• Journal of Welding and Joining
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• 제15권4호
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• pp.143-153
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• 1997

In this study, bending test was performed on the real-scale, built-up beam test model fabricated by the $CO_2$ arc spot welding to evaluate the applicability of the welding method to the production of the stiffened plate in car-carrying ship. The built-up beam models which were fixed at both ends in longitudinal direction or simply supported to the rigid foundation, depending on the restraint condition of the corresponding car decks considered, were subjected to simulated design vehicle loads or concentrated point loads. During the test, the central deflection and the longitudinal bending stresses were measured from several points on the longitudinal flange face to predict the section properties of the built-up beams. The longitudinal bending stress on each spot weld were also measured to calculate the average horizontal shear force subjected to spot welds. Test results revealed that the shear strength of spot welds with their current weld nugget size and welding pitch was adequate enough to withstand the horizontal shear forces under the design vehicle loads. Although the built-up beam fabricated by the arc spot welding was a discontinuous beam, its mechanical behavior was well explained by the continuous beam theory using the effective breadth of plate. Based on test results, the criterion for the size of spot weld of which the average shear stress might meet the allowable stress requirement of AWS Code could be established.

• Journal of Ginseng Research
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• 제42권1호
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• pp.107-115
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• 2018

Background: Depression is one of the most commonly diagnosed neuropsychiatric diseases, but the underlying mechanism and medicine are not well-known. Although Panax ginseng has been reported to exert protective effects in various neurological studies, little information is available regarding its antidepressant effects. Methods: Here, we examined the antidepressant effect and underlying mechanism of P. ginseng extract (PGE) in a chronic restraint stress (CRS)-induced depression model in mice. Results: Oral administration of PGE for 14 d decreased immobility (depression-like behaviors) time in forced swim and tail suspended tests after CRS induction, which corresponded with attenuation of the levels of serum adrenocorticotropic hormone and corticosterone, as well as attenuated c-Fos expression in the amygdala. PGE enhanced messenger RNA expression level of brain-derived neurotrophic factor but ameliorated microglial activation and neuroinflammation (the level of messenger RNA and protein expression of cyclooxygenase-2 and inducible nitric oxide synthase) in the amygdala of mice after CRS induction. Interestingly, 14-d treatment with celecoxib, a selective cyclooxygenase-2 inhibitor, and $N_{\omega}$-nitro-L-arginine methyl ester hydrochloride, a selective inducible nitric oxide synthase inhibitor, attenuated depression-like behaviors after CRS induction. Additionally, PGE inhibited the upregulation of the nuclear factor erythroid 2 related factor 2 and heme oxygenase-1 pathways. Conclusion: Taken together, our findings suggest that PGE exerts antidepressant-like effect of CRS-induced depression by antineuroinflammatory and antioxidant (nuclear factor erythroid 2 related factor 2/heme oxygenase-1 activation) activities by inhibiting the hypothalamo-pituitary-adrenal axis mechanism. Further studies are needed to evaluate the potential of components of P. ginseng as an alternative treatment of depression, including clinical trial evaluation.

• 동의생리병리학회지
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• 제17권6호
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• pp.1393-1403
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• 2003

The genetic effects of restraint stress challenge on HPA axis and the therapeutic effect of Boshimgeonbi-Tang on the stress were studied with cDNA microarray analyses on hypothalamus using an immobilization-stress mouse as stress model. Male CD-1 mice were restrained in a tightly fitted and ventilated vinyl holder for 2hours once a day, and this challenge was repeated for seven consecutive days. The body weights of the immobilization-stress mice were diminished about 25 percent degree as compared to normal ones. Seven days later, total RNA was extracted from the organs of the mouse, body-labeled with CyDye/sup TM/ fluorescence dyes (Amersham Bioscience Co., NJ), and then hybridized to cDNA microarray chip. Scanning and analyzing the array slides were carried out using GenePix 4000 series scanner and GenePix Pro/sup TM/ analyzing program, respectively. The expression profiles of 109 genes out of 6000 genes on the chip were significantly modulated in hypothalamus by the immobilization stress. Energy metabolism-, lipid metabolism-, apoptosis- and signal transduction-related genes were transcriptionally activated whereas DNA repair-, protein biosynthesis-, and structure integrity-related genes were down-regulated in hypothalamus. The 58 genes were up-regulated by the mRNA expression folds of 1.5 to 7.9. and the 51 genes were down-regulated by 1.5 - 3.5 fold. The 20 genes among them were selected to confirm the expression profiles by RT-PCR. The mRNA expression levels of Tnfrsf1a (apoptosis), Calm2 (cell cycle), Bag3 (apoptosis), Hspe1 (protein folding), Aatk (apoptosis), Dffa (apoptosis), Itgb1 (cell adhesion), Vcam1 (cell adhesion), Fkbp5 (protein folding), BDNF (neuron survival) were restored to the normal one by the treatment of Boshimgeonbi-Tang.

• Journal of Welding and Joining
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• 제17권6호
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• pp.53-61
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• 1999

The use of thick plate in increasing in recent years due to the rapid expansion of chemical plants, nuclear plants, ships and other industrial plants. Welding is the most popular joining techniques employed in manufacturing industrial machineries and structures. Normally, Groove shapes are prepared according to appropriate rules and regulations such as KS, JIS, AWS, LR, DNV and etc. for various thicknesses of plate. However those groove angles tend to be too large. As a result of large groove angle, residual stress, deformation of material and strength reduction is obtained. Therefore, the reliability and safety of structures and machinery tend to be decreasing. Therefore, in this paper, theoretical as well as experimental study are carried out to find optimum groove shapes for T-welded joint of mild steel. The test specimen are made in same condition with simulation model. Welding residual stresses measurement by sectional cutting method. ⅰ) The mechanical difference for change the thickness of plate and groove angle are not appeared. ⅱ) In a mechanical point of view minimum preparation angle(40°) is more suitable than maximum groove angle(60℃). ⅲ) The measurement value and distribution of welding residual stresses are not effected largely by groove angle. It is mechanical restraint that mainly affect welding residual stresses distribution. In mechanical point of view minimum groove angle is more suitable than maximum groove angle. Therefore, it is appropriate to minimize the size of groove shape in strength and safety.

• Korean Journal of Acupuncture
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• 제38권3호
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• pp.162-174
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• 2021

Objectives : We aimed to identify the antidepressant effect of liver tonification acupuncture treatment (ACU (LT); KI10, LR8, LU8, LR4) and four gate acupuncture treatment (ACU (FG); LI4, LR3) and its brain neural activity in the normal and chronic restraint stress (CRS)-induced mouse model. Methods : Firstly, normal mice were given ACU (LT) or ACU (FG) and the c-Fos expressions in each brain region were analyzed to examine brain neural activity. Secondly, CRS was administered to mice for 4 weeks, then ACU (LT) or ACU (FG) was performed for 2 weeks. The depression-like behavior was evaluated using open field test (OFT) before and after acupuncture treatment. Then, the c-Fos expressions in each brain region were analyzed to examine brain neural activity. Results : In normal mice, ACU (FG) regulated brain neural activities in the hypothalamus, hippocampus, and periaqueductal gray. ACU (LT) changed more brain regions in the prefrontal cortex, insular cortex, striatum, and hippocampus, including those altered by ACU (FG). In CRS-induced model, ACU (LT) alleviated depression-like behavior more than ACU (FG). Also, brain neural activities in the motor cortex area 2 (M2), agranular ventral part and piriform of insular cortex (AIV and Pir), and cornu ammonis (CA) 1 and CA3 of hippocampus were changed by ACU (LT), and those of AIV and CA3 were also changed by ACU (FG). As in normal mice, ACU (LT) resulted in changes in more brain regions, including those altered by ACU (FG) in CRS model. M2, Pir, and CA1 were only changed by ACU (LT) in depression model, suggesting that these brain regions reflect the specific effect of ACU (LT). Conclusions : ACU (LT) relieved depression-like behavior more than ACU (FG), and this acupuncture effect was associated with modulation of brain neural activities in the motor cortex, insular cortex, and hippocampus.

• Geomechanics and Engineering
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• 제7권5호
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• pp.495-524
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• 2014

To investigate the soil-pile interactive performance under lateral loads, a set of laboratory model tests was conducted on remoulded test bed of soft clay and medium dense sand. Then, a simplified boundary element analysis had been carried out assuming floating pile. In case of soft clay, it has been observed that lateral loads on piles can initiate the formation of a gap, soil heave and the tension crack in the vicinity of the soil surface and the interface, whereas in medium dense sand, a semi-elliptical depression zone can develop. Comparison of test and boundary element results indicates the accuracy of the solution developed. However, in the boundary element analysis, the possible shear stresses likely to be developed at the interface are ignored in order to simplify the existing complex equations. Moreover, it is unable to capture the influence of base restraint in case of a socketed pile. To bridge up this gap and to study the influence of the initial stress state and interface parameters, a field based case-study of laterally-loaded pile in layered soil with socketed tip is explored and modelled using the finite element method. The results of the model have been verified against known field measurements from a case-study. Parametric studies have been conducted to investigate the influence of the coefficient of lateral earth pressure and the interface strength reduction factor on the results of the model.

• 한국강구조학회 논문집
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• 제29권4호
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• pp.281-289
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• 2017

현재의 AASHTO LRFD 및 Eurocode 3 기준은 수평보강 플레이트거더의 휨강도를 과소 평가하는 것으로 나타났다. 이는 웨브보강으로 인한 웨브-플랜지 상호작용을 적절히 고려치 않는 것에 그 원인이 있다. 즉, 웨브 보강 시 압축플랜지의 회전을 구속하는 효과가 증가하여 압축플랜지의 좌굴강도가 증가한다. 또한 압축플랜지와 수평보강재가 웨브의 회전을 구속함으로써 웨브의 일정 영역이 항복강도에 도달하게 된다. 본 연구에서는 수평보강재로 1단 보강된 플레이트 거더에 대해 압축플랜지의 좌굴강도 증가와 웨브의 실제 응력분포를 고려하여 휨강도를 합리적으로 평가하기 위한 모델을 제안하였다. 일반강(SM490) 및 고강도강(HSB800) 플레이트거더에 대해 비선형해석으로부터 휨강도를 평가하고 본 제안 모델의 적용성을 분석하였다.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2009년도 춘계 학술발표회
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• pp.750-758
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• 2009

This study, as basic research which was intended to develope the surface reinforcement method using reinforcement material which is applicable to very soft ground in Korea, was aimed at proposing the design parameter for the surface ground improvement method. To that end, a wide width tensile test using geotextile, geogrid and steel bar (substitute for bamboo) and 25 kinds of the laboratory model tests with the end restraint conditions of the reinforcement that comprises the constrained and partially constrained (3 types) conditions were conducted. And the result indicated that the modulus of subgrade reaction or $N_c$ value (5.3) apparently overestimated the bearing capacity of very soft ground such as dredged ground. Moreover, as a result of model test by partially constraining the preload of 23.0kgf using geotextile, the effect of bearing capacity($q_1$) appeared to be the largest till the loading stress was $0.4tf/m^2$ due to cohesion, while it reached 75% of the maximum bearing force after $0.4tf/m^2$ due to increase in the effect of bearing capacity($q_2$) caused by the tensile force of the reinforcement. Such results tended to have appeared constantly or very similarly with each other, irrespective of the type of reinforcement (geogrid, steel bar) and constraint conditions.

• 한국도로학회논문집
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• 제16권2호
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• pp.25-34
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• 2014

PURPOSES : This paper numerically evaluates the contribution of transverse steel to the structural behavior of continuously reinforced concrete pavements to understand the role of transverse steel. METHODS : Two-lane continuously reinforced concrete pavements with and without transverse steel were analyzed through finite element analysis with the aid of commercial finite element analysis program DIANA; the difference in their structural behavior such as deflection, joint opening, and stress distribution was then evaluated. Twenty-node brick elements and three-node beam elements were used to model concrete and steel, respectively. Sub-layers were modeled with horizontal and vertical tensionless spring elements. The interactions between steel and surrounding concrete were considered by connecting their nodes with three orthogonal spring elements. Both wheel loading and environmental loading in addition to self-weight were considered. RESULTS : The use of transverse steel in continuously reinforced concrete pavements does not have significant effects on the structural behavior. The surface deflections change very little with the use of transverse steel. The joint opening decreases when transverse steel is used but the reduction is quite small. The transverse concrete stress, rather, increases when transverse steel is used due to the restraint exerted by the steel but the increase is quite small as well. CONCLUSIONS : The main role of transverse steel in continuously reinforced concrete pavements is supporting longitudinal steel and/or controlling unexpected longitudinal cracks rather than enhancing the structural capacity.

• 생명과학회지
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• 제32권8호
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• pp.601-610
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• 2022

동애등에는 파리목(Diptera) 동애등에과(Stratiomyidae)에 속한다. 최근에 곤충 산업은 식품, 동물사료 및 환경개선 이점으로 주목받고 있다. 가바 및 멜라토닌은 수면 및 우울증 조절에 관여하며, 가바는 억제성 신경전달물질이며, 유산균에 의해 MSG가 가바로 생체전환되어 합성된다. 본 연구에서는 MSG를 동애등에에 급여하여 가바 생성이 증가된 동애등에 추출물을 사용하였다. 스트레스 및 불면증에 대한 작용은 코르티코스테론에 의해 유도된 ER 스트레스 및 만성 구속 스트레스(CRS)에 노출된 마우스 모델과 마우스에 펜토바르비탈(45 mg/kg)-유도 수면개선에 미치는 메커니즘에 대해 조사하여 확인하였다. 본 연구에서 MSG를 급여하지 않은 동애등에 추출물과 MSG를 급여한 동애등에 추출물을 HPLC-ELSD기기분석을 통해 GABA 피크를 확인한 결과, MSG를 급여한 동애등에 추출물에서만 GABA 피크가 나타남을 확인하였다. 또한, MSG를 급여한 동애등에 물 추출물 및 동애등에 70% 에탄올 추출물이 CORT에 의해 유도된 인산화된 ERK1/2 및 CREB의 하향 조절에 대해 보호함으로써 신경세포 보호 효과가 있을 확인하였다. 동애등에 물 추출물(300 mg/kg)은 CRS-노출된 마우스에서 혈청 코르티코스테론 수치를 유의적으로 감소시켰다. 더 나아가, 동애등에 물 추출물(100 및 300 mg/kg)는 혈청 멜라토닌 증가에 관여하여 펜토바르비탈(45 mg/kg)로 유도된 수면 행동에서 입면시간 감소 및 총 수면 시간을 증가시켰다. 결론적으로, 동애등에 물 추출물은 혈청 코르티코스테론 및 멜라토닌 수치를 조절함으로써 항스트레스 및 수면 향상 효과가 있는 것으로 사료된다.