[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.9708/jksci.2019.24.09.097

The role of myokine Irisin on bone metabolism

Lee, Jin-Wook (Dept. of Exercise Prescription Rehabilitation, Dankook University)
Kim, Chan-Yang (graduate school, Dankook University)

Publication Information

Journal of the Korea Society of Computer and Information / v.24, no.9, 2019 , pp. 97-102 More about this Journal

Abstract

Several studies have recently demonstrated that skeletal muscle is an endocrine organ releasing and expressing myokines acting in an endocrine or paracrine manner. Irisin is a hormene-like myokine induced after physical exercise by muscle fibers. It was primarily recognized as a molecule able to advance the "browning response" in white adipose tissue, however, it has been recetly identified that irisin also has a fundamental role in the control of bone mass. We study evidence for its possible skeletal effects, including the fundamental role that irisin is involved in the control of bone mass, with beneficial effects on geometry and cortical mineral density. As loss of muscle mass and bone density occurs with immobility, metabolic disease and aging, future studies researching the efficacy of irisin in reversing muscle wasting and restoring bone would be important to proving irisin as a molecule that combines helpful effects for treating muscular atrophy and osteoporosis in elderly people.

Keywords

Irisin; bone metabolism; osteocyte; osteoblast; osteoclast;

Citations & Related Records

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