series classified by genre. Secondly, rearrange them chronologically(the principle of original order), and then we can find the comprehensive information about Chung, Man-Seok. For the hierarchical management of the Old document(Diploma) materials, we should establish a few concepts from the general, large group to specific, small item. The concepts can be organized as following; l)record group(Chung, Man-Seok record group) - 2)sub-group(personnel document, property document, family document, social activity document, political activity document, etc) - 3)series(gyoji-series, gyoseo-series, yuji-series etc. in the personnel document) - 4)folder(document with additions) - 5)item(one document). According to the the theory of the collective description, in the level of record group, there should be a collective description of Chung, Man-Seok's biography or a summary of record group. Similarly, there should be a collective description of a summary of sub-group in the level of sub-group and a summary of series in the level of series.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.18
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• pp.8653-8658
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• 2016

Background: Heparanase is believed to be involved in gastric carcinogenesis. However, the clinicopathologic features of gastric cancer with high heparanase expression remain unclear. Aim : The purpose of this study was to comprehensively and quantitatively summarize available evidence for the use of heparanase mRNA and protein expression to evaluate the clinicopathological associations in gastric cancer in Asian patients by meta-analysis. Materials and Methods: Relevant articles listed in MEDLINE, CNKI and the Cochrane Library databases up to MARCH 2015 were searched by use of several keywords in electronic databases. A meta-analysis was performed to clarify the impact of heparanase mRNA and protein on clinicopathological parameters in gastric cancer. Combined ORs with 95%CIs were calculated by Revman 5.0, and publication bias testing was performed by stata12.0. Results: A total of 27 studies which included 3,891 gastric cancer patients were combined in the final analysis. When stratifying the studies by the pathological variables of heparanase mRNA expression, the depth of invasion (633 patients) (OR=4.96; 95% CI=2.38-1.37; P<0.0001), lymph node metastasis (639 patients) (OR=6.22; 95%CI=2.70-14.34, P<0.0001), and lymph node metastasis (383 patients) (OR=6.85; 95% CI=2.04-23.04; P=0.002) were all significant. When stratifying the studies by the pathological variables of heparanase protein expression, this was the case for depth of invasion (1250 patients) (OR=2.76; 95% CI=1.52-5.03; P=0.0009), lymph node metastasis (1178 patients) (OR=4.79 ; 95% CI=3.37-6.80, P<0.00001), tumor size (727 patients) (OR=2.06 ; 95% CI=1.31-3.23; P=0.002) (OR=2.61; 95% CI=2.09-3.27; P=0.000), and TNM stage (1233 patients) (OR=6.85; 95% CI=2.04-23.04; P=0.002). Egger's tests suggested publication bias for depth of invasion, lymph node metastasis, lymph node metastasis and tumor size of heparanase mRNA and protein expression. Conclusions: This meta-analysis suggests that higher heparanase expression in gastric cancer is associated with clinicopathologic features of depth of invasion, lymph node metastasis and TNM stage at mRNA and protein levels, and of tumor size only at the protein level. Egger's tests suggested publication bias for these clinicopathologic features of heparanase mRNA and protein expression, and which may be caused by shortage of relevant studies. As a result, although abundant reports showed heparanase may be associated with clinicopathologic features in gastric cancer, this meta-analysis indicates that more strict studies were needed to evaluate its clinicopathologic significance.

• Korean Journal of Social Welfare
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• v.57 no.4
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• pp.147-175
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• 2005

Efforts to identify the public's perception of social welfare as an academic discipline have never been conducted in Korea since the establishment of social welfare department in 1947 at Ewha Womans University. Such efforts are very meaningful in identifying directions and tasks to strengthen Korean social welfare as well as in clarifying and promoting our understanding concerning status of the academic discipline. This study attempts to explore and describe the degree of the public's perception in Korea with analyzing data surveyed in 2004 by our interdisciplinary research team. This study develops and uses a questionnaire having a Likert scale format that is composed of 8 points and measures the public's perception in the following dimensions: (1) personal interests on academic discipline; (2) contribution of academic discipline; (3) prospect of academic discipline; (4) importance of academic discipline; (5) expertise of academic discipline; and (6) personal knowledge on academic discipline. To avoid social desirability and promote objectivity with comparative measurement, this study selects ten representative academic disciplines as follows: medicine; physics; biology; social welfare; economics; psychology; sociology; political science; library science; and communication & journalism. This study attempts to identify (1) the degree of the public's perception on ten academic disciplines; (2) the position of social welfare by comparing it with each academic discipline and by comparing mean of social welfare with overall mean of six social science disciplines in the six dimensions; (3) the differences in the public's perceptions of social welfare on six dimensions by the respondents' status factor(high school students, college and graduate students, and citizens) and gender factor by using MANCOVA, and (4) the differences in the public's perceptions of social welfare on six dimensions by major factor(social welfare, social science majors, and natural science majors) and gender factor of college and graduate school students by using MANCOVA. The results of data analysis are as follows: (1) while the 3,319 respondents gave relatively high rating on natural sciences in the dimensions of contribution and expertise, they did the same on social sciences in the dimensions of personal interests and personal knowledge; (2) in overall comparisons, while the 3,319 respondents gave relatively high rating on social welfare in the dimensions of contribution, prospect and importance, they gave the lowest rating on the expertise of social welfare; (3) in the comparisons with social science disciplines, while the 3,319 respondents gave relatively high rating on social welfare in the dimensions of contribution, prospect and importance, they gave the lowest rating on the expertise of social welfare; (4) when analyzing all the respondents, there were differences in the vector of personal interests, contribution, prospect, importance, expertise, and personal knowledge by status factor, gender factor, and interaction effect factor; and (5) when analyzing only the respondents in college and graduate schools, there were differences in the vector of personal interests, contribution, prospect, importance, expertise, and personal knowledge by only major factor and gender factor. The results provide empirical backgrounds for discussing current image, status and major characteristics of social welfare as a discipline in Korea. Indeed, this study provides new meaningful and thoughtful guide for further investigation on the topic. In addition, contributing to clarifying and broadening our understandings about the public's perception on social welfare in Korea, this study discusses the tasks for dealing with expertise issue that is the most vulnerable issue of Korean social welfare discipline and research directions to strengthen and promote social welfare discipline in Korea.