• Knowledge Management Research
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• v.23 no.4
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• pp.207-231
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• 2022

The purpose of this study is to identify the relationship between PJF(person-job fit) and members' organizational commitment focusing on the mediating factor. Previous Studies have found that person-job fit has positive effect on organizational commitment, and self-efficacy has positive effect on the organizational commitment. On the other hand, the studies to identify whether self-efficacy has a role in mediation between PJF and the members' organizational commitment has been insufficient. To that end, we considered self-efficacy as the mediator of the relationship between PJF and organizational commitment. We used the data which to perform national policy research from 690 workers at a small or medium firm. As a result of verifying the suitability of the research model, it was suitable for the acceptance criteria. Besides the hierarchical regression analysis, bootstrapping was conducted to verify significance of mediating effect of self-efficacy. The main results are as follows. First, the variables, PJF, self-efficacy and organizational commitment showed a positive correlation. Second, PJF has a positive effect on self-efficacy and organizational commitment significantly. Also self-efficacy has a positive effect on organizational commitment significantly. Third, the mediating effect of self-efficacy in the relationship between PJF and organizational commitment is significant. In order to improve person-job fit, this study suggested that SMEs' owners should consider job rotation system and career development program for employees. Based on this study result and implications, we discussed limit of research and direction for future research.

• CELLMED
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• v.8 no.2
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• pp.8.1-8.5
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• 2018

Nitric oxide (NO) is a small diffusible molecule which plays an important role in various physiological activities. NO is a notable molecule, functioning as a cytotoxic agent and cellular messenger. There has been considerable interest in NO production by activated macrophages because this gaseous metabolite plays a fundamental role in the cytotoxic and cytostatic effects of macrophages towards invasive micro-organisms and tumour cells. No is a bioactive free radical that has been implicated in many physiological functions, plays a critical role during inflammation and therefore constitutes a potential target for developing therapeutics for inflammatory diseases. The use of medicinal plants by the population has been an important alternative the resource in the treatment of various diseases. Its growing acceptance in the medical community has been due to the fact that several plants with biological activities have been scientifically investigated and their efficacy and safety have been proven. In this review, discussed suppressive effects of No production by traditional medicines in RAW 264.7 and THP-1 macrophages.

• Korean Journal of Biological Psychiatry
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• v.4 no.2
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• pp.179-187
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• 1997

The clinical efficacy of serotonin reuptake inhibitors such as clomipramine in the treatment of obsessive compulsive disorder(OCD) has fueled interest in the neurobiological basis of this illness. OCD is responsive exclucively to potent serotonin reuptake inhibitors clomipramine, fluoxetine, fluvoxamine, sertraline, and paroxetine and this point forms the important evidence supporting a cental role for serotonin in the pathogenesis of the disorder. Other serotonergic medications such as lithium, buspirone, trazodone, or fenfluramine may be useful as adjuvant treatments in treatmentrefractory OCD and adjuvant antipsychotics are useful in tic disorders, personality disorders, and psychotic disorders. This paper reviews results of treatment studies, investigations of biological markers, and neuroendocrine challenges and implications for the role of serotonin in pathophysiology and treatment of OCD.

• The Korean Journal of Nuclear Medicine
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• v.32 no.3
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• pp.211-224
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• 1998

The role of scintigraphic imaging has moved from the detection of lesions to the tissue-specific characterization of lesions over the past 2 decades. Major advances in nuclear medicine imaging include: 1) positron imaging, 2) improved instrumentation, such as the use of multidetector (dual or triple head) gamma cameras for single photon emission computed tomography, and 3) development of numerous new radiopharmaceuticals for positron or single photon imaging (labeled glucose analogue, amino acids, fatty acids, hormones, drugs, receptor ligands, monoclonal antibodies, etc). These advances have resulted in a significantly improved efficacy of radionuclide techniques for the evaluation of various tumors, including those within the liver. The current role of nuclear medicine in the evaluation of focal hepatic tumors is reviewed in this article with an emphasis on the clinical applications of various tracer studies and imaging findings.

• Journal of the Korea Society of Computer and Information
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• v.24 no.9
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• pp.97-102
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• 2019

Several studies have recently demonstrated that skeletal muscle is an endocrine organ releasing and expressing myokines acting in an endocrine or paracrine manner. Irisin is a hormene-like myokine induced after physical exercise by muscle fibers. It was primarily recognized as a molecule able to advance the "browning response" in white adipose tissue, however, it has been recetly identified that irisin also has a fundamental role in the control of bone mass. We study evidence for its possible skeletal effects, including the fundamental role that irisin is involved in the control of bone mass, with beneficial effects on geometry and cortical mineral density. As loss of muscle mass and bone density occurs with immobility, metabolic disease and aging, future studies researching the efficacy of irisin in reversing muscle wasting and restoring bone would be important to proving irisin as a molecule that combines helpful effects for treating muscular atrophy and osteoporosis in elderly people.

• Childhood Kidney Diseases
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• v.27 no.1
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• pp.1-10
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• 2023

Pediatric nephrotic syndrome (NS) is a clinical syndrome characterized by massive proteinuria, hypoalbuminemia, and generalized edema. Most childhood NS cases are idiopathic (with an unknown etiology). Traditional therapeutic approaches based on immunosuppressive agents largely support the key role of the immune system in idiopathic NS (INS), especially in the steroid-sensitive form. Although most previous studies have suggested the main role of T cell dysfunction and/or the abnormal secretion of certain glomerular permeability factors, recent studies have emphasized the role of B cells since the therapeutic efficacy of B cell depletion therapy in inducing and/or maintaining prolonged remission in patients with INS was confirmed. Furthermore, several studies have detected circulating autoantibodies that target podocyte proteins in a subset of patients with INS, suggesting an autoimmune-mediated etiology of INS. Accordingly, a new therapeutic modality using B cell-depleting drugs has been attempted, with significant effects in a subset of patients with INS. Currently, INS is considered an immune-mediated disorder caused by a complex interplay between T cells, B cells, soluble factors, and podocytes, which may vary among patients. More in-depth investigations of the pathogenic pathways of INS are required for an effective personalized therapeutic approach and to define precise targets for therapeutic intervention.

• Journal of Digital Convergence
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• v.18 no.10
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• pp.41-50
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• 2020

This study is about entrepreneurial intention of baby boomers who started retirement, starting with the second phase of life. A research model was constructed focusing on factors that will affect the entrepreneurial intention of baby boomers. In order to test the study model, a questionnaire was surveyed on baby boomers, and among them, 204 people, which was valid, was used for analysis. The hypothesis test was a structural equation model using the AMOS 23 statistical package. As a result of the hypothesis test, self-efficacy and social capital had a positive (+) relationship with entrepreneurial intention. Economic preparation was found to have a significant negative (-) relationship with entrepreneurial intention. Social capital was found to have the most influence on baby boomers' entrepreneurial intention. On the other hand, achievement experience and role model learning experience were the antecedent variables affecting self-efficacy. As a result of testing their relationship, achievement experience and role model learning experience had a significant positive (+) influence on self-efficacy. Based on the research results, academic and practical implications were presented.

• Korea Journal of Hospital Management
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• v.29 no.1
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• pp.32-45
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• 2024

Purpose: This study was performed to determine whether positive psychological capital and role conflict among hospital nurses influence patient safety competencies. Methods: Data were collected from nurses working at one hospital with more than 800 beds in J Province. Data were analyzed using descriptive statistics, t-test, ANOVA, Scheffé's test, Pearson's correlation analysis and hierarchical regression analysis using SPSS 26.0 program. Findings: In the hierarchical regression analysis, positive psychological capital, role conflict, bachelor's degree or higher as the highest level of education achieved, and three or more experiences reporting accidents impacting patient safety were found to significantly correlate with subjects patient safety competency. Among these, positive psychological capital emerged as the strongest factor, and the explanatory power of Model 4 was determined to be 38.1%. Conclusion: This study confirmed that hospital nurses' positive psychological capital and role conflict impact patient safety competency, underscoring the importance of organizational measures to increase patient safety awareness. Therefore, it is necessary to develop an educational program to strengthen hospital nurses' patient safety capabilities and conduct follow-up research to test its efficacy.

• Human Ecology Research
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• v.58 no.4
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• pp.539-560
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• 2020

This study presents work-family multiple-role planning by female university students as a new approach to worklife balance. Accordingly, this study examines university years as a key time frame during which students establish their career paths. This study integrates the social cognitive career theory and the planned behavior theory to design and evaluate a model that explains the work-family multiple-role planning process; in addition, it develops an optimal model to predict the intentions of female university students in work-family multiple-role planning. This study has conducted a structural survey with 500 female university students. After inspecting the data, the responses of 435 participants were used in the data analysis (SEM) with SPSS 21.0 and AMOS 21.0. The findings include the following. First, suitability of predictive model presents a satisfying fit. The major factors in this study's model (parental support, subjective norms, attitudes toward multiple-role planning, career decision self-efficacy, and outcome expectations) are verified as direct and indirect predictors of the work-family multiple-role planning intent of female university students. Second, the strongest predictive factor for the work-family multiple-role planning intent is the social environment factor (subjective norms), indicating that the influence of social pressure on intent is relatively large. The predictive model formulated under this study's integrated theoretical framework supplements existing research that focused on attitudes toward multiple-role planning as well as provides a more profound theoretical foundation on which work-family multiple-role planning behaviors can be better understood.

• Journal of Convergence for Information Technology
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• v.10 no.4
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• pp.115-123
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• 2020

The purpose of this study is to investigate how paid work affects self-efficacy and interpersonal relationships among the poor elderly. In addition, this study analyzes to measure the psychological and social effectiveness that can be obtained through paid work in poor life. This survey was conducted for poor elderly people in Seoul and Gyeonggi-do on the assumption that the quality of paid work would positive affect the interpersonal relationships of the poor elderly, and that the self-efficiency would play a mediating role between the quality of paid work and their interpersonal relations. The final sample of 165 of them was selected and analyzed. As a result of the analysis, the quality of paid work was analyzed to have a significant effect on the interpersonal relationship of the poor elderly, and the mediating effect of self-efficacy was also confirmed. Based on the results of these studies, the need for a policy to improve the quality of paid work for the elderly and practical measures to improve the self-efficacy of the elderly in the social welfare field were proposed.